Article
Multidisciplinary Sciences
Yida Huang, Shaoqian Du, Jun Liu, Weiyi Huang, Wanshan Liu, Mengji Zhang, Ning Li, Ruimin Wang, Jiao Wu, Wei Chen, Mengyi Jiang, Tianhao Zhou, Jing Cao, Jing Yang, Lin Huang, An Gu, Jingyang Niu, Yuan Cao, Wei-Xing Zong, Xin Wang, Kun Qian, Hongxia Wang
Summary: High-performance metabolic analysis using fast nanoparticle-enhanced laser desorption/ionization mass spectrometry (NPELDI-MS) was used to record serum metabolic fingerprints (SMFs) of breast cancer patients. The SMFs were used for machine learning to distinguish breast cancer from non-breast cancer, and also for constructing a metabolic prognosis scoring system. Additionally, a panel of differentially enriched metabolites and related pathways in breast cancer serum were identified.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Yujin Lee, Jie Ni, Julia Beretov, Valerie C. C. Wasinger, Peter Graham, Yong Li
Summary: Current clinical tools for breast cancer diagnosis are limited, but liquid biopsy has emerged as a minimally invasive strategy for real-time monitoring of tumor biomarkers. Extracellular vesicles (EVs) play a crucial role in tumor development and metastasis. Small EVs (sEVs) are being investigated as a potential source of novel biomarkers for breast cancer using advanced proteomics and sequencing technologies. This review highlights recent advancements in sEV isolation and analysis and summarizes the identified sEV biomarkers for breast cancer diagnosis, prognosis, and chemoresistance.
Review
Medicine, Research & Experimental
Nirali Shukla, Ankit Naik, Kamlesh Moryani, Molisha Soni, Jigna Shah, Heena Dave
Summary: This review focuses on the signaling pathways and biological activities of the TGF-beta family in breast cancer pathogenesis and highlights its potential as a biomarker and drug target. It is beneficial for early detection, disease monitoring, and treatment selection in breast cancer.
Article
Oncology
Tayyaba Zia, Liu Bangfan, Amun Nadeem, Abid Hussain, Mostafa A. Abdel-Maksoud, Adel M. Zakri, Muhammad Kazim Bashir, Mubarak Ali, Norina Jabeen, Muhammad Jamil, Wahidah H. Al-Qahtani, Taghreed N. Almanaa
Summary: This study aimed to identify, validate, and characterize key biomarkers with significant implications in the diagnosis, prognosis, and treatment of breast cancer. Through a combination of bioinformatic analysis and experimental validation, four key biomarkers (PGR, EGFR, ESR1, and ERBB2) were identified as having diagnostic, prognostic, and therapeutic relevance in breast cancer.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Medicine, General & Internal
Sul-Hee Lee, Youin Bae, Young-Lip Park
Summary: This study found a negative correlation between serum adiponectin levels and disease severity and pruritus in AD patients. However, no significant effects were observed with biologic treatment for AD. Therefore, adiponectin may serve as a potential biomarker for severity assessment in AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Chuanxu Luo, Shuang Zhao, Cheng Peng, Chengshi Wang, Kejia Hu, Xiaorong Zhong, Ting Luo, Juan Huang, Donghao Lu
Summary: The study identified 15 mammographic radiomics features associated with breast cancer iDFS in the craniocaudal view but none in the mediolateral oblique view. Two lead features, S(1,-1)SumAverg and WavEnLL_s-6, were found to be associated with favorable and poor iDFS, respectively. These features were linked to eight pathways primarily involving cell cycle regulation in tumor tissues.
BRITISH JOURNAL OF CANCER
(2022)
Article
Nutrition & Dietetics
Mohd Razif Shahril, Nor Syamimi Zakarai, Geeta Appannah, Ali Nurnazahiah, Hamid Jan Jan Mohamed, Aryati Ahmad, Pei Lin Lua, Michael Fenech
Summary: The study found that a dietary pattern characterized by high energy density, high saturated fat, and low fiber was associated with reduced high-molecular weight adiponectin concentration among breast cancer survivors, but not with leptin concentration. This suggests that an unhealthy dietary pattern may have negative effects on the health of breast cancer survivors.
Article
Oncology
Xuyong Wei, Renyi Su, Mengfan Yang, Binhua Pan, Jun Lu, Hanchao Lin, Wenzhi Shu, Rui Wang, Xiao Xu
Summary: This study explores proteomic profiling in hepatocellular carcinoma (HCC) samples based on alpha-fetoprotein (AFP) subgroups and identifies potential key targets involved in HCC progression. The results reveal four key prognostic biomarkers in HCC and provide opportunities for translational medicine and new treatment.
TRANSLATIONAL ONCOLOGY
(2022)
Review
Oncology
Nelson Rangel, Victoria E. Villegas, Milena Rondon-Lagos
Summary: Obesity is a growing health challenge and is recognized as a risk factor for breast cancer. While the exact mechanisms linking obesity to breast cancer are not fully understood, this association has been linked to impaired hormone secretion by dysfunctional adipose tissue. Altered secretion of androgens and adipokines are independently associated with breast cancer development, highlighting the potential for crosstalk between these factors and the androgen receptor signaling in cancer cells. Understanding these interactions is crucial for guiding the development of new therapeutic approaches aimed at preventing and treating obesity and breast cancer.
Article
Oncology
Xuan Zou, Tiansong Xia, Minghui Li, Tongshan Wang, Ping Liu, Xin Zhou, Zebo Huang, Wei Zhu
Summary: A signature of 12 serum miRNAs was identified in this study, showing potential for non-invasive diagnosis of BC.
Review
Biochemistry & Molecular Biology
Rawan Nehme, Mona Diab-Assaf, Caroline Decombat, Laetitia Delort, Florence Caldefie-Chezet
Summary: Obesity and breast cancer are serious threats to human health. There is strong evidence that overweight and obesity increase the risk of postmenopausal breast cancer. Adiponectin, produced by white adipose tissue, is considered a key factor in the obesity-cancer relationship and may prevent and protect individuals from developing breast cancer.
Article
Medicine, General & Internal
Mengxing Luo, Xin Zou, Qibing Zeng, Yaxing Wu, Hua Yang, Lianhua Qin, Ruijuan Zheng, Fangyou Yu, Yang Hu, Zhonghua Liu
Summary: This study found that elevated monocyte levels are associated with poor prognosis and poor pulmonary cavity closure in tuberculosis patients. Monocytes may serve as a simple and inexpensive prognostic biomarker in tuberculosis with anemia.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Paula Lucia Farre, Rocio Belen Duca, Cintia Massillo, Guillermo Nicolas Dalton, Karen Daniela Grana, Kevin Gardner, Ezequiel Lacunza, Adriana De Siervi
Summary: Breast cancer is the leading cause of death by cancer in women globally. A miRNA signature deregulated in preclinical and clinical BCa models was identified for potential biomarker discovery, useful for BCa diagnosis and/or prognosis. Certain miRNAs were up-regulated and down-regulated in BCa, showing negative correlation with the expression of related genes. Genes such as GAB1, GNG12, HBP1, and SESN1 have been found to have expression levels related to patient survival in aggressive BCa subtypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Daniel Martin Klotz, Theresa Link, Pauline Wimberger, Jan Dominik Kuhlmann
Summary: The study investigated the clinical relevance of circulating HGF in serum of ovarian cancer patients. Elevated levels of sHGF were found to be an independent predictor for shorter overall survival, proposing sHGF as an independent prognostic biomarker for ovarian cancer. Furthermore, sHGF could be implemented into clinical diagnostics as a CA125 auxiliary tumor marker for individualized prognosis stratification and therapy monitoring.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shasha Tang, Wenjing Liu, Liyun Yong, Dongyang Liu, Xiaoyan Lin, Yuan Huang, Hui Wang, Fengfeng Cai
Summary: KRT17 expression is closely associated with prognosis in breast cancer, especially in patients with high HER2 expression. KRT17 may be involved in multiple immune pathways and associated with various immune cells. This finding provides a promising biomarker for the diagnosis and prognosis of breast cancer.
Article
Substance Abuse
Jae Jeong Yang, Danxia Yu, Xiao-Ou Shu, Neal D. Freedman, Wanqing Wen, Shafiur Rahman, Sarah K. Abe, Eiko Saito, Prakash C. Gupta, Jiang He, Shoichiro Tsugane, Yu-Tang Gao, Yong-Bing Xiang, Jian-Min Yuan, Yasutake Tomata, Ichiro Tsuji, Yumi Sugawara, Keitaro Matsuo, Yoon-Ok Ahn, Sue K. Park, Yu Chen, Wen-Harn Pan, Mangesh Pednekar, Dongfeng Gu, Norie Sawada, Hui Cai, Hong-Lan Li, Woon-Puay Koh, Renwei Wang, Shu Zhang, Seiki Kanemura, Hidemi Ito, Myung-Hee Shin, Pei-Ei Wu, Keun-Young Yoo, Habibul Ahsan, Kee Seng Chia, Paolo Boffetta, Manami Inoue, Daehee Kang, John D. Potter, Wei Zheng
Summary: Our study found that low-intensity smoking and later initiation of smoking in Asians are associated with increased all-cause mortality, cardiovascular disease, and respiratory disease mortality, as well as a higher risk of lung cancer mortality. However, quitting smoking can reduce these risks.
Article
Oncology
Mihong Choi, Jiyeon Han, Bo Ram Yang, Myoung-jin Jang, Miso Kim, Dae-Won Lee, Tae-Yong Kim, Seock-Ah Im, Han-Byoel Lee, Hyeong-Gon Moon, Wonshik Han, Dong-Young Noh, Kyung-Hun Lee
Summary: Insulin or statin use prior to breast cancer diagnosis is associated with increased all-cause mortality. Subsequent analysis suggests metformin or statin use may be protective in patients with ER-negative disease, warranting further studies.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Andre Pfob, Chris Sidey-Gibbons, Han-Byoel Lee, Marios Konstantinos Tasoulis, Vivian Koelbel, Michael Golatta, Gaiane M. Rauch, Benjamin D. Smith, Vicente Valero, Wonshik Han, Fiona MacNeill, Walter Paul Weber, Geraldine Rauch, Henry M. Kuerer, Joerg Heil
Summary: The study developed and tested multivariate algorithms to accurately identify breast cancer patients without residual cancer after neoadjuvant treatment. The neural network showed the best performance with a specificity ranging from 65.2% to 67.2% in both test and external validation datasets.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Seol Hwa Jo, Woo Hang Heo, Hye-Youn Son, Mingji Quan, Bok Sil Hong, Ju Hee Kim, Han-Byoel Lee, Wonshik Han, Yeonju Park, Dong-Sup Lee, Nam Hoon Kwon, Min Chul Park, Jeesoo Chae, Jong-Il Kim, Dong-Young Noh, Hyeong-Gon Moon
Summary: The direct co-culture of breast cancer cells with non-tumorigenic mammary epithelial cells leads to substantial changes in the molecular and functional characteristics of the mammary epithelial cells, with enhanced proliferation, migration, colony formation, and sphere formation capabilities. Dysregulation of cancer-related pathways is observed, along with upregulation of S100A8 and S100A9, suggesting a potential transition program mediated by these proteins in non-tumorigenic epithelial cells.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Young-Il Hahn, Soma Saeidi, Su-Jung Kim, Se-Young Park, Na-Young Song, Jie Zheng, Do-Hee Kim, Han-Byoel Lee, Wonshik Han, Dong-Young Noh, Hye-Kyung Na, Young-Joon Surh
Summary: STAT3 and NF-kappa B are critical transcription factors in inflammation-associated tumorigenesis, working together at multiple levels. Breast carcinomas have a significant dependency on both classical and non-classical NF-kappa B pathways. STAT3 stabilizes and activates IKK alpha, leading to NF-kappa B activation and promoting breast cancer growth and progression.
Article
Oncology
Dong-Yun Kim, Eonju Park, Chan Yeong Heo, Ung Sik Jin, Eun Kyu Kim, Wonshik Han, Kyung Hwan Shin, In Ah Kim
Summary: The study found that there was no significant difference in breast-related complications between hypofractionated and conventional fractionated adjuvant radiotherapy in reconstructed breast cancer patients. Hypofractionated radiotherapy showed a significant advantage in reducing major contracture compared to conventional radiotherapy.
Article
Oncology
Su-Jung Kim, Soma Saeidi, Nam-Chul Cho, Seung Hyeon Kim, Han-Byoel Lee, Wonshik Han, Dong-Young Noh, Young-Joon Surh
Summary: Persistent activation of STAT3 and Nrf2 in basal-like breast cancer is shown to stimulate aggressive behavior, with their interaction accelerating BLBC growth through increased IL-23A expression.
Article
Oncology
Sungmin Park, Joon Jeong, Wonshik Han, Young Joo Lee, Hyun-Ah Kim, Seokwon Lee, Kyung Do Byun, Young Jin Choi, Jiyoung Kim, Soo Youn Bae
Summary: The study compared the prognoses of breast cancer patients who underwent mastectomy with immediate breast reconstruction (IBR) after neoadjuvant chemotherapy with those who only underwent mastectomy. The results showed that there was no significant difference in prognosis between the two groups in general, but patients in the mastectomy with IBR group had slightly better outcomes compared to those in the mastectomy group in clinical stage II patients. Individualized surgical decisions should be made based on patient-specific factors.
Article
Cell Biology
Eun-Hee Kim, Su-Jung Kim, Hye-Kyung Na, Wonshik Han, Nam-Jung Kim, Young-Ger Suh, Young-Joon Surh
Summary: The study found that 15d-PGJ2 activates VEGF expression through NRF2-driven induction of HO-1 in human breast cancer cells, suggesting a novel oncogenic mechanism. Elevated levels of 15d-PGJ2 during the inflammatory response were linked to poor clinical outcomes in breast cancer patients. Levels of 15d-PGJ2, COX-2, NRF2, and HO-1 were found to be increased in human breast cancer tissues.
Article
Gastroenterology & Hepatology
Doo-Ho Lee, Woongchang Yoon, Areum Lee, Youngmin Han, Yoonhyeong Byun, Jae Seung Kang, Hongbeom Kim, Wooil Kwon, Young-Ah Suh, Yonghwan Choi, Junghyun Namkung, Sangjo Han, Sung Gon Yi, Jin Seok Heo, In Woong Han, Joon Oh Park, Joo Kyung Park, Song Cheol Kim, Eunsung Jun, Chang Moo Kang, Woo Jin Lee, Hyeon Kook Lee, Huisong Lee, Seungyeoun Lee, Seung-Yong Jeong, Kyu Eun Lee, Wonshik Han, Taesung Park, Jin-Young Jang
Summary: This study developed a prediction model using a multi-marker panel as a diagnostic screening tool for pancreatic ductal adenocarcinoma and demonstrated its significant diagnostic performance in distinguishing pancreatic ductal adenocarcinoma from normal and benign pancreatic disease states, as well as patients with other cancers.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Multidisciplinary Sciences
Joo Heung Kim, Sunggyun Park, Hyung Seok Park, Ji Soo Park, Seung-Tae Lee, Sung-Won Kim, Jong Won Lee, Min Hyuk Lee, Sue K. Park, Woo-Chul Noh, Doo Ho Choi, Wonshik Han, Sung Hoo Jung
Summary: Genetic testing for BRCA1 and BRCA2 is crucial in diagnosing hereditary breast and ovarian cancer syndromes, but VUS results pose challenges to clinicians. A study of 676 breast cancer patients in Korea found numerous VUS on BRCA mutation tests, some of which were reclassified in the ClinVar database. Utilizing updated ClinVar information and calculating odds ratios can aid in the reclassification of VUSs in BRCA1/2.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
