Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver

Critical selection of reliable reference genes for gene expression study in the HepaRG cell line

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Historical perspective on the use of animal bioassays to predict carcinogenicity: Evolution in design and recognition of utility

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Utilizing toxicogenomic data to understand chemical mechanism of action in risk assessment

(2011) Vickie S. Wilson et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mdm2 links genotoxic stress and metabolism to p53

(2011) Zhongfeng Wang et al.   Protein & Cell

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(2010) Kerry L. Dearfield et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Gene expression-based in vivo and in vitro prediction of liver toxicity allows compound selection at an early stage of drug development

(2010) Adrian Roth et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds

(2010) K. Mathijs et al.   MUTAGENESIS

Improvement of in vivo genotoxicity assessment: Combination of acute tests and integration into standard toxicity testing

(2010) Andreas Rothfuss et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods

(2010) Michael D. Waters et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Time Series Analysis of Benzo[A]Pyrene-Induced Transcriptome Changes Suggests That a Network of Transcription Factors Regulates the Effects on Functional Gene Sets

(2010) Joost H. M. van Delft et al.   TOXICOLOGICAL SCIENCES

Activation of P53 in HepG2 cells as surrogate to detect mutagens and promutagens in vitro

(2010) Kathleen Boehme et al.   TOXICOLOGY LETTERS

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

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Discrimination for Genotoxic and Nongenotoxic Carcinogens by Gene Expression Profiling in Primary Mouse Hepatocytes Improves with Exposure Time

(2009) Karen Mathijs et al.   TOXICOLOGICAL SCIENCES

Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms

(2009) Heidrun Ellinger-Ziegelbauer et al.   TOXICOLOGICAL SCIENCES

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats

(2008) Takeki Uehara et al.   TOXICOLOGY

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

(2007) Heidrun Ellinger-Ziegelbauer et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS