Opportunities for an alternative integrating testing strategy for carcinogen hazard assessment?

Historical perspective on the use of animal bioassays to predict carcinogenicity: Evolution in design and recognition of utility

(2011) L. A. Beyer et al.   CRITICAL REVIEWS IN TOXICOLOGY

Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus)

(2011) Sheila Galloway et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A core in vitro genotoxicity battery comprising the Ames test plus the in vitro micronucleus test is sufficient to detect rodent carcinogens and in vivo genotoxins

(2011) David Kirkland et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

New public QSAR model for carcinogenicity

(2010) Natalja Fjodorova et al.   Chemistry Central Journal

Historical perspective on the development of the genetic toxicity test battery in the United States

(2010) Errol Zeiger   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Applications of the human p53 knock-in (Hupki) mouse model for human carcinogen testing

(2010) Ahmad Besaratinia et al.   FASEB JOURNAL

Review article Genetically modified animals for use in research and biotechnology

(2010) L.M. Chaible et al.   GENETICS AND MOLECULAR RESEARCH

Further analysis of Ames-negative rodent carcinogens that are only genotoxic in mammalian cells in vitro at concentrations exceeding 1 mM, including retesting of compounds of concern

(2010) D. Kirkland et al.   MUTAGENESIS

Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds

(2010) K. Mathijs et al.   MUTAGENESIS

Syrian Hamster Embryo (SHE) cell transformation assay with and without X-ray irradiation of feeder cells using Di(2-ethylhexyl)phthalate (DEHP) and N-nitroso-N-methylnitroguanidine (MNNG)

(2010) K. Pant et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): Summary of results in the collaborative trial

(2010) David Kirkland   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): Introduction to the collaborative trial

(2010) David Kirkland   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A Bhas 42 cell transformation assay on 98 chemicals: The characteristics and performance for the prediction of chemical carcinogenicity

(2010) Ayako Sakai et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies

(2010) Andreas Rothfuss et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Improvement of in vivo genotoxicity assessment: Combination of acute tests and integration into standard toxicity testing

(2010) Andreas Rothfuss et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods

(2010) Michael D. Waters et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

(2010) Federico M. Goodsaid et al.   NATURE REVIEWS DRUG DISCOVERY

Toxicogenomics and cancer risk assessment: A framework for key event analysis and dose–response assessment for nongenotoxic carcinogens

(2010) Joel P. Bercu et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: Genotoxicity. A COLIPA analysis

(2010) Stefan Pfuhler et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Toxicogenomics Applied to In Vitro Carcinogenicity Testing with Balb/c 3T3 Cells Revealed a Gene Signature Predictive of Chemical Carcinogens

(2010) Astrid Rohrbeck et al.   TOXICOLOGICAL SCIENCES

Application of Transcriptional Benchmark Dose Values in Quantitative Cancer and Noncancer Risk Assessment

(2010) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Chemical Carcinogenesis

(2010) S. M. Cohen et al.   TOXICOLOGICAL SCIENCES

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

(2010) Danyel G. J. Jennen et al.   TOXICOLOGICAL SCIENCES

Xenobiotic metabolism gene expression in the EpiDerm™ in vitro 3D human epidermis model compared to human skin

(2010) T. Hu et al.   TOXICOLOGY IN VITRO

BALB/c 3T3 cell transformation assay for the prediction of carcinogenic potential of chemicals and environmental mixtures

(2010) Maria Grazia Mascolo et al.   TOXICOLOGY IN VITRO

Morphological cell transformation of Syrian hamster embryo (SHE) cells by the cyanotoxin, cylindrospermopsin

(2010) M.-A. Maire et al.   TOXICON

An Evaluation of Chronic 6- and 12-Month Rat Toxicology Studies as Predictors of 2-Year Tumor Outcome

(2010) M. V. Reddy et al.   VETERINARY PATHOLOGY

Animal transgenesis: an overview

(2009) Miguel A. Gama Sosa et al.   Brain Structure & Function

Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models

(2009) Martijs J. Jonker et al.   CARCINOGENESIS

Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity

(2009) Mathieu Vinken et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Predictive Models for Carcinogenicity and Mutagenicity: Frameworks, State-of-the-Art, and Perspectives

(2009) E. BENFENATI et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Image analysis and automatic classification of transformed foci

(2009) C. URANI et al.   JOURNAL OF MICROSCOPY

Exercise Effects on Tumorigenesis in a p53-Deficient Mouse Model of Breast Cancer

(2009) LISA H. COLBERT et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Intralaboratory and interlaboratory evaluation of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay

(2009) Ting Hu et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Evaluation of the Vitotox™ and RadarScreen assays for the rapid assessment of genotoxicity in the early research phase of drug development

(2009) Walter M.A. Westerink et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities—Report from an ECVAM workshop

(2009) Stefan Pfuhler et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The development of RAD51C, Cystatin A, p53 and Nrf2 luciferase-reporter assays in metabolically competent HepG2 cells for the assessment of mechanism-based genotoxicity and of oxidative stress in the early research phase of drug development

(2009) Walter M.A. Westerink et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Cancer Risk Assessment Approaches at the FDA/CDER: Is the Era of the 2-Year Bioassay Drawing to a Close?

(2009) David Jacobson-Kram   TOXICOLOGIC PATHOLOGY

An Industry Perspective on the Utility of Short-Term Carcinogenicity Testing in Transgenic Mice in Pharmaceutical Development

(2009) Richard D. Storer et al.   TOXICOLOGIC PATHOLOGY

Alternative Mouse Models for Carcinogenicity Assessment: Industry Use and Issues with Pathology Interpretation

(2009) Gerald G. Long et al.   TOXICOLOGIC PATHOLOGY

A Review of the Molecular Mechanisms of Chemically Induced Neoplasia in Rat and Mouse Models in National Toxicology Program Bioassays and Their Relevance to Human Cancer

(2009) Mark J. Hoenerhoff et al.   TOXICOLOGIC PATHOLOGY

A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards

(2009) Alan R. Boobis et al.   TOXICOLOGIC PATHOLOGY

Integration of In Vivo Genotoxicity and Short-term Carcinogenicity Assays Using F344 gpt Delta Transgenic Rats: In Vivo Mutagenicity of 2,4-Diaminotoluene and 2,6-Diaminotoluene Structural Isomers

(2009) Naomi Toyoda-Hokaiwado et al.   TOXICOLOGICAL SCIENCES

Discrimination for Genotoxic and Nongenotoxic Carcinogens by Gene Expression Profiling in Primary Mouse Hepatocytes Improves with Exposure Time

(2009) Karen Mathijs et al.   TOXICOLOGICAL SCIENCES

Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms

(2009) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGICAL SCIENCES

Discrimination of a transformation phenotype in Syrian golden hamster embryo (SHE) cells using ATR-FTIR spectroscopy

(2009) Michael J. Walsh et al.   TOXICOLOGY

Comparison of gene expression profiles in BALB/c 3T3 transformed foci exposed to tumor promoting agents

(2009) Lin Ao et al.   TOXICOLOGY IN VITRO

The Limits of Two-Year Bioassay Exposure Regimens for Identifying Chemical Carcinogens

(2008) James Huff et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Use of rasH2 transgenic mice for carcinogenesis testing of medical implants

(2008) Xavier Palazzi et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Using Quantitative Structure–Activity Relationships (QSAR) to Predict Toxic Endpoints for Polycyclic Aromatic Hydrocarbons (PAH)

(2008) Erica D. Bruce et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Syrian hamster embryo (SHE) cell transformation assay with conditioned media (without X-ray irradiated feeder layer) using 2,4-diaminotoluene, 2,6-diaminotoluene and chloral hydrate

(2008) Kamala Pant et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

The hen's egg test for micronucleus induction (HET-MN): Novel analyses with a series of well-characterized substances support the further evaluation of the test system

(2008) Thorsten Wolf et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches

(2008) Kathryn Z. Guyton et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The transgenic mouse assay as an alternative test method for regulatory carcinogenicity studies—Implications for REACH

(2008) Monique Y. Wells et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

N-Methyl-N-Nitrosourea (MNU): A Positive Control Chemical for p53+/− Mouse Carcinogenicity Studies

(2008) Daniel Morton et al.   TOXICOLOGIC PATHOLOGY

Hepatocarcinogenic Susceptibility of Fenofibrate and Its Possible Mechanism of Carcinogenicity in a Two-Stage Hepatocarcinogenesis Model of rasH2 Mice

(2008) Masaomi Kawai et al.   TOXICOLOGIC PATHOLOGY

Evaluation of Dichloroacetic Acid for Carcinogenicity in Genetically Modified Tg.AC Hemizygous and p53 Haploinsufficient Mice

(2008) Grace E. Kissling et al.   TOXICOLOGICAL SCIENCES

Prediction of the health effects of polychlorinated biphenyls (PCBs) and their metabolites using quantitative structure–activity relationship (QSAR)☆☆☆

(2008) P. Ruiz et al.   TOXICOLOGY LETTERS

Predictivity and Reliability of QSAR Models: The Case of Mutagens and Carcinogens

(2008) Romualdo Benigni et al.   TOXICOLOGY MECHANISMS AND METHODS

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

(2007) Heidrun Ellinger-Ziegelbauer et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Structure–activity relationship analysis tools: Validation and applicability in predicting carcinogens

(2007) J. Mayer et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY