Article
Multidisciplinary Sciences
Shuangtao Ma, Donna H. Wang
Summary: Knocking out Trpa1 accelerates age-related myocardial fibrosis, ventricular dilation, and cardiac dysfunction.
Article
Biochemistry & Molecular Biology
Sen Guo, Bin-Bin Zhang, Lu Gao, Xiao-Yue Yu, Ji-Hong Shen, Fan Yang, Wen-Cai Zhang, Ya-Ge Jin, Gang Li, Yan-Ge Wang, Zhan-Ying Han, Yuan Liu
Summary: Heart failure severely impairs human health, and cardiac hypertrophy is one of the main causes. This study found that RNF13 plays a protective role in cardiac hypertrophy by activating the p62-NRF2 axis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jiayi Liu, Wei Li, Ke-Qiong Deng, Song Tian, Hui Liu, Hongjie Shi, Qian Fang, Zhen Liu, Ze Chen, Tian Tian, Shanyu Gan, Fengjiao Hu, Manli Hu, Xu Cheng, Yan-Xiao Ji, Peng Zhang, Zhi-Gang She, Xiao-Jing Zhang, Shaoze Chen, Jingjing Cai, Hongliang Li
Summary: The study found a close correlation between Trim16 expression and hypertrophy-related heart failure in both humans and mice. Trim16 deficiency exacerbated cardiomyocyte enlargement, while Trim16 overexpression attenuated cardiac hypertrophy and remodeling. Mechanistically, Prdx1 is an essential target of Trim16 in cardiac hypertrophy, and the Trim16-Prdx1 axis represents a promising therapeutic strategy for hypertrophy-related heart failure.
CIRCULATION RESEARCH
(2022)
Article
Biology
Mingyue Ji, Yun Liu, Zhi Zuo, Cheng Xu, Li Lin, Yong Li
Summary: This study suggests that AREG may reduce myocardial hypertrophy by inhibiting oxidative stress and apoptosis, and may be a target for future cardiac hypertrophy treatment.
Article
Pharmacology & Pharmacy
Vitor Sampaio Minassa, Andrew Vieira Aitken, Sara Cristina Hott, Glauciene Januario de Sousa, Thatiany Jardim Batista, Rita de Cassia Ribeiro Goncalves, Juliana Barbosa Coitinho, Julian Francis Richmond Paton, Vanessa Beijamini, Nazare Souza Bissoli, Karla Nivea Sampaio
Summary: This study investigated the effects of chlorpyrifos on the heart using a rat model. It was found that intermittent exposure to chlorpyrifos caused cardiac hypertrophy, impairment of cardiovascular reflexes, imbalance of autonomic tone, and oxidative stress, posing significant cardiovascular risks to individuals exposed to organophosphate compounds seasonally.
Article
Nutrition & Dietetics
Yu Li, Bo He, Chao Zhang, Yanji He, Tianyang Xia, Chunyu Zeng
Summary: In this study, it was found that naringenin, a natural antioxidant, can alleviate cardiac hypertrophy by inhibiting oxidative stress and the MAPK signaling pathway. These findings reveal the potential of naringenin in the treatment of cardiac hypertrophy.
Article
Biotechnology & Applied Microbiology
ManLi Yuan, Bei Zhao, Huaping Jia, Can Zhang, Xiaowen Zuo
Summary: Sinomenine has been demonstrated to alleviate cardiac hypertrophy by activating the Nrf2/ARE signaling pathway, which leads to reduced cell area, decreased apoptosis rate, and regulation of gene and protein expression levels associated with cardiac hypertrophy. Further research is needed to confirm these findings in human subjects.
Article
Pharmacology & Pharmacy
Nan Zhang, Hai-Han Liao, Hong Feng, Shan-Qi Mou, Wen-Jing Li, Xiahenazi Aiyasiding, Zheng Lin, Wen Ding, Zi-Ying Zhou, Han Yan, Si Chen, Qi-Zhu Tang
Summary: The study demonstrated that Sesn2 overexpression had little genetic toxicity in the hearts of mice and inhibited mTORC1 activation and oxidative stress to protect against pressure overload-induced cardiac hypertrophy in an AMPK alpha 2 dependent pathway. Thus, promoting Sesn2 expression may be a potential strategy for treating pathological cardiac hypertrophy and heart failure.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Peripheral Vascular Disease
Yi Yang, Xinquan Wang, Peng Yan, Dan Wang, Tao Luo, Yaqiong Zhou, Shichao Chen, Qiting Liu, Jixin Hou, Peijian Wang
Summary: Mitochondrial dysfunction is a critical factor in the development of pathological cardiac hypertrophy. TMEM117, a transmembrane protein, is involved in the regulation of oxidative stress and mitochondrial function. This study found that upregulation of TMEM117 contributes to the development of Ang-II-induced cardiac hypertrophy, while its deficiency attenuates hypertrophy. TMEM117 also affects oxidative stress, endoplasmic reticulum stress, and mitochondrial injury in hypertrophic hearts and cardiomyocytes.
HYPERTENSION RESEARCH
(2023)
Article
Nutrition & Dietetics
Miyuki Kobara, Nessa Naseratun, Hiroe Toba, Tetsuo Nakata
Summary: The study found that preconditioning with short-term dietary restriction can attenuate chronic pressure overload-induced cardiac hypertrophy and associated oxidative stress, ultimately improving heart function.
Article
Biochemistry & Molecular Biology
Mingyue Ji, Zhi Zuo, Mengyuan Zhang, Zhen Xu, Guoxin Hu
Summary: In this study, it was found that upregulation of OSTN can attenuate cardiac hypertrophy and fibrosis, possibly through suppressing oxidative stress.
Article
Environmental Sciences
Yen-Lun Kung, Cheng-You Lu, Khan Fareen Badrealam, Wei-Wen Kuo, Marthandam Asokan Shibu, Cecilia Hsuan Day, Ray-Jade Chen, Shang-Yeh Lu, Viswanadha Vijaya Padma, Chih-Yang Huang
Summary: The study demonstrates that AMG can alleviate Ang II-induced cardiomyocyte enlargement, reduce the expression of hypertrophic and inflammatory markers, and increase oxidative stress related proteins. These findings highlight the cardio-protective role of AMG against Ang II-induced cardiomyopathies.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Neoma T. Boardman, Baher Migally, Chantal Pileggi, Gaganvir S. Parmar, Jian Ying Xuan, Keir Menzies, Mary-Ellen Harper
Summary: GRX2 and SIRT3 play important roles in controlling cardiac mitochondrial redox and oxidative processes. However, their combined absence does not exacerbate effects, consistent with the overall conclusion that they function together in the complex redox and antioxidant systems in the heart.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Medicine, Research & Experimental
Shan Ren, Yuge Wang, Yanyan Zhang, Peimei Yan, Dan Xiao, Yu Zhao, Weiwei Jia, Lin Ding, Haiying Dong, Can Wei, Song Lin, Yan Lin
Summary: This study investigated the potential inhibitory effects and mechanism of paeoniflorin on oxidative stress of cardiac hypertrophy induced by AngII in vitro. The results showed that paeoniflorin significantly alleviated cardiac hypertrophy by modulating oxidative stress and the Nrf2 signaling pathway. Rating: 8/10.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Shuang Chen, Ping Sun, You Li, Wenqian Shen, Chao Wang, Peng Zhao, Hao Cui, Jing-Yi Xue, Guo-Qing Du
Summary: This study investigates the cardio-protective capabilities of the anti-oxidant melatonin for treating adverse right ventricular remodeling in pulmonary arterial hypertension (PAH). The findings suggest that melatonin activates the Mst1-Nrf2 pathway, reducing cardiomyocyte hypertrophy and mitochondrial oxidative stress. In vivo, melatonin pre-treatment significantly improves cardiac function, right ventricular hypertrophy, fibrosis, and dilation in PAH rats. These beneficial effects are associated with upregulation of the Mst1-Nrf2 pathway and reduced oxidative stress. Melatonin's therapeutic effects are similar to or even superior to N-acetyl cysteine, a confirmed antioxidant treatment for PAH.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Jasmine Chaudhary, Akash Jain, Randhir Dahiya
Summary: Liver disease is a major cause of increased morbidity and mortality worldwide. Currently, there are limited treatment options available, and the high cost of therapy is a significant hindrance. Researchers are focusing on the potential of herbal drugs for liver disorder management, as they have fewer side effects and lower costs. Saponins, among other phytochemicals, are considered promising candidates for the treatment of hepatic disorders.
NATURAL PRODUCTS JOURNAL
(2022)
Review
Medicine, Research & Experimental
Randhir Singh, Shah Asma Farooq, Ashi Mannan, Thakur Gurjeet Singh, Agnieszka Najda, Zawislak Grazyna, Ghadeer M. Albadrani, Amany A. Sayed, Mohamed M. Abdel-Daim
Summary: Diabetes is becoming more common worldwide, with the primary concern being the development of complications. Appropriate screening models are required to study pathogenesis and potential therapeutic agents for the disease. Various animal models are used to assess pharmacological potentials and investigate disease progression.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Medicinal
Nidhi Rani, Randhir Singh, Praveen Kumar
Summary: This study evaluated the antifungal potency of natural compounds through molecular modeling and ADME study. The findings suggest that curcumin can be used for lead optimization.
LETTERS IN DRUG DESIGN & DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Heena Khan, Thakur Gurjeet Singh, Randhir Singh Dahiya, Mohamed M. Abdel-Daim
Summary: Lipoic acid (alpha-LA), also known as thioctic acid, is a potent antioxidant compound with the potential to treat neurodegenerative disorders. It acts through various mechanisms and can easily cross the blood-brain barrier to reach the central nervous system. Therefore, it holds promise as a therapeutic ingredient for neurodegenerative diseases.
NEUROCHEMICAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Dhirendra Singh, Randhir Singh
Summary: Secondary metabolites in plants are natural sources of bioactive chemicals that can be used to treat human illnesses. Alpinetin, a flavonoid compound, possesses antioxidant, anti-inflammatory, anticancer, hepatoprotective, and renoprotective activities among other pharmacological properties.
CURRENT NUTRITION & FOOD SCIENCE
(2023)
Article
Integrative & Complementary Medicine
Ankit Kumar, Anoop Singh Negi, Ashutosh Chauhan, Ravindra Semwal, Rajnish Kumar, Ruchi Badoni Semwal, Randhir Singh, Tushar Joshi, Subhash Chandra, Sunil Kumar Joshi, Deepak Kumar Semwal
Summary: This study developed a polyherbal formulation (PHF) consisting of seven herbs for the treatment of type 2 diabetes and evaluated its inhibitory effect on sodium-glucose cotransporter protein-2 (SGLT2) in diabetic rats. The results showed that PHF significantly decreased blood glucose levels, reduced liver enzyme levels, and demonstrated strong binding to SGLT2 protein. The study concludes that PHF has promising antidiabetic activity without adverse effects.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Medicine, Research & Experimental
Ankita Sood, Isha Gautam, Gaaminepreet Singh, Jagdish Chandra Joshi, Randhir Singh Dahiya, Sandeep Arora
Summary: Dengue infection is a major public health concern in tropical and subtropical countries. Vascular dyshomeostasis and liver dysfunction are the major pathological manifestations. Inflammatory cytokines and anti-dengue viral protein antibodies contribute to vascular complications, and PAR-2 activation is associated with vascular dyshomeostasis and hepatic dysfunction.
MEDICAL HYPOTHESES
(2022)
Review
Chemistry, Organic
Nidhi Rani, Randhir Singh, Praveen Kumar
Summary: Imidazoles have significant importance in heterocyclic chemistry due to their diverse chemistry and pharmacology features. Imidazole is a biologically and pharmaceutically important nitrogen-containing heterocyclic ring. Therefore, researchers have shown interest in imidazole molecules. For the treatment of various diseases, several imidazole drugs have been synthesized and commercialized. In this report, we provide a detailed account of synthetic procedures for various imidazole drugs.
CURRENT ORGANIC SYNTHESIS
(2023)
Article
Immunology
Shubham Upadhayay, Richmond Arthur, Divya Soni, Poonam Yadav, UmaShanker Navik, Randhir Singh, Thakur Gurjeet Singh, Puneet Kumar
Summary: Monkeypox is a zoonotic disease similar to smallpox, transmitted through direct contact with infected animals or individuals with infectious sores, scabs, or body fluids. There is currently no definitive treatment, but antiviral medication can be used to alleviate symptoms and reverse skin lesions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mandeep Kumar, T. P. Nhung Nguyen, Jasleen Kaur, Thakur Gurjeet Singh, Divya Soni, Randhir Singh, Puneet Kumar
Summary: Artificial intelligence (AI) is a machine science that imitates human behavior and intelligent data analysis using specialized algorithms, deep learning, and machine learning. It provides an automated and reliable tool for accurately and rapidly making decisions in the digital world where a vast amount of medical data is generated daily. AI has been widely applied in various fields in pharmaceutical science, particularly in pharmacological research, aiding in the analysis of preclinical and clinical trial data, drug discovery/manufacturing, disease diagnosis, personalized treatment, clinical trial research, radiotherapy, surgical robotics, electronic health records, and epidemic outbreak prediction. Additionally, AI is instrumental in evaluating biomarkers and diseases. This review explains the models and processes of machine learning and discusses their role in pharmacological science, illustrating the relevance and potential of AI with deep learning and machine learning in pharmacological research.
PHARMACOLOGICAL REPORTS
(2023)
Review
Immunology
Anuja Singh, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Maaz Naqwi, Anil Mavi, Randhir Singh
Summary: This article discusses the potential and recent advancements in using stem cell-derived exosomes for the treatment of rheumatoid arthritis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kirti Goel, Md Sohel Ahmed, Randhir Singh, Vipin Saini, Seema Bansal
Summary: Solanum Nigrum has been widely used in traditional medicine systems for its therapeutic properties. It contains various bioactive constituents that have potential pharmacological activities, including antioxidant, anticancer, antidiabetic, and anti-asthmatic effects. This plant could be a promising natural source for developing alternative medicines.
JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS
(2022)
Review
Pharmacology & Pharmacy
Renu Saharan, Sarvesh K. Paliwal, Abhishek Tiwari, Varsha Tiwari, Randhir Singh, Suresh Kumar Beniwal, Preeti Dahiya, Suresh Sagadevan
Summary: Graphene, hailed as the wonder material, has made significant advancements in applied science and medical science. Its unique properties have attracted great attention for its potential applications in chemotherapy and advanced drug delivery systems. Graphene oxide, as a well-defined nanocarrier, has also emerged as a key component.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Sonia Kamboj, Jasmine Chaudhary, Akash Jain, Randhir Singh
Summary: This study evaluated the biological activity of a newly synthesised chromane and its analogues. The results showed that the new chromane and its O-alkyl substituents, especially S23, exhibited significant antidiabetic potential. However, other synthesised compounds showed moderate to mild effects. Additionally, the synthetic new chromane and O-alkyl substituent (S23) showed the highest antidiabetic activity in terms of lowering glucose concentration compared to the reference drug, metformin.
JOURNAL OF YOUNG PHARMACISTS
(2023)
Review
Food Science & Technology
Rishabh Chalotra, Tanya Gupta, Shivani Chib, Muhammed Amanat, Puneet Kumar, Randhir Singh
Summary: Diabetes mellitus is an endocrine disorder characterized by elevated blood sugar levels and can lead to serious complications. Current therapies fail to achieve absolute control of diabetes, and the side effects of pharmacotherapy worsen patients' quality of life. This review focuses on the therapeutic potential of flavonoids in the management of diabetes and diabetic complications.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)