Review
Medicine, General & Internal
Toshizo Takayama, Yasushi Tsuji
Summary: Surgical resection is the best curative option for gastric cancer, but patients with advanced disease have poor prognosis even after surgery. To reduce the risk of recurrence, perioperative chemotherapy has been combined with surgery, and different standard chemotherapy regimens have been developed in East Asia, Europe, and North America. In recent years, the use of novel agents such as molecular-targeted drugs and immune checkpoint inhibitors in perioperative therapy has shown promising results in these regions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Yu Mei, Xijia Feng, Tienan Feng, Min Yan, Zhenggang Zhu, Tian Li, Zhenglun Zhu
Summary: This retrospective study examined the role of adjuvant chemotherapy (ACT) in patients with pT2N0M0 gastric cancer who underwent radical resection. The study found that ACT was associated with higher 5-year overall survival and disease-specific survival rates. Patients with pT2N0M0 gastric cancer, regardless of high-risk factors, may be suitable for ACT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yu Mei, Tienan Feng, Min Yan, Zhenggang Zhu, Zhenglun Zhu
Summary: The study aimed to assess the benefit of adjuvant chemotherapy in early gastric cancer patients and identify prognostic factors. Patients with pT1 gastric cancer were analyzed, with lymph node metastasis, treatment regimens, and clinicopathological variables compared. Curative surgery was sufficient for pT1N0 and pT1N1 patients, while Xelox showed better survival outcomes for pT1N3 patients.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Oncology
Antonino Grassadonia, Antonella De Luca, Erminia Carletti, Patrizia Vici, Francesca Sofia Di Lisa, Lorena Filomeno, Giuseppe Cicero, Laura De Lellis, Serena Veschi, Rosalba Florio, Davide Brocco, Saverio Alberti, Alessandro Cama, Nicola Tinari
Summary: Gastric cancer is a major global cause of tumor-related death. Adjuvant systemic chemotherapy after surgery has been proven to improve outcomes, but approaches vary worldwide. Identifying high-risk patients and personalizing treatment are important considerations.
Article
Oncology
Yin Jin, Yilun Xu, Yanyan Li, Renpin Chen, Weiyang Cai
Summary: The study focuses on improving accuracy of prognosis in gastric cancer patients using enhanced computed tomography scanning. Radiogenomics approach combined with survival prediction model can identify candidates who may benefit from ACT, and explore potential drug metabolism mechanisms.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shinsuke Nagasawa, Tsutomu Sato, Junya Morita, Hiroki Kondo, Nobuhiro Tsuchiya, Sho Sato, Kazuhisa Takeda, Toru Aoyama, Norio Yukawa, Yasushi Rino, Chikara Kunisaki
Summary: This study aimed to investigate the influence of solitary living on the efficacy of adjuvant chemotherapy after curative gastrectomy in patients with gastric cancer. The study found that solitary living was associated with higher rates of discontinuation of chemotherapy and worse long-term survival. Solitary living was identified as an independent predictive factor for discontinuing adjuvant chemotherapy.
Article
Health Care Sciences & Services
Yan-juan Zhu, Xiao-yu Wu, Wei Wang, Xue-song Chang, Dan-dan Zhan, De-chang Diao, Jian Xiao, Yong Li, Dong Ma, Ming Hu, Jian-chang Li, Jin Wan, Guan-nan Wu, Chuan-feng Ke, Kai-yu Sun, Zhi-liang Huang, Tai-yuan Cao, Xiao-hui Zhai, Ya-dong Chen, Jian-jun Peng, Jun J. Mao, Hai-bo Zhang
Summary: This pilot study evaluated the effect of electro-acupuncture (EA) on the health-related quality of life and symptom burden of gastric cancer patients during adjuvant chemotherapy. The results showed that EA treatment improved the quality of life, relieved symptoms, and reduced toxicity. Additionally, patients in the EA groups had lower rates of leukopenia and neutropenia.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Review
Biochemistry & Molecular Biology
Joanna Japhet Tibenda, Yuhua Du, Shicong Huang, Guoqing Chen, Na Ning, Wenjing Liu, Mengyi Ye, Yi Nan, Ling Yuan
Summary: Licorice, a remarkable traditional Chinese medicine, has been used in China for centuries. Its active compounds possess multiple biological activities, including anti-tumor, anti-inflammatory, and antiviral functions. Furthermore, licorice compounds can serve as adjuvant chemotherapy agents, improving the quality of life of cancer patients.
Article
Oncology
Jianping Guo, Zhizhong Xiong, Shi Yin, Yue'e Wen, Longyang Jin, Caiqin Wang, Huaxian Chen, Dandong Luo, Zijian Deng, Dayin Huang, Xianzhe Li, Biying Yi, Chaobin Mao, Lei Lian
Summary: This study identified 75 years old as the optimal age cutoff for defining EGC, and found that EGC patients had significantly worse overall survival and cancer-specific survival compared to non-EGC group. Adjuvant chemotherapy was proved to be unbeneficial for stage II EGC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Pengfei Su, Lin Jiang, Yingjing Zhang, Tian Yu, Hongyun Huang, Moxi Chen, Can Cao, Weiming Kang, Yuqin Liu, Jianchun Yu
Summary: This study compared the efficacy of perioperative chemotherapy (PEC) and adjuvant chemotherapy (AC) in resectable locally advanced gastric cancer (LAGC) patients. The results showed that PEC led to a higher R0 resection rate and tumor downstage, without increasing postoperative complications or grade 3/4 adverse events related to AC. PEC was independently associated with better overall survival (OS) and disease-free survival (DFS) in resectable LAGC.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Oncology
Caroline Fong, Edwina Johnston, Naureen Starling
Summary: Gastric cancer requires a multimodality approach to achieve optimal curative rates. Preferences for neoadjuvant and adjuvant approaches vary across the globe, but a multimodal approach provides clear survival benefits compared to surgery alone. However, the completion rates of adjuvant therapy are low, highlighting the need for patient selection optimization and individualized treatment strategies.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Article
Oncology
Peng Jin, Xiaoyan Ji, Shuai Ma, Wenzhe Kang, Hao Liu, Yang Li, Fuhai Ma, Haitao Hu, Weikun Li, Yantao Tian
Summary: This retrospective study analyzed gastric cancer patients with pathological stage pT1N1M0 and found that adjuvant chemotherapy may provide survival benefits for selected patients. Independent risk factors for reduced survival included sex, number of examined lymph nodes, and receiving AC. Patients were divided into three risk categories based on sex and lymph node status, with significant differences in survival observed between the groups.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Jinming Shi, Wenzhe Kang, Yuan Tang, Ning Li, Liming Jiang, Lin Yang, Shulian Wang, Yongwen Song, Yueping Liu, Hui Fang, Ningning Lu, Shunan Qi, Bo Chen, Yexiong Li, Yantao Tian, Jing Jin
Summary: This study compares the survival benefit between adjuvant chemoradiotherapy (CRT) and chemotherapy (CT) in patients with stage III gastric or gastroesophageal junction (GEJ) cancer after D2/R0 resection. The results show that the addition of adjuvant chemoradiotherapy significantly improves overall survival and reduces regional recurrence in these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Junquan Song, Rongyuan Wei, Shiying Huo, Chenchen Liu, Xiaowen Liu
Summary: Studies have shown that VCAN expression plays an important role in the prognosis and response to treatment in gastric cancer patients. High VCAN expression is associated with poor prognosis, while low VCAN expression is associated with better response to adjuvant chemotherapy and chemoradiotherapy. Patients with high VCAN expression tend to be resistant to immunotherapy, suggesting that VCAN could be a promising indicator for predicting the response to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Minsig Choi, Sayaka Ishizawa, David Kraemer, Aaron Sasson, Eugene Feinberg
Summary: Markov decision analysis models show that perioperative chemotherapy improves median overall survival (mOS), quality-adjusted mOS, life expectancy (LE), and quality-adjusted life expectancy (QALE) for resectable gastric and gastroesophageal cancer patients compared to adjuvant chemotherapy strategies.
Article
Environmental Sciences
Ahmad M. Senousi, Xintao Liu, Junwei Zhang, Jianwei Huang, Wenzhong Shi
Summary: This study utilizes real smart card data to dynamically explore and evaluate the structure of large-scale public transit networks in Beijing, China. The overall network structure of these networks is found to follow heavy-tailed distributions. The modified centrality measures outperform the traditional centrality measures in estimating passenger flow.
