Article
Biochemistry & Molecular Biology
Linfeng Mao, Weijie Yuan, Kaimei Cai, Chen Lai, Changhao Huang, Yi Xu, Shangwei Zhong, Chen Yang, Ran Wang, Pengwei Zeng, Heyuan Huang, Zhikang Chen, Zihua Chen
Summary: EphA2, YES1, and ANXA2 form a signaling axis that promotes gastric cancer invasion and metastasis. Overexpression of YES1 increases invasion and migration of gastric cancer cells, while knockdown of ANXA2 decreases these processes.
Article
Oncology
Masao Saitoh
Summary: The epithelial-mesenchymal transition (EMT) is a process where epithelial cells transform into mesenchymal cells, which is associated with invasion, metastasis, and resistance to therapy in cancer. Transcription factors, such as ZEB1/ZEB2, SNAIL, and TWIST, play important roles in driving the EMT process. This review focuses on understanding the molecular mechanisms that sustain high levels of these transcription factors in aggressive carcinomas and their upregulation by transforming growth factor-β during cancer progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Fanrui Meng, Yukai Cao, Han Su, Tianyan Liu, Limin Tian, Yu Zhang, Jiarui Yang, Wei Xiao, Deshan Li
Summary: This study demonstrates that rNDV-VEGF-Trap significantly inhibits the growth and migration of tumor cells through anti-angiogenesis and apoptosis. It also reduces tumor volume and weight, suggesting its potential as a candidate for carcinoma therapy, especially for colon cancer.
Review
Biochemistry & Molecular Biology
Jessica Oyie Sousa Onyeisi, Carla Cristina Lopes, Martin Goette
Summary: Syndecan-4 plays crucial roles in cell behavior and interactions with growth factors, extracellular matrix molecules, and signaling proteins in various cancers. The expression level of syndecan-4 is important for understanding malignant transformation and it emerges as a target for cancer therapy and diagnosis.
Article
Medicine, General & Internal
Marta Tkacz, Maciej Tarnowski, Agata Poniewierska-Baran, Karol Serwin, Anna Madej-Michniewicz, Anna Deskur, Boguslaw Czerny, Teresa Starzynska
Summary: This study found that SDF-1, HGF and VEGF play important roles in gastric cancer progression. The concentrations of these cytokines were significantly elevated in the sera of gastric cancer patients and could promote the chemotaxis, adhesion, and proliferation potential of gastric cancer cells. Additionally, there was a significant relationship between tumor stage and chemotactic/adhesion response.
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Wen-Juan Yang, He-Ping Zhao, Yan Yu, Ji-Han Wang, Lei Guo, Jun-Ye Liu, Jie Pu, Jing Lv
Summary: Gastric cancer is a complex and heterogeneous disease with multiple risk factors, and it remains a significant global health burden despite declining incidence and mortality rates. In China, gastric cancer ranks third in both incidence and mortality globally, accounting for a large proportion of new cases and deaths. There are regional differences in the incidence and mortality rates, with rapid increases in some developing regions. Therefore, there is an urgent need for early preventive and screening strategies, as well as the development of novel immunotherapies for the management of gastric cancer patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Tian Zheng, Mingyao Sun, Lanzai Liu, Yanfen Lan, Lihua Wang, Fan Lin
Summary: The study found that GPR116 is significantly upregulated in gastric cancer tissues and is positively correlated with tumor staging and invasion, high GPR116 expression is associated with poor overall survival in gastric cancer patients, and GPR116 overexpression is an independent prognostic indicator for poor outcomes in gastric cancer patients.
