Editorial Material
Biochemistry & Molecular Biology
Rebekah Honce, Stacey Schultz-Cherry
Summary: Avian influenza viruses can infect mammals, and the mutations accumulated in viruses obtained from humans infected with emerging avian H3N8 viruses can promote respiratory droplet transmission and disease in mammals.
Editorial Material
Biology
Arturo Barbachano-Guerrero, Daniel R. Perez, Sara L. Sawyer
Summary: The H3N2 canine influenza virus, originating from birds, is undergoing evolution to increase its transmissibility among dogs.
Article
Virology
Dorothea Bestle, Hannah Limburg, Diana Kruhl, Anne Harbig, David A. Stein, Hong Moulton, Mikhail Matrosovich, Elsayed M. Abdelwhab, Juergen Stech, Eva Boettcher-Friebertshaeuser
Summary: The transmembrane protease TMPRSS2 is identified as the major activating protease of various avian influenza virus HA subtypes in human and murine airway cells, suggesting its potential as a target for treatment of human infections with avian influenza viruses. Additionally, a TMPRSS2-orthologous protease from duck is shown to activate avian influenza virus HAs with a monobasic cleavage site, indicating its role as a potential virus-activating protease in waterfowl.
JOURNAL OF VIROLOGY
(2021)
Review
Immunology
Lucas J. Kerstetter, Stephen Buckley, Carly M. Bliss, Lynda Coughlan
Summary: The ongoing threat to global health posed by infectious diseases, which have the potential for spillover from animal reservoirs, has increased in frequency due to changes in human behavior. Influenza A viruses present a pandemic threat and are a major concern for human health, with challenges in vaccine development. Non-replicating adenoviral vectors offer advantages for vaccine development against highly pathogenic avian influenza viruses, with exemplary safety and immunogenicity profiles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Eun-Ha Kim, Young-ll Kim, Se Mi Kim, Kwang-Min Yu, Mark Anthony B. Casel, Seung-Gyu Jang, Philippe Noriel Q. Pascua, Richard J. Webby, Young Ki Choi
Summary: This study highlights the ability of wild migratory birds to carry various low-pathogenic avian influenza viruses that can infect land-based poultry and mammalian hosts while causing minimal signs of clinical disease. These viruses pose a significant threat to human health, emphasizing the need for continued surveillance.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Infectious Diseases
Yeping Sun, Kun Zhang, Heyuan Qi, He Zhang, Shuang Zhang, Yuhai Bi, Linhuan Wu, Lei Sun, Jianxun Qi, Di Liu, Juncai Ma, Po Tien, Wenjun Liu, Jing Li
Summary: Researchers have developed a computational tool based on viral genomes to evaluate the human infectivity of avian influenza H7N9 strains, allowing for prediction of the potential risk of these strains infecting humans. Experimental results showed that strains predicted to have high human infectivity by the model replicated more efficiently in mammalian cells and were more infective in mice. This novel tool can serve as a powerful predictor of human infectivity and cross-species transmission risks of H7N9 avian strains.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Virology
Chieh-Yu Liang, Iris Huang, Julianna Han, Boopathi Sownthirarajan, Katarina Kulhankova, Nathan B. Murray, Mehrnoush Taherzadeh, Stephanie Archer-Hartmann, Lauran Pepi, Senthamizharasi Manivasagam, Jesse Plung, Miranda Sturtz, Yolanda Yu, Olivia A. Vogel, Matheswaran Kandasamy, Francoise A. Gourronc, Aloysius J. Klingelhutz, Biswa Choudhury, Lijun Rong, Jasmine T. Perez, Parastoo Azadi, Paul B. McCray Jr, Sriram Neelamegham, Balaji Manicassamy
Summary: Different strains of influenza A viruses can utilize various types of glycoconjugates for host cell infection, and avian influenza A viruses demonstrate a broader repertoire of glycoconjugates compared to human influenza A viruses. This study highlights the importance of glycoconjugates in the infection process and the adaptability of avian influenza A viruses.
