Review
Biochemistry & Molecular Biology
Massimo De Felici, Francesca Gioia Klinger, Federica Campolo, Carmela Rita Balistreri, Marco Barchi, Susanna Dolci
Summary: In the human embryo, the genetic program responsible for germ cell specification involves a balance between epigenetic and transcriptional mechanisms, resulting in a unique cell population that can exhibit both germness and pluripotency features. Germ cell tumors, originating from fetal or neonatal germ cells, maintain this balance and can display a wide range of phenotypes with either pluripotent or germness characteristics. This review highlights the similarities in transcriptional and epigenetic programs between human primordial germ cells and germ cell tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Weigang Xiu, Jiyun Pang, Yang Hu, Huashan Shi
Summary: In this review, the current research progress on the pathogenesis, diagnosis, and treatment of extragonadal germ cell tumors (EGCTs) from an immunology perspective are summarized. EGCTs have a histological origin related to gonads but are located outside. They can occur in various areas and have great morphological variation. The unclear pathogenesis and extensive differential diagnosis of EGCTs pose challenges. This review provides ideas for applying immunology in combating these diseases, which is currently a hot topic.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pathology
Yao Li, Xiang Huang, Xue Meng, Yuqing Luo, Shuai Luo, Jinjing Wang
Summary: This report presents a rare case of primary mixed extragonadal germ cell tumor in the shoulder. The patient underwent surgery and chemotherapy, and showed no signs of recurrence during follow-up. The importance of further research on this rare disease to develop effective treatment strategies is emphasized.
DIAGNOSTIC PATHOLOGY
(2023)
Article
Pediatrics
Sriharsha Talluri, Michael A. Goedde, Susan Coventry, Eran Rosenberg, Katie L. Canalichio, Dennis Peppas, Jeffrey T. White
Summary: Pediatric testis tumors are rare, with mixed germ cell tumors being even rarer in prepubertal males. Patients typically present with painless scrotal masses, and treatment involves ultrasound, computed tomography, and tumor markers for evaluation.
FRONTIERS IN PEDIATRICS
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yu-Chin Wu, Chia-Hung Kao, Shung-Shung Sun, Te-Chun Hsieh
Summary: We report a case of a 20-year-old male diagnosed with metastatic embryonal carcinoma, which was subsequently confirmed as burned-out testicular mixed germ cell tumor.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Oncology
Madhu Kumar, Akanksha Singh, Damini Singh
Summary: We report a very rare case of immature gastric teratoma in an infant based on clinicoradiological and pathological findings. The patient was a 6-month-old male child born through full-term vaginal delivery. He presented with abdominal distension and a palpable mass, along with a history of Malena for the past 10 days. Computed tomography scan revealed a large well-defined multilobulated solid cystic lesion with multiple calcifications. Surgical exploration showed a tumor mass arising from the lesser curvature of the posterior wall of the stomach. Total excision of the mass was performed, and the child is currently doing well on regular follow-up visits.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Review
Pediatrics
Jun Liu, Luxiong Fang, Songtao Qi, Ye Song, Lei Han
Summary: This article discusses the occurrence of extracranial metastasis in intracranial germ cell tumors (GCTs) and highlights the importance of early detection of extracranial tumors. It also emphasizes the need for regular follow-up with patients. The case presented in the article reinforces the severe prognosis and the need for early detection of extracranial malignancy in intracranial NGGCTs.
Article
Medicine, General & Internal
Alaaeddin Alrohaibani, Philipp W. Raess
Summary: AML frequently arises in ovarian MGCT with poor prognosis, requiring close inspection for concurrent presence.
CLINICAL CASE REPORTS
(2021)
Article
Clinical Neurology
Brian Fiani, Juliana Runnels, James Brazdzionis, Dan Miulli
Summary: Intracranial germ cell tumors are rare and can present with a variety of symptoms. Rarely, these tumors can transform into alternative malignancies, leading to challenging treatment options. This article reports a rare case of metastatic adenosquamous carcinoma transformed from a yolk sac tumor in atypical locations of the brain.
ACTA NEUROCHIRURGICA
(2022)
Article
Pathology
Mithraa Devi Sekar, Immanuel Pradeep, Bheemanathi Hanuman Srinivas, Smita Kayal
Summary: This study describes a heterogeneous group of extragonadal germ cell tumors (EGCTs) and examines their clinicopathological correlation. The findings reveal that EGCTs predominantly occur in post-pubertal adolescents and young adults, with common sites being the mediastinum, sacrococcyx, retroperitoneum, and central nervous system. The different types of germ cell tumors were confirmed using immunohistochemistry markers. After treatment, tumor marker levels decreased significantly or remained normal.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Review
Oncology
Daniel L. Geisler, Mason Marshall, Sheldon I. Bastacky, Samer N. Khader
Summary: Cytologic techniques can be used as reliable and accurate methods for diagnosing extragonadal germ cell tumors (EGGCTs), and their importance is particularly prominent in cases where preoperative chemotherapy is involved.
