Article
Cell Biology
Sha Zhou, Jianhong Peng, Liuniu Xiao, Caixia Zhou, Yujing Fang, Qingjian Ou, Jiayi Qin, Mengzhong Liu, Zhizhong Pan, Zhenlin Hou
Summary: TRIM25 is identified as an epigenetic regulator of oxaliplatin resistance in colorectal cancer patients, affecting disease-free survival and recurrence rates. Its overexpression promotes stem cell properties in CRC cells and resistance to chemotherapy. Targeting TRIM25 may be a potential strategy for managing OXA resistance in clinical practice.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Minhao Yu, Hao Wang, Wei Zhao, Xiaoxiao Ge, Wei Huang, Fengjuan Lin, Wenbo Tang, Ang Li, Sailiang Liu, Rong-Kun Li, Shu-Heng Jiang, Junli Xue
Summary: This study reveals the significant role of PIPKI?? in oxaliplatin resistance and provides a key mechanism of exosomal PD-L1 in colorectal cancer with potential therapeutic implications.
Article
Oncology
Sadayuki Kawai, Nozomi Takeshima, Yu Hayasaka, Akifumi Notsu, Mutsumi Yamazaki, Takanori Kawabata, Kentaro Yamazaki, Keita Mori, Hirofumi Yasui
Summary: The study compared the efficacy and toxicity profiles of IRI- and Ox-based regimens as first-line treatments for mCRC, finding no significant difference in terms of overall survival, progression-free survival, and objective response rate between the two groups. However, there were differences in toxicity profile, with IRI-based regimens associated with higher incidence of certain adverse events, while Ox-based regimens had different toxicities such as thrombocytopenia and peripheral sensory neuropathy.
Article
Pharmacology & Pharmacy
Chengzhi Huang, Minjia Wang, Junjiang Wang, Deqing Wu, Yuan Gao, Kaihong Huang, Xueqing Yao
Summary: The study revealed that overexpression of MGP in colorectal cancer may contribute to oxaliplatin resistance and be associated with cancer stage and patient prognosis. Inhibition of MGP expression can increase sensitivity of CRC cells to OXA, potentially reversing resistance and reducing tumor growth.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Polymer Science
Naser Rasouli, Daryoush Shahbazi-Gahrouei, Simin Hematti, Behzad Baradaran, Roya Salehi, Jaleh Varshosaz, Abbas Jafarizad
Summary: This study investigates the potential of oxaliplatin-loaded iodine nanoparticles in the treatment of colorectal cancer. The results show that these nanoparticles can enhance the radiosensitivity and promote apoptosis of cancer cells. Additionally, the nanoparticles have no impact on cell cycle development. Therefore, iodine nanoparticles may be used as a treatment for colorectal cancer.
Article
Pharmacology & Pharmacy
Sijie Zha, Ting Li, Qingshan Zheng, Lujin Li
Summary: This study clarifies the benefits and risks of postoperative adjuvant chemotherapy compared with surgery alone in patients with stage II/III colorectal cancer using model analysis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Kazuaki Okamoto, Hiroaki Nozawa, Shigenobu Emoto, Koji Murono, Kazuhito Sasaki, Soichiro Ishihara
Summary: This study aimed to investigate the tolerability and efficacy of adjuvant CAPOX therapy in elderly patients compared to young patients. The results showed that adjuvant CAPOX therapy was well-tolerated in elderly Japanese patients, and the prognosis of elderly patients with stage III CRC was similar to that of their younger counterparts. Therefore, advanced age may not be a contraindication for adjuvant chemotherapy in CRC.
Article
Biochemistry & Molecular Biology
Joris van de Haar, Xuhui Ma, Salo N. Ooft, Pim W. van der Helm, Louisa R. Hoes, Sara Mainardi, David J. Pinato, Kristi Sun, Lisa Salvatore, Giampaolo Tortora, Ina Valeria Zurlo, Silvana Leo, Riccardo Giampieri, Rossana Berardi, Fabio Gelsomino, Valeria Merz, Federica Mazzuca, Lorenzo Antonuzzo, Gerardo Rosati, Chara Stavraka, Paul Ross, Maria Grazia Rodriquenz, Michele Pavarana, Carlo Messina, Timothy Iveson, Federica Zoratto, Anne Thomas, Elisabetta Fenocchio, Margherita Ratti, Ilaria Depetris, Massimiliano Cergnul, Cristina Morelli, Michela Libertini, Alessandro Parisi, Michele De Tursi, Nicoletta Zanaletti, Ornella Garrone, Janet Graham, Raffaella Longarini, Stefania Maria Gobba, Angelica Petrillo, Emiliano Tamburini, Nicla La Verde, Fausto Petrelli, Vincenzo Ricci, Lodewyk F. A. Wessels, Michele Ghidini, Alessio Cortellini, Emile E. Voest, Nicola Valeri
Summary: Genomic analysis identified KRAS(G12) mutations as potential biomarkers of resistance to trifluridine/tipiracil treatment in metastatic colorectal cancer. Real-world data and phase 3 clinical trial data confirmed the significant association between KRAS(G12) mutations and reduced overall survival. These findings provide important implications for precision medicine in approximately 28% of patients with metastatic colorectal cancer.
Article
Oncology
Camille Julio, Stephane Benoist, Marc-Antoine Allard, Francis Navarro, Patrick Pessaux, Antonio Sa Cunha, Antoine Brouquet
Summary: The background outcome of patients with resectable metachronous colorectal liver metastases after adjuvant oxaliplatin-based chemotherapy for colorectal cancer is not well defined, and the value of preoperative chemotherapy is controversial.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Hironaga Satake, Hiroki Hashida, Hiroaki Tanioka, Yasuhiro Miyake, Shinichi Yoshioka, Takanori Watanabe, Masato Matsuura, Takahisa Kyogoku, Michio Inukai, Takeshi Kotake, Yoshihiro Okita, Toshihiko Matsumoto, Hisateru Yasui, Masahito Kotaka, Takeshi Kato, Satoshi Kaihara, Akihito Tsuji
Summary: The three-month adjuvant CAPOX treatment is well-tolerated and may be a promising strategy for post-curative resection of CLM, showing potential effectiveness and tolerability for patients.
Article
Biochemistry & Molecular Biology
Sara Cherradi, Veronique Garambois, Johanna Marines, Augusto Faria Andrade, Alexandra Fauvre, Olivia Morand, Manon Fargal, Ferial Mancouri, Adeline Ayrolles-Torro, Nadia Vezzo-Vie, Marta Jarlier, Gerald Loussaint, Steve Huvelle, Nicolas Joubert, Thibault Mazard, Celine Gongora, Philippe Pourquier, Florence Boissiere-Michot, Maguy Del Rio
Summary: The expression of the tight junctional protein claudin 1 (CLDN1) in liver metastases of colorectal cancer (CRC) patients after chemotherapy was found to be significantly correlated with the histologic response to chemotherapy. Further experiments showed that conventional chemotherapies used in CRC treatment could induce CLDN1 expression, which was associated with resistance to apoptosis. Targeting chemotherapy-induced CLDN1 expression may represent a therapeutic opportunity to overcome resistance and improve the outcome of advanced CRC patients.
CELL AND BIOSCIENCE
(2023)
Article
Cell Biology
Vanessa Rodriguez-Fanjul, Rosa Guerrero-Lopez, Beatriz Fernandez-Varas, Rosario Perona, Ana Sastre-Perona, Leandro Sastre
Summary: This article explores the relationship between colorectal cancer stem cells and oxaliplatin-resistant cells. The results show that cancer stem cells have increased resistance to the chemotherapy drug oxaliplatin, and resistant cells contain more cancer stem cells. Additionally, both cell types exhibit increased cell invasion capacity and epithelial-mesenchymal transition. mRNA expression analysis reveals a significant proportion of commonly regulated genes in these two cell types.