GEOCARTO INTERNATIONAL
(2022)
Article
Environmental Sciences
Yu Duan, Wei Zhou, Haiyang Shao, Zhibo Zhang, Wenyan Shi, Gang Xu
Summary: In this study, electron beam irradiation was used to degrade indomethacin (IDM) in aqueous solution, and the main degradation pathways of IDM were found to be under the actions of oxidative and reductive radicals. The degradation effect was influenced by the presence of NO3-, NO2-, CO32-, HCO3-, SO2-, and humic acid.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Genetics & Heredity
Ying Chen, Zhili Wang, Yi Jiang, Yun Lin, Xueling Wang, Zhentao Wang, Zheng Tang, Yi Wang, Jimei Wang, Yunge Gao, Wentao Shi, Zhiwu Huang, Yun Li, Junbo Shi, Xue Wang, Qiongfei Yu, Yunqian Ma, Jin Zhou, Tao Yang, Hao Wu
Summary: This study quantitatively assessed the incidence of hearing loss in individuals with the p.V37I variant in GJB2 gene in relation to age. The results showed a gradually increasing incidence of hearing loss associated with this genetic variant as age increased. Most individuals carrying the biallelic p.V37I variant may develop significant hearing loss in adulthood. Early diagnosis and intervention through widespread genetic screening can be beneficial for these individuals.
GENETICS IN MEDICINE
(2022)
Article
Mathematics, Interdisciplinary Applications
Hongyan Jia, Zhonggao Chen, Wenxin Shi, Guoyuan Qi
Summary: The paper introduces a new generalized Hamiltonian chaotic system with transient quasi-periodic flows and intermittent chaos, which exhibits conservative characteristics and various coexisting flows. The Hamiltonian energy of the system meets certain conditions and is only related to initial points.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2022)
Review
Materials Science, Multidisciplinary
Xiao-Jing Dai, Xin-Xin Niu, Wang-Qin Fu, Dong Zheng, Wen-Xian Liu, Wen-Hui Shi, Jian-Wei Nai, Fang-Fang Wu, Xie-Hong Cao
Summary: Bismuth (Bi) has shown promise in the field of aqueous batteries and seawater desalination due to its high energy density and low redox potential. This review comprehensively summarizes the unique properties, synthetic methods, and applications of Bi-based electrodes, as well as the challenges and future research direction. Commonly used preparation methods of Bi-based electrodes and their applications in aqueous batteries and water desalination are also discussed.
Article
Energy & Fuels
Ming Yang, Zhifeng Wang, Junfeng Yang, Guofeng Yuan, Weisheng Wang, Wenhui Shi
Summary: District solar heating plant is a promising low-carbon technology to decrease coal use in space heating, especially in solar-rich areas. Cash flow and thermal analysis are used to determine the actual heating price, considering parameters such as solar collecting system, thermal storage, solar fraction, auxiliary energy price, and loan period. The analysis shows that solar fraction greatly affects the contribution of depreciation and loan to heating price.
Article
Microbiology
Marcia Dinis, Melissa Agnello, Lujia Cen, Bhumika Shokeen, Xuesong He, Wenyuan Shi, David T. W. Wong, Renate Lux, Nini Chaichanasakul Tran
Summary: Dental caries is the most common chronic disease in children, and the role of Streptococcus mutans in its development is still not fully understood. This study explored the correlation between S. mutans levels and other microorganisms in the saliva of caries-concordant and discordant populations. The results showed that the salivary microbial communities clustered based on S. mutans levels and were independent of caries experience. Disease-associated species were increased in populations with high S. mutans levels, while health-associated species were more abundant in populations with low S. mutans levels. The study highlights the importance of considering additional microbial markers in conjunction with S. mutans for the diagnosis and management of dental caries in the discordant population.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xingxiu Yan, Shengchun Wang, Zhao Liu, Yujie Luo, Pengjie Wang, Wenyan Shi, Xiaotian Qi, Zhiliang Huang, Aiwen Lei
Summary: A precise electro-reduction strategy for the synthesis of gem-difluoroalkenes is reported. Direct or indirect electrolysis is used for precise reduction, and a catalyst- and metal-free condition is developed. Furthermore, a novel electro-Ni-catalytic system is established for the electrochemical synthesis of gem-difluoroalkenes.
SCIENCE CHINA-CHEMISTRY
(2022)
Article
Engineering, Chemical
Xiumei Song, Jiaxin Ni, Dongmei Liu, Wenxin Shi, Yixing Yuan, Fuyi Cui, Jiayu Tian, Wei Wang
Summary: In this study, molybdenum disulfide (MoS2) was used as a co-catalyst to enhance the degradation performance of nanoscale zero valent iron (nZVI) activated peroxydisulfate (PDS) process for sulfamethoxazole (SMX) degradation. The addition of MoS2 accelerated the Fe2+/Fe3+ cycle, leading to enhanced decomposition of PDS and improved catalytic degradation of SMX. Under optimal conditions, up to 98.6% degradation efficiency of SMX and 29.6% removal of total organic carbon (TOC) were achieved.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Oncology
Teng Li, Yin-Ping Zhang, Jun-Juan Kong, Min Kong, Ge Meng, Wen-Xin Shi
Summary: The study evaluated the effectiveness of timing it right (TIR) applications in patients undergoing radiotherapy for head and neck cancer. The TIR intervention program significantly improved the unmet needs and psychological pain of these patients. The TIR group showed significant improvements in various aspects, including information needs, health and psychological problems, healthcare staff, physical symptoms, health facilities and services, religious/spiritual support, and psychological pain.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Thermodynamics
Zixu Yang, Hongli Sun, Baolong Wang, Hansong Xiao, Xian Dong, Wenxing Shi, Borong Lin
Summary: This study investigates the thermal performances of fan coil units (FCUs) and room air conditioners (RACs) and their impact on indoor environmental factors. The results demonstrate that proper operating conditions can improve the performance of heating devices and create a comfortable indoor environment.
Article
Biochemistry & Molecular Biology
Wen-Tao Shi, Biliang Zhang, Meng-Lin Li, Ke-Han Liu, Jian Jiao, Chang-Fu Tian
Summary: Bacterial adaptation is influenced by horizontal gene transfer, xenogeneic silencing and anti-silencing mechanisms. This study identifies a novel DNA bridger called MucR, which plays a critical role in legume symbiosis in alpha-proteobacterium Sinorhizobium fredii. The self-assembly of MucR and its domains are necessary for bridging complex formation and maximizing its stability, transcriptional silencing and symbiotic efficiency.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Business, Finance
Wen Shi, Xiaogang Bi
Summary: This research examines the impact of Buddhism on mergers & acquisitions (M&As) performance using data from 4622 M&A transactions of Chinese public firms between 2004 and 2018. The findings provide ample evidence that acquirers located in regions with a higher intensity of Buddhism achieve better short-term and long-term performance after the merger. Furthermore, the study reveals that state ownership plays a crucial role in mitigating this effect, and the value creation is driven by higher deal completion rates and fewer violation cases for acquiring firms. Finally, the study addresses the issue of endogeneity, and the results remain unchanged.
ACCOUNTING AND FINANCE
(2023)
Review
Chemistry, Physical
Lanlan Yu, Kaizhu Zeng, Chenghang Li, Xiaorong Lin, Hanwen Liu, Wenhui Shi, Hua-Jun Qiu, Yifei Yuan, Yonggang Yao
Summary: High-entropy alloys (HEAs) with their unique multielement composition space and high-entropy mixing structure have been developed as catalysts for complex carbon and nitrogen loop reactions. However, the design, synthesis, and understanding of HEA catalysts are challenging due to the complexity of both high-entropy materials and reactions.
Article
Green & Sustainable Science & Technology
Dong Zheng, Wenxian Liu, Xiaojing Dai, Jinxiu Feng, Xilian Xu, Ruilian Yin, Wenbin Que, Wenhui Shi, Fangfang Wu, Huaping Wu, Xiehong Cao
Summary: This study develops a novel cathode material for flexible zinc-air batteries and demonstrates its potential application in flexible electronics. The material exhibits excellent battery performance and sensing sensitivity, which is crucial for achieving high-performance and integrated power sources.
ADVANCED ENERGY AND SUSTAINABILITY RESEARCH
(2022)