Article
Immunology
Minyuan Cao, Yun Deng, Yiqi Deng, Jing Wu, Chongyi Yang, Zijun Wang, Qianqian Hou, Huancheng Fu, Zhixiang Ren, Xuyang Xia, Yue Li, Wei Wang, Heng Xu, Xin Liao, Yang Shu
Summary: This study explores the heterogeneity and evolution of neuroectodermal cells within immature ovarian teratomas (PDT) at the single cell level through single-cell RNA sequencing and bioinformatic analysis. The study also reveals the role of immune cells in the tumor microenvironment and highlights the potential usage of CDTs as a model for PDT research.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pathology
Vladimir Samal, Tomas Jirasek, Vit Paldus, Igor Richter, Ondrej Hes
Summary: This case report presents a rare case of urachal yolk sac tumor with glandular and hepatoid structures in a male patient presenting with macroscopic hematuria. Immunohistochemistry confirmed the presence of these structures, supporting the diagnosis.
DIAGNOSTIC PATHOLOGY
(2022)
Review
Oncology
Daniel L. Geisler, Mason Marshall, Sheldon I. Bastacky, Samer N. Khader
Summary: Cytologic techniques can be used as reliable and accurate methods for diagnosing extragonadal germ cell tumors (EGGCTs), and their importance is particularly prominent in cases where preoperative chemotherapy is involved.
CANCER CYTOPATHOLOGY
(2023)
Article
Pediatrics
Xiao Ma, Dongyan Cao, Peng Peng, Yu Xiao, Jiaxin Yang, Huifang Huang, Ying Zhang, Mei Yu, Jinhui Wang, Huimei Zhou, Ninghai Cheng, Tao Wang, Keng Shen
Summary: This study summarized the clinical features, treatment modalities, outcomes, and prognosis of extragonadal yolk sac tumors (YSTs) of the female genital tract. The results showed that BEP chemotherapy can be preferred for vaginal and uterine YSTs, and vaginohysteroscopy and pediatric rhinoscopy can be used for diagnosis and evaluation of treatment efficacy in pediatric patients.
FRONTIERS IN PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Massimo De Felici, Francesca Gioia Klinger, Federica Campolo, Carmela Rita Balistreri, Marco Barchi, Susanna Dolci
Summary: In the human embryo, the genetic program responsible for germ cell specification involves a balance between epigenetic and transcriptional mechanisms, resulting in a unique cell population that can exhibit both germness and pluripotency features. Germ cell tumors, originating from fetal or neonatal germ cells, maintain this balance and can display a wide range of phenotypes with either pluripotent or germness characteristics. This review highlights the similarities in transcriptional and epigenetic programs between human primordial germ cells and germ cell tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Weigang Xiu, Jiyun Pang, Yang Hu, Huashan Shi
Summary: In this review, the current research progress on the pathogenesis, diagnosis, and treatment of extragonadal germ cell tumors (EGCTs) from an immunology perspective are summarized. EGCTs have a histological origin related to gonads but are located outside. They can occur in various areas and have great morphological variation. The unclear pathogenesis and extensive differential diagnosis of EGCTs pose challenges. This review provides ideas for applying immunology in combating these diseases, which is currently a hot topic.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pathology
Khaleel Al-Obaidy, Sean R. Williamson, Nathan Shelman, Muhammad T. Idrees, Thomas M. Ulbright
Summary: Rare hepatoid teratomas (HTs) in testicular germ cell tumor patients present distinct histological features and immunohistochemical profiles compared to hepatoid yolk sac tumor (HYST) and hepatocellular carcinoma (HCC).