JOURNAL OF VIROLOGY
(2023)
Article
Microbiology
Carolin Lieber, Megha Aggarwal, Jeong-Joong K. Yoon, Robert A. Cox, Hae-Ji M. Kang, Julien A. Sourimant, Mart T. Toots, Scott M. Johnson, Cheryl Jones, Zachary R. Sticher, Alexander G. Kolykhalov, Manohar Saindane, Stephen K. Tompkins, Oliver Planz, George Painter, Michael Natchus, Kaori Sakamoto, Richard Plemper
Summary: The nucleoside analog 4'-fluorouridine has been shown to effectively inhibit a broad spectrum of influenza viruses in various cell culture and animal models. It acts as a chain terminator of the influenza virus polymerase and has the potential to be a therapeutic option for vulnerable patient groups and pandemic influenza.
Article
Immunology
Honglei Sun, Fangtao Li, Qingzhi Liu, Jianyong Du, Litao Liu, Haoran Sun, Chong Li, Jiyu Liu, Xin Zhang, Jizhe Yang, Yuhong Duan, Yuhai Bi, Juan Pu, Yipeng Sun, Qi Tong, Yongqiang Wang, Xiangjun Du, Yuelong Shu, Kin-Chow Chang, Jinhua Liu
Summary: The study found that farmed minks are commonly infected with both human and avian influenza viruses. Human influenza viruses may be transmitted from humans to minks, while avian influenza viruses may be transmitted through feed to farmed minks. Therefore, feeding minks with raw poultry by-products should be prohibited to reduce the risk of novel pandemic virus emergence.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Infectious Diseases
Junki Mine, Ryota Tsunekuni, Taichiro Tanikawa, Yuko Uchida, Nikita Dubovitskiy, Anastasiya Derko, Ivan Sobolev, Alexander Shestopalov, Kirill Sharshov, Takehiko Saito
Summary: This study investigated the outbreaks of H5N8 highly pathogenic avian influenza in Japan during the winter of 2020-2021 and found that the viruses may have emerged through reassortment events with Siberian avian influenza viruses. The study also revealed that H5N2 and H5N8 viruses isolated from wild birds in Siberia during the previous summer may have spread to both Asia and Europe in the following winter.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Fatima-Zohra Sikht, Mariette Ducatez, Charifa Drissi Touzani, Adam Rubrum, Richard Webby, Mohammed El Houadfi, Nour-Said Tligui, Christelle Camus, Siham Fellahi
Summary: This study monitored and assessed the presence of H9N2 avian influenza virus in eight different regions of Morocco, and analyzed the phylogenetic and molecular evolution of the virus between 2016 and 2019. The results showed that the virus was still present in 2018-2019 regardless of vaccination status. Molecular analysis identified mutations related to virulence and increased resistance to antiviral drugs in the Moroccan H9N2 viruses.
Article
Infectious Diseases
Mohsen Bashashati, David H. Chung, Mohammad Hossein Fallah Mehrabadi, Dong-Hun Lee
Summary: The evolutionary history of H9N2 avian influenza viruses in Iran shows that only the Iran 4 subgroup has survived and currently circulates in the country; the viruses possess molecular markers associated with mammalian adaption; continued surveillance of H9N2 viruses is needed to monitor their evolution and potential threat to public health.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Immunology
Yan Zhao, Fengming Huang, Zhen Zou, Yuhai Bi, Yang Yang, Cong Zhang, Qiang Liu, Daozhen Shang, Yiwu Yan, Xiangwu Ju, Song Mei, Peng Xie, Xiao Li, Mingyao Tian, Shuguang Tan, Huijun Lu, Zongsheng Han, Kangtai Liu, Yuqing Zhang, Junbo Liang, Zhu Liang, Qingchao Zhang, Jiahui Chang, William J. Liu, Cong Feng, Tanshi Li, Michael Q. Zhang, Xiaoyue Wang, George F. Gao, Yingxia Liu, Ningyi Jin, Chengyu Jiang
Summary: Innate immunity plays a critical role in antiviral defense. Avian influenza viruses (AIVs) utilize a mechanism called transcriptional readthrough (TRT) to suppress host innate immune responses. The viruses induce TRT by reducing the expression of SSU72, leading to impaired host antiviral defense.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Elien Vandoorn, Wojciech Stadejek, Isabel Leroux-Roels, Geert Leroux-Roels, Anna Parys, Kristien Van Reeth
Summary: IAV H3 subtype viruses that infect humans are antigenically different from those in birds, horses, and swine, raising potential pandemic risks. We studied the prevalence and replication of different IAV strains in Belgium and found that swine H3 IAVs had the highest seroprevalence rates and replication efficiency. This suggests that swine H3 IAVs pose the highest public health risk among the tested animal-origin IAVs.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Agriculture, Dairy & Animal Science
Xiaoquan Wang, Huafen Zheng, Ruyi Gao, Leyao Ren, Mingxia Jin, Zhuxing Ji, Xin Wang, Xiaolong Lu, Wenhao Yang, Min Gu, Xiaowen Liu, Shunlin Hu, Kaituo Liu, Xiufan Liu
Summary: Avian influenza viruses have the ability to infect mammals, posing a significant threat to public health. The H7N9 subtype of avian influenza virus that emerged in China in 2013 resulted in a large number of human infections, the reasons for which are still unclear. The presence of a mammal-adapted H7N9 virus in poultry in 2013 could be a significant factor contributing to the unusually high number of human infections during that period.
Article
Emergency Medicine
Yuwarat Monteerarat, Roongsak Limthongthang, Panai Laohaprasitiporn, Torpon Vathana
Summary: This study investigated the reliability and validity of CRT, and found that CRT is reliable when used at appropriate areas. The most dependable site is the finger pulp, with a proposed cutoff of 3 seconds.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Virology
Narach Khorattanakulchai, Suwimon Manopwisedjaroen, Kaewta Rattanapisit, Chalisa Panapitakkul, Taratorn Kemthong, Nutchanat Suttisan, Kanjana Srisutthisamphan, Suchinda Malaivijitnond, Arunee Thitithanyanont, Anan Jongkaewwattana, Balamurugan Shanmugaraj, Waranyoo Phoolcharoen
Summary: The spread of SARS-CoV-2 variants poses a severe public health problem globally, necessitating the development of effective vaccines and optimized booster vaccination strategies. This study demonstrates that plant-produced RBD-Fc vaccines can enhance the immune response against various SARS-CoV-2 variants. The Delta and Epsilon RBD-Fc vaccines show cross-reactive immunogenicity and have the potential to induce broadly neutralizing antibodies.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Supinya Phakaratsakul, Suwimon Manopwisedjaroen, Chompunuch Boonarkart, Pawinee Kupatawintu, Dootchai Chaiwanichsiri, Thaneeya Roytrakul, Prasert Auewarakul, Arunee Thitithanyanont
Summary: The study observed the longitudinal changes in antibody levels of COVID-19 recovered patients, showing differences in dynamics between neutralizing antibodies and binding antibodies. Some patients had consistently high levels of neutralizing antibodies, while their binding antibodies rapidly decreased. Additionally, the presence of binding antibodies to S2 suggested an immune response to other coronaviruses.
Article
Plant Sciences
Narach Khorattanakulchai, Kanjana Srisutthisamphan, Balamurugan Shanmugaraj, Suwimon Manopwisedjaroen, Kaewta Rattanapisit, Chalisa Panapitakkul, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Arunee Thitithanyanont, Anan Jongkaewwattana, Waranyoo Phoolcharoen
Summary: The three-dose regimen of Baiya SARS-CoV-2 Vax 1 vaccine elicits a neutralizing immune response against SARS-CoV-2 variants.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Chih-Yen Lin, Wen-Hung Wang, Meng-Chi Li, Yu-Ting Lin, Zih-Syuan Yang, Aspiro Nayim Urbina, Wanchai Assavalapsakul, Arunee Thitithanyanont, Kai-Ren Chen, Chien-Cheng Kuo, Yu-Xen Lin, Hui-Hua Hsiao, Kun-Der Lin, Shang-Yi Lin, Yen-Hsu Chen, Ming-Lung Yu, Li-Chen Su, Sheng-Fan Wang
Summary: In this study, a quick and precise phase-sensitive surface plasmon resonance (PS-SPR) biosensor integrated with a newly generated anti-S monoclonal antibody was developed for highly sensitive detection of SARS-CoV-2 and its variants.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Dermatology
Kumutnart Chanprapaph, Chutima Seree-aphinan, Ploysyne Rattanakaemakorn, Cherrin Pomsoong, Yanisa Ratanapokasatit, Chavachol Setthaudom, Arunee Thitithanyanont, Aphinyaphiwat Suriyo, Thanitta Suangtamai, P. Suchonwanit, COVIDVAC DERM study Grp
Summary: A study investigated the impact of immune-mediated dermatological diseases (IMDDs) on SARS-CoV-2-specific immunity and side effects after ChAdOx1-S [recombinant] vaccination, and found that patients with IMDDs had lower immunogenicity and may require treatment escalation.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Infectious Diseases
Suvimol Niyomnaitham, Anan Jongkaewwattana, Atibordee Meesing, Nawamin Pinpathomrat, Sira Nanthapisal, Nattiya Hirankarn, Sarawut Siwamogsatham, Suppachok Kirdlarp, Romanee Chaiwarith, Saranath Lawpoolsri, Supranee Phanthanawiboon, Arunee Thitithanyanont, Pokrath Hansasuta, Sansanee Chaiyaroj, Punnee Pitisuttithum
Summary: This study aimed to compare the immunogenicity and safety of fractional (half) third doses of heterologous COVID-19 vaccines (AZD1222 or BNT162b2) to full doses after the two-dose CoronaVac and when boosting after three different extended intervals. The results showed no difference in immunogenicity between half doses and full doses, but the full doses and longer intervals substantially improved immunogenicity.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Virology
Kanyarat Ruangrung, Warunya Chakritbudsabong, Songkran Thongon, Sasitorn Rungarunlert, Methichit Wattanapanitch, Chompunuch Boonarkart, Ornpreya Suptawiwat, Naraporn Sirinonthanawech, Duncan Richard Smith, Prasert Auewarakul
Summary: The study found that human induced pluripotent stem cells (hiPSCs) and their derived ectodermal, mesodermal, and endodermal cells are susceptible to infection by Influenza A virus (IAV). These cells express the receptor for IAV infection, alpha 2,6-linked sialic acid, on their surface. While hiPSCs could produce infectious viral progenies for up to 7 days and spread to other cells, the germ-layer cells showed a decline in viral titers, indicating a lack of viral spreading. Among the three germ layers, endodermal cells were found to be less susceptible to IAV infection. These findings suggest a potential risk of detrimental effects of IAV infection on early human embryonic development.
Article
Infectious Diseases
Rujipas Sirijatuphat, Amorn Leelarasamee, Thanapat Puangpet, Arunee Thitithanyanont
Summary: This study evaluated the virucidal efficacy of 0.4% PVP-I nasal spray against SARS-CoV-2 in the patients' nasopharynx. The results showed that viral titers were reduced in some patients at 3 minutes post-spray, but there was minimal change in viral titers at 4 hours post-spray. The 0.4% PVP-I nasal spray demonstrated poor virucidal activity and is unlikely to reduce transmission of SARS-CoV-2 in prophylaxis use.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Integrative & Complementary Medicine
Viwan Jarerattanachat, Chompunuch Boonarkart, Supa Hannongbua, Prasert Auewarakul, Ruchuta Ardkhean
Summary: This study identified Isoquercitrin, a compound found in Ginseng and Notoginseng, as a potential inhibitor of Dengue NS5 protein. Isoquercitrin showed significant antiviral activity against Dengue virus by reducing viral RNA and protein synthesis with low cell toxicity.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2023)
Article
Chemistry, Analytical
Lung-Chien Chen, Meng-Chi Li, Kai-Ren Chen, Yu-Jui Cheng, Xun-Ying Wu, Sih-An Chen, Meng-Jey Youh, Chien-Cheng Kuo, Yu-Xen Lin, Chih-Yen Lin, Chu-Feng Wang, Chung-Feng Huang, Shang-Yi Lin, Wen-Hung Wang, Yen-Hsu Chen, Ming-Lung Yu, Arunee Thitithanyanont, Sheng-Fan Wang, Li-Chen Su
Summary: Researchers developed a wavelength-based SPR sensor using 3D printing technology and synthesized stable NIR-emitting perovskite nanocomposites. This portable sensor can detect the coronavirus in a quick and simple manner, making it suitable for on-site detection.