Article
Integrative & Complementary Medicine
Shumei Rao, Lifang Zhao, Xia Zheng, Shiwei Li, Xifeng Tian
Summary: This study investigated the correlation of serum interleukin-17 (IL-17), vascular endothelial growth factor (VEGF), and lactate dehydrogenase (LDH) levels with the prognosis of gastric cancer patients. The results showed that serum IL-17, LDH, and VEGF levels were closely correlated with the TNM stage and patients' prognosis in gastric cancer, and could serve as effective indicators for evaluating the prognosis of gastric cancer.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Medicine, Research & Experimental
Niuniu Zhong, Yi Yu, Jun Chen, Yuanyuan Shao, Zhiqiang Peng, Junhe Li
Summary: This study explored the clinicopathological characteristics, survival outcomes, and prognosis of very young gastric cancer (GC) patients. The results showed that very young GC patients were predominantly female, with diffuse and poorly differentiated types, and most patients were diagnosed at an advanced stage. The common sites of metastasis were the ovary and peritoneum. TNM stage and radical surgery were identified as independent prognostic factors for the overall survival of very young GC patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Momoko Akiyama, Ryosuke Ueki, Masataka Yanagawa, Mitsuhiro Abe, Michio Hiroshima, Yasushi Sako, Shinsuke Sando
Summary: In this study, a synthetic receptor agonist was designed using a DNA aptamer as a building block to fine-tune agonism. The developed synthetic partial agonist can regulate therapeutically relevant cellular activities by eliciting finely-tuned receptor signaling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Cell Biology
Vanessa M. Ruscetta, Taj J. J. Seaton, Aleen Shakeel, Stanley N. S. Vasconcelos, Russell D. D. Viirre, Marc J. J. Adler, Michael F. F. Olson
Summary: Cytoskeleton organization and dynamics are regulated by post-translational modifications of key target proteins, including the phosphorylation of myosin light chain proteins by MRCK kinases. Compared to ROCK kinases, the contributions of MRCK kinases are less characterized due to the late discovery of selective inhibitors. The recent development of selective MRCK inhibitors has expanded the tools to study MRCK function and shown therapeutic benefits in cancer studies.
Review
Cell Biology
Stefano Fumagalli, Mario Pende
Summary: This article reviews the potential mechanisms of S6K1's action on cell size by considering its main functional targets: substrates involved in nucleic acid and protein synthesis, fat mass accumulation, retrograde control of insulin action, senescence program, and cytoskeleton organization. The interconnection between cell size, regenerative and aging responses, in which S6K1 may be involved, is also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Zhiya Hu, Ziyi Zuo, Han Miao, Zhijie Ning, Youyuan Deng
Summary: This study developed two nomograms for predicting the prognosis of patients with T4a gastric cancer. The results showed that age, tumor size, race, histologic type, N stage, surgery status, radiotherapy, and chemotherapy were identified as independent prognostic factors for both overall survival and cancer-specific survival in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Anam Arif, Ameer A. Alameri, Umer Bin Tariq, Shakeel Ahmed Ansari, Hader Ibrahim Sakr, Maytham T. Qasim, Fadhil F. M. Aljoborae, Andres Alexis Ramirez-Coronel, Hijran Sanaan Jabbar, Gamal A. Gabr, Rasoul Mirzaei, Sajad Karampoor
Summary: Currently, cancer is the second leading cause of death worldwide, and the burden of cancer continues to increase. Understanding the molecular pathways involved in cancer initiation and development may lead to new treatments. Recent research suggests that TRIB3 plays a significant role in oncogenesis in various types of cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Jiandong Mei, Zhilan Xiao, Chenglin Guo, Qiang Pu, Lin Ma, Chengwu Liu, Feng Lin, Hu Liao, Zongbing You, Lunxu Liu
