Toxicity of pristine versus functionalized fullerenes: mechanisms of cell damage and the role of oxidative stress

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

(2012) Paul D. Ray et al.   CELLULAR SIGNALLING

Genotoxicity evaluation of fullerene C60 nanoparticles in a comet assay using lung cells of intratracheally instilled rats

(2012) Makoto Ema et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Variation in the internalization of differently sized nanoparticles induces different DNA-damaging effects on a macrophage cell line

(2011) Mingyi Zhang et al.   ARCHIVES OF TOXICOLOGY

Cytotoxic effects of hydroxylated fullerenes on isolated rat hepatocytes via mitochondrial dysfunction

(2011) Yoshio Nakagawa et al.   ARCHIVES OF TOXICOLOGY

Neuronal uptake and intracellular superoxide scavenging of a fullerene (C60)-poly(2-oxazoline)s nanoformulation

(2011) Jing Tong et al.   BIOMATERIALS

Aqueous fullerene aggregates (nC60) generate minimal reactive oxygen species and are of low toxicity in fish: a revision of previous reports

(2011) Theodore B Henry et al.   CURRENT OPINION IN BIOTECHNOLOGY

Genotoxicity of Colloidal Fullerene C60

(2011) Shun Matsuda et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Pathological features of rat lung following inhalation and intratracheal instillation of C60fullerene

(2011) Akira Ogami et al.   INHALATION TOXICOLOGY

Cytotoxicity and photocytotoxicity of structure-defined water-soluble C60/micelle supramolecular nanoparticles

(2011) Tanapak Metanawin et al.   NANOTECHNOLOGY

Fullerol in human lens and retinal pigment epithelial cells: time domain fluorescence spectroscopy and imaging

(2011) Paola Taroni et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells

(2011) J.G. Saathoff et al.   TOXICOLOGY IN VITRO

Nanoparticles: molecular targets and cell signalling

(2010) Francelyne Marano et al.   ARCHIVES OF TOXICOLOGY

Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells

(2010) Hiroki Tsumoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Solubilization of fullerene C60 in micellar solutions of different solubilizers

(2010) Vukosava Milic Torres et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Fullerene-polyvinylpyrrolidone clathrate localizes in the cytoplasm to prevent Ultraviolet-A ray-induced DNA-fragmentation and activation of the transcriptional factor NF-kappaB

(2010) Li Xiao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hazard Assessments of Manufactured Nanomaterials

(2010) Yasuo Morimoto et al.   JOURNAL OF OCCUPATIONAL HEALTH

Super-highly hydroxylated fullerene derivative protects human keratinocytes from UV-induced cell injuries together with the decreases in intracellular ROS generation and DNA damages

(2010) Yasukazu Saitoh et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Biological safety of water-soluble fullerenes evaluated using tests for genotoxicity, phototoxicity, and pro-oxidant activity

(2010) Hisae Aoshima et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Oxidative stress-mediated hemolytic activity of solvent exchange-prepared fullerene (C60) nanoparticles

(2010) Andreja Trpkovic et al.   NANOTECHNOLOGY

Genotoxicity testing of nanomaterials – Conclusions

(2010) Helmut Greim et al.   Nanotoxicology

Effect of carbon nanoparticles on renal epithelial cell structure, barrier function, and protein expression

(2010) Bonnie L. Blazer-Yost et al.   Nanotoxicology

Inflammogenic effect of well-characterized fullerenes in inhalation and intratracheal instillation studies

(2010) Yasuo Morimoto et al.   Particle and Fibre Toxicology

Review of fullerene toxicity and exposure – Appraisal of a human health risk assessment, based on open literature

(2010) Karin Aschberger et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Clearance Kinetics of Fullerene C60 Nanoparticles from Rat Lungs after Intratracheal C60 Instillation and Inhalation C60 Exposure

