Article
Immunology
Dominique Baeten, Iannis E. Adamopoulos
Summary: This article discusses the pathobiology of axial spondyloarthritis, particularly the role of IL-23/IL-17 axis, and shares relevant lessons learned for translating emerging biological insights into clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Alireza Rezaiemanesh, Mahdi Mahmoudi, Ali Akbar Amirzargar, Mahdi Vojdanian, Farhad Babaie, Jila Mahdavi, Misagh Rajabinejad, Ahmad Reza Jamshidi, Mohammad Hossein Nicknam
Summary: ER stress in macrophages from AS patients plays a role in the increased production of IL-23. The autophagy pathway is not involved in the modulation of IL-23 production by AS macrophages.
Article
Immunology
Zhihua Yin, Hui-Ying Low, Brian Shiian Chen, Kuo-Shu Huang, Yue Zhang, Yu-Hsun Wang, Zhizhong Ye, James Cheng-Chung Wei
Summary: This study found a higher risk of ankylosing spondylitis (AS) in patients with endometriosis, suggesting clinicians should be aware of the occurrence of AS in patients with endometriosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Dennis McGonagle, Abdulla Watad, Kassem Sharif, Charlie Bridgewood
Summary: IL-23 plays a crucial role in spondyloarthritis, with implications in the genetic basis, disease progression and treatment efficacy. However, further studies are necessary to determine the specific effects and mechanisms of IL-23 in different disease sites.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Luca Franco, Raj Sengupta, Logan Wade, Dario Cazzola
Summary: The study introduced a wearable sensor protocol for assessing spinal ROM and kinematics, showing low error in measurements and high level of agreement in reliability analysis. The protocol demonstrated potential for clinical application, but further validation on Axial Spondyloarthritis patients is needed.
Article
Medicine, General & Internal
Ming-Han Chen, Huai-Chia Chuang, Yi-Chen Yeh, Chung-Tei Chou, Tse-Hua Tan
Summary: This study investigated the potential roles of dual-specificity phosphatase (DUSPs) in ankylosing spondylitis (AS). Results showed that mRNA levels of DUSP4, DUSP5, DUSP6, DUSP7, and DUSP14 in peripheral T cells were significantly higher in AS patients compared to healthy controls, while DUSP22 mRNA levels were significantly lower. DUSP22 was found to play a crucial role in the pathogenesis and regulation of disease activity of AS.
Article
Rheumatology
Desiree van der Heijde, Mikkel Ostergaard, John D. Reveille, Xenofon Baraliakos, Andris Kronbergs, David M. Sandoval, Xiaoqi Li, Hilde Carlier, David H. Adams, Walter P. Maksymowych
Summary: This study evaluates the long-term effect of IXE on radiographic changes in the spine in patients with r-axSpA and identifies potential predictors of progression. The majority of patients had no radiographic progression in the spine through 2 years of treatment.
JOURNAL OF RHEUMATOLOGY
(2022)
Editorial Material
Rheumatology
Juergen Braun, Robert B. M. Landewe
Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Yu Zhang, Sixi Wei, Qingqing Wu, Xue Shen, Wanrong Dai, Zhiqi Zhang, Man Chen, Hai Huang, Li Ma
Summary: IL-35 is a potent cytokine that suppresses CD4(+) effector T cell proliferation and promotes Treg expansion. This study investigates the effects of IL-35 on Bregs in AS patients and finds that reduced IL-35 production may be associated with Bregs defects in AS patients. Furthermore, IL-35 can induce the proliferation of CD19(+)CD24(hi)CD38(hi) Bregs and IL-10 production, suggesting its potential as a therapeutic target for AS.
CLINICAL RHEUMATOLOGY
(2022)
Review
Medicine, General & Internal
Giuseppe Scalise, Antonio Ciancio, Daniele Mauro, Francesco Ciccia
Summary: Ankylosing spondylitis is a chronic inflammatory disease characterized by inflammation of axial joints and the pelvis. Intestinal dysbiosis may play a role in the pathogenesis of the disease, with microbial metabolism potentially influencing disease onset.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Meng Gao, Teng Li, ZeLong Song, XiangYu Wang, XueSong Zhang, WeiBo Liu
Summary: The meta-analysis revealed that IL-1 gene polymorphism IL-1A-889 (rs1800587) increases the risk of ankylosing spondylitis (AS) in English and Tunisian populations. Conversely, IL1F7 exon 2 (rs3811047) is negatively correlated with susceptibility to AS in Canadian and Chinese populations. Further studies are required for more in-depth exploration.
BIOCHEMICAL GENETICS
(2022)
Review
Medicine, General & Internal
Mingguang Yan, Xiao Fang, Jianjun Guo, Weibing Yin
Summary: This protocol aims to evaluate the efficacy and safety of IL-17A inhibitors in patients with ankylosing spondylitis through systematic review and meta-analysis. By searching multiple electronic databases, the current evidence will be synthesized. The results of this protocol can provide strong evidence for clinicians in managing ankylosing spondylitis.
Article
Medicine, General & Internal
Yi-Ping Tang, Quan-Bo Zhang, Fei Dai, Xia Liao, Zeng-Rong Dong, Ting Yi, Yu-Feng Qing
Summary: Differentially expressed circRNAs were found in PBMCs of AS patients, which may be involved in the occurrence and development of AS. Among them, hsa_circRNA_012732 has the potential to be an indicator of disease activity, and hsa_circRNA_001544 has the potential to be a molecular marker for AS diagnosis.
