Article
Biochemistry & Molecular Biology
Jing Wang, Hongling Chen, Wanrong Li, Lingling Shan
Summary: This study aimed to examine the effect of cordyceps acid (CA) on lung cancer in mice. The results showed that CA inhibited lung cancer by regulating the Nrf-2/HO-1/NLRP3/NF-kappa B signal pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kavita Mallya, Shailendra K. Gautam, Abhijit Aithal, Surinder K. Batra, Maneesh Jain
Summary: Mouse models have played a central role in understanding and optimizing therapeutic modalities for PDAC, evolving from simple cell line-based xenografts to complex genetically engineered models. They provide new insights and understanding about the pathobiology of PDAC, and have been extensively used for evaluating immunotherapies and other treatments to guide clinical trials.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Mathematics, Interdisciplinary Applications
Levente Kovacs, Bence Czako, Mate Siket, Tamas Ferenci, Andras Furedi, Balazs Gombos, Gergely Szakacs, Daniel Andras Drexler
Summary: An algorithm for optimizing cancer therapy using control engineering approach is proposed and tested in a mouse model. The results demonstrate that remission can be induced within a 28-day interval using the algorithm.
Article
Medicine, Research & Experimental
Renze Gu, Qingchuan Zhang
Summary: Prostate cancer is the most prevalent tumor in men globally. This study demonstrated that the combination of low-dose bufalin and hydroxycamptothecin significantly inhibited CRPC tumors in vivo by regulating the PI3K/AKT/GSK-3 beta and p53-dependent apoptosis signaling pathways.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Teresita del N. J. Flores-Tellez, Esther Baena
Summary: Tumor heterogeneity in prostate cancer plays a crucial role in prognosis, therapy selection, relapse, and treatment resistance, influenced by various intrinsic and extrinsic factors. Recent studies have highlighted the diverse heterogeneity of prostate cancer, focusing on characterizing the complexity of tumors to guide more precise therapies. Understanding tumor heterogeneities will enhance patient risk stratification and help design more effective treatments for this constantly changing disease.
Article
Anatomy & Morphology
Stefan Linsler, Simon J. Mueller, Andreas Mueller, Sebastian Senger, Joachim M. Oertel
Summary: This study investigated fluorescent image-guided resection with somatostatin receptor labelled fluorescence dye for intracranial meningioma in nude mice, demonstrating the value of this method in clearly identifying tumor margins and promoting complete tumor resection. A new experimental animal model for fluorescence meningioma surgery was also established.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Biotechnology & Applied Microbiology
Hongwei Wu, Zhengxi He, Xianan Li, Xuezheng Xu, Wu Zhong, Jie Bu, Gang Huang
Summary: The study established an orthotropic osteosarcoma model using a novel method of cell sheet culture and transplantation. The results demonstrated that cell sheet implantation could rapidly form tumors with high consistency in growth rate and size, suggesting its potential as an efficient approach for tumor research and reduction in mice consumption.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Lauren B. Peiffer, Jessica Hicks, Rebecca Y. Sosa, Angelo M. De Marzo, Karen S. Sfanos, Janielle P. Maynard
Summary: This study provides a detailed protocol for resecting subcutaneous prostate cancer allografts in mice, resulting in local tumor recurrence and the development of distant metastases, offering a new model system to study prostate cancer metastasis in vivo.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kwan-Ling Yip, Tsen-Ni Tsai, I-Ping Yang, Zhi-Feng Miao, Yen-Cheng Chen, Ching-Chun Li, Wei-Chih Su, Tsung-Kun Chang, Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Jaw-Yuan Wang
Summary: Metformin enhances the chemosensitivity of colorectal cancer cells to 5-fluorouracil and oxaliplatin by inducing cell cycle arrest and apoptosis through modulation of mitochondria-related proteins.
Article
Medicine, Research & Experimental
Luting Yu, Yihan Zhou, Shaozheng Sun, Runlin Wang, Weihong Yu, Hanyu Xiao, Zhuxi Yu, Chen Luo
Summary: This study investigates the relationship between Reg3A expression, colorectal cancer (CRC) development, and immune cell alteration in patients. The results show that high expression of Reg3A is associated with CRC and increased immune cell infiltration. Reg3A overexpression inhibits cell proliferation and promotes apoptosis, leading to a tumor-suppressive effect. Additionally, Reg3A activates and recruits T cells, resulting in cytotoxic tumor suppression.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Bingqing Wang, Yuqing Yang, Yichen Wang, Yanxin Yang, Yi Li, Chenxi Hu, Changyue Xue
Summary: This study examined the effects of matrix stiffness on neovascular homeostasis in nude mice and found that a softer matrix is conducive to maintaining neovascular homeostasis through autophagy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Medicine, Research & Experimental
Michael Beshiri, Supreet Agarwal, Juan Juan Yin, Kathleen Kelly
Summary: Organoid technology has revolutionized translational research in oncology by developing patient-specific living biobanks. Prostate cancer research has been limited to a few in vitro models, hindering the translation of experimental findings to heterogeneous patient populations. Organoid culture methods have expanded the diversity of tractable models, including luminal stem/progenitor cells and patient-derived cancers, enabling more accurate therapeutic predictions and informative clinical trials. This article examines the current use of prostate organoid technology, potential therapeutic applications, and existing challenges.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Yingqiu Yin, Junling Xie, Feng Peng, Liming Tan, Yun Xiao, Huiying Zheng, Lingzhi Yin, Huijing Situ, Shanqiang Zhang
Summary: This study investigated the mechanism by which CPT-11 affects the growth and metastasis of lung cancer cells through the EGFR/MAPK pathway. Bioinformatics analysis identified EGFR as the target protein of CPT-11, and in vivo experiments confirmed that CPT-11 enhances lung cancer cell growth and metastasis by inhibiting the activation of the EGFR/MAPK pathway. Furthermore, it was found that EGFR promotes lung cancer cell growth and metastasis via the activation of the MAPK pathway.