JooYong Park, Ji-Yeob Choi, Jaesung Choi, Seokang Chung, Nan Song, Sue K. Park, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Jong Won Lee, Mi Kyung Kim, Sun Ha Jee, Wanqing Wen, Manjeet K. Bolla, Qin Wang, Joe Dennis, Kyriaki Michailidou, Mitul Shah, Don M. Conroy, Patricia A. Harrington, Rebecca Mayes, Kamila Czene, Per Hall, Lauren R. Teras, Alpa V. Patel, Fergus J. Couch, Janet E. Olson, Elinor J. Sawyer, Rebecca Roylance, Stig E. Bojesen, Henrik Flyger, Diether Lambrechts, Adinda Baten, Keitaro Matsuo, Hidemi Ito, Pascal Guenel, Therese Truong, Renske Keeman, Marjanka K. Schmidt, Anna H. Wu, Chiu-Chen Tseng, Angela Cox, Simon S. Cross, Irene L. Andrulis, John L. Hopper, Melissa C. Southey, Pei-Ei Wu, Chen-Yang Shen, Peter A. Fasching, Arif B. Ekici, Kenneth Muir, Artitaya Lophatananon, Hermann Brenner, Volker Arndt, Michael E. Jones, Anthony J. Swerdlow, Reiner Hoppe, Yon-Dschun Ko, Mikael Hartman, Jingmei Li, Arto Mannermaa, Jaana M. Hartikainen, Javier Benitez, Anna Gonzalez-Neira, Christopher A. Haiman, Thilo Doerk, Natalia V. Bogdanova, Soo Hwang Teo, Nur Aishah Mohd Taib, Olivia Fletcher, Nichola Johnson, Mervi Grip, Robert Winqvist, Carl Blomqvist, Heli Nevanlinna, Annika Lindblom, Camilla Wendt, Vessela N. Kristensen, Rob A. E. M. Tollenaar, Bernadette A. M. Heemskerk-Gerritsen, Paolo Radice, Bernardo Bonanni, Ute Hamann, Mehdi Manoochehri, James V. Lacey, Maria Elena Martinez, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Keun-Young Yoo, Daehee Kang
Summary: The study focused on gene-environment interactions related to estrogen exposure or metabolism in Korean women, finding two interactions that were not replicated in a larger European and Asian population. This highlights the specificity of breast cancer risk in Koreans.
Article
Oncology
Sung Gwe Ahn, Seok Jin Nam, Sei Hyun Ahn, Yongsik Jung, Heung Kyu Park, Soo Jung Lee, Sung Soo Kang, Wonshik Han, Kyong Hwa Park, Yong Lai Park, Jihyoun Lee, Hyun Jo Youn, Jun Hyun Kim, Youngbum Yoo, Jeong Yoon Song, Byung Kyun Ko, Geumhee Gwak, Min Sung Chung, Sung Yong Kim, Seo Heon Cho, Doyil Kim, Myung Chul Chang, Byung In Moon, Lee Su Kim, Sei Joong Kim, Min Ho Park, Tae Hyun Kim, Jihyoung Cho, Cheol Wan Lim, Young Tae Bae, Gyungyub Gong, Young Kyung Bae, Ahwon Lee, Joon Jeong
Summary: Adjuvant letrozole treatment demonstrates favorable efficacy and tolerability in patients with breast cancer, independent of ER expression levels.
JOURNAL OF BREAST CANCER
(2021)
Article
Education, Scientific Disciplines
Ji Han Lee, Yong Jin Kim, Sung Woo Kim, Hoon Kim, Wonshik Han, Seung-Yup Ku
Summary: This retrospective study reviewed records of 164 women who underwent breast cancer surgery, finding that bone mineral density (BMD) in L1-4, femur neck, and femur total was significantly lower at follow-up than at initial visit. The change in BMD was positively correlated with age and endometrial thickness (EMT) change, suggesting that EMT could be an alternative screening marker for BMD decrease in breast cancer survivors during follow-up.
Article
Oncology
Hong-Kyu Kim, Young Wook Ju, Jun Woo Lee, Kyoung-Eun Kim, Jigwang Jung, Yumi Kim, Han-Byoel Lee, Hyeong-Gon Moon, Dong-Young Noh, Kwan Sik Seo, Wonshik Han
Summary: This study evaluated the risk factors for lymphedema in breast cancer surgery and adjuvant treatments, and found that the number of retrieved sentinel lymph nodes was not associated with the incidence of lymphedema.
JOURNAL OF BREAST CANCER
(2021)