CHINESE MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Sylwia Bialy, Milena Iwaszko, Jerzy Swierkot, Bartosz Bugaj, Katarzyna Kolossa, Slawomir Jeka, Katarzyna Bogunia-Kubik
Summary: This study investigated the relationship between IL5 and IL9 gene variants and susceptibility to AS, clinical parameters, and response to TNF inhibitor therapy. The results demonstrated significant associations between IL5 and IL9 polymorphisms and response to anti-TNF therapy, indicating a significant role for IL-5 and IL-9 in the development and response to treatment of AS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Joachim Sieper, Joachim Listing, Denis Poddubnyy, In-Ho Song, Kay-Geert Hermann, Johanna Callhoff, Uta Syrbe, Juergen Braun, Martin Rudwaleit
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Rheumatology
Kristina Conrad, Peihua Wu, Joachim Sieper, Uta Syrbe
ARTHRITIS RESEARCH & THERAPY
(2015)
Article
Rheumatology
Janine Bleil, Joachim Sieper, Rene Maier, Uwe Schlichting, Axel Hempfing, Uta Syrbe, Heiner Appel
ARTHRITIS RESEARCH & THERAPY
(2015)
Article
Rheumatology
Uta Syrbe, Johanna Callhoff, Kristina Conrad, Denis Poddubnyy, Hildrun Haibel, Susann Junker, Klaus W. Frommer, Ulf Mueller-Ladner, Elena Neumann, Joachim Sieper
ARTHRITIS & RHEUMATOLOGY
(2015)
Article
Immunology
Pawel Durek, Karl Nordstroem, Gilles Gasparoni, Abdulrahman Salhab, Christopher Kressler, Melanie De Almeida, Kevin Bassler, Thomas Ulas, Florian Schmidt, Jieyi Xiong, Petar Glazar, Filippos Klironomos, Anupam Sinha, Sarah Kinkley, Xinyi Yang, Laura Arrigoni, Azim Dehghani Amirabad, Fatemeh Behjati Ardakani, Lars Feuerbach, Oliver Gorka, Peter Ebert, Fabian Mueller, Na Li, Stefan Frischbutter, Stephan Schlickeiser, Carla Cendon, Sebastian Froehler, Baerbel Felder, Nina Gasparoni, Charles D. Imbusch, Barbara Hutter, Gideon Zipprich, Yvonne Tauchmann, Simon Reinke, Georgi Wassilew, Ute Hoffmann, Andreas S. Richter, Lina Sieverling, Hyun-Dong Chang, Uta Syrbe, Ulrich Kalus, Juergen Eils, Benedikt Brors, Thomas Manke, Juergen Ruland, Thomas Lengauer, Nikolaus Rajewsky, Wei Chen, Jun Dong, Birgit Sawitzki, Ho-Ryun Chung, Philip Rosenstiel, Marcel H. Schulz, Joachim L. Schultze, Andreas Radbruch, Joern Walter, Alf Hamann, Julia K. Polansky
Article
Immunology
Matthias Pink, Boris A. Ratsch, Maibritt Mardahl, Pawel Durek, Julia K. Polansky, Martin Karl, Ria Baumgrass, Stefan Wallner, Cristina Cadenas, Kathrin Gianmoena, Stefan Floess, Wei Chen, Karl Nordstroem, Sascha Tierling, Sven Olek, Joern Walter, Alf Hamann, Uta Syrbe
JOURNAL OF IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Maibritt Mardahl, Micha F. Schroeter, Dirk Engelbert, Matthias Pink, Markus Sperandio, Alf Hamann, Uta Syrbe
MOLECULAR IMMUNOLOGY
(2016)
Article
Rheumatology
Janine Bleil, Rene Maier, Axel Hempfing, Joachim Sieper, Heiner Appel, Uta Syrbe
ARTHRITIS & RHEUMATOLOGY
(2016)
Article
Genetics & Heredity
Line Dam Heftdal, Thomas Andersen, Ditte Jaehger, Anders Woetmann, Rene Ostgard, Elisabeth E. Kenngott, Uta Syrbe, Joachim Sieper, Malene Hvid, Bent Deleuran, Tue W. Kragstrup
JOURNAL OF MOLECULAR MEDICINE-JMM
(2017)
Article
Immunology
B. A. Szilagyi, J. Triebus, C. Kressler, M. de Almeida, S. Tierling, P. Durek, M. Mardahl, A. Szilagyi, S. Floess, J. Huehn, U. Syrbe, J. Walter, J. K. Polansky, A. Hamann
MUCOSAL IMMUNOLOGY
(2017)
Article
Rheumatology
U. Syrbe, X. Baraliakos
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2018)
Editorial Material
Gastroenterology & Hepatology
Uta Syrbe, Britta Siegmund
Article
Rheumatology
Ursula Schulte-Wrede, Till Soerensen, Joachim R. Gruen, Thomas Haeupl, Heike Hirseland, Marta Steinbrich-Zoellner, Peihua Wu, Andreas Radbruch, Denis Poddubnyy, Joachim Sieper, Uta Syrbe, Andreas Gruetzkau
ARTHRITIS RESEARCH & THERAPY
(2018)
Article
Rheumatology
Agnes Hartl, Joachim Sieper, Uta Syrbe, Joachim Listing, Kay-Geert Hermann, Martin Rudwaleit, Denis Poddubnyy
ARTHRITIS RESEARCH & THERAPY
(2017)
Article
Rheumatology
Sara Marie Atkinson, Janine Bleil, Rene Maier, Anja A. Kuehl, Mette Thorn, Kyle Serikawa, Brian Fox, Kim Kruse, Claus Haase, Soren Skov, Anneline Nansen, Uta Syrbe
ARTHRITIS RESEARCH & THERAPY
(2016)