Article
Biochemistry & Molecular Biology
Xiangdong Zhang, Xiaoxuan Jin, Yibao Li, Mimi Xu, Yao Yao, Kaiyang Liu, Chijuan Ma, Yuchen Zhang, Jiangjiang Ru, Yunfan He, Jianhua Gao
Summary: This study aims to clarify the process of extracellular matrix (ECM) remodeling and its relationship with adipocyte survival and adipogenesis after fat grafting. The results demonstrate the various preservation modes of fat grafts after transplantation and underscore the importance of macrophage-mediated ECM remodeling in graft preservation.
Article
Psychology, Biological
A. Resasco, A. MacLellan, M. A. Ayala, L. Kitchenham, A. M. Edwards, S. Lam, S. Dejardin, G. Mason
Summary: The study demonstrated construct validity for a novel mouse judgment bias test, which can be used to assess animal welfare and the impact of disease on affective states. Results showed that environmentally-enriched mice exhibited more 'optimistic' responses, while tumor-bearing mice displayed more pessimistic attitudes.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Oncology
Lluis Lopez-Barcons, Barry J. Maurer, Min H. Kang, C. Patrick Reynolds
INTERNATIONAL JOURNAL OF CANCER
(2017)
Review
Andrology
Lluis-A Lopez-Barcons
ASIAN JOURNAL OF ANDROLOGY
(2010)
Review
Andrology
Lluis-A. Lopez-Barcons
ASIAN JOURNAL OF ANDROLOGY
(2010)
Article
Hematology
Claudia P. Hernandez, Kevin Morrow, Lluis A. Lopez-Barcons, Jovanny Zabaleta, Rosa Sierra, Cruz Velasco, John Cole, Paulo C. Rodriguez
Meeting Abstract
Oncology
Lluis Lopez-Barcons, Min H. Kang, Barry J. Maurerl, C. Patrick Reynolds
Meeting Abstract
Oncology
A. N. Ali, L. A. Lopez-Barcons, P. L. Feingold, G. Sica, M. Willard, S. Muller, R. Diaz
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2010)
Review
Cell Biology
Lluis-A. Lopez-Barcons
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2010)
Article
Oncology
Ashly Hindle, Balakrishna Koneru, Monish Ram Makena, Lluis Lopez-Barcons, Wan Hsi Chen, Thinh H. Nguyen, C. Patrick Reynolds
Summary: High MGMT expression is associated with resistance to alkylating agents and TMZ+IRN in preclinical neuroblastoma models. The MGMT inhibitor O6BG enhances the anticancer effect of TMZ+IRN in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Sameer Phadke, Lluis Lopez-Barcons, Nathalie Vandecan, Zhifen Wu, Taylor K. Johnson, Eric J. Lachacz, Sofia D. Merajver, Matthew B. Soellner
Summary: The study presents a design strategy to generate a combination of kinase inhibitors with different hinge-binders and DFG-pocket groups, and investigates their selectivity. Through analysis, two selective inhibitors with low nanomolar potency against Axl or clinically relevant mutants of Abl were identified.
RSC MEDICINAL CHEMISTRY
(2022)
Meeting Abstract
Oncology
Athena M. Apfel, Nathan M. Merrill, Nathalie M. Vandecan, Liwei Bao, Xu Cheng, Lluis A. Lopez-Barcons, Kathleen C. Day, Phillip L. Palmbos, Mark L. Day, Aaron M. Udager, Matthew B. Soellner, Sofia D. Merajver
Meeting Abstract
Oncology
Sameer Phadke, Lluis Lopez-Barcons, Taylor K. Johnson, Eric J. Lachacz, Sofia D. Merajver, Matthew B. Soellner
Review
Biochemistry & Molecular Biology
Lluis A. Lopez-Barcons, Arif N. Ali, Roberto Diaz
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2011)
Article
Oncology
Marie-Emmanuelle Legrier, Chia-Ping Huang Yang, Han-Guang Yan, Lluis Lopez-Barcons, Steven M. Keller, Roman Perez-Soler, Susan Band Horwitz, Hayley M. McDaid
Meeting Abstract
Oncology
H. M. McDaid, M. Legrier, C. H. Yang, H. G. Yan, L. Lopez-Barcons, S. M. Keller, S. B. Horwitz
JOURNAL OF CLINICAL ONCOLOGY
(2007)