Review
Immunology
Niraj Parihar, Lokesh Kumar Bhatt
Summary: The ubiquitin-proteasome pathway plays a crucial role in the development of autoimmune diseases, with DUBs regulating protein ubiquitination to influence immune responses.
INFLAMMOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Holly A. Byers, Amy N. Brooks, Janakiram R. Vangala, Jacqueline M. Grible, Alex Feygin, Charles V. Clevenger, J. Chuck Harrell, Senthil K. Radhakrishnan
Summary: Proteasome subunit transcript levels are elevated in all breast cancer subtypes, with triple-negative breast cancer showing the highest sensitivity to proteasome inhibition. Targeting NRF1 could enhance the efficacy of proteasome inhibitors in triple-negative breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Aixin Song, Zachary Hazlett, Dulith Abeykoon, Jeremy Dortch, Andrew Dillon, Justin Curtiss, Sarah Bollinger Martinez, Christopher P. Hill, Clinton Yu, Lan Huang, David Fushman, Robert E. Cohen, Tingting Yao
Summary: UCH37, also known as UCHL5, is a highly conserved deubiquitinating enzyme that associates with the 26S proteasome and is activated by contacts with hydrophobic patches of distal Ub molecules in branched Ub chains. RPN13 further enhances branched-chain specificity by restricting linear Ub chains from accessing the UCH37 active site. In cultured human cells, UCH37 promotes substrate clearance by binding and deubiquitinating branched polyubiquitin.
Review
Biochemistry & Molecular Biology
Xiang Chen, Zaw Min Htet, Erika Lopez-Alfonzo, Andreas Martin, Kylie J. Walters
Summary: The 26S proteasome is responsible for regulated proteolysis in eukaryotic cells, with substrates targeted to it through post-translational modification with ubiquitin. Deubiquitinating enzymes (DUBs) play a crucial role in catalyzing ubiquitin chain hydrolysis, coupling deubiquitination to substrate unfolding and degradation. This intricate machinery of proteasomes and ubiquitin-modified substrates remains an active area of investigation, with potential for therapeutic targeting.
Article
Biochemistry & Molecular Biology
Yan Jia, Jianing Zhao, Tao Yu, Xue Zhang, Xiaozhen Qi, Tongxin Hao, Zeyuan Jin, Xiaoqing Zhao
Summary: PSMC3 is identified as a novel AGO2 binding partner and its role in regulating AGO2 stability is revealed. Depletion of PSMC3 decreases AGO2 protein amount and promotes AGO2 ubiquitination degradation, thus affecting the activity of RNAi.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Hae-Seul Choi, Eun-Su Lim, Kwang-Hyun Baek
Summary: The study identified the deubiquitinating enzyme USP12 as being associated with Bax and showed that USP12 regulates Bax by detaching ubiquitin on K63-linked chains. The site-directed mutagenesis of putative ubiquitination sites on Bax confirmed the half-life of the protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Wonhee Han, Youngmu Koo, Leila Chaieb, Byeong-Rak Keum, Jin-Kwan Han
Summary: This study identifies UCHL5 as a negative regulator of Wnt signaling and reveals its important role in the regulation of Axin1 protein. The study shows that UCHL5 is required for both the stabilization and the polymerization of Axin1 proteins.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Anmol Sharma, Heena Khan, Thakur Gurjeet Singh, Amarjot Kaur Grewal, Agnieszka Najda, Malgorzata Kawecka-Radomska, Mohamed Kamel, Ahmed E. Altyar, Mohamed M. Abdel-Daim
Summary: The ubiquitin-proteasome pathway is crucial in regulating various biological functions and plays a significant role in tumor development. Inhibiting specific enzymes within this pathway can be an effective treatment for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sang -Soo Park, Hyeon-Ah Do, Hong-Beom Park, Hae-Seul Choi, Kwang-Hyun Baek
Summary: a-synuclein, a protein involved in neurodegenerative diseases like Parkinson's disease and Lewy body dementia, is regulated by the ubiquitin-proteasome system (UPS). In this study, researchers found that the deubiquitinating enzyme YOD1 interacts with a-synuclein and removes multiple types of ubiquitin chains from it. YOD1 also destabilizes a-synuclein by upregulating the E3 ligase NEDD4. These findings suggest that YOD1 may be a new regulator in the NEDD4-a-synuclein pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Oncology
Yuming Lou, Minfeng Ye, Chaoyang Xu, Feng Tao
Summary: This article provides an overview of the research progress on USP44, including its physiological roles in various biological processes and its pathophysiological roles in different cancer types. The article evaluates the therapeutic potential of USP44 for cancer treatment.
Review
Biochemistry & Molecular Biology
Seonghyeon Moon, Srinivasan Muniyappan, Sung-Bae Lee, Byung-Hoon Lee
Summary: The 26S proteasome is a key enzyme for intracellular protein degradation, and recent studies have revealed its dynamic conformational states and substrate binding modes. Deubiquitinases play crucial roles in substrate degradation by customizing degradation events based on proteasome conformation and processing steps.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Xiaolong Li, Ge Yang, Wenyao Zhang, Biying Qin, Zifan Ye, Huijing Shi, Xinmeng Zhao, Yihang Chen, Bowei Song, Ziqing Mei, Qi Zhao, Feng Wang
Summary: This article provides an overview of the recent advances in the structure and function of USP13, its relationship with diseases, and the discovery and development of inhibitors. These studies contribute to a better understanding of the molecular mechanisms of USP13 and facilitate the development of more potent inhibitors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Shilong Zhang, Yi Guo, Shenjie Zhang, Zhi Wang, Yewei Zhang, Shi Zuo
Summary: The ubiquitin-proteasome system is a crucial degradation pathway in vivo, and deubiquitylases play a pivotal role in regulating the degradation of ubiquitinated proteins. This review focuses on ubiquitin-specific protease 2 (USP2) and its involvement in malignant tumors, highlighting its molecular mechanisms and potential therapeutic applications. USP2 reverses ubiquitin-mediated protein degradation and contributes to various processes in tumor development, including proliferation, migration, invasion, apoptosis, and drug resistance. Moreover, USP2 has been explored as a therapeutic target for several malignancies, and the current state of pharmacological research on USP2 is discussed.
Article
Computer Science, Artificial Intelligence
Peizhen Bai, Filip Miljkovic, Bino John, Haiping Lu
Summary: DrugBAN is a deep bilinear attention network framework that explicitly learns the local interactions between drugs and targets, and adapts to out-of-distribution data. It achieves the best performance on three benchmark datasets compared to five state-of-the-art baseline models. The visualized bilinear attention map provides interpretable insights from prediction results.
NATURE MACHINE INTELLIGENCE
(2023)
Article
Cell Biology
Jianing Tang, Yongwen Luo, Guo Long, Ledu Zhou
Summary: This study identified MINDY1 as a potential deubiquitylase of ERα in breast cancer, showing a positive correlation between high MINDY1 expression and poor prognosis. By interacting with ERα, MINDY1 mediates the deubiquitination of ERα to increase its stability, inhibiting the ubiquitination process on ERα protein. Targeting MINDY1 may be a promising strategy for patients with ERα-positive breast cancer.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Yu-Shui Ma, Xiao-Li Yang, Rui Xin, Ji-Bin Liu, Da Fu
Summary: Exosomes, derived from the nuclear endosome and plasma membrane, are effective carriers of intercellular signals, efficiently transferring proteins, lipids, and nucleic acids between cells. They have stable biological characteristics, diverse contents, non-invasive signaling molecule introduction pathways, and rapid detection capabilities, making them promising clinical diagnostic markers for various pathological conditions.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Medicine, Research & Experimental
Chunxiao Miao, Wanli Zhang, Lixing Feng, Xiaofan Gu, Qiang Shen, Shanshan Lu, Meng Fan, Yiwei Li, Xianling Guo, Yushui Ma, Xuan Liu, Hui Wang, Xiongwen Zhang
Summary: Cancer cachexia is a metabolic disorder syndrome with severe muscle wasting, and clinical samples show a correlation between serum exosome concentrations and its development. Exosomes enriched with miRNAs might induce muscle atrophy by targeting Bcl-2-mediated apoptosis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Oncology
Dan-Dan Zhang, Wen-Er Wang, Yu-Shui Ma, Yi Shi, Jie Yin, Ji-Bin Liu, Xiao-Li Yang, Rui Xin, Da Fu, Wen Jie Zhang
Summary: The study identified the miR-212-3p/SLC6A1 axis as a potential crucial therapeutic target for HCC. Analysis of gene expression and protein levels confirmed the down-regulated expression of SLC6A1 in HCC tissues, as well as the negative correlation between SLC6A1 expression and DNA methylation.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Wen Li, Ji-Bin Liu, Li-Kun Hou, Fei Yu, Jie Zhang, Wei Wu, Xiao-Mei Tang, Feng Sun, Hai-Min Lu, Jing Deng, Jie Bai, Juan Li, Chun-Yan Wu, Qin-Lu Lin, Zhong-Wei Lv, Gao-Ren Wang, Geng-Xi Jiang, Yu-Shui Ma, Da Fu
Summary: Primary lung cancer is a common malignant tumor in China, and liquid biopsy technology plays a crucial role in early diagnosis and individualized treatment. Liquid biopsy, with advantages of being nontraumatic, easy to obtain, and allowing real-time monitoring of the overall state of the tumor, has been widely researched and applied.
Article
Cell Biology
Mingxi Jia, Yi Shi, Yang Xie, Wen Li, Jing Deng, Da Fu, Jie Bai, Yushui Ma, Zavuga Zuberi, Juan Li, Zheng Li
Summary: Lung adenocarcinoma (LUAD) is a common malignancy, and effective biomarkers for early detection and prognostic prediction are still lacking. In this study, RNA sequencing data of LUAD samples were comprehensively analyzed, and differentially expressed long non-coding RNAs, microRNAs, and mRNAs associated with c-Myc were identified. The WT1-AS/IGF2BP2 axis was found to be a potential prognostic biomarker in LUAD. The results of reverse transcription-polymerase chain reaction and Western blotting validated the bioinformatics analysis.
Review
Multidisciplinary Sciences
Ning Guo, Ji-Bin Liu, Wen Li, Yu-Shui Ma, Da Fu
Summary: CRISPR/Cas9, derived from the microbial innate immune system, is a powerful gene editing tool that has been widely applied in treating various genetic and non-genetic diseases, including cancer. With its high specificity and efficiency, this technology offers new possibilities for disease treatment through gene therapy and immune therapy.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Oncology
Rui Xin, Xiao-Mei Tang, Ying-Jie Jiang, Fei Yu, Sha Li, Cheng-You Jia, Gao-Ren Wang, Da Fu, Ji-Bin Liu, Yu-Shui Ma
Summary: This study identified a novel MYC-associated ceRNA regulatory network in CRC and identified potential prognostic markers for COAD.
JOURNAL OF ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Rui Xin, Biao Shen, Zhong-Yan Huang, Ji-Bin Liu, Sha Li, Geng-Xi Jiang, Jie Zhang, Ya-Hong Cao, Da-Zhi Zou, Wen Li, Chun-Guang Li, Yu-Shui Ma, Da Fu
Summary: Resveratrol has multiple functions, including protecting the heart and nervous system and exerting antidiabetic, anti-inflammatory, anti-aging, and antitumor effects. It has been found to impede the occurrence and development of tumors in various cancer types through inducing tumor cell apoptosis, inhibiting cell cycle and angiogenesis, and altering tumor-related expression patterns. However, the exact mechanism underlying its action remains unclear.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Oncology
Rui Xin, Biao Shen, Ying-Jie Jiang, Ji-Bin Liu, Sha Li, Li-Kun Hou, Wei Wu, Cheng-You Jia, Chun-Yan Wu, Da Fu, Yu-Shui Ma, Geng-Xi Jiang
Summary: A PTEN-related ceRNA regulatory network was discovered, and potential prognostic markers associated with LUAD were identified. The LINC00460/miR-150-3p axis was found to be a clinical prognostic factor, and the predicted target genes were closely related to overall survival and prognosis. This study provides a new direction and theoretical basis for targeted therapy of LUAD.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Xue-Chen Yu, Ji-Bin Liu, Qing-Hai Tang, Xun Diao, Qi-Yu Fan, Zhong-Yan Huang, Xiao-Mei Tang, Sha Li, Yong-Feng Cao, Yu-Shui Ma, Da Fu
Summary: The incidence of stage I liver cancer has increased over the study period, with an increase in age of diagnosis, decrease in tumor size, and generally stable overall survival rate with slight decrease. These trends emphasize the importance of early detection, regular screening, and better treatment for high-risk populations.
ANNALS OF MEDICINE
(2022)
Retraction
Medicine, Research & Experimental
Yu-Shui Ma, Kai-Jian Chu, Chang-Chun Ling, Ting-Miao Wu, Xu-Chao Zhu, Ji-Bin Liu, Fei Yu, Zhi-Zhen Li, Jing-Han Wang, Qing-Xiang Gao, Bin Yi, Hui-Min Wang, Li-Peng Gu, Liu Li, Lin-Lin Tian, Yi Shi, Xiao-Qing Jiang, Da Fu, Xiong-Wen Zhang
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Multidisciplinary Sciences
Sha Li, Pei Xue, Xun Diao, Qi-Yu Fan, Kun Ye, Xiao-Mei Tang, Jia Liu, Zhong-Yan Huang, Qing-Hai Tang, Cheng-You Jia, Rui Xin, Zhong-Wei Lv, Ji-Bin Liu, Yu-Shui Ma, Da Fu
Summary: This study identified AURKB, CCNB2, and CDKN3 as MYC-associated molecular targets in liver cancer. These genes were overexpressed in patients with high MYC expression and associated with poor prognosis, hypomethylated promoters, advanced disease stage, metastasis, and immune cell infiltration. Functional analysis revealed their involvement in the p53 signaling pathway and cell cycle. Targeting these MYC-related genes may offer new strategies for liver cancer treatment.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Oncology
Jun-Hong Guo, Yu-Shui Ma, Jie-Wei Lin, Geng-Xi Jiang, Juan He, Hai-Min Lu, Wei Wu, Xun Diao, Qi-Yu Fan, Chun-Yan Wu, Ji-Bin Liu, Da Fu, Li-Kun Hou
Summary: This study identified frequent mutations in the PI3K signaling pathways in LCLC, which may serve as potential targets for the treatment of this aggressive type of lung cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Medicine, Research & Experimental
Yunfei He, Wenqian Luo, Yingjie Liu, Yuan Wang, Chengxin Ma, Qiuyao Wu, Pu Tian, Dasa He, Zhenchang Jia, Xianzhe Lv, Yu-Shui Ma, Haitang Yang, Ke Xu, Xue Zhang, Yansen Xiao, Peiyuan Zhang, Yajun Liang, Da Fu, Feng Yao, Guohong Hu
Summary: This study revealed the role of IL-20RB in promoting bone metastasis of lung cancer. IL-20RB facilitated the growth of lung cancer cells in the bone by activating JAK1/STAT3 signaling. Blocking IL-20RB significantly suppressed the bone metastasis of lung cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Oncology
Zong-Yuan Jiang, Ji-Bin Liu, Xiao-Feng Wang, Yu-Shui Ma, Da Fu
Summary: Osteosarcoma is a common malignant tumor in the skeletal system, primarily occurring in children and adolescents. Recent advancements in molecular biology and tissue bioengineering have greatly improved treatment methods, especially limb salvage surgery, which has significantly enhanced patients' quality of life and survival rates.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
