Article
Microbiology
Kristi Jones, Federico Cunha, Soo Jin Jeon, Johanny Perez-Baez, Segundo Casaro, Peixin Fan, Ting Liu, Shinyoung Lee, Kwangcheol Casey N. Jeong, Yongqiang Yang, Klibs N. Galvao
Summary: This study investigated the source and route of bacterial colonization in the uterus of dairy cows. It found that the gastrointestinal tract is likely the source of bacteria that colonize the reproductive tract, ascending through the lower genital tract to reach the uterus. Cow-to-cow transmission was also observed, and strains were not specific to body site or health status.
VETERINARY MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Julia Koch, Valerio Marques Portela, Esdras Correa dos Santos, Daniele Missio, Leonardo Guedes de Andrade, Zigomar da Silva, Bernardo Garziera Gasperin, Alfredo Quites Antoniazzi, Paulo Bayard Dias Goncalves, Gustavo Zamberlam
Summary: This study found that the inhibition of the interaction between the Hippo effector YAP or its transcriptional co-activator TAZ with the TEAD family of transcription factors is critical for the cumulus expansion-related events induced by the EGF network in cumulus-oocyte complexes (COCs). These findings provide important insights into the functional relevance of cumulus expansion and oocyte maturation in monovulatory species, and may serve as potential targets to improve the efficiency of in vitro maturation (IVM) systems.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Reproductive Biology
Ugur Topaloglu, Muzaffer Aydin Ketani
Summary: Homeobox proteins are found to play critical roles in regulating uterine and placental physiology in cows, with varying immunoreactivity observed in different trimesters of gestation. These proteins may be involved in the regulation of endometrial functions and the proliferation and differentiation of endometrial and placental cells in cows.
Review
Cell Biology
Meina He, Tuo Zhang, Yi Yang, Chao Wang
Summary: Meiosis is essential for sexual reproduction, with oocytes in female mammals beginning meiosis before birth and sustaining it through dictyate stage before ovulation. Fine-tuning of meiotic progression is crucial for fertility, as any disruption can lead to oogenesis failure and impact overall reproductive health. Understanding the regulatory network of oocyte meiosis is key to comprehending mammalian reproduction and the consequences of misregulation on infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Karolina Wolodko, Juan Castillo-Fernandez, Gavin Kelsey, Antonio Galvao
Summary: Maternal obesity can lead to impaired leptin signaling, resulting in high levels of estrogen and leptin in the bloodstream, which adversely affects ovarian function. This review highlights the potential impact of impaired leptin signaling on folliculogenesis and oocyte developmental competence in both mice and women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)
Article
Reproductive Biology
Jiahe Zhou, Hui Mo, Qian Feng, Li Li, Jiahui La
Summary: This study investigated the expression of ApoC3 in the ovaries of PCOS patients and its potential role in the progression of PCOS. The results showed that ApoC3 levels were higher in PCOS patients, and its expression increased with PCOS progression. The study suggests that ApoC3 may be involved in the regulation of oocyte development in PCOS.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
David Brownell, Stephane Chabaud, Stephane Bolduc
Summary: Female gynecological organ dysfunction has a negative impact on the quality of life for women, and current treatment options are inadequate. Tissue engineering provides a potential alternative for repairing or replacing dysfunctional gynecological organs, with the aim of restoring female fertility and sexual wellbeing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Mayako Fujihara, Jun-ichi Shiraishi, Manabu Onuma, Yoshiyuki Ohta, Miho Inoue-Murayama
Summary: This study investigates the effect of ovaries storage on oocytes for the purpose of cryopreserving avian female gametes by using chickens as a model. The results show that storing the ovaries at low temperatures (4 degrees C) can maintain the viability and morphology of oocytes, while storage at room temperature leads to rapid decline and apoptosis. Additionally, the study demonstrates that ovarian tissues stored at low temperatures can recover after cryopreservation.
Article
Oncology
Sri Harsha Kombathula, Anthea Cree, Priya V. Joshi, Nesrin Akturk, Lisa H. Barraclough, Kate Haslett, Ananya Choudhury, Peter Hoskin
Summary: This study combines experience from two large UK centres in palliative radiotherapy for gynaecological cancers and finds that palliative radiotherapy is effective for symptom control in advanced FGTC with low toxicity.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhu, Qingling Yang, Hui Li, Yujiao Wang, Yuqing Jiang, Huan Wang, Luping Cong, Jianmin Xu, Zhaoyang Shen, Wenhui Chen, Xinxin Zeng, Mengchen Wang, Min Lei, Yingpu Sun
Summary: SIRT3 plays a critical role in maintaining the ovarian follicle reserve and oocyte quality in aging mice, but its role in the testis remains unclear.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Environmental Sciences
Huijuan Kuang, Wanyi Zhang, Lin Yang, Zoraida P. Aguilar, Hengyi Xu
Summary: This study investigated the effects of ZnO nanoparticles on the female and male reproductive organs in mice, finding that ZnO NPs caused more severe reproductive toxicity in male mice. This included decreased testes weight, imbalance of hematological and serum biochemical parameters, and cell apoptosis. The study suggests that ZnO NPs could pose exposure-related risks to reproductive health, especially in occupational settings.
ENVIRONMENTAL TOXICOLOGY
(2021)
Review
Endocrinology & Metabolism
Jiachen Wu, Yang Liu, Yinhua Song, Lingjuan Wang, Jihui Ai, Kezhen Li
Summary: Ovarian aging is the main manifestation of female reproductive system aging, characterized by a gradual decline in the number and quality of oocytes. This review discusses the characteristics and mechanisms of ovarian aging, and explores intervention strategies, including stem cells and cryopreservation techniques, to delay ovarian aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Chia Lin Chang, Wei-Che Lo, Ta-Hsien Lee, Jia-Yi Sung, Yen Ju Sung
Summary: This study investigates the physiological role of oocyte-derived ADM2 in regulating ovarian folliculogenesis. The results suggest that disruption of the Adm2 gene in oocytes leads to an increase in the number of ovulated oocytes, impairment of fertilized egg development, and a decrease in corpus luteum size, possibly due to reduced ovarian cyclin D2-associated signaling.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Leandro M. Velez, Marcus Seldin, Alicia B. Motta
Summary: PCOS is a common endocrinopathy affecting 5-10% of women of reproductive age, characterized by ovarian cysts, ovulation disorders, and hyperandrogenism, along with metabolic abnormalities. Chronic inflammation may play a pivotal role in the pathogenesis of PCOS.
BIOLOGY OF REPRODUCTION
(2021)
Article
Reproductive Biology
Jose Denis-Robichaud, Artur C. C. Fernandes, Jose E. P. Santos, Ronaldo L. A. Cerri
Summary: This study evaluated the factors influencing fertilization and embryo development. The study found that structures from primiparous cows, cows with higher progesterone concentration, and cows with fewer accessory spermatozoa were less likely to be fertilized or of better quality. Additionally, embryos with more blastomeres or without nonviable blastomeres were more likely to be of better quality.
Article
Agriculture, Dairy & Animal Science
M. G. Zenobi, J. M. Bollatti, A. M. Lopez, B. A. Barton, C. L. Hixson, F. P. Maunsell, W. W. Thatcher, K. Miller-Cushon, J. E. P. Santos, C. R. Staples, C. D. Nelson
Summary: The supplementation of rumen-protected choline (RPC) during late pregnancy in Holstein cows was found to have a positive effect on offspring immunity and growth, potentially through uteroplacental and colostrum-dependent mechanisms.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
I. J. Lean, S. J. LeBlanc, D. B. Sheedy, T. Duffield, J. E. P. Santos, H. M. Golder
Summary: Data from three countries were analyzed to evaluate the association between parity and disease in Holstein cows. The study found that higher parity was associated with increased disease risk and changes in metabolite concentrations.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
M. B. Poindexter, R. Zimpel, A. Vieira-Neto, A. Husnain, A. C. M. Silva, A. Faccenda, A. Sanches de Avila, P. Celi, C. Cortinhas, J. E. P. Santos, C. D. Nelson
Summary: The objectives of this experiment were to determine the effects of supplementing 25-hydroxyvitamin D3 compared with vitamin D3 at 1 or 3 mg/d in late gestation on production outcomes of dairy cows. The results showed that feeding 25-hydroxyvitamin D3 increased colostrum and milk yield compared to vitamin D3. The effect of 25-hydroxyvitamin D3 on milk yield may be related to serum calcium concentrations.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Paula C. C. Molinari, Brittney D. Davidson, Jimena Laporta, Geoffrey E. Dahl, I. Martin Sheldon, John J. Bromfield
Summary: Heat stress increases susceptibility to uterine diseases in dairy cows. This study shows that implementing evaporative cooling to alleviate heat stress during late pregnancy can have carry-over effects on postpartum innate immunity, potentially reducing the incidence of uterine disease.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
I. J. Lean, H. M. Golder, S. J. LeBlanc, T. Duffield, J. E. P. Santos
Summary: In this retrospective meta-analysis, individual cow data was used to assess the associations between parity, level of production, and pasture-based or intensively fed systems with fertility. The study found that parity and milk production measures had significant effects on reproductive outcomes. Differences in production systems also influenced reproductive measures.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
U. Arshad, A. Husnain, M. B. Poindexter, R. Zimpel, M. C. Perdomo, J. E. P. Santos
Summary: The objective of this study was to investigate the effect of increasing supplementation of rumen-protected choline (RPC) on hepatic metabolism in cows. The results showed that supplementation of RPC reduced hepatic triacylglycerol and increased glycogen content. Additionally, RPC supplementation had an impact on serum haptoglobin levels, but did not affect the concentrations of fatty acids, BHB, glucose, triacylglycerol, and total cholesterol in the blood.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
A. Husnain, U. Arshad, M. B. Poindexter, R. Zimpel, M. Nehme Marinho, M. C. Perdomo, P. Fan, K. C. Jeong, C. D. Nelson, I. M. Sheldon, J. J. Bromfield, J. E. P. Santos
Summary: The objective of this experiment was to study the effect of inducing endometrial inflammation by infusing utero-pathogenic bacteria on productive performance and reproduction in lactating cows. The results showed that induced endometrial inflammation compromised milk production and reproduction in cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biology
Paula C. C. Molinari, John J. Bromfield
Summary: Cattle under heat stress experience reduced fertility, milk production, and increased uterine infection. Exposure of endometrial cells to heat stress further increases expression of inflammatory mediators in response to bacterial components. Heat shock proteins HSP1A1 and HSF1 help to restrain inflammatory responses.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Biology
Thomas J. R. Ormsby, Sian E. Owens, Matthew L. Turner, James G. Cronin, John J. Bromfield, I. Martin Sheldon
Summary: Glucocorticoids increase the intrinsic protection of tissue cells against pore-forming toxins by activating the glucocorticoid receptor and HMGCR. Treating cell lines with glucocorticoids can prevent cell damage caused by bacterial pore-forming toxins.
COMMUNICATIONS BIOLOGY
(2023)
Article
Reproductive Biology
Ali Husnain, Usman Arshad, Roney Zimpel, Eduardo Schmitt, Mackenzie J. Dickson, Milerky C. Perdomo, Mariana N. Marinho, Nadia Ashrafi, Stewart F. Graham, Jeanette Bishop, Thomas R. Hansen, Kwang C. Jeong, Angela M. Gonella-Diaza, Ricardo C. Chebel, I. Martin Sheldon, John J. Bromfield, Jose E. P. Santos
Summary: Endometrial inflammation in cows is associated with reduced pregnancy rates and increased pregnancy loss. Induced endometritis alters histotroph composition and induces inflammatory signatures on conceptus, compromising their development. Bacterial-induced endometritis impairs conceptus development by altering histotroph composition and conceptus gene expression in dairy cattle.
BIOLOGY OF REPRODUCTION
(2023)
Article
Agriculture, Dairy & Animal Science
S. Casaro, J. G. Prim, T. D. Gonzalez, C. C. Figueiredo, R. S. Bisinotto, R. C. Chebel, J. E. P. Santos, C. D. Nelson, S. J. Jeon, R. C. Bicalho, J. P. Driver, K. N. Galvao
Summary: The objective of this study was to identify metabolites associated with metritis and investigate the cellular mechanisms affected during the transition into lactation. The results showed significant changes in metabolism, lipolysis, cell death, oxidative stress, and immune activation in cows with metritis, indicating a predisposition to metritis development.
JOURNAL OF DAIRY SCIENCE
(2023)