ANALYTICAL CHEMISTRY
(2023)
Article
Evolutionary Biology
Pakorn Aiewsakun, Worakorn Phumiphanjarphak, Natali Ludowyke, Priyo Budi Purwono, Suwimon Manopwisedjaroen, Chanya Srisaowakarn, Supanuch Ekronarongchai, Ampa Suksatu, Jirundon Yuvaniyama, Arunee Thitithanyanont
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, and scientists have found that the virus undergoes cell culture adaptation during laboratory growth. This study systematically explored the cell culture adaptation of two SARS-CoV-2 variants propagated in different cell lines, revealing numerous potential adaptation changes across the viral genome. The results highlight the high adaptability of SARS-CoV-2 and emphasize the importance of deep-sequencing cultured viral samples for intricate and sensitive biological experiments.
GENOME BIOLOGY AND EVOLUTION
(2023)
Article
Immunology
Waranyoo Phoolcharoen, Balamurugan Shanmugaraj, Narach Khorattanakulchai, Piyanate Sunyakumthorn, Sathit Pichyangkul, Pornnarin Taepavarapruk, Wanlapa Praserthsee, Suchinda Malaivijitnond, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Kanjana Srisutthisamphan, Anan Jongkaewwattana, Mark Tomai, Christopher B. Fox, Suthira Taychakhoonavudh
Summary: Cost-effective and accessible vaccines are crucial for mass immunization against COVID-19, especially in LMIC. A preclinical study evaluated the immunogenicity, efficacy, and safety of a plant-based SARSCoV-2 RBD vaccine with 3M-052 (TLR7/8 agonist)-Alum adjuvant. The vaccine induced significant antibody responses and immune protection against SARSCoV-2.
Article
Virology
Kunlakanya Jitobaom, Thanyaporn Sirihongthong, Chompunuch Boonarkart, Supinya Phakaratsakul, Ornpreya Suptawiwat, Prasert Auewarakul
Summary: Schlafen (SLFN) proteins are interferon-stimulated early response genes that have antiviral properties. Previous research has demonstrated the antiviral mechanism of SLFN11 in inhibiting HIV-1 virus production in a codon usage-specific manner. This study investigates the effect of SLFN11 on influenza A virus (IAV) replication and finds that SLFN11 inhibits IAV in a codon-specific manner, suggesting its potential role in innate defense against IAV.
Article
Biochemistry & Molecular Biology
Zih-Syuan Yang, Wen-Hung Wang, Yu-Ting Lin, Chih-Yen Lin, Aspiro Nayim Urbina, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: This study investigates the individual and collaborative roles of DC-SIGN and Gal3 in H5N1 and H7N9 avian influenza virus (AIV) infection. It is found that DC-SIGN expression significantly promotes viral infection, while Gal3 knockdown reduces viral infection. The co-expression of DC-SIGN and Gal3 enhances infectivity of H5N1 and H7N9 viruses, with stronger regulatory capabilities for H5N1. The study reveals the significance of DC-SIGN and Gal3 in regulating AIV infection and suggests the potential of targeting their interaction with HA protein as antiviral strategies.
