Article
Virology
Laurence Dossou, Agnes Pinel-Galzi, Jamel Aribi, Nils Poulicard, Laurence Albar, Sorho Fatogoma, Marie Noelle Ndjiondjop, Daouda Kone, Eugenie Hebrard
Summary: Rice yellow mottle virus (RYMV) is a major constraint to rice cultivation in Africa, with high genetic diversity. This study developed specific RT-PCR primers to infer the resistance-breaking abilities of RYMV isolates, providing a molecular tool for optimizing the deployment strategy of resistant rice lines.
Article
Agriculture, Multidisciplinary
Guili Zhao, Wenjuan Zhang, Xiaodong Fu, Xin Xie, Song Bai, Xiangyang Li
Summary: The viral protein genome-linked protein of telosma mosaic virus plays an important role in viral reproduction. This study explored the expression conditions of the protein and synthesized a series of novel compounds. The compounds exhibited excellent binding affinity to the viral protein and inhibited its expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Virology
Reid Warsaba, Nicolas Salcedo-Porras, Stephane Flibotte, Eric Jan
Summary: This study developed a novel bioinformatics approach to identify VPg sequences in viral genomes and found 717 dicistrovirus genomes containing VPgs. VPg duplications were also identified in aquamavirus and mosavirus genomes. The results indicate that VPg duplications are more widespread than anticipated and suggest co-evolution between VPgs and viral genomes.
Article
Virology
Reid Warsaba, Nikolay Stoynov, Kyung-Mee Moon, Stephane Flibotte, Leonard Foster, Eric Jan
Summary: Viral protein genome-linked (VPg) plays an essential role in protein-primed replication of plus-stranded RNA viruses. Some viruses have multiple VPgs, but their roles are not well-defined. This study using cricket paralysis virus as a model reveals a relationship between VPg copy number and IRES translation activity, and uncovers a novel viral strategy where VPg copies in dicistrovirus genomes compensate for differences in IRES translation efficiencies to promote infection.
JOURNAL OF VIROLOGY
(2022)
Article
Plant Sciences
Ye-Rin Lee, Muhammad Irfan Siddique, Do-Sun Kim, Eun Su Lee, Koeun Han, Sang-Gyu Kim, Hye-Eun Lee
Summary: Genome editing, especially CRISPR/Cas9 technology, is a state-of-the-art approach for trait development in breeding programs. In this study, targeted mutation was generated in the eIF(iso)4E gene of a TuMV-susceptible Chinese cabbage cultivar using CRISPR/Cas9, resulting in the development of TuMV-resistant plants. The edited T-1 plants showed heritable mutations and resistance to TuMV, indicating the potential of CRISPR/Cas9 to improve traits in Chinese cabbage plants.
HORTICULTURE RESEARCH
(2023)
Article
Microbiology
Yaowen Zhang, Kangkang Liu, Zhenbiao Zhang, Sai Tian, Meiling Liu, Xinge Li, Yiran Han, Kunpeng Zhu, Hongbo Liu, Chaojie Yang, H. O. N. G. B. O. Liu, Xinying Du, Qi Wang, Hui Wang, Mingjuan Yang, Ligui Wang, Hongbin Song, Haiyan Yang, Ying Xiang, Shaofu Qiu
Summary: The outbreak of severe gastrointestinal symptoms caused by Salmonella enterica serovar Enteritidis in China had high attack rate, typical symptoms and was traced back to contaminated egg fried rice. The pathogen responsible was found to be a multi-drug resistant strain and carried various virulence genes, possibly contributing to the severity of the symptoms. Strategies to monitor and prevent similar outbreaks in the future are suggested.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Poppy Sephton-Clark, Jennifer L. Tenor, Dena L. Toffaletti, Nancy Meyers, Charles Giamberardino, Sile F. Molloy, Julia R. Palmucci, Adrienne Chan, Tarsizio Chikaonda, Robert Heyderman, Mina Hosseinipour, Newton Kalata, Cecilia Kanyama, Christopher Kukacha, Duncan Lupiya, Henry C. Mwandumba, Thomas Harrison, Tihana Bicanic, John R. Perfect, Christina A. Cuomo
Summary: The genetic diversity of Cryptococcus neoformans is associated with clinically relevant phenotypes and animal model pathogenesis, shedding light on the survival mechanisms and pathways involved in yeast persistence.
Article
Biotechnology & Applied Microbiology
Sebastian Gonzalez-Catrilelbun, Julio Cartagena, Deborah Vargas, Pamela Breguel-Serrano, Ana Maria Sandino, Andrea Rivas-Aravena
Summary: This research demonstrates that IPNV mRNAs are linked to Vpg and that this protein inhibits cap-dependent translation on infected cells. Also, it is demonstrated that Vpg interacts with eIF4E and that rapamycin treatment partially diminishes the viral protein synthesis.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yaling Zhao, Xue Cao, Weihua Zhong, Shunkang Zhou, Zhanbiao Li, Hong An, Xiahua Liu, Ruifeng Wu, Surakshya Bohora, Yan Wu, Zhenyi Liang, Jiahao Chen, Xin Yang, Guohui Zhou, Tong Zhang
Summary: This study reveals the molecular mechanism of transmission of the Southern rice black-streaked dwarf virus (SRBSDV), finding that the SRBSDV-encoded P6 protein regulates rice ethylene signaling to coordinate viral infection and transmission. In early infection, P6 interacts with OsRTH2 to activate ethylene signaling and enhance virus proliferation, repelling the insect vector. In late infection, P6 enters the nucleus and interacts with OsEIL2 to suppress ethylene signaling, attracting the insect vector for viral transmission.
Article
Multidisciplinary Sciences
Hehong Zhang, Fengmin Wang, Weiqi Song, Zihang Yang, Lulu Li, Qiang Ma, Xiaoxiang Tan, Zhongyan Wei, Yanjun Li, Junmin Li, Fei Yan, Jianping Chen, Zongtao Sun
Summary: In monocotyledonous plants, different viral pathogens can disrupt the synergistic antiviral immunity mediated by SA and JA by promoting the degradation of OsNPR1. Unrelated viral proteins from different rice viruses also interfere with the OsNPR1-mediated SA-JA interplay to facilitate viral pathogenicity.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Mazen Alazem, John Bwalya, Pai Hsuan, Jisuk Yu, Huong Cam Chu, Tessa Burch-Smith, Kook-Hyung Kim
Summary: Viral synergism occurs when mixed infection of susceptible plants by multiple viruses increases susceptibility to at least one of the viruses. This study found that bean pod mottle virus disrupts soybean's extreme resistance against soybean mosaic virus by impairing the downstream defense mechanism induced by the Rsv3 R gene.
Article
Multidisciplinary Sciences
Zhitao Li, Bo Wang, Wei Luo, Yunyuan Xu, Jinjuan Wang, Zhihui Xue, Yuda Niu, Zhukuan Cheng, Song Ge, Wei Zhang, Jingyu Zhang, Qizhai Li, Kang Chong
Summary: Abnormal temperature caused by global climate change poses a threat to rice production. This study identified a major QTL, COLD11, which is responsible for chilling tolerance in rice. The repeat numbers of GCG sequence in the first exon of COLD11 were found to be subjected to strong selection during the domestication of rice. Manipulating key genes in the rice genome, such as COLD11, could be a potential strategy to enhance chilling tolerance through molecular designing.
Review
Public, Environmental & Occupational Health
Parinita Majumdar, Sougata Niyogi
Summary: The outbreak of pneumonia-like respiratory disorder in China and its global spread resulted in a public health emergency, putting the SARS-CoV-2 virus in the spotlight. Betacoronaviruses, known for their high mutation rate, recombination, and interspecies transmission, have shown considerable mutations in different proteins, with single-nucleotide substitutions being predominant. Specific mutations in spike glycoprotein and RNA-dependent RNA polymerase have emerged as dominant globally, posing challenges for therapeutics and vaccines.
EPIDEMIOLOGY AND INFECTION
(2021)
Article
Biotechnology & Applied Microbiology
Stephanie Riederer, Ana del Canizo, Javier Navas, Marlowe G. Peter, Ellen K. Link, Gerd Sutter, Juan J. Rojas
Summary: It was found that the B2 nuclease in vaccinia viruses inhibits the cGAS signaling pathway activated by cytoplasmic viral replication. Deletion of the B2R gene enhances the antitumor activity and immune response against tumor antigens in tumor cells infected with vaccinia viruses.
CANCER GENE THERAPY
(2023)
Article
Multidisciplinary Sciences
Yuting Tang, Yang Liu, Xiaoshu Zhu, Yanlin Chen, Xinluan Jiang, Siyang Ding, Que Zheng, Ming Zhang, Jiashu Yang, Yunfei Ma, Mengying Xing, Zongyu Zhang, Huimin Ding, Yucui Jin, Changyan Ma
Summary: The downregulated long noncoding RNA HS3ST3B1-IT1 has been found to be associated with osteoarthritis. Its overexpression promotes chondrocyte viability and extracellular matrix synthesis, inhibiting the progression of osteoarthritis. It exerts its effects by upregulating its maternal gene HS3ST3B1.
Article
Biochemistry & Molecular Biology
Justine Charon, Amandine Barra, Jocelyne Walter, Pauline Millot, Eugenie Hebrard, Benoit Moury, Thierry Michon
MOLECULAR BIOLOGY AND EVOLUTION
(2018)
Article
Plant Sciences
Eugenie Hebrard, Agnes Pinel-Galzi, Aderonke Oludare, Nils Poulicard, Jamel Aribi, Sandrine Fabre, Souley Issaka, Cedric Mariac, Alexis Dereeper, Laurence Albar, Drissa Silue, Denis Fargette
Article
Virology
Issiaka Bagayoko, Marcos Giovanni Celli, Gustavo Romay, Nils Poulicard, Agnes Pinel-Galzi, Charlotte Julian, Denis Filloux, Philippe Roumagnac, Drissa Sereme, Claude Bragard, Eugenie Hebrard
Summary: This study investigated the genetic diversity of the rice stripe necrosis virus (RSNV) and found unexpected differences with the beet necrotic yellow vein virus (BNYVV), suggesting a complex evolutionary history of the genus Benyvirus. The RSNV molecular diversity had a geographical structure with two main RSNV lineages distributed in America and in Africa.
Article
Virology
Souley Issaka, Oumar Traore, Regis Dimitri Skope Longue, Agnes Pinel-Galzi, Mandev S. Gill, Simon Dellicour, Paul Bastide, Stephane Guindon, Eugenie Hebrard, Marie-Jo Dugue, Yacouba Sere, Silla Semballa, Severin Ake, Philippe Lemey, Denis Fargette
Summary: The spread of the Rice yellow mottle virus (RYMV) along the Niger River in West Africa was mainly driven by changes in rice cultivation practices, rather than long-distance dissemination through natural waterways.
Article
Virology
Essowe Palanga, Ezechiel Bionimian Tibiri, Martine Bangratz, Denis Filloux, Charlotte Julian, Agnes Pinel-Galzi, Moustapha Koala, James Bouma Neya, Christophe Brugidou, Fidele Tiendrebeogo, Philippe Roumagnac, Eugenie Hebrard
Summary: Pearl millet is a staple food widely cultivated in sub-Saharan Africa, and a new virus called Pennisetum glaucum marafivirus was discovered in Burkina Faso in 2018, belonging to the Marafivirus genus. The complete nucleotide sequence of PGMV shares 68.5% identity with sorghum bicolor marafivirus and its coat protein shares 58.5% identity with oat blue dwarf virus. Phylogenetic analysis confirms that the pearl millet virus is grouped with Marafivirus genus members in the Tymoviridae family.
ARCHIVES OF VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Merike Somera, Denis Fargette, Eugenie Hebrard, Cecilia Sarmiento
Summary: The family Solemoviridae consists of viruses with icosahedral particles, a genome of 4-6 kb positive- sense, monopartite, polycistronic RNA, and a narrow host range. Transmission methods vary among different genera within the family.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Plant Sciences
Melia Bonnamy, Agnes Pinel-Galzi, Lucille Gorgues, Veronique Chalvon, Eugenie Hebrard, Sophie Cheron, Trang Hieu Nguyen, Nils Poulicard, Francois Sabot, Helene Pidon, Antony Champion, Stella Cesari, Thomas Kroj, Laurence Albar
Summary: The RYMV3 gene in rice codes for a NLR immune receptor that detects the rice yellow mottle virus (RYMV) by forming a recognition complex with the viral coat protein (CP). The virus escapes detection by mutating its CP, interfering with the formation of the recognition complex. This study reveals the immune function of NLRs in monocotyledonous plants and provides insights into virus adaptation and the development of resistance against viral diseases.
Article
Virology
Laurence Dossou, Agnes Pinel-Galzi, Jamel Aribi, Nils Poulicard, Laurence Albar, Sorho Fatogoma, Marie Noelle Ndjiondjop, Daouda Kone, Eugenie Hebrard
Summary: Rice yellow mottle virus (RYMV) is a major constraint to rice cultivation in Africa, with high genetic diversity. This study developed specific RT-PCR primers to infer the resistance-breaking abilities of RYMV isolates, providing a molecular tool for optimizing the deployment strategy of resistant rice lines.
Article
Microbiology
H. Tall, J. Aribi, S. Camara, A. Pinel-Galzi, N. Poulicard, D. Fargette, E. Hebrard
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)
Article
Virology
Mbolarinosy Rakotomalala, Bram Vrancken, Agnes Pinel-Galzi, Perle Ramavovololona, Eugenie Hebrard, Jean Stephan Randrianangaly, Simon Dellicour, Philippe Lemey, Denis Fargette
Article
Microbiology
Mbolarinosy Rakotomalala, Bayuh Belay Abera, Jacqueline Rakotoarisoa, Dawit Alemu, Eugenie Hebrard, Agnes Pinel-Galzi, Denis Fargette
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)
Article
Biology
Agnes Pinel-Galzi, Eugenie Hebrard, Oumar Traore, Drissa Silue, Laurence Albar
Meeting Abstract
Plant Sciences
E. Hebrard, A. Pinel-Galzi, A. Oludare, N. Poulicard, J. Aribi, S. Fabre, S. Issaka, C. Mariac, A. Dereeper, L. Albar, D. Silue, D. J. Fargette
Article
Microbiology
Antony Kigaru Adego, Nils Poulicard, Agnes Pinel-Galzi, Benard Mukoye, Denis Fargette, Hassan Karakacha Were, Eugenie Hebrard
GENOME ANNOUNCEMENTS
(2018)
Article
Microbiology
Innocent Ndikumana, Agnes Pinel-Galzi, Denis Fargette, Eugenie Hebrard
GENOME ANNOUNCEMENTS
(2017)