Article
Respiratory System
Zhilan Xiao, Christphor Cao, Jiandong Mei, Hu Liao, Tristan Yan, Lunxu Liu
JOURNAL OF THORACIC DISEASE
(2016)
Article
Multidisciplinary Sciences
Manisha Singh, Christina Vianden, Mark J. Cantwell, Zhimin Dai, Zhilan Xiao, Meenu Sharma, Hiep Khong, Ashvin R. Jaiswal, Faisal Faak, Yared Hailemichael, L. M. E. Janssen, Uddalak Bharadwaj, Michael A. Curran, Adi Diab, Roland L. Bassett, David J. Tweardy, Patrick Hwu, Willem W. Overwijk
NATURE COMMUNICATIONS
(2017)
Article
Medicine, Research & Experimental
Yared Hailemichael, Amber Woods, Tihui Fu, Qiuming He, Michael C. Nielsen, Farah Hasan, Jason Roszik, Zhilan Xiao, Christina Vianden, Hiep Khong, Manisha Singh, Meenu Sharma, Faisal Faak, Derek Moore, Zhimin Dai, Scott M. Anthony, Kimberly S. Schluns, Padmanee Sharma, Victor H. Engelhard, Willem W. Overwijk
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Immunology
Hiep Khong, Annika Volmari, Meenu Sharma, Zhimin Dai, Chinonye S. Imo, Yared Hailemichael, Manisha Singh, Derek T. Moore, Zhilan Xiao, Xue-fei Huang, Thomas D. Horvath, David H. Hawke, Willem W. Overwijk
JOURNAL OF IMMUNOLOGY
(2018)
Article
Chemistry, Multidisciplinary
Jun Zhao, Zhilan Xiao, Tingting Li, Huiqin Chen, Ying Yuan, Y. Alan Wang, Cheng-Hui Hsiao, Diana S-L. Chow, Willem W. Overwijk, Chun Li
Meeting Abstract
Oncology
Jun Zhao, Zhilan Xiao, Willem Overwijk, Chun Li
Letter
Cardiac & Cardiovascular Systems
Hu Liao, Zhilan Xiao
ANNALS OF THORACIC SURGERY
(2019)
Article
Chemistry, Medicinal
Han Yang, Nan Li, Youlian Zhou, Zhilan Xiao, Haoming Tian, Ming Hu, Sheyu Li
DRUG DESIGN DEVELOPMENT AND THERAPY
(2020)
Article
Immunology
Shubhra Singh, Zhilan Xiao, Karishma Bavisi, Jason Roszik, Brenda D. Melendez, Zhiqiang Wang, Mark J. Cantwell, Richard E. Davis, Greg Lizee, Patrick Hwu, Sattva S. Neelapu, Willem W. Overwijk, Manisha Singh
Summary: The study demonstrates that the IL-1 alpha signaling pathway plays a crucial role in melanoma resistance to immunotherapy. Targeting the IL-1 signaling pathway could enhance the efficacy of immunotherapies against melanoma.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Automation & Control Systems
Wenrui Chen, Yaonan Wang, Zhilan Xiao, Zilong Zhao, Cuo Yan, Zhiyong Li
Summary: This article explores the application of hand synergy in robot hand design, aiming to achieve versatile grasping functions by reconstructing key biomechanical characteristics. By combining human hand synergies with anatomy and biomechanics, a mechanical simplification design method is proposed for robot hands.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2022)
Article
Oncology
Zhilan Xiao, Shubhra Singh, Manisha Singh
Summary: IL-1 in tumors can induce immune suppression and resistance to immunotherapy, thus targeting the IL-1 pathway may enhance the efficacy of immunotherapy.
Proceedings Paper
Automation & Control Systems
Wenrui Chen, Zhilan Xiao, Jingwen Lu, Zilong Zhao, Yaonan Wang
2020 IEEE INTERNATIONAL CONFERENCE ON ROBOTICS AND AUTOMATION (ICRA)
(2020)
Article
Oncology
Yasmin A. Lyons, Sunila Pradeep, Sherry Y. Wu, Monika Haemmerle, Jean M. Hansen, Michael J. Wagner, Alejandro Villar-Prados, Archana S. Nagaraja, Robert L. Dood, Rebecca A. Previs, Wei Hu, Yang Zhao, Duncan H. Mak, Zhilan Xiao, Brenda D. Melendez, Gregory A. Lizee, Imelda Mercado-Uribe, Keith A. Baggerly, Patrick Hwu, Jinsong Liu, Willem W. Overwijk, Robert L. Coleman, Anil K. Sood
Meeting Abstract
Oncology
Meenu Sharma, Faisal Fa'ak, Louise Janssen, Hiep Khong, Zhilan Xiao, Yared Hailemichael, Manisha Singh, Christina Vianden, Adi Diab, Jonathan Zalevsky, Ute Hoch, Willem Overwijk
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2017)