Article
Multidisciplinary Sciences
Lei Zhang, Qixin Li, Chenhao Hu, Zhe Zhang, Junjun She, Feiyu Shi
Summary: This study investigated whether elderly patients (>= 70 years) with colorectal cancer (CRC) benefit from surgery and adjuvant therapy. The results showed that surgical resection was significantly associated with improved overall survival (OS) and cancer-specific survival (CSS) in CRC patients aged >= 70 years. Adjuvant therapy also led to a significant prognostic advantage for elderly advanced CRC patients who underwent surgery.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Leonard B. Saltz, Stephen Clarke, Eduardo Diaz-Rubio, Werner Scheithauer, Arie Figer, Ralph Wong, Sheryl Koski, Mikhail Lichinitser, Tsai-Shen Yang, Fernando Rivera, Felix Couture, Florin Sirzen, Jim Cassidy
Summary: The purpose of this study was to evaluate the efficacy and safety of adding bevacizumab to first-line oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. The results showed that adding bevacizumab significantly improved progression-free survival, but had no significant effect on overall survival and response rate.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Robert A. Nagourney, Steven Evans, Peter H. Tran, Adam J. Nagourney, Paul H. Sugarbaker
Summary: Patients with colon cancer who have received specific drug treatments are more likely to exhibit resistance to oxaliplatin, reducing the efficacy of heated intraperitoneal chemotherapy (HIPEC).
Review
Psychiatry
Pedro L. Ballester, Maria T. Romano, Taiane de Azevedo Cardoso, Stefanie Hassel, Stephen C. Strother, Sidney H. Kennedy, Benicio N. Frey
Summary: The study conducted a systematic review and meta-analysis to evaluate accelerated brain aging in individuals with mood or psychotic disorders. The results showed that individuals with these disorders may undergo a process of accelerated brain aging, with older individuals showing a more pronounced brain age gap, indicating a possible cumulative biological effect of illness burden.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Engineering, Electrical & Electronic
Mohamed L. Seghier
Summary: Researchers have a significant discrepancy in implementing, evaluating, and reporting the performance of machine learning methods for biomedical data classification or segmentation, resulting in poor conclusions. To improve transparency, interpretability, reproducibility, and usefulness, clear descriptions of all data processing stages and method performance evaluations, along with justified parameter and metric choices, are essential.
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY
(2022)
Article
Clinical Neurology
F. Elizabeth Godkin, Erin Turner, Youness Demnati, Adam Vert, Angela Roberts, Richard H. Swartz, Paula M. McLaughlin, Kyle S. Weber, Vanessa Thai, Kit B. Beyer, Benjamin Cornish, Agessandro Abrahao, Sandra E. Black, Mario Masellis, Lorne Zinman, Derek Beaton, Malcolm A. Binns, Vivian Chau, Donna Kwan, Andrew Lim, Douglas P. Munoz, Stephen C. Strother, Kelly M. Sunderland, Brian Tan, William E. McIlroy, Karen Van Ooteghem
Summary: The study found that continuous multi-sensor remote health monitoring is feasible in individuals with cerebrovascular disease or neurodegenerative disease, with high adherence to device wearing, mainly during daytime, and positive feedback from both participants and study partners.
