Innate Lymphoid Cells in Inflammatory Bowel Disease

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

(2017) Yannick Simoni et al.   IMMUNITY

Interleukin-7 Availability Is Maintained by a Hematopoietic Cytokine Sink Comprising Innate Lymphoid Cells and T Cells

(2017) Christopher E. Martin et al.   IMMUNITY

Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing

(2017) Jian Li et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease

(2017) Danny W. Bruce et al.   JOURNAL OF CLINICAL INVESTIGATION

Crohn's disease

(2017) Joana Torres et al.   LANCET

The differential frequency of Lineage−CRTH2−CD45+NKp44−CD117−CD127+ILC subset in the inflamed terminal ileum of patients with Crohn’s disease

(2016) Jian Li et al.   CELLULAR IMMUNOLOGY

Significant association of the KIR2DL3/HLA-C1 genotype with susceptibility to Crohn’s disease

(2016) Roberto Díaz-Peña et al.   HUMAN IMMUNOLOGY

Human innate lymphoid cells

(2016) Jenny Mjösberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection

(2016) Christoph Wilhelm et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD8αβ+γδ T Cells: A Novel T Cell Subset with a Potential Role in Inflammatory Bowel Disease

(2016) Mohammad Kadivar et al.   JOURNAL OF IMMUNOLOGY

IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection

(2016) V S Pelly et al.   Mucosal Immunology

Interleukin-12 and -23 Control Plasticity of CD127+ Group 1 and Group 3 Innate Lymphoid Cells in the Intestinal Lamina Propria

(2015) Jochem H. Bernink et al.   IMMUNITY

ICOS:ICOS-Ligand Interaction Is Required for Type 2 Innate Lymphoid Cell Function, Homeostasis, and Induction of Airway Hyperreactivity

(2015) Hadi Maazi et al.   IMMUNITY

Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease

(2015) Neil E. McCarthy et al.   JOURNAL OF CLINICAL INVESTIGATION

Unique and redundant functions of NKp46+ILC3s in models of intestinal inflammation

(2015) Christina Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions

(2015) Laurel A. Monticelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells

(2015) M. R. Hepworth et al.   SCIENCE

CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes

(2015) Emma C. Mackley et al.   Nature Communications

Group 2 Innate Lymphoid Cell Proportions Are Diminished in Young Helminth Infected Children and Restored by Curative Anti-helminthic Treatment

(2015) Norman Nausch et al.   PLoS Neglected Tropical Diseases

Group 2 Innate Lymphoid Cells Are Critical for the Initiation of Adaptive T Helper 2 Cell-Mediated Allergic Lung Inflammation

(2014) Timotheus Y.F. Halim et al.   IMMUNITY

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

(2014) Christopher J. Oliphant et al.   IMMUNITY

Cross-talk Between RORγt+ Innate Lymphoid Cells and Intestinal Macrophages Induces Mucosal IL-22 Production in Crohnʼs Disease

(2014) Shinta Mizuno et al.   INFLAMMATORY BOWEL DISEASES

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

(2014) Y. Goto et al.   SCIENCE

RORγt+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44

(2013) Timor Glatzer et al.   IMMUNITY

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

(2013) Matthew R. Hepworth et al.   NATURE

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

(2013) Jochem H Bernink et al.   NATURE IMMUNOLOGY

IL-13 Promotes Collagen Accumulation in Crohn’s Disease Fibrosis by Down-Regulation of Fibroblast MMP Synthesis: A Role for Innate Lymphoid Cells?

(2013) Jennifer R. Bailey et al.   PLoS One

Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease

(2012) E. R. Mann et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cutting Edge: Lymphoid Tissue Inducer Cells Maintain Memory CD4 T Cells within Secondary Lymphoid Tissue

(2012) D. R. Withers et al.   JOURNAL OF IMMUNOLOGY

Ulcerative colitis

(2012) Ingrid Ordás et al.   LANCET

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Functional Differences between Human NKp44− and NKp44+ RORC+ Innate Lymphoid Cells

(2012) Kerim Hoorweg et al.   Frontiers in Immunology

Deficit of Gammadelta T Lymphocytes in the Peripheral Blood of Patients with Crohn’s Disease

(2011) Juan Carlos Andreu-Ballester et al.   DIGESTIVE DISEASES AND SCIENCES

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota

(2011) Shinichiro Sawa et al.   NATURE IMMUNOLOGY

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

Increased proportion of CD16+ NK cells in the colonic lamina propria of inflammatory bowel disease patients, but not after azathioprine treatment

(2010) A. W. Steel et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Imbalance of NKp44+NKp46− and NKp44−NKp46+ Natural Killer Cells in the Intestinal Mucosa of Patients With Crohn's Disease

(2010) Tetsuro Takayama et al.   GASTROENTEROLOGY

Study of killer immunoglobulin-like receptor genes and human leukocyte antigens class I ligands in a Caucasian Brazilian population with Crohn's disease and ulcerative colitis

(2010) Timothy J. Wilson et al.   HUMAN IMMUNOLOGY

A novel population of human CD56+human leucocyte antigen D-related (HLA-DR+) colonic lamina propria cells is associated with inflammation in ulcerative colitis

(2009) S. C. Ng et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Susceptibility to Crohn’s disease is mediated by KIR2DL2/KIR2DL3 heterozygosity and the HLA-C ligand

(2009) Jill A. Hollenbach et al.   IMMUNOGENETICS

The Survival of Memory CD4+ T Cells within the Gut Lamina Propria Requires OX40 and CD30 Signals

(2009) D. R. Withers et al.   JOURNAL OF IMMUNOLOGY

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

(2008) Marina Cella et al.   NATURE

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY