Article
Biochemistry & Molecular Biology
Mohammad-Masoud Zavvarian, James Hong, Mohamad Khazaei, Jonathon Chon Teng Chio, Jian Wang, Anna Badner, Michael G. Fehlings
Summary: This study demonstrated that intraperitoneal injection of midostaurin in injured rats led to alterations in local inflammasome and gene expression, resulting in enhanced recovery and improved coordination between forelimbs and hindlimbs after injury. Histological analysis also indicated improved tissue preservation and functionality in treated animals during the chronic phase of injury. Overall, systemic administration of midostaurin proved to be an effective strategy for mitigating cervical secondary SCI damage.
Article
Immunology
Xiao Xiao, Xing-Yu Chen, Yin-Hui Dong, Hao-Ru Dong, Long-Nian Zhou, Yuan-Qing Ding, Gong Chen, Jian-Lan Zhao, Rong Xie
Summary: This study aimed to investigate whether rapamycin could suppress SCI-induced neuronal inflammatory injury via the AIM2 signaling pathway in vitro and in vivo. The results showed that pre-treatment with rapamycin transformed BV-2 cells to the M2 phenotype and protected against neuronal injury through the AIM2 signaling pathway. Similarly, rapamycin pre-treatment improved the outcomes of rats with cervical SCI through the AIM2 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Chao Tang, Yuan He Fan, Ye Hui Liao, Qiang Tang, Fei Ma, Qing Wang, De Jun Zhong
Summary: This study introduces a morphology-based classification for unilateral cervical facet interlocking injuries, aiming to clarify the injury mechanism, radiological characteristics, and neurological deficits in different types of UCLF. The proposed classification system can aid in preoperative closed reduction assessment and guide surgical approach selection.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Briana P. Meyer, Lydiane Hirschler, Seongtaek Lee, Shekar N. Kurpad, Jan M. Warnking, Emmanuel L. Barbier, Matthew D. Budde
Summary: This study optimized pCASL for the rodent cervical spinal cord and demonstrated its utility in identifying perfusion deficits in an acute contusion injury model. Results showed that perfusion was clearly decreased at the site of injury after moderate contusion.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Timothy Chryssikos, Jesse A. Stokum, Abdul-Kareem Ahmed, Chixiang Chen, Aaron Wessell, Gregory Cannarsa, Nicholas Caffes, Jeffrey Oliver, Joshua Olexa, Phelan Shea, Mohamed Labib, Graeme Woodworth, Alexander Ksendzovsky, Uttam Bodanapally, Kenneth Crandall, Charles Sansur, Gary Schwartzbauer, Bizhan Aarabi
Summary: Real-time intraoperative ultrasound (IOUS) can be used as a supplement to postoperative MRI and CT myelography for the assessment of spinal cord decompression.
Article
Medicine, General & Internal
Yannick Rau, Roland Thietje, Arndt-Peter Schulz, Marc Auerswald, Ralf Bothig, Sven Hirschfeld
Summary: This study found a significant correlation between cervical fusion length and rehabilitation success after trauma, which can be used to predict functional outcomes. Cervical fusion length is an independent predictor of functional outcomes, affecting range of motion and injury severity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Alex B. Bak, Ali Moghaddamjou, Anahita Malvea, Michael G. Fehlings
Summary: This study compares the impact of high-energy and low-energy mechanisms of injury on the neurological outcomes of cervical sensorimotor complete tSCI. The results show that high-energy mechanisms of injury are associated with poorer motor recovery. This suggests that the mechanism of injury should be considered when predicting and understanding the diversity of outcomes after acute tSCI.
Article
Critical Care Medicine
Ravindran Visagan, Ellaine Boseta, Argyro Zoumprouli, Marios C. Papadopoulos, Samira Saadoun
Summary: This study found that breathing function in patients with acute cervical traumatic spinal cord injuries is dependent on spinal cord perfusion pressure (SCPP). SCPP in the range of 80-90 mmHg is associated with optimal diaphragmatic and intercostal muscle function.
Review
Multidisciplinary Sciences
Xinli Hu, Yu Xu, Haojie Zhang, Yao Li, Xiangyang Wang, Cong Xu, Wenfei Ni, Kailiang Zhou
Summary: This review summarizes the role of necroptosis in central nervous system trauma and its therapeutic implications, providing important suggestions for researchers conducting in-depth research. The study focuses on the necroptosis signaling pathway, execution, temporal patterns of RIPKs in CNS trauma, association of miRNAs with necroptosis, and different types of CNS trauma cell death. It also highlights potential agents for curtailing necroptosis-related cell death in CNS trauma.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Veterinary Sciences
Koen M. Santifort, Ines Carrera, Simon Platt
Summary: This case report highlights the MRI-based diagnosis of traumatic hemorrhagic myelopathy in a dog and achieved a fair short-term outcome with conservative treatment.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Multidisciplinary Sciences
Masataka Miura, Satoshi Maki, Kousei Miura, Hiroshi Takahashi, Masayuki Miyagi, Gen Inoue, Kazuma Murata, Takamitsu Konishi, Takeo Furuya, Masao Koda, Masashi Takaso, Kenji Endo, Seiji Ohtori, Masashi Yamazaki
Summary: This study evaluated the performance of a convolutional neural network (CNN) in diagnosing cervical spine diseases, particularly ossification, and found that the CNN showed superior accuracy in identifying ossification, outperforming most spine surgeons. The accuracy of the CNN was higher than that of most experts and was statistically equal to the accuracy of the majority of them, demonstrating its potential to aid in the diagnosis of cervical spine conditions.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
M. Dobran, D. Aiudi, V. Liverotti, M. R. Fasinella, S. Lattanzi, C. Melchiorri, A. Iacoangeli, S. Campa, G. Polonara
Summary: The aim of this study was to evaluate the prognostic value of certain features documented on preoperative MRI in patients with acute cervical spinal cord injury. The length of the spinal cord lesion, the diameter of the canal at the level of spinal cord compression, and the presence of intramedullary hemorrhage were significantly associated with the SCIM questionnaire score at one year follow-up. Shorter spinal cord lesion, larger canal diameter at the level of spinal cord compression, and absence of intramedullary hemorrhage were predictors of better outcome.
EUROPEAN SPINE JOURNAL
(2023)
Review
Neurosciences
Anne Huntemer-Silveira, Nandadevi Patil, Megan A. Brickner, Ann M. Parr
Summary: Traumatic brain and spinal cord injuries often result in loss of the myelin sheath, impacting functional recovery of the nervous system. Current research focuses on enhancing endogenous responses and cell-based replacement strategies due to limited mechanisms for remyelination in the CNS.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Serena Silvestro, Emanuela Mazzon
Summary: Central nervous system trauma, such as traumatic brain injury and spinal cord injury, has become a significant health burden due to its preventability and complex medical care required. Deficiencies in neurodegeneration, such as oxidative stress and neuronal apoptosis, are common in these injuries. The transcriptional factor Nrf2 has been found to play a crucial role in regulating the antioxidant response and can be activated by natural compounds. These compounds show neuroprotective properties in experimental models of CNS trauma, making them potential therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ajay Pal, HongGeun Park, Aditya Ramamurthy, Ahmet S. Asan, Thelma Bethea, Meenu Johnkutty, Jason B. Carmel
Summary: In this study, the researchers developed a plasticity protocol in rats that aims to activate both sensory and motor connections in the spinal cord. They found that repeated application of this protocol in rats with spinal cord injury improved their forelimb dexterity and reduced hyperreflexia. This study shows the importance of targeting the sensory and motor systems in the spinal cord for promoting recovery after spinal cord injury.