Journal
CANCERS
Volume 13, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/cancers13102370
Keywords
breast cancer; estrogen; gene-environment interaction
Categories
Funding
- Seoul National University Hospital
- Seoul National University Hospital Research Fund [0320150110 (2015-1126)]
- Cancer Research UK [C1287/A16563, C1287/A10118, C1287/A10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565, C490/A10124, C490/A16561]
- European Union [634935, 633784]
- European Community [223175, HEALTH-F2-2009-223175]
- Cancer UK [C1287/A16563]
- Government of Canada through Genome Canada
- Canadian Institutes of Health Research [GPH-129344]
- Ministere de l'Economie, Science et Innovation du Quebec through Genome Quebec
- Quebec Breast Cancer Foundation
- European Community's Seventh Framework Programme [223175 (HEALTH-F2-2009-223175)]
- National Institutes of Health [CA128978]
- Department of Defence [W81XWH-10-1-0341]
- Canadian Institutes of Health Research (CIHR)
- Komen Foundation for the Cure
- Breast Cancer Research Foundation
- Ovarian Cancer Research Fund
- National Cancer Institute (USA) [UM1 CA164920]
- National Health and Medical Research Council of Australia
- New South Wales Cancer Council
- Victorian Health Promotion Foundation (Australia)
- Victorian Breast Cancer Research Consortium
- Dutch Cancer Society [RUL 1997-1505, NKI 2007-3839, 2009 4363]
- Breast Cancer Research Trust, UK
- NIHR Manchester Biomedical Research Centre
- Allan Turing Institute under the EPSRC [EP/N510129/1]
- ELAN-Fond of the University Hospital of Erlangen
- Fondation de France
- Institut National du Cancer (INCa)
- Ligue Nationale contre le Cancer
- Agence Nationale de la Recherche (ANR)
- Chief Physician Johan Boserup and Lise Boserup Fund
- Danish Medical Research Council
- Herlev and Gentofte Hospital
- Instituto de Salud Carlos III
- Red Tematica de Investigacion Cooperativa en Cancer
- Asociacion Espanola Contra el Cancer
- Fondo de Investigacion Sanitario [PI11/00923, PI12/00070]
- American Cancer Society
- National Cancer Institute of the National Institutes of Health [U01-CA199277, P30-CA033572, P30-CA023100, UM1-CA164917, R01CA077398]
- California Department of Public Health [103885]
- Centers for Disease Control and Prevention's National Program of Cancer Registries [5NU58DP006344]
- National Cancer Institute's Surveillance, Epidemiology and End Results Program [HHSN261201800032I, HHSN261201800015I, HHSN261201800009I]
- Baden Wurttemberg Ministry of Science, Research and Arts
- Robert Bosch Foundation, Stuttgart
- Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany
- Breast Cancer Now
- CRUK
- Helsinki University Hospital Research Fund
- Finnish Cancer Society
- Sigrid Juselius Foundation
- MEXT Kakenhi from the Ministry of Education, Science, Sports, Culture and Technology of Japan [170150181, 26253041]
- Ministry Health, Labour, and Welfare of Japan
- Ministry Health of Labour and Welfare of Japan
- National Cancer Center Research and Development Fund
- Japan Agency for Medical Research and development, AMED [15ck0106177h0001, 20ck0106553]
- Cancer Bio Bank Aichi
- German Research Foundation [Do 761/10-1]
- Biomedical Research Centre at Guy's and St Thomas' N.H.S. Foundation Trust and King's College London
- Stockholm County Council
- Karolinska Institutet
- Swedish Cancer Society
- Gustav V Jubilee foundation
- Bert von Kantzows foundation
- Marit and Hans Rausings Initiative Against Breast Cancer
- special Government Funding (VTR) of Kuopio University Hospital grants
- Cancer Fund of North Savo
- Finnish Cancer Organizations
- University of Eastern Finland
- National Breast Cancer Foundation
- Queensland Cancer Fund
- Cancer Council of South Australia
- Cancer Foundation of Western Australia
- United States Army Medical Research and Materiel Command [DAMD17-01-1-0729]
- Cancer Council New South Wales
- Cancer Council South Australia
- Cancer Foundation ofWestern Australia
- Cancer Council Tasmania
- National Health and Medical Research Council of Australia (NHMRC) [400413, 400281, 199600]
- NHMRC
- Cancer Australia
- National Institute of Health (USA)
- California Breast Cancer Research Program [1RB-0287, 3PB-0102, 5PB-0018, 10PB-0098]
- California Department of Health
- National Cancer Institute's Division of Cancer Prevention and Control Surveillance, Epidemiology, and End Results Program [N01CN25403]
- Stichting tegen Kanker
- FWO
- Deutsche Krebshilfe e.V. [70-2892-BR I, 106332, 108253, 108419, 110826, 110828]
- Hamburg Cancer Society
- German Cancer Research Center (DKFZ)
- Federal Ministry of Education and Research (BMBF) Germany [01KH0402, 01KW9975/5, 01KW9976/8, 01KW9977/0, 01KW0114]
- Italian Association for Cancer Research (AIRC)
- NIH [R01CA64277, R01CA148667, UMCA182910, R37CA70867, U19 CA148065, R35CA253187, R01CA192393, R01CA116167, R01CA176785, CA63464, CA54281, CA098758, CA132839, CA164973, R01CA100374]
- NIH Specialized Program of Research Excellence (SPORE) in Breast Cancer [P50CA116201]
- VicHealth
- Australian National Health and Medical Research Council [209057, 396414, 1074383]
- Cancer Council Victoria
- Malaysian Ministry of Higher Education [RP046B-15HTM, UM.C/HlR/MOHE/06]
- Cancer Research Malaysia
- Yayasan Sime Darby LPGA Tournament
- K.G. Jebsen Centre for Breast Cancer Research
- Research Council of Norway [193387/V50, 193387/H10]
- Norwegian Cancer Society
- Finnish Cancer Foundation
- Academy of Finland [250083, 122715, 251314]
- University of Oulu
- University of Oulu Support Foundation
- special Governmental EVO funds for Oulu University Hospital-based research activities
- U.S. National Cancer Institute of the National Institutes of Health [U01CA164920, U01CA167551]
- Biobanking and Biomolecular Resources Research Infrastructure [BBMRI-NL CP16]
- Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services, USA
- Agency for Science, Technology and Research of Singapore (A*STAR.)
- U.S. National Institute of Health (NIH)
- Susan G. Komen Breast Cancer Foundation
- Genetic Associations and Mechanisms in Oncology (GAME-ON) Network [U19 CA148065]
- Sheffield Experimental Cancer Medicine Centre
- UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge
- BRL (Basic Research Laboratory) program through the National Research Foundation of Korea - Ministry of Education, Science and Technology [2012-0000347]
- National Research Foundation Singapore
- National University Cancer Institute Singapore (NCIS) Centre Grant
- Breast Cancer Prevention Programme
- Biomedical Research Council [05/1/21/19/425]
- Taiwan Biobank project of the Institute of Biomedical Sciences, Academia Sinica, Taiwan
- Institute of Cancer Research (ICR), London
- NHS
- Institute of Cancer Research
- Manchester NIHR Biomedical Research Centre [IS-BRC-1215-20007]
- Cancer Research UK
- Agence Nationale de Securite Sanitaire, de l'Alimentation, de l'Environnement et du Travail (ANSES)
- German Cancer Aid (Deutsche Krebshilfe)
- Deutsches Krebsforschungszentrum (DKFZ), Heidelberg
- Post-Cancer GWAS initiative (GAME-ON initiative) [1U19 CA148537, 1U19 CA148065, 1U19 CA148112]
- Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum
- Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London
- National Health and Medical Research Council (NHMRC)
- Cancer Council of New South Wales
- Cancer Council of Victoria
- Cancer Council of Tasmania
- South Eastern Norway Health Authority [39346]
- Breast Cancer Now Tissue Bank
- NUS
- Asian Breast Cancer Research Fund
- NMRC Clinician Scientist Award (SI Category)
- DF.Z
- [PSRSIIRI-701]
- [P30 CA68485]
- Grants-in-Aid for Scientific Research [26253041] Funding Source: KAKEN
Ask authors/readers for more resources
The study focused on gene-environment interactions related to estrogen exposure or metabolism in Korean women, finding two interactions that were not replicated in a larger European and Asian population. This highlights the specificity of breast cancer risk in Koreans.
Simple Summary Breast cancer is the most common cancer in females worldwide. To date, many gene-environment interaction (GxE) studies have been conducted to better understand how genetic factors combine with environmental factors to influence risk. However, previous studies have not found or found only a few interactions by using SNPs which were discovered from genome-wide association studies and have been conducted, for the most part, within European populations. In this study, we focused on estrogen-related lifestyle factors that have been identified for breast cancer, including several well-established reproductive factors that are mediated by hormonal mechanisms. We aimed to examine whether there are any gene and environmental factor interactions related to estrogen exposure or metabolism using a candidate approach in Korean women. We found two interactions in this study, although they were not replicated in the independent large consortium data. These findings suggest specificity in Koreans for breast cancer risk. In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE|2df model (p-2df = 1.2 x 10(-3)). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE|2df model (p-2df = 1.1 x 10(-4)). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available