JOURNAL OF NEUROLOGY
(2022)
Editorial Material
Engineering, Electrical & Electronic
Mohamed L. Seghier
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY
(2022)
Article
Oncology
Ian P. Hayes, Elasma Milanzi, Rachel M. Pelly, Peter Gibbs, Jeanette C. Reece
Summary: This study aims to clarify whether the prognostic outcomes of locally advanced rectal adenocarcinomas achieving downstaging after neoadjuvant chemoradiotherapy are associated with reduced recurrence.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Ian P. Hayes, Elasma Milanzi, Peter Gibbs, Ian Faragher, Jeanette C. Reece
Summary: Increasing lymph node count with right hemicolectomy for right-sided colon cancer may improve overall survival, but this benefit is only seen in node-negative tumors.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Anatomy & Morphology
Mohamed L. Seghier
Summary: In this review, the functions of the angular gyrus (AG) were evaluated based on evidence from TMS/TES and EEG/MEG studies. The results showed that the AG plays a causal role in semantic processing, attention, self-guided movement, memory, and self-processing. A three-phase unifying model of sensemaking was proposed, suggesting that the AG is involved early on in defining the current context and later in attention re-orientation and cross-modal integration. However, the evidence for the semantic role of the AG is still weak.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Oncology
Jonathan M. Downie, Moeen Riaz, Jing Xie, Minyi Lee, Andrew T. Chan, Peter Gibbs, Suzanne G. Orchard, Suzanne E. Mahady, Robert P. Sebra, Anne M. Murray, Finlay Macrae, Eric Schadt, Robyn L. Woods, John J. McNeil, Paul Lacaze, Manish Gala
Summary: MUTYH carriers have an increased risk of colorectal cancer, particularly in males, according to this prospective cohort study. Mutational signatures associated with early loss of heterozygosity were not observed in gastrointestinal epithelial cancers of carriers. This suggests diverse mechanisms of carcinogenesis in carriers compared to those who inherit biallelic MUTYH mutations.
CANCER PREVENTION RESEARCH
(2022)
Editorial Material
Engineering, Electrical & Electronic
Mohamed L. Seghier
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY
(2022)
Article
Psychiatry
Farhana Islam, Victoria S. Marshe, Leen Magarbeh, Benicio N. Frey, Roumen Milev, Claudio N. Soares, Sagar Parikh, Franca Placenza, Stephen C. Strother, Stefanie Hassel, Valerie H. Taylor, Francesco Leri, Pierre Blier, Rudolf Uher, Faranak Farzan, Raymond W. Lam, Gustavo Turecki, Jane A. Foster, Susan Rotzinger, Sidney H. Kennedy, Daniel J. Mueller
Summary: Cytochrome P450 drug-metabolizing enzymes, specifically CYP2C19 and CYP2D6 gene variants, have an impact on antidepressant outcomes. Poor metabolizers of CYP2C19 and CYP2D6 show less symptom improvement during treatment with escitalopram alone and are more likely to experience central nervous system side effects when taking escitalopram alone or in combination with aripiprazole.
TRANSLATIONAL PSYCHIATRY
(2022)
Editorial Material
Engineering, Electrical & Electronic
Mohamed L. Seghier
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY
(2023)
Article
Health Care Sciences & Services
Jennifer Philip, Aaron Wong, Leeanne Pasanen, Andrew A. Somogyi, Justin Rubio, Pal Klepstad, Anna Collins, Peter Gibbs, Brian Le
Summary: This study examined the feasibility of establishing an opioid pharmacogenomics registry for cancer patients. The results showed that establishing such a registry is feasible and acceptable by both patients and clinicians.
JOURNAL OF PALLIATIVE MEDICINE
(2023)
Editorial Material
Engineering, Electrical & Electronic
Mohamed L. Seghier
INTERNATIONAL JOURNAL OF IMAGING SYSTEMS AND TECHNOLOGY
(2023)
Letter
Medicine, General & Internal
Peter Gibbs, Wei Hong, Jeanne Tie
Summary: The use of biomarkers in cancer medicine is gaining increasing attention, but evaluating their effectiveness remains challenging. Ongoing discussions are being held regarding the optimal trial methodologies and evidence requirements for biomarker validation. This debate is crucial in optimizing clinical trial design and improving patient care.
Review
Anatomy & Morphology
Mohamed L. Seghier
Summary: One commonly used metric in lesion-symptom mapping is lesion load, which measures the amount of damage to a specific region of interest in the brain. It aims to simplify the complex 3D lesion information into a feature that reflects both the location and size of the damage. However, there are several methodological issues that need to be considered when estimating lesion load.
BRAIN STRUCTURE & FUNCTION
(2023)