Article
Oncology
Emir Sehovic, Sara Urru, Giovanna Chiorino, Philipp Doebler
Summary: This study aimed to evaluate the overall diagnostic performance and sources of heterogeneity of cell-free circulating microRNAs as diagnostic biomarkers for breast cancer. The results showed that cell-free circulating microRNAs have high sensitivity and specificity. Multiple microRNA panels performed better than single panels, and there was comparable diagnostic performance between studies using serum and plasma as sample types. miRNAs based on endogenous normalizers tended to have higher diagnostic performance. However, lack of standardization and result reproducibility remained the major issues in this field.
Article
Medicine, General & Internal
Cheng Peng, Jiale Wang, Wenzhe Gao, Lihua Huang, Yunfei Liu, Xia Li, Zhiqiang Li, Xiao Yu
Summary: Circulating miRNAs show satisfactory diagnostic performance for pancreatic cancer, including early-stage cases. The combination of miRNAs and CA19-9 significantly improves diagnostic accuracy, offering a novel strategy for pancreatic cancer diagnosis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Amir Hossein Aalami, Farnoosh Aalami, Amirhossein Sahebkar
Summary: A meta-analysis was conducted to evaluate the diagnostic performance of circulating miRNAs in gastric cancer. The results suggest that circulating miRNAs can serve as diagnostic biomarkers for this malignancy.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Immunology
Evangeline Ann Daniel, Balakumaran Sathiyamani, Kannan Thiruvengadam, Sandhya Vivekanandan, Hemanathan Vembuli, Luke Elizabeth Hanna
Summary: This study systematically reviewed the role of host miRNAs in tuberculosis diagnosis and evaluated their involvement in the immune response to Mycobacterium tuberculosis (Mtb). The results revealed that miR-31 showed the highest diagnostic accuracy and could serve as a potential biomarker for rapid tuberculosis detection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Surgery
Fangcheng Hong, Ning Li, Zheming Feng, Yuxin Zheng, Chunyue Zhu, Fenghua Zhang
Summary: Exosomal miRNAs derived from circulating tumor cells have potential diagnostic value in breast cancer, serving as a promising adjunct tool for improving diagnosis.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Endocrinology & Metabolism
Lingli Ma, Yan Wen, Zimeng Li, Nan Wu, Qing Wang
Summary: This study found that miRNAs can be used as potential diagnostic markers for DR, with high accuracy of diagnoses observed with the detection of miRNAs in plasma and serum.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Tong Liu, Duo Liu, Shangwei Guan, Mei Dong
Summary: This meta-analysis found that circulating miR-21 has moderate sensitivity and good specificity in CRC diagnosis, indicating its potential diagnostic value.
ANNALS OF MEDICINE
(2021)
Review
Clinical Neurology
Jimin He, Yao Jiang, Liang Liu, Zhihua Zuo, Chun Zeng
Summary: A meta-analysis was conducted on 24 studies involving a total of 2,170 glioma patients and 1,456 healthy participants, which revealed the potential of circulating miRNAs as diagnostic biomarkers for gliomas, pending validation through large prospective studies.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Daniel Sur, Shailesh Advani, Dejana Braithwaite
Summary: The findings of this study suggest that miRNA panels, especially those derived from serum, can serve as powerful and promising biomarkers for early CRC screening. These panels have high sensitivity and specificity, and show excellent diagnostic accuracy for CRC.
FRONTIERS IN MEDICINE
(2022)
Review
Medicine, Research & Experimental
Masoud Rezaei, Mahsa Faramarzpour, Parnian Shobeiri, Homa Seyedmirzaei, Mohammad Sharifi Sarasyabi, Shahriar Dabiri
Summary: Glaucoma is the leading cause of blindness worldwide, and early diagnosis can greatly impact patients' prognoses. The disease is complicated by a combination of genetic and epigenetic factors. Identifying early diagnostic biomarkers and understanding the underlying mechanisms are crucial for mitigating the global burden of glaucoma.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Oncology
Saira R. Ali, Ayla Orang, Shashikanth Marri, Ross A. McKinnon, Robyn Meech, Michael Z. Michael
Summary: High-fiber diets with butyrate can prevent colorectal cancer by modulating gene and microRNA expression, providing insights into potential novel drug targets for cancer prevention and treatment.
Article
Biochemistry & Molecular Biology
Eman Radwan, Asmaa S. Shaltout, Shima Gafar Mansor, Engy A. Shafik, Wael A. Abbas, Mahmoud Refaat Shehata, Maha Ali
Summary: Plasma levels of microRNA-211 and microRNA-25 were found to be associated with high transforming growth factor-beta expression and lymph node metastasis in colorectal cancer patients. These microRNAs may serve as potential biomarkers for the diagnosis of colorectal cancer.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Psychiatry
Wenhui Li, Xingxing Li, Yannan Li, Yi Chen, Lingqun Zhu, Rongjuan Guo
Summary: This study aims to determine the diagnostic value of microRNAs for depression. Through literature review and meta-analysis, it is found that microRNAs have high sensitivity and specificity in diagnosing depression and could be potential diagnostic biomarkers for depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Review
Oncology
Yunhui Xiang, Liuyun Zhang, Pinpin Xiang, Juan Zhang
Summary: This meta-analysis evaluates the potential of circulating miRNAs in diagnosing multiple myeloma (MM), demonstrating high accuracy and specificity. Factors such as miRNA clusters, detailed patient stage, and Ig isotypes have an impact on the diagnostic results, suggesting standardized recommendations for future studies. Additionally, circulating miRNAs show promise as valuable biomarkers for MM prognosis and treatment response prediction, expanding their clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Wen-Ting Zhang, Guo-Xun Zhang, Shuai-Shuai Gao
Summary: This meta-analysis suggests that circulating microRNAs can be a promising noninvasive biomarker for early diagnosis of leukemia. Specifically, microRNA clusters in plasma type may offer better diagnostic accuracy for leukemia patients.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)