Article
Immunology
Shuang Li, Dawei Zou, Wenhao Chen, Yating Cheng, Gavin W. Britz, Yi-Lan Weng, Zhaoqian Liu
Summary: BATF is a critical transcription factor that drives the effector program of allogeneic CD8(+) T cells and plays an important role in transplant rejection. BATF(-/-) CD8(+) T cells display a dysfunctional phenotype, lack terminal effector cell differentiation, and show impaired effector differentiation at the memory phase.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sarah Adamo, Jan Michler, Yves Zurbuchen, Carlo Cervia, Patrick Taeschler, Miro E. Raeber, Simona Baghai Sain, Jakob Nilsson, Andreas E. Moor, Onur Boyman
Summary: Researchers used spectral flow cytometry combined with cellular indexing of transcriptomes and T cell receptor sequencing to longitudinally characterize individual SARS-CoV-2-specific CD8(+) T cells from patients with COVID-19, identifying a distinct signature marking long-lived memory CD8(+) T cells. The study found that SARS-CoV-2-specific memory CD8(+) T cells persisting 1 year after acute infection express specific markers and exhibit characteristics resembling effector memory T cells, and that certain transcriptional signatures and signaling pathways are associated with the fate of individual clones of these cells.
Article
Multidisciplinary Sciences
Nicholas J. Hess, David P. Turicek, Jeremiah Riendeau, Sean J. McIlwain, Emmanuel Contreras Guzman, Kalyan Nadiminti, Amy Hudson, Natalie S. Callander, Melissa C. Skala, Jenny E. Gumperz, Peiman Hematti, Christian M. Capitini
Summary: An important aspect of allogeneic hematopoietic cell transplantations is finding a way to prevent graft-versus-host disease (GVHD) while still maintaining the graft-versus-leukemia (GVL) activity of donor T cells. In an observational clinical study, a specific type of T cell called CD4+/CD8+ double-positive T cell (DPT) was identified in recipients of allo-HCT, and its presence was found to be predictive of severe GVHD. Further experiments using a transplant model revealed that DPTs develop from antigen-stimulated CD8 T cells and exhibit distinct characteristics from single-positive CD4 and CD8 T cells. These findings highlight the role of DPTs in GVHD pathology.
Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Review
Immunology
Nan-Ping Weng
Summary: The aging of T cells plays a role in the increased susceptibility to diseases among older adults. To better understand T cell aging, improved measurements of age-related cellular changes in T cells are necessary. The recent development of machine learning-assisted transcriptome-based quantification of individual CD8+ T cell age is a significant step forward in this regard.
TRENDS IN IMMUNOLOGY
(2023)
Article
Immunology
Shi-Peng Li, Jin-Ming Zhang, Xiao-Jie Chen, Guang-Peng Zhou, Jie Sun, Bin Cui, Liu-Xin Zhou, Hai-Ming Zhang, Wei-Tao Que, Li-Ying Sun, Zhi-Jun Zhu
Summary: DPT cells are increased in liver transplant patients, especially in rejection cases. These cells show contiguity with Treg cells and their exhaustion is enhanced by increased PD-1 expression. These findings suggest that DPT cells may play a role in immune tolerance and could be targeted for preventing liver transplant rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Liang Tan, Yanan Xu, Gongbin Lan, Hongxia Wang, Zhanfeng Liang, Zhaoqi Zhang, Qianchuan Tian, Yangxiao Hou, Yong Zhao, Xubiao Xie
Summary: This study found that deficiency of TSC1 in T cells accelerates acute allograft rejection. TSC1 deficiency leads to increased accumulation of CD8(+) T cells in the allografts and enhances their responsiveness to alloantigens. TSC1-deficient recipients may be more resistant to mTOR inhibitor-mediated immunosuppression during organ transplantation.
Article
Multidisciplinary Sciences
Asuka Tanaka, Kentaro Ide, Yuka Tanaka, Masahiro Ohira, Hiroyuki Tahara, Hideki Ohdan
Summary: Pretransplant desensitization with rituximab was found to enhance anti-donor CD4(+) T cell responses in DSA-positive transplant recipients, while IL-10(+) CD5(+) B cells were shown to suppress excessive responses of anti-donor CD4(+) T cells.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Elise Gressier, Jonas Schulte-Schrepping, Lev Petrov, Sophia Brumhard, Paula Stubbemann, Anna Hiller, Benedikt Obermayer, Jasper Spitzer, Tomislav Kostevc, Paul G. Whitney, Annabell Bachem, Alexandru Odainic, Carolien van de Sandt, Thi H. O. Nguyen, Thomas Ashhurst, Kayla Wilson, Clare V. L. Oates, Linden. J. Gearing, Tina Meischel, Katharina Hochheiser, Marie Greyer, Michele Clarke, Maike Kreutzenbeck, Sarah S. Gabriel, Wolfgang Kastenmueller, Christian Kurts, Sarah L. Londrigan, Axel Kallies, Katherine Kedzierska, Paul J. Hertzog, Eicke Latz, Yu-Chen E. Chen, Kristen J. Radford, Michael Chopin, Jan Schroeder, Florian Kurth, Thomas Gebhardt, Leif E. Sander, Birgit Sawitzki, Joachim L. Schultze, Susanne V. Schmidt, Sammy Bedoui
Summary: Bedoui and colleagues discovered a sequential integration process in APCs that enhances their ability to activate antiviral CD8(+) T cell responses. This process involves the gradual induction of specific transcriptional regulators and co-stimulatory molecules, led by CD4(+) T cell-mediated CD40 stimulation and interferon-alpha/interferon-beta activation. These findings highlight the importance of APC-T cell interactions in antiviral immunity.
Article
Medicine, Research & Experimental
Huiling Li, Yihan Chen, Qiaofeng Jin, Ya Wu, Cheng Deng, Yongkang Gai, Zhenxing Sun, Yuman Li, Jing Wang, Yali Yang, Qing Lv, Yongxue Zhang, Rui An, Xiaoli Lan, Li Zhang, Mingxing Xie
Summary: The study developed a radiolabeled probe Tc-99m-HYNIC-mAb(CD4) for visualization of CD4+ T lymphocyte infiltration and detection of acute rejection after heart transplantation, showing high affinity and specificity for binding to CD4+ T lymphocytes.
MOLECULAR PHARMACEUTICS
(2021)
Article
Medicine, Research & Experimental
Armin Rehm, Anthea Wirges, Dana Hoser, Cornelius Fischer, Stefanie Herda, Kerstin Gerlach, Sascha Sauer, Gerald Willimsky, Uta E. Hoepken
Summary: Insight into the processes that determine CD8(+) T cell memory formation has been gained from infection models. This study investigates the impact of tumor cells or minor histocompatibility antigen-mismatched leukocytes on CD8(+) T cell fate decisions. By comparing single-cell transcriptomes, the study reveals differential distribution of subpopulations between Ebag9(+/+) and Ebag9(-/-) T cells, suggesting the involvement of EBAG9 in the differentiation and survival of CD8(+) memory cells.
Article
Immunology
Edward L. Y. Chen, Patrick M. Brauer, Elisa C. Martinez, Xiaotian Huang, Ning Yu, Michele K. Anderson, Yang Li, Juan Carlos Zuniga-Pflucker
Summary: Human T cell development requires successful rearrangement of the TCR gene loci, with RAG2 playing a crucial role in this process. While RAG2-KO T lineage progenitors in humans can progress to the DP stage without TCR beta rearrangements, cells expressing rearranged TCR beta-chains exhibit increased survival and proliferation compared to control cells. Transcriptomic analysis revealed differences in gene pathways related to survival and proliferation between TCR beta- and control-transduced RAG2-KO DPs.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, Samuel M. Behar
Summary: CD4 T cells play a crucial role in immunity to tuberculosis by enhancing CD8 effector functions and preventing exhaustion, promoting the survival of infected mice. Vaccines that elicit both CD4 and CD8 T cells are more likely to be successful in generating protective responses against M. tuberculosis infection.
Article
Multidisciplinary Sciences
Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Young-Jun Ju, Hee-Ok Kim, Cheol-Heui Yun, Jae-Ho Cho
Summary: The study revealed that STAT1 plays a crucial role in maintaining the quiescence of naive CD8(+) T cells, with its deficiency leading to increased proliferation and abnormal expansion of memory/activated cells. This phenomenon is paradoxically dependent on type I interferon and its alternative signaling pathway.
Article
Biochemistry & Molecular Biology
Alessia Furgiuele, Franca Marino, Emanuela Rasini, Massimiliano Legnaro, Alessandra Luini, Maria Giulia Albizzati, Alessia di Flora, Barbara Pacchetti, Marco Cosentino
Summary: This study investigated the effects of CBD on human peripheral blood mononuclear cells (PBMCs) and CD4+ T cells, and found that CBD can affect cytokine production, cell proliferation, and the functional properties of regulatory T cells. However, the effects of CBD on cell proliferation and protein production were inconsistent, suggesting a complex activity that warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Justin M. Gregory, Alan D. Cherrington, Daniel J. Moore
Editorial Material
Medicine, General & Internal
Justin M. Gregory, Daniel J. Moore
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Justin M. Gregory, James C. Slaughter, Sara H. Duffus, T. Jordan Smith, Lauren M. LeStourgeon, Sarah S. Jaser, Allison B. McCoy, James M. Luther, Erin R. Giovannetti, Schafer Boeder, Jeremy H. Pettus, Daniel J. Moore
Summary: The study found that patients with diabetes, both type 1 and type 2, have an increased risk of hospitalization and illness severity due to COVID-19. Factors such as HbA(1c) in type 1 diabetes were significantly associated with illness severity, emphasizing the need to mitigate the risk of severe acute respiratory syndrome coronavirus 2 infection in this community.
Article
Pediatrics
Catherine S. Forster, Suong T. Nguyen, Weston T. Powell, Daniel J. Moore, Jacqueline Ho, Melvin B. Heyman, Tara L. Wenger, Fernando Gonzalez, Margaret Hostetter, Andrew Nowalk, Caroline E. Rassbach, Debra Boyer, Pnina Weiss, Rebecca L. Blankenburg, Jordan S. Orange, Kate G. Ackerman, Audrea M. Burns
Summary: The COVID-19 pandemic has significantly impacted the careers of current medical trainees, particularly pediatric physician-scientist trainees, who are facing unprecedented challenges such as lack of in-person conferences, decreased academic productivity, uncertain job prospects, and mental health challenges. This article provides guidance and suggestions for trainees, mentors, educational leaders, and institutions to support pediatric physician-scientist trainees during these difficult times, with a goal of maintaining the pipeline for future professionals in this field.
PEDIATRIC RESEARCH
(2021)
Letter
Endocrinology & Metabolism
Justin M. Gregory, James C. Slaughter, Sara H. Duffus, T. Jordan Smith, Lauren M. LeStourgeon, Sarah S. Jaser, Allison B. McCoy, James M. Luther, Erin R. Giovannetti, Schafer Boeder, Jeremy H. Pettus, Daniel J. Moore
Article
Endocrinology & Metabolism
Daniel R. Tilden, Karishma A. Datye, Daniel J. Moore, Benjamin French, Sarah S. Jaser
Summary: A study conducted during the pandemic found that rapid transition to telemedicine did not significantly impact access to diabetes care for most demographic groups, but lower rates of telemedicine visits were observed for non-English-speaking and Medicaid-insured pediatric patients.
Editorial Material
Pediatrics
Audrea M. Burns, Daniel J. Moore, Catherine S. Forster, Weston Powell, Satid Thammasitboon, Margaret K. Hostetter, Pnina Weiss, Debra Boyer, Mark A. Ward, Rebecca Blankenburg, Melvin B. Heyman, Caroline E. Rassbach, Heather McPhillips, Anthony French, Suong Nguyen, Bobbi J. Byrne, Donald Williams Parsons, Fernando Gonzalez, Andrew J. Nowalk, Jacqueline Ho, Shelley Kumar, Jordan S. Orange, Kate G. Ackerman
JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
John Virostko, Richard C. Craddock, Jonathan M. Williams, Taylor M. Triolo, Melissa A. Hilmes, Hakmook Kang, Liping Du, Jordan J. Wright, Mara Kinney, Jeffrey H. Maki, Milica Medved, Michaela Waibel, Thomas W. H. Kay, Helen E. Thomas, Siri Atma W. Greeley, Andrea K. Steck, Daniel J. Moore, Alvin C. Powers
Summary: A standardized MRI protocol for pancreas imaging was developed, showing reproducibility of pancreas size, surface area to volume ratio, diffusion, and longitudinal relaxation time measurements. This allows for quantitative MRI of the pancreas to be compared across multiple locations in clinical trials for individuals with type 1 or type 2 diabetes. Non-standardized image processing led to greater variation in MRI measurements.
Article
Immunology
Bryan A. Joosse, James H. Jackson, Alberto Cisneros, Austin B. Santhin, Scott A. Smith, Daniel J. Moore, Leslie J. Crofford, Erin M. Wilfong, Rachel H. Bonami
Summary: Antigen-specific B cells (ASBCs) play a crucial role in autoimmune diseases and may be disconnected from autoantibody secretion, underscoring the importance of studying and targeting ASBCs for developing therapies for autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Christopher S. Wilson, Blair T. Stocks, Emilee M. Hoopes, Jillian P. Rhoads, Kelsey L. McNew, Amy S. Major, Daniel J. Moore
Summary: The study suggests that targeting glucose and mitochondrial metabolism can enable endogenous immune tolerance mechanisms to respond to tolerance induction in an animal model of lupus, potentially restoring durable immune tolerance and offering a new approach for autoimmune and transplant settings.
Review
Immunology
Lynsa M. Nguyen, Joel I. Omage, Kristen Noble, Kelsey L. McNew, Daniel J. Moore, David M. Aronoff, Ryan S. Doster
Summary: Group B Streptococcus is a common bacterium in the human gut microbiota that can cause invasive infections during pregnancy. Individuals with diabetes mellitus are at a higher risk for these infections, highlighting the importance of monitoring and prevention strategies.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Letter
Endocrinology & Metabolism
Justin M. Gregory, Daniel J. Moore
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Raphael Roger, Melissa A. Hilmes, Jonathan M. Williams, Daniel J. Moore, Alvin C. Powers, R. Cameron Craddock, John Virostko
Summary: Pancreas volume is reduced in individuals with diabetes and those at risk for developing type 1 diabetes. This study developed a deep learning algorithm for automated pancreas volume measurement in individuals with diabetes. Training the algorithm on multiple cohorts showed high overlap and excellent correlation with manual segmentations.
BMC MEDICAL IMAGING
(2022)
Correction
Endocrinology & Metabolism
Justin M. Gregory, James C. Slaughter, Sara H. Duffus, T. Jordan Smith, Lauren M. LeStourgeon, Sarah S. Jaser, Allison B. McCoy, James M. Luther, Erin R. Giovannetti, Schafer Boeder, Jeremy H. Pettus, Daniel J. Moore
Article
Multidisciplinary Sciences
Christopher S. Wilson, Emilee M. Hoopes, Alexander C. Falk, Daniel J. Moore
Summary: The immune system of healthy individuals is capable of regulating autoimmunity. However, in Type 1 Diabetes (T1D), natural IgM is unable to perform its normal immunoregulatory function. Treating diabetic mice with IgM from healthy donors or an IgM-enriched preparation called Pentaglobin can reverse the disease and boost protective immunity.
SCIENTIFIC REPORTS
(2022)