CANCER CYTOPATHOLOGY
(2023)
Article
Medicine, General & Internal
Qi-Fan Xiao, Jie Li, Bin Tang, Yu-Qing Zhu
Summary: Our report of a rare case of TMGCT in a male patient presenting with recurrent fever and left supraclavicular lymphadenectasis instead of testicular enlargement and pain, along with a literature review, may serve as a basis for early diagnosis.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Urology & Nephrology
Christian Winter, Friedemann Zengerling, Jonas Busch, Julia Heinzelbecker, David Pfister, Christian Ruf, Julia Lackner, Peter Albers, Sabine Kliesch, Stefanie Schmidt, Carsten Bokemeyer
Summary: This study aims to present the current evidence and development of studies on the management of extragonadal germ cell tumors (EGCT). The results show that the current insights on EGCT are limited, mainly based on case series and studies with small patient numbers. Non-seminomatous EGCT have a poorer prognosis compared to testicular germ cell tumors, while seminomatous EGCT have a similar prognosis to patients with metastatic testicular seminoma. Systemic treatment should be performed like in testicular metastatic germ cell tumors, but upfront dose intensification of chemotherapy should be considered for mediastinal non-seminomatous EGCT patients.
WORLD JOURNAL OF UROLOGY
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Duygu Has Simsek, Caner Civan, Meltem Ekenel, Serkan Kuyumcu, Yasemin Sanli
Summary: Overexpression of prostate-specific membrane antigen (PSMA) is demonstrated in various tumors, and radionuclide therapies directed at PSMA might be effective in treating PSMA-avid malignancies. A case study of a 46-year-old male with progressive metastatic testicular mixed germ cell tumor showed mixed response in Ga-68-PSMA PET/CT after Lu-177-PSMA therapy, suggesting the need for further optimization of treatment strategies.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Oncology
Paolo Pedrazzoli, Giovanni Rosti, Eleonora Soresini, Silvia Ciani, Simona Secondino
Summary: Germ cell tumors (GCTs) are a solid tumor type curable in most patients, with specific biochemical markers such as HCG, AFP, and LDH used for diagnosis and monitoring. Recent studies are exploring the use of miRNAs as serum biomarkers. Serum tumor markers play a crucial role in the diagnosis, staging, prognosis, monitoring of response, and follow-up of GCTs.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Andrology
B. Lei, R. Xing, X. Zhou, D. Lv, B. Wan, F. Shu, L. Zhong, H. Wu, X. Mao
Article
Andrology
Bin Lei, Xuming Zhou, Daojun Lv, Bo Wan, Huayan Wu, Liren Zhong, Fangpeng Shu, Xiangming Mao
ASIAN JOURNAL OF ANDROLOGY
(2017)
Article
Pathology
Bin Lei, Wenjuan Qi, Yunfei Zhao, Yumei Li, Shuguang Liu, Xiaoyan Xu, Chen Zhi, Liyan Wan, Hong Shen
Article
Genetics & Heredity
Fangpeng Shu, Xumin Zhou, Fenxia Li, Daojun Lu, Bin Lei, Qi Li, Yu Yang, Xuexi Yang, Rong Shi, Xiangming Mao
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2015)
Article
Urology & Nephrology
Bin Lei, Bo Wan, Jian Peng, Yu Yang, Daojun Lv, Xuming Zhou, Fangpeng Shu, Fei Li, Liren Zhong, Huayan Wu, Xiangming Mao
JOURNAL OF UROLOGY
(2015)
Article
Obstetrics & Gynecology
Shoubo Zhang, Yuanshu Zhao, Bin Lei, Chunjing Li, Xiangming Mao
REPRODUCTIVE SCIENCES
(2015)
Article
Oncology
Xumin Zhou, Qi Li, Jincan He, Liren Zhong, Fangpeng Shu, Rongwei Xing, Daojun Lv, Bin Lei, Bo Wan, Yu Yang, Huayan Wu, Xiangming Mao, Yaguang Zou
Article
Oncology
Daojun Lv, Huayan Wu, Rongwei Xing, Fangpeng Shu, Bin Lei, Chengyong Lei, Xumin Zhou, Bo Wan, Yu Yang, Liren Zhong, Xiangming Mao, Yaguang Zou
Article
Oncology
Bo Wan, Hua-Yan Wu, Dao-Jun Lv, Xu-Min Zhou, Li-Ren Zhong, Bin Lei, Shou-Bo Zhang, Xiang-Ming Mao
Article
Oncology
Tieqiu Li, Qianqian Wang, Xiuqin Hong, Huahua Li, Ke Yang, Jiahui Li, Bin Lei
CANCER MANAGEMENT AND RESEARCH
(2019)
Article
Andrology
Bin Lei, Lixia Xie, Shoubo Zhang, Daojun Lv, Fangpeng Shu, Yushu Deng
Article
Immunology
Lixia Xie, Yuanlan Lin, Yushu Deng, Bin Lei
Summary: The study indicates that SARS-CoV-2 infection affects the size of the spleen and T lymphocyte count. Especially in recovered patients, reduced spleen size and decreased T lymphocytes count were observed.
Article
Andrology
Yaodong Jiang, Chunlian Liu, Bin Lei, Xian Xu, Baisong Lu
Article
Oncology
Chunjing Li, Fangpeng Shu, Bin Lei, Daojun Lv, Shoubo Zhang, Xiangming Mao
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2015)
Article
Oncology
Shuguang Liu, Xingen Wang, Bin Lei, Hongmei Ma, Jing Li, Dong Guo, Shengmei Xu
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2015)