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Oncology
Xianzhong Cheng, Qian Zhao, Xia Xu, Wenwen Guo, Hongyuan Gu, Rui Zhou, Chen Chen, Dawei Ma, Yinan Wu, Jing Ni, Xiaoxiang Chen
Summary: Yolk sac tumors originating from the endometrium and the broad ligament are very rare, with controversial treatment strategies. Both cases were treated with surgery combined with chemotherapy using the BEP regimen.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Margaretha A. Skowron, Mara Kotthoff, Felix Bremmer, Katja Ruhnke, Fatma Parmaksiz, Annika Richter, Stefan Kueffer, Kirsten Reuter-Jessen, Stella Pauls, Anja Stefanski, Philipp Stroebel, Kai Stuehler, Daniel Nettersheim
Summary: This study identified a novel CLDN6-ADC for targeting germ cell tumors (GCT) and discovered pharmacological inhibitors that block FGF, VGF, PDGF, mTOR, CHEK1, AURKA, or PARP signaling for the treatment of refractory yolk-sac tumors (YST). Furthermore, the study shed light on the mechanisms of therapy resistance in YST.
MOLECULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Shih-Hsiang Chen, Chia-Jui Du, Jin-Yao Lai, Tsung-Yen Chang, Chao-Ping Yang, Iou-Jih Hung, Tang-Her Jaing, Yung-Ching Ming, Chuen Hsueh
Summary: This study analyzed data from 15 children with malignant sacrococcygeal germ cell tumors (MSGCTs) in Taiwan. Some patients were found to have sacrococcygeal tumors present at birth. All patients presented with a bulging mass at the buttock region and normal alpha-fetoprotein levels. The main treatment approach was primary excision of the tumor.
Article
Surgery
Xuzhen Wang, Shaojie Zhao, Min Zhao, Dandan Wang, Haixia Chen, Liping Jiang
Summary: This study presented the clinicopathologic features and treatments of two cases of extragonadal yolk sac tumor (EGYST) in young females, highlighting the potential benefit of adding targeted therapy and immunotherapy to traditional chemotherapy regimens to improve patient outcomes and reduce recurrence rates.
Article
Pathology
Andres M. Acosta, Khaleel Al-Obaidy, Lynette M. Sholl, Brendan C. Dickson, Neal Lindeman, Michelle S. Hirsch, Katrina Collins, Christopher D. Fletcher, Muhammad T. Idrees
Summary: This study found that 60% of SYST tumors in TGCTs carry rare somatic oncogenic mutations, and the presence of these mutations is associated with aggressive clinical progression. High-grade SYST tumors have a higher risk of disease-specific death compared to low-grade tumors, and the presence of somatic mutations increases the risk of disease-specific mortality.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Review
Medicine, General & Internal
Taiki Isaji, Kenichiro Iwami, Fuminori Ato, Tadashi Watanabe, Emiko Takahashi, Shigeru Miyachi
Summary: Yolk sac tumor (YST) is a rare brain tumor that mainly affects patients under 30 years old, with the most common sites being the pineal and suprasellar regions. YSTs in the medulla oblongata are extremely rare and can be difficult to diagnose due to their uncommon growth patterns. They have a poor prognosis, but this case study presents a 50-year-old woman who remained tumor-free during an 18-month follow-up.
Article
Clinical Neurology
Brian Fiani, Juliana Runnels, James Brazdzionis, Dan Miulli
Summary: Intracranial germ cell tumors are rare and can present with a variety of symptoms. Rarely, these tumors can transform into alternative malignancies, leading to challenging treatment options. This article reports a rare case of metastatic adenosquamous carcinoma transformed from a yolk sac tumor in atypical locations of the brain.
ACTA NEUROCHIRURGICA
(2022)
Article
Oncology
Dimitrios Nasioudis, Melissa K. Frey, Eloise Chapman-Davis, Thomas A. Caputo, Kevin M. Holcomb
Summary: A surveillance only strategy for patients with stage I malignant ovarian germ cell tumors is associated with excellent survival outcomes for patients with grade 2 or 3 immature teratoma or mixed germ cell tumors. Patients with yolk sac tumors who received chemotherapy had better overall survival compared to those who did not receive chemotherapy.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)