(2010) Naohide Shinohara et al.   TOXICOLOGICAL SCIENCES

Carbon fullerenes (C60s) can induce inflammatory responses in the lung of mice

(2010) Eun-Jung Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction

(2010) Denise N. Johnson-Lyles et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fullerene antioxidants decrease organophosphate-induced acetylcholinesterase inhibition in vitro

(2010) Marion Ehrich et al.   TOXICOLOGY IN VITRO

Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles

(2010) Teresa L. Leavens et al.   TOXICOLOGY LETTERS

Intrinsic biological property of colloidal fullerene nanoparticles (nC60): Lack of lethality after high dose exposure to human epidermal and bacterial cells

(2010) Xin R. Xia et al.   TOXICOLOGY LETTERS

Biological Safety of LipoFullerene composed of Squalane and Fullerene-C60 upon Mutagenesis, Photocytotoxicity, and Permeability into the Human Skin Tissue

(2009) Shinya Kato et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Opposite effects of nanocrystalline fullerene (C60) on tumour cell growth in vitro and in vivo and a possible role of immunosupression in the cancer-promoting activity of C60

(2009) Nevena S. Zogovic et al.   BIOMATERIALS

The protection of cells from nitric oxide-mediated apoptotic death by mechanochemically synthesized fullerene (C60) nanoparticles

(2009) Maja S. Misirkic et al.   BIOMATERIALS

Highly hydroxylated or γ-cyclodextrin-bicapped water-soluble derivative of fullerene: The antioxidant ability assessed by electron spin resonance method and β-carotene bleaching assay

(2009) Shinya Kato et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Difference in Phototoxicity of Cyclodextrin Complexed Fullerene [(γ-CyD)2/C60] and Its Aggregated Derivatives toward Human Lens Epithelial Cells

(2009) Baozhong Zhao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Comparative Toxicity of C60Aggregates toward Mammalian Cells: Role of Tetrahydrofuran (THF) Decomposition

(2009) Michael Kovochich et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Comparative Photoactivity and Antibacterial Properties of C60Fullerenes and Titanium Dioxide Nanoparticles

(2009) Léna Brunet et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: Predictive tests and biomarkers

(2009) Petia P. Simeonova et al.   INHALATION TOXICOLOGY

Pulmonary responses to polyhydroxylated fullerenols, C60(OH)x

(2009) Jing-Ying Xu et al.   JOURNAL OF APPLIED TOXICOLOGY

Noninvasive in vivo electron paramagnetic resonance study to estimate pulmonary reducing ability in mice exposed to NiO or C60 nanoparticles

(2009) Hidekatsu Yokoyama et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Fullerene-C60/liposome complex: Defensive effects against UVA-induced damages in skin structure, nucleus and collagen type I/IV fibrils, and the permeability into human skin tissue

(2009) Shinya Kato et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Safety evaluation of highly purified fullerenes (HPFs): based on screening of eye and skin damage

(2009) Hisae Aoshima et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Effects of fullerenol C60(OH)24 on the frequency of micronuclei and chromosome aberrations in CHO-K1 cells

(2009) Jasminka Mrđanović et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Research Highlights

(2009) R Banerjee   Nanomedicine

Preparation and biodistribution of radiolabeled fullerene C60nanocrystals

(2009) Nadežda Nikolić et al.   NANOTECHNOLOGY

Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells

(2009) An Xu et al.   Particle and Fibre Toxicology

Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis

(2009) Lise K Vesterdal et al.   Particle and Fibre Toxicology

Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

(2009) Nicklas Jacobsen et al.   Particle and Fibre Toxicology

Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems

(2009) Yukari Totsuka et al.   Particle and Fibre Toxicology

Translocation Pathway of the Intratracheally Instilled C60 Fullerene from the Lung into the Blood Circulation in the Mouse: Possible Association of Diffusion and Caveolae-mediated Pinocytosis

