Review
Oncology
Aaron P. Thrift, Theresa Nguyen Wenker, Hashem B. El-Serag
Summary: Gastric cancer is a major cause of cancer-related mortality worldwide, with dynamic temporal trends and different risk factors for its two anatomical subtypes. There have been declines in some regions and demographic groups, but also exceptions of stable or increasing rates. H. pylori infection is an important factor and eradication studies have emerged in recent years. This review highlights the latest trends and addresses gaps in knowledge and public health practice to reduce the global burden of gastric cancer.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Yannan Lin, Li-Jung Liang, Ruiwen Ding, Ashley Elizabeth Prosper, Denise R. Aberle, William Hsu
Summary: Screening with low-dose computed tomography (CT) can reduce mortality from lung cancer, but adherence to Lung-RADS recommendations has been low. Identifying factors associated with nonadherence may improve overall screening adherence.
Article
Nutrition & Dietetics
Sang Young Kim, Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Summary: Dietary factors, such as high meal frequency, overeating, and preference for spicy or salty foods, significantly increase the risk of gastric cancer.
Article
Oncology
Lorna McWilliams, Helen Ruane, Fiona Ulph, Victoria G. Woof, Fiona Harrison, D. Gareth Evans, David P. French
Summary: Risk-stratified breast screening is being considered for national breast screening programmes. This study aimed to explore the psychological impact of undergoing risk-stratified screening within England's NHS Breast Screening Programme. The findings suggest that risk-stratified breast screening is generally accepted but issues related to risk communication and access to care pathways need to be considered for implementation.
BRITISH JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Zhiwen Huang, Wei Liu, Roy Rillera Marzo, Zhijian Hu, Li Ping Wong, Yulan Lin
Summary: This study investigated the knowledge level of risk factors and symptoms of gastric cancer among individuals aged 40 years and above in China, and found that income level, perceived benefits, perceived severity, previous gastric cancer screening experience, perceived poor overall health, and perceived barriers were key predictors of screening intention. The high-risk population aged 40 years and above in China expressed high intention to receive gastric cancer screening.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Saloa Unanue-Arza, Maite Solis-Ibinagagoitia, Marta Diaz-Seoane, Isabel Mosquera-Metcalfe, Isabel Idigoras, Isabel Bilbao, Isabel Portillo
Summary: A systematic review was conducted to identify the health risk factors and social inequalities associated with non-participation in colorectal cancer screening programmes. Although no definitive patterns were found, factors such as not visiting a doctor, being under 60, obese, smoker, and sedentary were associated with nonparticipation.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Oncology
Maomao Cao, He Li, Dianqin Sun, Siyi He, Fan Yang, Xinxin Yan, Shaoli Zhang, Zhenqiu Zha, Jinyi Zhou, Pengfei Luo, Jiyong Gong, Hengmin Ma, Shaokai Zhang, Xibin Sun, Changfa Xia, Ji Peng, Wanqing Chen
Summary: This study aims to investigate the participation rates and factors affecting participation rates, as well as report the detection rate for liver cancer in an organized screening program. The results show that older age, being female, being positive for hepatitis B surface antigen, having a family history of liver cancer, chronic depression, and low income are significant factors affecting participation rates. The detection rate for liver cancer is estimated to be 0.41%.
Article
Oncology
Xiao-Han Fan, Yang Zhang, Pei Wang, Qian-Qian Song, Mona Wang, Raquel Mejias-Luque, Zhe-Xuan Li, Tong Zhou, Jing-Ying Zhang, Wei-Dong Liu, Lan-Fu Zhang, Wen-Qing Li, Wei-Cheng You, Markus Gerhard, Yu-Chen Jiao, Xiao-Bing Wang, Kai-Feng Pan
Summary: This study explores noninvasive multianalytical biomarkers and constructs integrative models for risk assessment and gastric cancer (GC) screening. Methylation, mutation, and H. pylori-specific antibody panels were established and validated, and integrated models incorporating these biomarkers outperformed traditional models for risk assessment and GC detection. This study provides new insights for a more precise GC screening strategy in the future.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Foqiang Liao, Zhenhua Zhu, Shusheng Zhu, Jianhua Wan, Chenglai Fan, Xu Zhang, Xu Shu, Nonghua Lu
Summary: This study aimed to determine the prevalence and risk factors of H. pylori infection in a low-risk area of gastric cancer in China, and evaluate the value of different gastric cancer screening methods. The study found that the infection rate of H. pylori is relatively low in the low-risk area of gastric cancer in China. Low income, loss of appetite, high PG II, and high G-17 were identified as risk factors for H. pylori infection, while alcohol consumption was a protective factor. Moreover, the new gastric cancer screening method showed better prediction of low-grade intraepithelial neoplasia compared to the ABC method and the new ABC method.
ANNALS OF MEDICINE
(2023)
Review
Oncology
Dhavan Shah, David Bentrem
Summary: Gastric cancer is a diverse and prevalent disease, with reduced prevalence of traditional environmental risk factors in the United States. However, genetic risks and risks associated with inflammation still exist. Most cases are sporadic, with only a small percentage showing familial clustering. Hereditary gastric cancer accounts for a low percentage of cases. This review examines the genetic and environmental risk factors associated with the disease.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Tomosuke Mukoyama, Shingo Kanaji, Ryuichiro Sawada, Hitoshi Harada, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
Summary: This study aimed to investigate the risk factors and severity of delayed gastric emptying (DGE) after gastrectomy. Female sex, diabetes, and distal gastric tumors were identified as independent risk factors for DGE. The DGE group had a longer hospital stay compared to the non-DGE group, and most DGE cases occurred after 1 week following surgery.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Jun Park, Hyunju Park, Tae Hyuk Kim, Sun Wook Kim, Hye Won Jang, Jae Hoon Chung
Summary: This study analyzed the trends of childhood thyroid cancer in Korean between 1999 and 2017, finding an increase in incidence rate, especially in the 14-18 age group. Factors such as seaweed intake, medical examinations, obesity prevalence, and lifestyle choices were identified as potential contributors to the rising rates of thyroid cancer in Korean children.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Timothy D. O'Brien, Amiee B. Potter, Catherine C. Driscoll, Gregory Goh, John H. Letaw, Sarah McCabe, Jane Thanner, Arpita Kulkarni, Rossana Wong, Samuel Medica, Tiana Week, Jacob Buitrago, Aaron Larson, Katie Johnson Camacho, Kim Brown, Rachel Crist, Casey Conrad, Sara Evans-Dutson, Ryan Lutz, Asia Mitchell, Pavana Anur, Vanessa Serrato, Autumn Shafer, Lisa K. Marriott, K. J. Hamman, Amelia Mulford, Wojciech Wiszniewski, Jone E. Sampson, Andrew Adey, Brian J. O'Roak, Christina A. Harrington, Jackilen Shannon, Paul T. Spellman, C. Sue Richards
Summary: The Healthy Oregon Project is a statewide initiative that aims to improve the health of Oregonians by providing no-cost genetic screening for inherited cancers and familial hypercholesterolemia. This unbiased population screening has successfully detected at-risk individuals who may have been missed by conventional medical approaches. The project has faced challenges in terms of developing a cost-effective test and scaling up the clinical laboratory to process a large number of samples.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Oncology
Ji-Hyeon Park, Eunjung Kim, Eun-Mi Seol, Seong-Ho Kong, Do Joong Park, Han-Kwang Yang, Jong-Ho Choi, Shin-Hoo Park, Hwi-Nyeong Choe, Meera Kweon, Jiwon Park, Yunhee Choi, Hyuk-Joon Lee
Summary: A prediction model was accurately developed to identify gastric cancer patients at high risk of malnutrition 6 months after gastrectomy, with low preoperative BMI, female sex, and total or proximal gastrectomy being the three independent risk factors. The model showed significant BMI loss at 6 months after gastrectomy and had a high predictive accuracy with a C-index of 0.91.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Jiang Li, Jianguo Xu, Yadi Zheng, Ya Gao, Siyi He, He Li, Kaiyong Zou, Ni Li, Jinhui Tian, Wanqing Chen, Jie He
Summary: Esophageal cancer is a common cancer globally, with higher incidence rates in China, particularly in esophageal squamous cell carcinoma. The overall incidence rate of esophageal cancer is decreasing worldwide, influenced by factors such as regional economic development and dietary habits. Early diagnosis and screening can reduce the incidence and mortality of esophageal cancer.
CHINESE JOURNAL OF CANCER RESEARCH
(2021)