Article
Cell Biology
Domenico Aprile, Nicola Alessio, Ibrahim H. Demirsoy, Tiziana Squillaro, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi
Summary: The study demonstrated that multi-lineage stem cells can be isolated from a mouse model, offering a valid alternative for disease research and cell therapy, and showing potential applications for these cells.
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Xiaoru Xu, Shuang Song, Xiangdong Liu, Yuchao Zhou, Shaojie Shi, Guoqiang Zhao, Xingxing Wang, Xutao Chen, Wenshuang Zhao, Sijia Zhang, Wei Ma, Yingliang Song
Summary: Cell sheet technology utilizing adipose-derived stromal cells (ASCs) shows promise in promoting angiogenesis and may have valuable clinical applications.
STEM CELLS INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Marta Dymowska, Aleksandra Aksamit, Katarzyna Zielniok, Monika Kniotek, Beata Kaleta, Aleksander Roszczyk, Michal Zych, Filip Dabrowski, Leszek Paczek, Anna Burdzinska
Summary: Although both BM-MSCs and WJ-MSCs have the ability to interact reciprocally with macrophages, the source of MSCs could slightly but significantly modify the response under clinical settings. WJ-MSCs secreted significantly more IL-6 than BM-MSCs and showed higher responsiveness to M1-derived chemotactic signals.
Review
Biochemistry & Molecular Biology
Raphael Gorodetsky, Wilhelm K. Aicher
Summary: MSCs from different sources can release pro-regenerative and anti-inflammatory factors, with hPSCs from the fresh human placenta being a preferred source for abundant cell harvesting. The f-hPSCs from neonate tissues of the placenta can undergo extended expansion with low risk of senescence, making them competent cells for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Furkan Yigitbilek, Sabena M. Conley, Hui Tang, Ishran M. Saadiq, Kyra L. Jordan, Lilach O. Lerman, Timucin Taner
Summary: MSCs from liver and adipose tissue showed similar proliferation and migration properties, but had differences in immunomodulatory and pro-angiogenic abilities. Selecting cell-based therapy according to the specific characteristics of different cell sources may be important for treating certain diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Cansu Gorgun, Chiara Africano, Maria Chiara Ciferri, Nadia Bertola, Daniele Reverberi, Rodolfo Quarto, Silvia Ravera, Roberta Tasso
Summary: This study demonstrates that EVs derived from MSCs preconditioned with hypoxia inflammatory cytokines can attenuate inflammaging and alleviate age-related inflammation and mitochondrial dysfunction.
Review
Biochemistry & Molecular Biology
Yujie Song, Christian Jorgensen
Summary: This review highlights the potential of mesenchymal stromal cells (MSCs) in treating osteoarthritis (OA), focusing on their chondrogenic and immunomodulatory potential. The review provides an overview of the effects of MSCs in preclinical and clinical studies of OA treatment, comparing different MSC sources. Furthermore, the review summarizes the current evidence for the assessment of cartilage in OA using magnetic resonance imaging (MRI) and second-look arthroscopy after MSC therapy.
Review
Biochemistry & Molecular Biology
Giusi Alberti, Eleonora Russo, Simona Corrao, Rita Anzalone, Peter Kruzliak, Vitale Miceli, Pier Giulio Conaldi, Francesca Di Gaudio, Giampiero La Rocca
Summary: Extracellular vesicles (EVs) are one of the main mechanisms of communication between cells and the surrounding tissue or at distance. Recent studies have revealed the molecular composition and clinical indications of EVs derived from adult mesenchymal stromal cells (MSCs). These EVs maintain some of the properties of their parent cells and have important implications for cell-free therapies.
Article
Cell & Tissue Engineering
Sara Bucar, Andre Dargen de Matos Branco, Marcia F. Mata, Joao Coutinho Milhano, Iris Caramalho, Joaquim M. S. Cabral, Ana Fernandes-Platzgummer, Claudia L. da Silva
Summary: The study compared the capacity of MSC from different sources to expand UCB CD34(+) cells ex vivo, with AT-derived MSC showing superior expansion potential and maintenance of primitive cells. UCM-derived MSC demonstrated inferior hematopoietic supportive capacity compared to MSC from adult tissues. Further research is needed to determine the impact of HPL on the hematopoietic supportive capacity of MSC.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Maria Rosaria Ambrosio, Giusy Mosca, Teresa Migliaccio, Domenico Liguoro, Gisella Nele, Fabrizio Schonauer, Francesco D'Andrea, Federica Liotti, Nella Prevete, Rosa Marina Melillo, Carla Reale, Concetta Ambrosino, Claudia Miele, Francesco Beguinot, Vittoria D'Esposito, Pietro Formisano
Summary: This study demonstrates that high glucose levels enhance the aggressiveness of breast cancer cells and promote a pro-tumorigenic phenotype in mammary adipose tissue-derived mesenchymal stromal/stem cells (MAT-MSCs). The findings suggest that metabolic control may be important for reducing cancer outgrowth and preserving the functions of the adipose microenvironment.
Article
Immunology
Fabiany da Costa Goncalves, Sander S. Korevaar, Maitane Ortiz Virumbrales, Carla C. Baan, Marlies E. J. Reinders, Ana Merino, Eleuterio Lombardo, Martin J. Hoogduijn
Summary: Mesenchymal stromal cells (MSC) show promise as a therapy for inflammatory diseases, but their large size leads to entrapment in the lungs after intravenous infusion, limiting their effectiveness. Researchers have developed nanometer-sized particles from MSC membranes (membrane particles, MP) to extend the reach of MSC immunoregulatory therapy beyond the lungs. These particles exhibit immunomodulatory properties and are taken up by macrophages and human umbilical vein endothelial cells (HUVEC) in a dose, time, and temperature-dependent manner. The uptake of MP depends on specific endocytic pathways and is influenced by cell type and inflammatory conditions, with anti-inflammatory M2 macrophages showing increased uptake compared to pro-inflammatory M1 macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell & Tissue Engineering
Hesham Soliman, Marine Theret, Wilder Scott, Lesley Hill, Tully Michael Underhill, Boris Hinz, Fabio M. Rossi
Summary: MSCs are essential for the development, maintenance, function, and regeneration of most tissues. They play a crucial role in responding to injury, promoting regeneration through secretion of trophic factors and ECM molecules, and contributing to fibrotic reparative processes. Through fate mapping and single cell omics, tissue-specific MSC identities and functions are being elucidated, providing unprecedented insights into the secret lives of tissue-resident MSCs.
Article
Biochemistry & Molecular Biology
Raluca Tutuianu, Ana-Maria Rosca, Daniela Madalina Iacomi, Maya Simionescu, Irina Titorencu
Summary: This study found that MSC-derived exosomes enhance the biological properties of key cell types involved in wound healing, including macrophages, endothelial cells, keratinocytes, and dermal fibroblasts, thus accelerating the process of wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Andreas Ritter, Nina-Naomi Kreis, Susanne Roth, Alexandra Friemel, Babek Kahn Safdar, Samira Catharina Hoock, Julia Maria Wildner, Roman Allert, Frank Louwen, Christine Solbach, Juping Yuan
Summary: This study reveals how obesity affects the phenotype of breast adipose tissue-derived mesenchymal stromal/stem cells (bASCs) and highlights the molecular changes inside breast cancer cells upon cell-cell interaction with these cancer-educated bASCs. These findings provide a new intervention strategy for breast cancer patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Orthopedics
Wu Wei, Yvonne M. Bastiaansen-Jenniskens, Mathijs Suijkerbuijk, Nicole Kops, Pieter K. Bos, Jan A. N. Verhaar, Anne-Marie Zuurmond, Francesco Dell'Accio, Gerjo J. V. M. van Osch
JOURNAL OF ORTHOPAEDIC RESEARCH
(2017)
Article
Cell & Tissue Engineering
Panithi Sukho, Jolle Kirpensteijn, Jan Willem Hesselink, Gerjo J. V. M. van Osch, Femke Verseijden, Yvonne M. Bastiaansen-Jenniskens
STEM CELL REVIEWS AND REPORTS
(2017)
Article
Orthopedics
Sohrab Khatab, Gerben M. van Buul, Nicole Kops, Yvonne M. Bastiaansen-Jenniskens, P. Koen Bos, Jan A. Verhaar, Gerjo J. van Osch
AMERICAN JOURNAL OF SPORTS MEDICINE
(2018)
Article
Orthopedics
U. T. Timur, M. M. J. Caron, Y. M. Bastiaansen-Jenniskens, T. J. M. Welting, L. W. van Rhijn, G. J. V. M. van Osch, P. J. Emans
OSTEOARTHRITIS AND CARTILAGE
(2018)
Review
Cell & Tissue Engineering
Panithi Sukho, Abigael Cohen, Jan Willem Hesselink, Jolle Kirpensteijn, Femke Verseijden, Yvonne M. Bastiaansen-Jenniskens
TISSUE ENGINEERING PART B-REVIEWS
(2018)
Article
Orthopedics
Lizette Utomo, Susanne M. Eijgenraam, Duncan E. Meuffels, Sita M. A. Bierma-Zeinstra, Yvonne M. Bastiaansen-Jenniskens, Gerjo J. V. M. van Osch
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Orthopedics
Arne van de Vyver, Stefan Clockaerts, Chris H. A. van de Lest, Wu Wei, Jan Verhaar, Gerjo J. V. M. Van Osch, Yvonne M. Bastiaansen-Jenniskens
Article
Multidisciplinary Sciences
Panithi Sukho, Geesien S. A. Boersema, Nicole Kops, Johan F. Lange, Jolle Kirpensteijn, Jan Willem Hesselink, Yvonne M. Bastiaansen-Jenniskens, Femke Verseijden
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Susanne M. Eijgenraam, Frans A. T. Bovendeert, Joost Verschueren, Jasper van Tiel, Yvonne M. Bastiaansen-Jenniskens, Marinus A. Wesdorp, Kazem Nasserinejad, Duncan E. Meuffels, Jamal Guenoun, Stefan Klein, Max Reijman, Edwin H. G. Oei
EUROPEAN RADIOLOGY
(2019)
Article
Engineering, Biomedical
F. Razzi, L. E. Fratila-Apachitei, N. Fahy, Y. M. Bastiaansen-Jenniskens, I Apachitei, E. Farrell, A. A. Zadpoor
BIOMEDICAL MATERIALS
(2020)
Article
Orthopedics
Marinus A. Wesdorp, Susanne M. Eijgenraam, Duncan E. Meuffels, Sita M. A. Bierma-Zeinstra, Gert-Jan Kleinrensink, Yvonne M. Bastiaansen-Jenniskens, Max Reijman
AMERICAN JOURNAL OF SPORTS MEDICINE
(2020)
Article
Cell & Tissue Engineering
S. Khatab, G. J. V. M. van Osch, N. Kops, Y. M. Bastiaansen-Jenniskens, P. K. Bos, J. A. N. Verhaar, M. R. Bernsen, G. M. van Buul
EUROPEAN CELLS & MATERIALS
(2018)
Article
Engineering, Biomedical
Panithi Sukho, Geesien S. A. Boersema, Abigael Cohen, Nicole Kops, Johan F. Lange, Jolle Kirpensteijn, Jan Willem Hesselink, Yvonne M. Bastiaansen-Jenniskens, Femke Verseijden
Article
Engineering, Biomedical
Lizette Utomo, Geesien S. A. Boersema, Yves Bayon, Johan F. Lange, Gerjo J. V. M. van Osch, Yvonne M. Bastiaansen-Jenniskens
BIOMEDICAL MATERIALS
(2017)