Article
Chemistry, Medicinal
Larisa Antonova, Anton Kutikhin, Viktoriia Sevostianova, Elena Velikanova, Vera Matveeva, Tatiana Glushkova, Andrey Mironov, Evgeniya Krivkina, Amin Shabaev, Evgeniya Senokosova, Leonid Barbarash
Summary: The two-layer structure of vascular grafts incorporating bFGF and SDF-1 alpha along with VEGF demonstrates higher primary patency and improved in vivo performance.
Article
Agriculture, Dairy & Animal Science
Pedro Pinto-Bravo, Maria Rosa Rebordao, Ana Amaral, Carina Fernandes, Antonio Galvao, Elisabete Silva, Pedro Pessa-Santos, Graca Alexandre-Pires, Rosario P. Roberto da Costa, Dariusz J. Skarzynski, Graca Ferreira-Dias
Summary: The oviduct provides ideal conditions for fertilization and early embryonic development, with proper vascularization being essential for its physiological function. This study examined differences in microvascular density across different portions of the equine oviduct and found that angiogenic factors and their receptors are expressed in all studied regions, in line with microvascular patterns.
Article
Biotechnology & Applied Microbiology
Xinlong Xie, Qiying Wu, Yuhong Liu, Chunyang Chen, Zeguo Chen, Chao Xie, Mingzhe Song, Zhenlin Jiang, Xiaoke Qi, Sixi Liu, Zhenjie Tang, Zhongshi Wu
Summary: This study evaluated the effect of VEGF on neointimal hyperplasia and local inflammatory responses in decellularized small-diameter vascular grafts. The results showed that local administration of VEGF attenuated neointimal hyperplasia by inducing macrophage M2 polarization and modulating the inflammatory response.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yingkai Li, Songyuan He, Cong Wang, Wen Jian, Xueqian Shen, Yuchen Shi, Jinghua Liu
Summary: Vascular calcification is common in clinical practice and is associated with adverse events. Oxidative stress plays a role in the formation of vascular calcification. Fibroblast growth factor 21 (FGF21) has been shown to inhibit vascular calcification by restoring the level of antioxidant SOD and reducing oxidative stress. This study provides further evidence for FGF21 as a potential drug for cardiovascular protection.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Qing-Yun Xie, Lu-Ping Huang, Feng-Wei Gao, Da-Qing Liu, Xia Wang, Kang-Yi Jiang, Jie Gong, Xin Zhao, Ben-Jian Gao, Ze-Hua Lei
Summary: This study investigated the therapeutic efficacy of lenvatinib combined with sequential TACE on primary HCC and its effects on serum bFGF and VEGF. The results showed that the combination treatment group had a higher objective response rate, lower serum bFGF and VEGF levels, and better survival rates.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Guihong Liu, Tao Chen, Zhenyu Ding, Yang Wang, Yuquan Wei, Xiawei Wei
Summary: The FGF-FGFR signaling pathway and the VEGF-VEGFR signaling pathway play important roles in the treatment of tumors, and inhibitors targeting these two pathways can optimize therapeutic effects and expand the antitumor range. In addition, biomarkers should be developed in the future to predict efficacy, and combination with immune checkpoint inhibitors is a promising direction.
CELL PROLIFERATION
(2021)
Article
Biology
Tao Jia, Thibault Jacquet, Fabien Dalonneau, Pauline Coudert, Elisabeth Vaganay, Chloe Exbrayat-Heritier, Julien Vollaire, Veronique Josserand, Florence Ruggiero, Jean-Luc Coll, Beatrice Eymin
Summary: In this study, it was demonstrated that FGF-2 promotes angiogenesis by activating a SRSF1/SRSF3/SRPK1 network that regulates VEGFR1 alternative splicing in endothelial cells, which could also contribute to lung tumor progression.
