Review
Pharmacology & Pharmacy
Noelia Miret, Carolina A. Pontillo, Sol Bujan, Florencia A. Chiappini, Andrea S. Randi
Summary: This literature review addresses the role of the aryl hydrocarbon receptor (AhR) and its ligands in breast cancer. The study explores the biological mechanisms of AhR agonists in interfering with breast endocrine functions and their impact on breast cancer development and progression. The findings suggest that exposure to AhR agonists stimulates pathways that promote breast cancer and contribute to tumor progression. Therefore, the evaluation and regulation of industrial and agricultural chemicals and other toxicants are essential in reducing the risk of breast cancer.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
So Jeong Paik, Dong Joon Kim, Sung Keun Jung
Summary: Skin is directly exposed to external factors like ultraviolet and particulate matter, which can cause chronic skin diseases. Phytochemicals have the potential to prevent and treat skin diseases by regulating signaling pathways. Further research is needed to validate the clinical potential of phytochemicals in skin disease prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hamza Hanieh, Mohammad Bani Ismail, Manal A. Alfwuaires, Hairul-Islam M. Ibrahim, Mahdi Farhan
Summary: Aryl hydrocarbon receptor (AhR) has emerged as a potential molecular target in cancer research. It regulates complex transcriptional processes in normal and malignant cells through its canonical and non-canonical pathways. Different classes of AhR ligands have shown anticancer potential, while antagonistic ligands inhibit AhR activity as a potential therapeutic strategy. Recent advancements include the development of cancer immunotherapeutic drugs targeting AhR signaling pathways and the tumor microenvironment.
Article
Toxicology
Lucia Sladekova, Eliska Zgarbova, Radim Vrzal, David Vanda, Miroslav Soural, Klara Jakubcova, Gerardo Vazquez-Gomez, Jan Vondracek, Zdenek Dvorak
Summary: Microbial indoles have been found to selectively activate or bind to the PXR and AhR receptors. By studying the effects of derivatives of the indole microbial metabolite tryptamine, researchers have discovered that subtle chemical modifications can greatly change their activities as agonists for these receptors. These modified compounds have also demonstrated anti-inflammatory and epithelial barrier-protective activities.
TOXICOLOGY LETTERS
(2023)
Article
Plant Sciences
Han Li, Yun-hang Gao, Ling Song, Teng-fei Chen, Guang-ping Zhang, Zu-guang Ye, Yue Gao, Wang Huo
Summary: Ginsenoside Rg1 is a potential medication for protecting against TCDD-associated liver injury.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meixi Wang, Zuqi Zhang, Panpan Ruan, Guangchen Zhang, Chengrong Xiao, Yuguang Wang, Yue Gao
Summary: The study found that the metabolism of emodin to 5-hydroxyemodin by CYP1A plays an important role in the hepatocellular toxicity of emodin. CYP1A1 and AhR can be used to predict and validate liver injury caused by PMT or other herbs containing emodin.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Noelia Miret, Lorena Zarate, Fernando Erra Diaz, M. Agustina Leguizamon, Carolina A. Pontillo, Florencia A. Chiappini, Leandro Ceballos, Jorge Geffner, Andrea S. Randi
Summary: A reduction in extracellular pH promotes breast cancer progression by activating the AhR/c-Src axis, which increases cell migration and MMP-9 activity.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Ziyue Kou, Wei Dai
Summary: Aryl hydrocarbon receptor (AHR) is a cellular protein involved in detoxification of xenobiotic compounds. Research has shown that AHR plays important roles in normal development and homeostasis, and its deficiency can lead to various developmental abnormalities.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Binoy Shivanna, Chun Chu, Bhagavatula Moorthy
Summary: The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor that plays a vital role in the development of liver and regulation of various physiological processes. This review summarizes the mechanistic role(s) and therapeutic potential of AHR in acute lung injury, chronic obstructive pulmonary disease, and bronchopulmonary dysplasia, highlighting its translational potential for managing these lung disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Claudia Rejano-Gordillo, Ana Ordiales-Talavero, Ana Nacarino-Palma, Jaime M. Merino, Francisco J. Gonzalez-Rico, Pedro M. Fernandez-Salguero
Summary: The transcription factor aryl hydrocarbon receptor (AHR) is a key regulator involved in cell functions and tumor progression. It can act as either an oncogene or a tumor suppressor, depending on the specific organ, tissue and cell type. In addition to its role in cell adhesion and migration, AHR has potential as a therapeutic tool, diagnosis and prognosis marker.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Nutrition & Dietetics
Keisuke Satake, Takenobu Ishii, Taiki Morikawa, Teruo Sakamoto, Yasushi Nishii
Summary: Quercetin, a flavonoid with various pharmacological activities, has been found to prevent TCDD-induced cleft palate by inhibiting CYP1A1 through AhR. This study suggests the potential of quercetin as a preventive measure for cleft palate.
Review
Pharmacology & Pharmacy
Lucia Sladekova, Sridhar Mani, Zdenek Dvorak
Summary: The aryl hydrocarbon receptor (AhR) is a crucial member of the helix-loop-helix transcription factors family, playing a central role in host physiology and various pathophysiologies. Activation of AhR is ligand-driven and the pharmacology of activation is dependent on the type and quantity of ligand. Therefore, understanding AhR ligands is essential for further advancements in the field. This minireview clarifies misconceptions and explores the true nature of AhR activation by discussing selected chemical classes and their qualification as true receptor ligands.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ting Xiang Lim, Muneer Ahamed, David C. Reutens
Summary: This article reviews the role of the aryl hydrocarbon receptor (AhR) in glioblastoma tumorigenesis and highlights its potential as a novel biomarker for glioma therapies targeting the tumor immune response and PET diagnostics.
DRUG DISCOVERY TODAY
(2022)
Review
Pharmacology & Pharmacy
Colleen S. Curran, Jeffrey B. Kopp
Summary: The aryl hydrocarbon receptor (AHR) plays an important role in the development of chronic kidney disease (CKD) by binding various endogenous and xenobiotic ligands and regulating kidney stability, transcriptional activity, and cell signaling. AHR activity is closely associated with kidney damage and protection, with its cross-talk with estrogen, peroxisome proliferator-activated receptor-gamma, and NF-kappa B pathways contributing to the diversity of AHR responses in different forms and stages of CKD. Understanding the roles of AHR in kidney fibrosis, metabolism, and the renin-angiotensin system can provide insights into the pathogenesis and therapies of CKD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Xiaoyu Xi, Qinbin Ye, Danping Fan, Xiaoxue Cao, Qiong Wang, Xing Wang, Mengxiao Zhang, Yuan Xu, Cheng Xiao
Summary: Several factors, including genetic, epigenetic, and environmental factors, play important roles in the pathogenesis of rheumatoid arthritis (RA), with polycyclic aromatic hydrocarbons (PAHs) being a recently highlighted environmental factor. This review summarizes the recent progress in understanding the mechanisms of PAHs and aryl hydrocarbon receptors (AHRs) in RA, and discusses the development of therapeutic drugs targeting AHRs. Challenges and prospects of AHR application in the future are also discussed.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Tim Spannbrucker, Niloofar Ale-Agha, Christine Goy, Nadine Dyballa-Rukes, Philipp Jakobs, Kirsten Jander, Joachim Altschmied, Klaus Unfried, Judith Haendeler
EXPERIMENTAL GERONTOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Matteo Ottolini, Kwangseok Hong, Eric L. Cope, Zdravka Daneva, Leon J. DeLalio, Jennifer D. Sokolowski, Corina Marziano, Nhiem Y. Nguyen, Joachim Altschmied, Judith Haendeler, Scott R. Johnstone, Mohammad Y. Kalani, Min S. Park, Rakesh P. Patel, Wolfgang Liedtke, Brant E. Isakson, Swapnil K. Sonkusare
Review
Physiology
Vanessa Brinkmann, Niloofar Ale-Agha, Judith Haendeler, Natascia Ventura
FRONTIERS IN PHYSIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Julia Rosen, Philipp Jakobs, Niloofar Ale-Agha, Joachim Altschmied, Judith Haendeler
Review
Hematology
Jedrzej Hoffmann, Gavin Richardson, Judith Haendeler, Joachim Altschmied, Vicente Andres, Ioakim Spyridopoulos
Summary: Shortened telomeres have been associated with various chronic diseases, particularly coronary artery disease, but the exact mechanisms are unclear. The role of telomerase in cardiovascular pathology is debated, with potential as a therapeutic target. Mitochondrial telomerase reverse transcriptase's antioxidative function may have atheroprotective effects, suggesting it as a possible target for clinical trials.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kirsten Jander, Jan Greulich, Stefanie Gonnissen, Niloofar Ale-Agha, Christine Goy, Philipp Jakobs, Sabrina Farrokh, Corina Marziano, Swapnil K. Sonkusare, Judith Haendeler, Joachim Altschmied
Summary: The transcription factor Grainyhead-like 3 (GRHL3) has essential functions in endothelial cells beyond the nucleus. Mutants of GRHL3 can retain the ability to inhibit endothelial cell apoptosis, suggesting that the core function of this protein may be related to NO production.
Article
Biochemistry & Molecular Biology
Christian Hundhausen, Rebekka Schneckmann, Yanina Ostendorf, Jacqueline Rimpler, Anette von Glinski, Christina Kohlmorgen, Nina Pasch, Luca Rolauer, Florian von Ameln, Olaf Eckermann, Joachim Altschmied, Niloofar Ale-Agha, Judith Haendeler, Ulrich Floegel, Jens W. Fischer, Maria Grandoch
Summary: The study found that blocking hyaluronan (HA) synthesis did not treat inflammatory bowel disease (IBD), but exacerbated the severity of the disease; while global Has3 deficiency had a protective effect on experimental colitis, reducing colitis scores and immune cell infiltration in the colon.
Article
Cell Biology
Andrey Bogorodskiy, Ivan Okhrimenko, Ivan Maslov, Nina Maliar, Dmitrii Burkatovskii, Florian von Ameln, Alexey Schulga, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Alexandros Katranidis, Ivan Sorokin, Alexey Mishin, Valentin Gordeliy, Georg Buldt, Wolfgang Voos, Thomas Gensch, Valentin Borshchevskiy
Summary: The study shows that a new microinjection method can be used to directly observe protein transport in living cells. The researchers found that releasing nascent polypeptides from translating ribosomes with puromycin increased the import rate of proteins into mitochondria.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dennis Merk, Johannes Ptok, Philipp Jakobs, Florian von Ameln, Jan Greulich, Pia Kluge, Kathrin Semperowitsch, Olaf Eckermann, Heiner Schaal, Niloofar Ale-Agha, Joachim Altschmied, Judith Haendeler
Summary: The study showed that APEX1(1-20) can inhibit EC apoptosis, and identified SELENOT as a potential regulator gene to reduce LPS-induced EC activation and apoptosis. SELENOT, along with APEX1(1-20), can protect EC from activation and apoptosis effects, providing new therapeutic approaches for sepsis.
Article
Cardiac & Cardiovascular Systems
Niloofar Ale-Agha, Philipp Jakobs, Christine Goy, Mark Zurek, Julia Rosen, Nadine Dyballa-Rukes, Sabine Metzger, Jan Greulich, Florian von Ameln, Olaf Eckermann, Klaus Unfried, Fedor Brack, Maria Grandoch, Matthias Thielmann, Markus Kamler, Nilgun Gedik, Petra Kleinbongard, Andre Heinen, Gerd Heusch, Axel Godecke, Joachim Altschmied, Judith Haendeler
Summary: By generating new mouse models with either mitochondrial TERT or nuclear TERT, it was discovered that mitochondrial TERT plays a critical role in protecting the heart, improving complex I activity, reducing infarct size, and promoting vascularization. Mitochondrial TERT has positive effects on the functions of cardiomyocytes, fibroblasts, and endothelial cells, suggesting therapeutic potential for cardiac protection.
Review
Cell Biology
Fiona Frederike Cox, Angelina Misiou, Annika Vierkant, Niloofar Ale-Agha, Maria Grandoch, Judith Haendeler, Joachim Altschmied
Summary: Cardiovascular diseases (CVDs) are a major cause of global mortality. Aging and obesity, which are also global problems, are major risk factors for CVDs. Both aging and obesity are associated with oxidative stress, mitochondrial dysfunction, metabolic abnormalities, and inflammation. Curcumin, a plant substance found in turmeric root, has shown promise in attenuating multiple risk factors for CVDs in aging and obesity. However, more clinical trials are needed to fully understand its potential.
Review
Cell Biology
Andrey Bogorodskiy, Ivan Okhrimenko, Dmitrii Burkatovskii, Philipp Jakobs, Ivan Maslov, Valentin Gordeliy, Norbert A. Dencher, Thomas Gensch, Wolfgang Voos, Joachim Altschmied, Judith Haendeler, Valentin Borshchevskiy
Summary: This article summarizes the latest knowledge about the mitochondrial protein import machinery and its known interrelation with age-related neurodegenerative and cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Vanessa Brinkmann, Margherita Romeo, Lucie Larigot, Anne Hemmers, Lisa Tschage, Jennifer Kleinjohann, Alfonso Schiavi, Swantje Steinwachs, Charlotte Esser, Ralph Menzel, Sara Giani Tagliabue, Laura Bonati, Fiona Cox, Niloofar Ale-Agha, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Xavier Coumoul, Natascia Ventura
Summary: The aryl hydrocarbon receptor (AhR) and Nrf2/SKN-1 pathway play important roles in mediating the anti-aging effects of curcumin. Curcumin can extend lifespan through AhR-dependent mechanism in Caenorhabditis elegans, but it also exhibits AhR-independent anti-aging activities. These findings provide insights into the mechanisms of curcumin's effects on aging.
Editorial Material
Cell Biology
Natascia Ventura, Judith Haendeler
Article
Endocrinology & Metabolism
Maria Grandoch, Ulrich Floegel, Sam Virtue, Julia K. Maier, Tomas Jelenik, Christina Kohlmorgen, Kathrin Feldmann, Yanina Ostendorf, Tamara R. Castaneda, Zhou Zhou, Yu Yamaguchi, Emmani B. M. Nascimento, Vivekananda G. Sunkari, Christine Goy, Martina Kinzig, Fritz Soergel, Paul L. Bollyky, Patrick Schrauwen, Hadi Al-Hasani, Michael Roden, Susanne Keipert, Antonio Vidal-Puig, Martin Jastroch, Judith Haendeler, Jens W. Fischer