P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models
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Title
P450 inhibitor ketoconazole increased the intratumor drug levels and antitumor activity of fenretinide in human neuroblastoma xenograft models
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 141, Issue 2, Pages 405-413
Publisher
Wiley
Online
2017-03-25
DOI
10.1002/ijc.30706
References
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Related references
Note: Only part of the references are listed.- Neuroblastoma (Peripheral neuroblastic tumours)
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- Reactive Oxygen Species Mediates the Synergistic Activity of Fenretinide Combined with the Microtubule Inhibitor ABT-751 against Multidrug-Resistant Recurrent Neuroblastoma Xenografts
- (2016) N. E. Chen et al. MOLECULAR CANCER THERAPEUTICS
- Advances in the translational genomics of neuroblastoma: From improving risk stratification and revealing novel biology to identifying actionable genomic alterations
- (2015) Kristopher R. Bosse et al. CANCER
- Abstract 2616: Comparison of the cytotoxicity and increase of reactive oxygen species and dihydroceramides of fenretinide to its major metabolites (4-oxo- and 4-methoxyphenyl fenretinide) in T-cell lymphoid malignancy, neuroblastoma, and ovarian cancer cell lines
- (2015) Michael M. Song et al. CANCER RESEARCH
- Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations
- (2014) Ahsan S. Farooqi et al. JOURNAL OF NEURO-ONCOLOGY
- Phase I trial of fenretinide delivered orally in a novel organized lipid complex in patients with relapsed/refractory neuroblastoma: A report from the new approaches to neuroblastoma therapy (NANT) consortium
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- Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure
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- Phase II Study of Oral Capsular 4-Hydroxyphenylretinamide (4-HPR/Fenretinide) in Pediatric Patients with Refractory or Recurrent Neuroblastoma: A Report from the Children's Oncology Group
- (2011) J. G. Villablanca et al. CLINICAL CANCER RESEARCH
- Synergistic Activity of Fenretinide and the Bcl-2 Family Protein Inhibitor ABT-737 against Human Neuroblastoma
- (2011) H. Fang et al. CLINICAL CANCER RESEARCH
- Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases
- (2010) NA Illingworth et al. BRITISH JOURNAL OF PHARMACOLOGY
- Anti-GD2 Antibody with GM-CSF, Interleukin-2, and Isotretinoin for Neuroblastoma
- (2010) Alice L. Yu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma
- (2009) Roos Cuperus et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Dose translation from animal to human studies revisited
- (2007) Shannon Reagan-Shaw et al. FASEB JOURNAL
- The xenobiotic inhibitor profile of cytochrome P4502C8
- (2003) Chin-Eng Ong et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
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