Article
Biochemistry & Molecular Biology
Ni Yang, Yucong Zhang, Yi Huang, Jinhua Yan, Zonghao Qian, Han Li, Pengcheng Luo, Zhen Yang, Mandi Luo, Xiuxian Wei, Hao Nie, Lei Ruan, Yi Hao, Shangbang Gao, Kai Zheng, Cuntai Zhang, Le Zhang
Summary: This study explored the effects of serum FGF21 on vascular endothelial cells and found that FGF21 within the physiological concentration range has a beneficial effect on the cells, potentially through the regulation of SIRT1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Endocrinology & Metabolism
Giovanni Vitale, Alessia Cozzolino, Pasqualino Malandrino, Roberto Minotta, Giulia Puliani, Davide Saronni, Antongiulio Faggiano, Annamaria Colao
Summary: Neuroendocrine neoplasms are tumors originating from neuroendocrine cells in different organs, with dysregulation of receptor tyrosine kinases playing a crucial role in their development and progression. Research on the role of the fibroblast growth factor receptor system in NENs and the potential of FGFR selective inhibitors shows promising anti-tumor activity in advanced NEN patients, with further studies needed for confirmation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Haiyan Yang, Cancan He, Yang Bi, Xu Zhu, Dan Deng, Tingting Ran, Xiaojuan Ji
Summary: This study found that VEGF and SDF-1 alpha synergistically enhance the migration, differentiation, and proliferation capabilities of EPCs, but not VSMCs. This finding provides a promising strategy for the prevention of vascular stenosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniela Lener, Maria Noflatscher, Elke Kirchmair, Axel Bauer, Johannes Holfeld, Can Gollmann-Tepekoylue, Rudolf Kirchmair, Markus Theurl
Summary: Myocardial infarction (MI) causes irreversible tissue damage and eventual heart failure. Therapeutic angiogenesis using the neuropeptide catestatin (CST) has shown to restore perfusion in a mouse hind limb ischemia model. CST promotes capillary like tube formation, cell proliferation, and protects cardiomyocytes from apoptosis, indicating its potential as a therapy for MI.
Article
Urology & Nephrology
Liqiong Jiang, Qing Yin, Min Yang, Min Li, Mingming Pan, Yuchen Han, Zhen Zhao, Zhi Wang, Lili Zhu, Qing Wei, Yan Tu, Min Gao, Hong Liu, Xiaoliang Zhang, Bi-cheng Liu, Bin Wang
Summary: The study revealed that circulating FGF21 levels were significantly higher in hemodialysis patients, and were closely associated with vascular calcification, serving as a potential predictor and promoter.
Article
Chemistry, Analytical
Meihong Peng, Xu Zhao, Chao Wang, Lihao Guan, Kai Li, Chaoyue Gu, Yuqing Lin
Summary: In this study, a facile strategy was developed to construct a flexible and stretchable glucose sensor for investigating the glucose metabolism mechanism of stretched endothelial cells in hyperglycemia. The GOx@ZIF-8/Au SE sensor was successfully used for monitoring the glucose metabolism of mechanically stimulated cells in hyperglycemia, and it was found that the glucose utilization ability of cells under static conditions is higher than that in the stretched state.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yu Ran Na, Jin Young Kim, Chang Ho Song, Mikyung Kim, Yen Thi Do, Tam Thuy Lu Vo, Eunsom Choi, Eunyoung Ha, Ji Hae Seo, So-Jin Shin
Summary: This study demonstrated the promising antitumor effects of AZD4547 in ovarian cancer cells, including inhibition of proliferation, induction of apoptosis, suppression of migration and invasion, reduction of stem cell activity and angiogenesis, as well as inhibition of in vivo tumor growth in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hyoung Won Bae, Wungrak Choi, Ah Reum Hwang, Sang Yeop Lee, Gong Je Seong, Chan Yun Kim
Summary: The study found that hypoxic preconditioning significantly increased the survival rate of primary retinal ganglion cells, with VEGF playing an important regulatory role in this process. Over-inhibition of VEGF negatively impacted the survival of RGCs mediated by hypoxic preconditioning.
Editorial Material
Cell & Tissue Engineering
A. Eitner, B. Wildemann
BONE & JOINT RESEARCH
(2021)
Review
Cell Biology
Franka Klatte-Schulz, Kathi Thiele, Markus Scheibel, Georg N. Duda, Britt Wildemann
Summary: The subacromial bursa, previously considered as friction-reducing tissue, is now recognized for its stem cell potential and ability to enhance the regeneration of adjacent tissues. This review explores the role of bursal inflammation as a pain generator and a potential initiator of healing. Therapeutic targets to overcome bursal inflammation and pain are discussed, and further research is needed to fully understand the interplay between the subacromial bursa and rotator cuff tendons.
Article
Biochemistry & Molecular Biology
Manuela Thierbach, Estelle Heyne, Michael Schwarzer, Lauren G. Koch, Steven L. Britton, Britt Wildemann
Summary: The risk of tendon disorders or ruptures increases with age, and intrinsic fitness also plays a role in affecting tendon properties. Low intrinsic fitness accelerates aging of tendons and leads to further impairment, resulting in decreased healing potential and elasticity.
Article
Biochemical Research Methods
Stefan Pentzold, Britt Wildemann
Summary: Mechanical overload decreases tenogenic differentiation and increases extracellular matrix remodeling/inflammation in stimulated fibroblasts, whereas physiological load may induce opposite effects.
JOURNAL OF BIOLOGICAL ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Felix Christian Kohler, Philipp Schenk, Paul Koehler, Britt Wildemann, Gunther Olaf Hofmann, Steffen Derlien, Uta Biedermann, Isabel Graul, Jakob Hallbauer
Summary: The direction of PM screw fixation does not affect the primary stability of osteosynthesis of a posterior malleolus fracture. However, anterior to posterior screw fixation may result in slightly greater movement of the fracture. Anterior to posterior screw fixation could be a minimally invasive but stable surgical strategy for posterior malleolus fractures without significant dislocation.
APPLIED SCIENCES-BASEL
(2022)
Article
Microbiology
Marina Garcia-Moreno, Paul M. Jordan, Kerstin Guenther, Therese Dau, Christian Fritzsch, Monika Vermes, Astrid Schoppa, Anita Ignatius, Britt Wildemann, Oliver Werz, Bettina Loeffler, Lorena Tuchscherr
Summary: This study investigated the interaction between Staphylococcus aureus and osteoblasts or osteocytes during infection. The results showed that osteoblasts can induce an antimicrobial response and eliminate intracellular S. aureus, while osteocytes recruit immune cells and enhance inflammation but have a poor capacity for clearing bacterial infection. Additionally, signals from osteocytes enhance intracellular bacterial clearance by osteoblasts.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Cell & Tissue Engineering
G. G. Schulze-Tanzil, M. Delgado-Calcares, R. Stange, B. Wildemann, D. Docheva
Summary: Tendon healing is a major challenge due to its poor blood supply and slow metabolic rate. The disruption of cell-extracellular matrix interactions and uncontrolled inflammation can hinder successful healing. Optimizing Achilles tendon (AT) healing outcomes may involve adapting mechanical stimulation, restricting neoangiogenesis, and modifying stem cell niche parameters.
BONE & JOINT RESEARCH
(2022)
Article
Medicine, General & Internal
T. Fintan Moriarty, Willem-Jan Metsemakers, Mario Morgenstern, Marloes Hofstee, Alejandro Vallejo Diaz, James E. Cassat, Britt Wildemann, Melissa Depypere, Edward M. Schwarz, R. Geoff Richards
Summary: Fracture-related infection (FRI) is a common complication of bone fractures, where pathogenic bacteria enter the wound and hinder the healing process. This Primer provides an overview of the epidemiology, pathobiology, diagnosis, and management of these infections, as well as their impact on patient quality of life.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Medicine, General & Internal
Felix Christian Kohler, Philipp Schenk, Theresa Nies, Jakob Hallbauer, Gunther Olaf Hofmann, Uta Biedermann, Heike Kielstein, Britt Wildemann, Roland Ramm, Bernhard Wilhelm Ullrich
Summary: In the treatment of ankle fractures, complications related to wound healing after open reduction and internal fixation are a significant issue. A minimally invasive nail stabilization technique has been proposed as an alternative. This biomechanical study aimed to determine if this technique is comparable to the established method. The results showed that both the nail and plate fixations resulted in reduced stability and rotational stiffness compared to the intact ankle. While the nail fixation had greater rotational stiffness, both methods fell short of the native stability. The study suggests that weight-bearing after nail fixation should be evaluated on a case-by-case basis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shibarjun Mandal, Astrid Tannert, Christina Ebert, Rustam R. Guliev, Yvonne Ozegowski, Lina Carvalho, Britt Wildemann, Simone Eiserloh, Sina M. Coldewey, Bettina Loeffler, Luis Bastiao Silva, Verena Hoerr, Lorena Tuchscherr, Ute Neugebauer
Summary: Osteomyelitis, a difficult-to-treat bone infection caused by Staphylococcus aureus, was studied using mouse models. Fluorescence imaging and label-free Raman spectroscopy were used to characterize tissue changes and bacterial localization. The results showed that bacteria formed abscesses in the infected tissue, with lower numbers found in surrounding muscle tissue and trabecular bone tissue. Raman spectroscopic imaging revealed a metabolic state of the bacteria with reduced activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Manuela Thierbach, Michelle Mueller, Richard Stange, Daniel Kronenberg, Matthias Aurich, Britt Wildemann
Summary: Although prophylactic use of vancomycin is routinely performed after ACL reconstruction, it may potentially harm the tissue and cells. A comprehensive study was conducted to investigate its effect on tendon tissue and isolated tenocytes, and the results demonstrated that vancomycin at clinically used concentrations had no negative impact on cell viability, gene expression, histology, and mechanical integrity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Nicole Bormann, Aysha Schmock, Anja Hanke, Volker Eras, Norus Ahmed, Maya S. Kissner, Britt Wildemann, Jan C. Brune
Summary: Bone defects and infections present challenges for treatment, and this study evaluated the efficacy of different bone allografts in antibiotic absorption and release. The fibrous grafts showed the highest absorption capacity, while mineralized cancellous bone had the lowest absorption capacity. The fibrous grafts also exhibited prolonged antibiotic release and activity, making them suitable carrier grafts for antibiotic administration.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Medicine, General & Internal
Jakob Hallbauer, Philipp Schenk, Lea Herrmann, Bernhard Wilhelm Ullrich, Uta Biedermann, Britt Wildemann, Gunther Olaf Hofmann, Felix Christian Kohler
Summary: The hook test is commonly used to assess syndesmosis stability during surgery, but there are no guidelines for the force required or the reliability of the test. In this study, ten experienced surgeons performed hook tests on cadaver bone models, with forces recorded in a blinded manner. Standardized hook tests were also performed on cadaver lower legs, revealing that the force and instability of the syndesmosis significantly influenced syndesmosis diastasis. However, even with maximum instability, only a small percentage of specimens showed significant diastasis (>2 mm). The hook test shows high variability and is not able to detect relevant syndesmosis injuries, even when performed in a standardized manner.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Stefan Ferdinand Hertling, David Alexander Back, Britt Wildemann, Ekkehard Schleussner, Mario Kaiser, Isabel Graul
Summary: Mentoring programs have a positive impact on students' career planning, but the participation of surgical specialties is low. Increasing the availability of mentoring programs, with a special focus on women and more surgical content, can help address the shortage of surgical trainees.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Runa Kinitz, Estelle Heyne, Lauren G. Koch, Steven L. Britton, Manuela Thierbach, Britt Wildemann
Summary: Old age, adiposity, and metabolic disorders are risk factors for chronic tendinopathy, and aging seems to play a prominent role in molecular and structural alterations of Achilles tendon tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
