U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells

Post-translational and Post-transcriptional Modifications of Pregnane X Receptor (PXR) in Regulation of the Cytochrome P450 Superfamily

(2013) Tomas Smutny et al.   CURRENT DRUG METABOLISM

The role of residues T248, Y249 and T422 in the function of human pregnane X receptor

(2012) Aneta Doricakova et al.   ARCHIVES OF TOXICOLOGY

Liver-Based In Vitro Technologies for Drug Biotransformation Studies - A Review

(2012) Pius Fasinu et al.   CURRENT DRUG METABOLISM

The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches

(2012) Antonella De Luca et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human Hepatocytes

(2012) Petr Pavek et al.   Frontiers in Pharmacology

Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells

(2011) Aneta Novotna et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells

(2010) Hanqing Dong et al.   BMC BIOCHEMISTRY

Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes

(2010) A. RULCOVA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mitogen-activated protein kinases in hepatocellular carcinoma development

(2010) Lihua Min et al.   SEMINARS IN CANCER BIOLOGY

Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene

(2009) Petr Pavek et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of Cytochrome P450 Expression by Ras- and β-Catenin-Dependent Signaling

(2009) Albert Braeuning   CURRENT DRUG METABOLISM

A Phosphomimetic Mutation at Threonine-57 Abolishes Transactivation Activity and Alters Nuclear Localization Pattern of Human Pregnane X Receptor

(2009) S. R. Pondugula et al.   DRUG METABOLISM AND DISPOSITION

Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress

(2009) Makoto Osabe et al.   FEBS LETTERS

Cyclic AMP-dependent Protein Kinase Signaling Modulates Pregnane x Receptor Activity in a Species-specific Manner

(2009) Kristin Lichti-Kaiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Systematic Analysis of Predicted Phosphorylation Sites within the Human Pregnane X Receptor Protein

(2009) K. Lichti-Kaiser et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Expression of xenobiotic and steroid hormone metabolizing enzymes in hepatocellular tumors of the non-cirrhotic liver

(2009) Susanne Haas et al.   PATHOLOGY RESEARCH AND PRACTICE

Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes

(2008) Radim Vrzal et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cell Lines: A Tool for In Vitro Drug Metabolism Studies

(2008) M. Gomez-Lechon et al.   CURRENT DRUG METABOLISM

Comparison of Two Immortalized Human Cell Lines to Study Nuclear Receptor-Mediated CYP3A4 Induction

(2008) S. Harmsen et al.   DRUG METABOLISM AND DISPOSITION

Cyclin-dependent Kinase 2 Negatively Regulates Human Pregnane X Receptor-mediatedCYP3A4Gene Expression in HepG2 Liver Carcinoma Cells

(2008) Wenwei Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines

(2008) Katerina Pospechova et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY