Review
Biochemistry & Molecular Biology
Alexander G. Raufi, Michael S. May, Matthew J. Hadfield, Attila A. Seyhan, Wafik S. El-Deiry
Summary: Pancreatic cancer is a highly aggressive malignancy with late detection and high recurrence rate. Liquid biopsies represent an emerging group of technologies that can help with diagnosis, prognosis, treatment response prediction, and recurrence detection. Although not yet approved for routine use, the increasing sensitivity and specificity of contemporary liquid biopsy platforms will likely change clinical practice in the near future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Christoffer Trier Mansson, Johan Vad-Nielsen, Peter Meldgaard, Anders Lade Nielsen, Boe Sandahl Sorensen
Summary: Determining tumour-specific transcription using cfChIP has the potential to enhance tumour diagnostics and therapeutics by expanding the utility of liquid biopsy-based cfDNA analyses. This study demonstrates the proof-of-principle that cfChIP can identify tumour-specific transcriptional activity of mutated alleles, such as the EGFR-L858R mutation.
MOLECULAR ONCOLOGY
(2021)
Article
Cell Biology
Daniel W. Hagey, Maximilian Kordes, Andre Gorgens, Metoboroghene O. Mowoe, Joel Z. Nordin, Carlos Fernandez Moro, J-Matthias Lohr, Samir El Andaloussi
Summary: This study focused on extracellular vesicles as an important source of tumor-derived DNA in liquid biopsies, and conducted experiments by collecting blood samples from 17 pancreatic cancer patients. The results showed that tumor-derived DNA was mainly present in LEVs and SEVs in the early stage of disease progression, and in SEVs and SP in the late stage of disease progression.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Review
Oncology
Justin Mencel, Susanna Slater, Elizabeth Cartwright, Naureen Starling
Summary: Circulating tumour DNA (ctDNA) has potential applications in gastric cancer for screening, detecting minimal residual disease (MRD), treatment decision making, and therapeutic monitoring. It provides a less invasive and convenient method to capture the tumoural genomic landscape compared to tissue-based next-generation DNA sequencing (NGS), and it has the potential to overcome the challenges of tumour heterogeneity seen with tissue-based NGS. Although the evidence for ctDNA in gastric cancer is still evolving, its potential utility is far reaching and may shape the management of this disease in the future.
Review
Oncology
Amaia Sandua, Estibaliz Alegre, Alvaro Gonzalez
Summary: Lung cancer is a major cause of cancer-related deaths globally, with late detection and frequent treatment resistance being common issues. Exosomes, as microvesicles secreted by cells, especially tumor cells, play a crucial role in lung cancer development and can be utilized for diagnosis, prognosis, and follow-up. However, the isolation and analysis of exosomes can be challenging, yet their cargo proteins, RNA, and DNA provide valuable insights into lung cancer progression and management.
Review
Chemistry, Inorganic & Nuclear
Jiayi Tan, Yu Wen, Ming Li
Summary: Exosomes, a class of extracellular vesicles secreted by cells, have been identified as promising diagnostic biomarkers for various diseases. Current research focuses on developing biosensors for exosomes with improved performance, aiming at practical applications in clinical and point-of-care diagnostics.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Oncology
Atocha Romero, Roberto Serna-Blasco, Virginia Calvo, Mariano Provencio
Summary: Recent technological advances have facilitated the development of liquid biopsy-based approaches, specifically the analysis of ctDNA. This has led to significant improvements in non-invasive biomarker testing, therapeutic target identification, treatment monitoring, early detection of resistance mutations, and tailoring treatments for lung cancer patients. Additionally, advancements in assay sensitivity have allowed for the detection of ctDNA at very low allele frequencies, aiding in the measurement of minimal residual disease and improving the efficiency of lung cancer screening programs.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Review
Oncology
Angela Carvalho, Gabriela Ferreira, Duarte Seixas, Catarina Guimaraes-Teixeira, Rui Henrique, Fernando J. Monteiro, Carmen Jeronimo
Summary: Despite significant efforts in cancer diagnosis and treatment, lung cancer (LCa) remains the leading cause of cancer-related mortality worldwide. Liquid biopsy, an emerging field, has evolved significantly in recent years due to its minimally invasive nature and potential to assess various disease biomarkers.
Article
Oncology
Ji Li, Wen Dong, Li Na Liu, Yi Jiang Huang, Mei Fang Xiao
Summary: The study found that patients with specific mutations who did not have detectable CTCs after surgery showed better RFS, and changes in cfDNA within 7 months post-surgery impacted risk detection. Monitoring CTCs and cfDNA variations in the short term holds promise for early risk detection and better disease control.
Review
Oncology
Marta Sant, Adria Bernat-Peguera, Eudald Felip, Mireia Margeli
Summary: Circulating tumor DNA (ctDNA) plays an important role in breast cancer research and clinical practice, allowing for screening, diagnosis, treatment selection, and prognosis assessment. Analysis of ctDNA provides a more accurate understanding of the heterogeneity of breast cancer, enabling monitoring of disease progression and resistance mutations. With the application of new bioinformatics tools, the use of ctDNA in breast cancer will become more frequent, enhancing our knowledge of tumor biology.
Article
Oncology
A. N. Markou, D. Londra, D. Stergiopoulou, I. Vamvakaris, K. Potaris, I. S. Pateras, A. Kotsakis, V. Georgoulias, E. Lianidou
Summary: By comparing blood samples from early-stage NSCLC patients, it was found that simultaneous analysis of plasma-cfDNA and CTC-derived DNA can provide complementary molecular information and greater genomic diversity for cancer treatment and prognosis.
Article
Medical Laboratory Technology
Matthias F. Froelich, Ettore Capoluongo, Zsolt Kovacs, Simon J. Patton, Evi S. Lianidou, Verena Haselmann
Summary: Disruptive imaging and laboratory technologies have the potential to improve clinical decision processes and outcomes in oncology. However, there are obstacles that need to be overcome in order to fully implement these technologies as part of standard care. An integrative diagnostic approach offers a unique opportunity to unlock the full diagnostic potential and pave the way for personalized cancer diagnostics.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Oncology
Maha Elazezy, Katharina Prieske, Lan Kluwe, Leticia Oliveira-Ferrer, Sven Peine, Volkmar Mueller, Linn Woelber, Barbara Schmalfeldt, Klaus Pantel, Simon A. Joosse
Summary: The study found that BRCA1 promoter hypermethylation is frequently observed in ovarian cancer patients and often reversed upon recurrence, indicating the selection of therapy-resistant clones and unfavorable clinical outcomes.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Shiyu Li, Ming Yi, Bing Dong, Ximin Tan, Suxia Luo, Kongming Wu
Summary: Exosomes, as a new type of liquid biopsy, have the potential to be diagnostic or prognostic biomarkers by delivering cargos including nucleic acids and protein, involving in tumorigenesis, tumor growth, metastasis, and drug resistance.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Xiaoxu Fang, Shaokun Yu, Yingying Jiang, Yan Xiang, Kaihua Lu
Summary: ctDNA is a valuable detection tool for evaluating tumor burden, specific cancer mutations, and minimal residual disease. Recent clinical trials have shown the rationality and feasibility of using ctDNA to identify mutations and guide treatments in non-small cell lung cancer (NSCLC).
FRONTIERS IN ONCOLOGY
(2022)
Review
Food Science & Technology
Shan-Shan Feng, Wen Li, Yong-Jun Hu, Jian-Xiang Feng, Jing Deng
Summary: Monascus pigments (MPs) are microbial pigments with stability and biological activities, widely used in the food industry. However, their safety needs further discussion and exploration. This review provides new insights into the production, application, and reduction of citrinin of MPs.
INTERNATIONAL JOURNAL OF FOOD ENGINEERING
(2022)
Article
Environmental Sciences
Zhaoyue Yang, Zhendong Yang, Sheng Yang, Ziliang Liu, Zhenghua Liu, Yongjun Liu, Lukasz Drewniak, Chengying Jiang, Qian Li, Wen Li, Huaqun Yin
Summary: This study analyzed and compared the environmental and economic impacts of two major copper hydrometallurgical routes in China, heap leaching and heap-agitation leaching. The results showed that heap-agitation leaching had a larger environmental impact but also a higher economic benefit compared to heap leaching. The findings can be used to inform government policies on ecological compensation and sustainable development in the copper industry.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Cell Biology
Wen Li, Shan-Shan Feng, Hao Wu, Jing Deng, Wang-Yan Zhou, Ming-Xi Jia, Yi Shi, Liang Ma, Xiao-Xi Zeng, Zavuga Zuberi, Da Fu, Xiang Liu, Zhu Chen
Summary: This study identified long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs associated with CDK1 in lung adenocarcinoma (LUAD) patients. The regulatory axis of LINC00460/LINC00525-hsa-mir-338-FAM111B/ZWINT was determined, and abnormal up-regulation of FAM111B/ZWINT was found to be related to hypomethylation in LUAD. Results also suggested that FAM111B/ZWINT could affect LUAD development and prognosis by regulating the immune microenvironment and promoting tumor spread through EMT. Potential target medicines for LUAD treatment were identified using bioinformatics analysis.
Review
Food Science & Technology
JinTao He, Wen Li, Jing Deng, QinLu Lin, Jie Bai, Lin Zhang, Yong Fang
Summary: This article discusses the impact of probiotic dairy products on quality characteristics, as well as the physiological functions, effectiveness, and safety of probiotic dairy products. It also compares dairy products containing inactivated microorganisms with probiotic products.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pathology
Shaoling Li, Yan Huang, Lingping Zhang, Zhengwei Dong, Wei Wu, Wei Zhang, Chunyan Wu, Likun Hou
Summary: Dual-block elastic stain increases the positivity of visceral pleural invasion and can help predict the invasion status in patients with peripheral non-small cell lung carcinoma (NSCLC).
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Rui Xin, Biao Shen, Zhong-Yan Huang, Ji-Bin Liu, Sha Li, Geng-Xi Jiang, Jie Zhang, Ya-Hong Cao, Da-Zhi Zou, Wen Li, Chun-Guang Li, Yu-Shui Ma, Da Fu
Summary: Resveratrol has multiple functions, including protecting the heart and nervous system and exerting antidiabetic, anti-inflammatory, anti-aging, and antitumor effects. It has been found to impede the occurrence and development of tumors in various cancer types through inducing tumor cell apoptosis, inhibiting cell cycle and angiogenesis, and altering tumor-related expression patterns. However, the exact mechanism underlying its action remains unclear.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Cell Biology
Lang Xia, Junhong Guo, E. Haoran, Wei Zhang, Yan Huang, Liping Zhang, Deping Zhao, Dong Xie, Chunyan Wu, Likun Hou
Summary: The significance of %RVT in the pathological assessment of lung adenocarcinoma cohorts remains undetermined. For patients receiving neoadjuvant chemotherapy, %RVT is a strong indicator of prognosis, while for those receiving neoadjuvant targeted therapy, residual high-grade pathological patterns might be more suitable for prognostic evaluation.
Review
Biochemistry & Molecular Biology
Wen Jing Zhang, Ying Yi Li, Zhen Hang Xiang, Jing Deng, Wen Li, Qin Lu Lin, Yong Fang, Fang Liu, Jie Bai, Lin Zhang, Juan Li
Summary: Food nutrition and human health remain important international issues. The transfer of plant-derived microRNAs to mammalian organisms can affect the occurrence and progression of colorectal cancer. This review aims to summarize the current pathways and effects of plant-derived microRNAs on colorectal cancer and explore their potential as anti-cancer agents.
Article
Multidisciplinary Sciences
Sha Li, Pei Xue, Xun Diao, Qi-Yu Fan, Kun Ye, Xiao-Mei Tang, Jia Liu, Zhong-Yan Huang, Qing-Hai Tang, Cheng-You Jia, Rui Xin, Zhong-Wei Lv, Ji-Bin Liu, Yu-Shui Ma, Da Fu
Summary: This study identified AURKB, CCNB2, and CDKN3 as MYC-associated molecular targets in liver cancer. These genes were overexpressed in patients with high MYC expression and associated with poor prognosis, hypomethylated promoters, advanced disease stage, metastasis, and immune cell infiltration. Functional analysis revealed their involvement in the p53 signaling pathway and cell cycle. Targeting these MYC-related genes may offer new strategies for liver cancer treatment.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Oncology
Jun-Hong Guo, Yu-Shui Ma, Jie-Wei Lin, Geng-Xi Jiang, Juan He, Hai-Min Lu, Wei Wu, Xun Diao, Qi-Yu Fan, Chun-Yan Wu, Ji-Bin Liu, Da Fu, Li-Kun Hou
Summary: This study identified frequent mutations in the PI3K signaling pathways in LCLC, which may serve as potential targets for the treatment of this aggressive type of lung cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Cell Biology
Qiang Zheng, Likun Hou, Guoguo Shang, Xiaowei Qi, Mengmeng Zhang, Yan Jin, Yue Wang, Qianqian Xue, Chunyan Wu, Yuan Li
Summary: This study describes a series of rare peripheral pulmonary neoplasms called peripheral type squamous cell neoplasm of uncertain malignant potential (PSCN-UMP) and investigates their relationship with bronchiolar adenoma (BA) and squamous cell carcinoma (SCC). The study found significant differences in histologic, immunohistochemical, and genetic features between PSCN-UMPs, BAs, and SCCs.
Review
Environmental Sciences
Yu Zhuo, JinTao He, Wen Li, Jing Deng, QinLu Lin
Summary: Rapid economic growth and urbanization have led to significant changes in consumption patterns, particularly in the demand for the food takeaway industry. The convenience brought by the industry also results in environmental pressure from waste packaging materials. This review provides a comprehensive analysis of the types of takeaway food and packaging materials, their impact on human health and the environment, relevant policies and regulations, treatment methods, and the outlook for green takeaway packaging. The review emphasizes the need for more recycling and the development of sustainable packaging materials to promote the industry's sustainable development.
ENVIRONMENTAL POLLUTION
(2023)
Article
Food Science & Technology
Wenli Lin, Wen Li, Tianyu Huang, Chunfeng Yin, Fang Liu, Biya Gong, Kejia He, Fulian Xiao, Shuizhi Yang, Fanwen Bu, Fang Tang, Jinhua Cao
Summary: This study investigated the inhibition effect of exogenous vanillin treatment on the bacterial pathogen Pseudomonas syringae pv. actinidiae (Psa) and its impact on the quality of kiwifruits. The results showed that treatment with 8.0 mg.mL(-1) vanillin significantly reduced weight loss and rotting rate in kiwifruits, while maintaining high levels of total soluble solids and firmness. Additionally, vanillin treatment increased the activity values of superoxide, catalase, and peroxidase dismutase. In conclusion, exogenous vanillin treatment effectively inhibited the growth and dissemination of Psa and maintained the quality of kiwifruits.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2023)
Review
Biochemistry & Molecular Biology
Boyong Hu, Yi Shi, Chunyue Lu, Haixin Chen, Yuqing Zeng, Jing Deng, Lin Zhang, Qinlu Lin, Wen Li, Yuan Chen, Feifei Zhong, Xu Xia
Summary: Neurodegenerative diseases are prevalent neurological disorders caused by neuronal damage, and oxidative stress plays a crucial role in their development. Raspberry polyphenols, rich in bioactive substances, have shown potential in alleviating these diseases. This review summarizes the current understanding of how raspberry polyphenols regulate the gut-brain axis and intestinal flora, and discusses their therapeutic effects on neurodegenerative diseases through modulation of ROS signals and intestinal microorganisms. Additionally, methods to enhance the digestibility and utilization of raspberry polyphenols are proposed to ensure the health of the human nervous system.
Review
Environmental Sciences
Jintao He, Suxuan Xia, Wen Li, Jing Deng, Qinlu Lin, Lin Zhang
Summary: The food processing industry is one of the largest consumers of potable water globally. Agri-food wastewater systems consume about 70% of the world's fresh water and result in significant deforestation. In recent years, the potential for resource recovery and reuse of food wastewater has drawn considerable attention due to its nutrient-rich residues and low levels of harmful substances. This review explores the sources, characteristics, and treatment methods of different types of food wastewater, with a particular focus on resource recovery and reuse.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)