(2009) Misaki Naota et al.   TOXICOLOGIC PATHOLOGY

The Biological Mechanisms and Physicochemical Characteristics Responsible for Driving Fullerene Toxicity

(2009) Helinor J. Johnston et al.   TOXICOLOGICAL SCIENCES

Gene expression profiles in rat lung after inhalation exposure to C60 fullerene particles

(2009) Katsuhide Fujita et al.   TOXICOLOGY

Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines

(2009) Yuanyuan Su et al.   TOXICOLOGY

The co-application effects of fullerene and ascorbic acid on UV-B irradiated mouse skin

(2009) Shinobu Ito et al.   TOXICOLOGY

Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents

(2009) Xin R. Xia et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Phototoxicity and cytotoxicity of fullerol in human retinal pigment epithelial cells

(2009) Albert R. Wielgus et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles

(2009) Naohide Shinohara et al.   TOXICOLOGY LETTERS

Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products

(2009) O. Bottasso et al.   INFLAMMOPHARMACOLOGY

In vivoBiology and Toxicology of Fullerenes and Their Derivatives

(2008) Gunnar Damgård Nielsen et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Polyhydroxylated C60Fullerene (Fullerenol) Attenuates Neutrophilic Lung Inflammation in Mice

(2008) Martin Roursgaard et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Biomedical potential of the reactive oxygen species generation and quenching by fullerenes (C60)

(2008) Zoran Markovic et al.   BIOMATERIALS

Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer

(2008) Rade Injac et al.   BIOMATERIALS

Pristine (C60) and Hydroxylated [C60(OH)24] Fullerene Phototoxicity towards HaCaT Keratinocytes: Type I vs Type II Mechanisms

(2008) Baozhong Zhao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Genotoxicity, cytotoxicity, and reactive oxygen species induced by single‐walled carbon nanotubes and C60fullerenes in the FE1‐Muta™Mouse lung epithelial cells

(2008) Nicklas Raun Jacobsen et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Oxidatively Damaged DNA in Rats Exposed by Oral Gavage to C 60 Fullerenes and Single-Walled Carbon Nanotubes

(2008) Janne K. Folkmann et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

C60 fullerene: A powerful antioxidant or a damaging agent? The importance of an in-depth material characterization prior to toxicity assays

(2008) P. Spohn et al.   ENVIRONMENTAL POLLUTION

Mechanisms of Photochemistry and Reactive Oxygen Production by Fullerene Suspensions in Water

(2008) Ernest M. Hotze et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Delineating Oxidative Processes of Aqueous C60Preparations: Role of THF Peroxide

(2008) Bo Zhang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

OXIDATIVE STRESS AND GROWTH INHIBITION IN THE FRESHWATER FISH CARASSIUS AURATUS INDUCED BY CHRONIC EXPOSURE TO SUBLETHAL FULLERENE AGGREGATES

(2008) Xiaoshan Zhu et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The translocation of fullerenic nanoparticles into lysosome via the pathway of clathrin-mediated endocytosis

(2008) Wei Li et al.   NANOTECHNOLOGY

Photo-induced Reactive Oxygen Species Generation by Different Water-soluble Fullerenes (C60) and Their Cytotoxicity in Human Keratinocytes

(2008) Baozhong Zhao et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Cytotoxicity of Aggregated Fullerene C60 Particles on CHO and MDCK Cells

(2008) Binbing Han et al.   SCANNING

Phototoxicity and cytotoxicity of fullerol in human lens epithelial cells

(2008) Joan E. Roberts et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activity of Antioxidative Enzymes in Erythrocytes after a Single Dose Administration of Doxorubicin in Rats Pretreated with Fullerenol C60(OH)24

(2008) Vukosava Djordjevic Milic et al.   TOXICOLOGY MECHANISMS AND METHODS

C60Colloid Formation in Aqueous Systems: Effects of Preparation Method on Size, Structure, and Surface Charge

(2007) Laura K. Duncan et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY