Article
Cell Biology
Marta Gerasymchuk, Gregory Ian Robinson, Alyssa Groves, Lucie Haselhorst, Sanjana Nandakumar, Cora Stahl, Olga Kovalchuk, Igor Kovalchuk
Summary: Through research on the effects of pCBs on skin rejuvenation, it was found that THC and CBD can promote cell growth and reduce senescence within a certain concentration range. They also alter nuclear architecture and genes related to cell cycle regulation and ECM production. In addition, compared to other common anti-aging substances, THC and CBD showed better wound healing effects in replicative senescent skin fibroblasts.
Article
Chemistry, Medicinal
Ilekuttige Priyan Shanura Fernando, Soo-Jin Heo, Mawalle Kankanamge Hasitha Madhawa Dias, Dissanayaka Mudiyanselage Dinesh Madusanka, Eui-Jeong Han, Min-Ju Kim, Kalu Kapuge Asanka Sanjeewa, Kyounghoon Lee, Ginnae Ahn
Summary: The study evaluated the protective effects of HTT isolated from brown algae against UVB-induced skin aging in HDFs. HTT suppressed ROS generation, mitochondrial hyperpolarization, apoptotic body formation, and inflammatory cytokines, as well as downregulated matrix metalloproteinase activity, suggesting its potential for use in UV protective products.
Article
Biochemistry & Molecular Biology
Sara Ceccacci, Kevin Roger, Ines Metatla, Cerina Chhuon, Khaled Tighanimine, Stefano Fumagalli, Adriana De Lucia, Iwona Pranke, Corinne Cordier, Maria Chiara Monti, Ida Chiara Guerrera
Summary: This study demonstrates the biological effects of the hydrophilic extract of Oenothera biennis cell cultures (ObHEx) on senescent cells through deep proteomic analysis. The results show that ObHEx can restore levels of crucial mitotic proteins and reactivate senescent cell proliferation to a small but significant extent. The study also provides a comprehensive panel of deregulated proteins associated with stress-induced premature senescence (SIPS), which can contribute to further understanding of senescence and potential modulators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Patricia Lavandoski, Vinicius Pierdona, Rafael Moura Maurmann, Lucas Kich Grun, Fatima T. C. R. Guma, Florencia Maria Barbe-Tuana
Summary: This study provides insights into the mechanisms underlying the pro-aging effects of CCL11 in the lungs of asthmatic patients. Understanding the role of CCL11 in senescence development may have important implications for the treatment of age-related lung diseases, such as asthma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Rosaria Arvia, Krystyna Zakrzewska, Lisa Giovannelli, Sara Ristori, Elena Frediani, Mario Del Rosso, Alessandra Mocali, Maria A. Stincarelli, Anna Laurenzana, Gabriella Fibbi, Francesca Margheri
Summary: The study found that infection with parvovirus B19 (B19V) can induce senescence in normal dermal fibroblasts and lead to the production of pro-inflammatory factors similar to fibrosis. B19V infection also resulted in DNA damage, indicating its potential role in fibrotic processes.
Article
Engineering, Chemical
Jehun Choi, Gwi-Yeong Jang, Jeonghoon Lee, Hae-Young Chung, Hyung-Jun Noh, Geum-Soog Kim, Seung-Eun Lee
Summary: Senescence is characterized by physiological decline in organisms, with cellular senescence marked by an inhibition of cell cycle progression. The study showed that DZ extract significantly reduced SA-beta-gal activity in HDFs and decreased age-related oxidative stress and inflammation in aged rat aortas. DZ extract may have a role in preventing vascular inflammatory responses during aging by inhibiting NF-kappa B activation and inflammation.
Article
Cell Biology
Min Ji Song, Chi-Hyun Park, Haesoo Kim, Sangbum Han, Si Hyung Lee, Dong Hun Lee, Jin Ho Chung
Summary: Aging is characterized by impaired mitochondrial function and cellular senescence. This study reveals a novel role of carnitine acetyltransferase (CRAT) in the development of mitochondrial dysfunction and cellular senescence. CRAT deficiency induces mitochondrial damage, leading to the secretion of senescence-associated secretory phenotype (SASP) and the initiation of aging.
Article
Toxicology
Gabriele Horn, Catherine Schaefers, Horst Thiermann, Sandra Voelkl, Annette Schmidt, Simone Rothmiller
Summary: This study demonstrates for the first time that human dermal fibroblasts undergo senescence in a time- and concentration-dependent manner after exposure to SM, exhibiting characteristic senescence phenotype and expressing various senescence markers. Senescent fibroblasts affected by SM can be considered a contributor to the SM-induced chronic wound healing disorder.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Plant Sciences
Kyeong Eun Yang, Soo-Bin Nam, Minsu Jang, Junsoo Park, Ga-Eun Lee, Yong-Yeon Cho, Byeong-Churl Jang, Cheol-Jung Lee, Jong-Soon Choi
Summary: Ginsenoside Rb2, a major active component of Panax ginseng, has the potential to reverse cellular senescence by activating autophagy via the AMPK-mTOR pathway and inducing the expression of DRAM2. These findings suggest that Rb2 may have value as an anti-aging agent.
JOURNAL OF GINSENG RESEARCH
(2023)
Article
Geriatrics & Gerontology
Fariba Nosrati, Johannes Grillari, Mahnaz Azarnia, Mohammad Nabiuni, Reza Moghadasali, Latifeh Karimzadeh, Ingo Laemmermann
Summary: Tissue fibrosis is a common issue in organ aging, caused by the chronic accumulation of senescent cells. Fibroblasts, especially in the skin, play a crucial role in fibrosis by proliferating and depositing excessive extracellular matrix (ECM). This study aims to investigate the influence of senescent fibroblasts and their secretome on dermal fibrosis. The results show that senescent fibroblasts have the potential to be profibrotic, but their secretome failed to induce a fibrotic response in non-senescent cells, contrary to studies on lung fibroblasts.
Article
Medicine, Research & Experimental
Wannita Klinngam, Phetploy Rungkamoltip, Saowarose Thongin, Jaruwan Joothamongkhon, Phattharachanok Khumkhrong, Mattaka Khongkow, Katawut Namdee, Surapun Tepaamorndech, Puxvadee Chaikul, Mayuree Kanlayavattanakul, Nattaya Lourith, Kitiya Piboonprai, Uracha Ruktanonchai, Udom Asawapirom, Tawin Iempridee
Summary: Polymethoxyflavones extracted from Kaempferia parviflora can inhibit skin aging by reducing reactive oxygen species, promoting tropocollagen synthesis, and restoring essential components of the extracellular matrix, leading to anti-aging effects and increased skin stability.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Chieh Ming Liao, Tianjiao Luo, Juliane von der Ohe, Blanca de Juan Mora, Roland Schmitt, Ralf Hass
Summary: Exosomes derived from MSC have been shown to promote proliferation and reduce senescence in kidney cells, suggesting their therapeutic potential in combating renal senescence. This study demonstrates that exosome treatment efficiently reduces senescence markers and SASP factors in kidney cells, indicating a promising approach for organ rejuvenation and regenerative therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Chuan Sun, Zheng Huang, Houbing Qin, Jing Zhang, Sanying Wang, Xiaogang Xu, Shibo Ying, Genxiang Mao
Summary: Rapid population aging has led to a global burden of late-life diseases, with aging being a major risk factor for age-related diseases and closely related to both genotype and external factors. Exposure to 10 Hz pulsed magnetic fields for 2 weeks induced DNA damage in cellular senescence, highlighting the potential impact of electromagnetic fields on aging.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Cell Biology
Sophia Wedel, Ines Martic, Lena Guerrero Navarro, Christian Ploner, Gerhard Pierer, Pidder Jansen-Duerr, Maria Cavinato
Summary: Knocking down GDF15 expression leads to mitochondrial dysfunction and premature senescence, while the loss of GDF15 in a human skin model causes thinning of the epidermis, a hallmark of skin aging.
Article
Biochemistry & Molecular Biology
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao
Summary: Cellular senescence is a complex process affecting various biological processes, with characteristics including senescence-associated phenotype and cell cycle arrest. Persistent senescence is associated with aging pathologies, while transient senescence is linked to beneficial programs.
Article
Geriatrics & Gerontology
Hye-Na Cha, Soyoung Park, Yongwook Dan, Jae-Ryong Kim, So-Young Park
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Geriatrics & Gerontology
Yun-Ui Bae, Youlim Son, Chang-Hyun Kim, Kwang Seok Kim, Se Hee Hyun, Hyun Goo Woo, Byul A. Jee, Jun-Hyuk Choi, Hoon-Ki Sung, Hyung-Chul Choi, So Young Park, Ju-Hyun Bae, Kyung-Oh Doh, Jae-Ryong Kim
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Jung-Hwa Han, Suji Kim, Sujin Kim, Heejung Lee, So-Young Park, Chang-Hoon Woo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Oncology
Khurshid Ahmad, Eun Ju Lee, Sibhghatulla Shaikh, Anuj Kumar, Kummara Madhusudana Rao, So-Yong Park, Jun O. Jin, Sung Soo Han, Inho Choi
Summary: Integrins play key roles in cancer progression by regulating critical biological functions and their expressions are frequently altered. Nanotechnology-based approaches have shown to be more precise, safer, and highly effective therapeutic tools compared to conventional therapies, but still face challenges such as inadequate knowledge of nano-bio interactions and the complexities of clinical trials.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jae-Ho Kim, Hye-Na Cha, Yong-Woon Kim, So-Young Park
Summary: The results of this study suggest that Prx2 does not affect high-fat diet-induced oxidative stress and insulin resistance in mice.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Cell Biology
Eun Ju Lee, Sibhghatulla Shaikh, Dukhwan Choi, Khurshid Ahmad, Mohammad Hassan Baig, Jeong Ho Lim, Yong-Ho Lee, Sang Joon Park, Yong-Woon Kim, So-Young Park, Inho Choi
Article
Biochemistry & Molecular Biology
Eun Ju Lee, Sibhghatulla Shaikh, Khurshid Ahmad, Syed Sayeed Ahmad, Jeong Ho Lim, Soyoung Park, Hye Jin Yang, Won-Kyung Cho, Sang-Joon Park, Yong-Ho Lee, So-Young Park, Jin-Yeul Ma, Inho Choi
Summary: Research shows that the extract from G. uralensis can promote myoblast proliferation and differentiation, as well as enhance muscle regeneration after cardiotoxin-induced muscle injury. The active compounds in the extract have the potential to increase myoblast proliferation and differentiation, indicating a possible therapeutic effect for muscle-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Shiva Pathak, Suman Acharya, Shobha Regmi, Prakash Shrestha, Zhiwei You, Young Kyung Bae, Min Hui Park, Simmyung Yook, Jae-Ryong Kim, So Young Park, Daewon Jeong, Chul Soon Yong, Jong Oh Kim, Jae Hoon Chang, Jee-Heon Jeong
Summary: Recent studies have shown that a single dose of mFK+CLO can induce tolerance to islet xenografts by reducing the antigen presenting and T cell activation capacity of dendritic cells, as well as promoting the generation of regulatory T cells. This immunosuppressive protocol may pave the way for improving therapeutic outcomes of clinical islet transplantation by enhancing the generation of tolerogenic dendritic cells and regulatory T cells.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Hye-Na Cha, Chang-Hoon Woo, Hwa-Young Kim, So-Young Park
Summary: The study indicates that deficiency of MsrB3 gene can inhibit high-fat diet-induced insulin resistance, possibly through increased mitochondrial biogenesis and antioxidant induction.
Article
Engineering, Biomedical
Le Minh Pham, Eok-Cheon Kim, Wenquan Ou, Cao Dai Phung, Tien Tiep Nguyen, Thanh Tung Pham, Kishwor Poudel, Milan Gautam, Hanh Thuy Nguyen, Jee-Heon Jeong, Chul Soon Yong, So-Young Park, Jae-Ryong Kim, Jong Oh Kim
Summary: This study found that CD9 antibody-modified nanoparticles showed high cellular uptake in vitro models, reducing oxidative stress and inflammation in senescent cells, and improving cell viability. In vivo experiments demonstrated that these nanoparticles effectively targeted senescent areas, delivering anti-senescence drugs to atherosclerotic plaques and alleviating the progression of atherosclerosis. This suggests a novel and precise therapeutic approach for treating atherosclerosis by targeting senescent cells.
Article
Geriatrics & Gerontology
Hyunjung Lee, Tae Youl Ha, Chang Hwa Jung, Farida Sukma Nirmala, So-Young Park, Yang Hoon Huh, Jiyun Ahn
Summary: The study revealed that acute insulin resistance coincides with mitochondrial dysfunction in skeletal muscle, leading to impaired mitochondrial function and the development of acute insulin resistance. Improving mitochondrial function has significant potential in treating acute insulin resistance.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Eun Ju Lee, Sibhghatulla Shaikh, Mohammad Hassan Baig, So-Young Park, Jeong Ho Lim, Syed Sayeed Ahmad, Shahid Ali, Khurshid Ahmad, Inho Choi
Summary: This study reports the potential of novel peptides MIF1 and MIF2 derived from MSTN in enhancing myogenesis and reducing adipogenesis. Modified MIF1 and MIF2 showed better cell proliferation and differentiation compared to non-modified peptides. Pretreatment of mice with (Ac)-MIF1 or (Ac)-MIF2-(NH2) promoted muscle regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ju Hee Lee, Kafi N. Ealey, Yash Patel, Navkiran Verma, Nikita Thakkar, So Young Park, Jae-Ryong Kim, Hoon-Ki Sung
Summary: The increased prevalence of obesity and metabolic diseases has led to the study of adipose tissue biology. Using CyTOF technology, this study characterized immune and stromal cells in different adipose tissue depots and identified distinct subtypes of adipose precursor cells with different responses to high-fat diet.
Review
Physiology
Mohammad Hassan Baig, Khurshid Ahmad, Jun Sung Moon, So-Young Park, Jeong Ho Lim, Hee Jin Chun, Afsha Fatima Qadri, Ye Chan Hwang, Arif Tasleem Jan, Syed Sayeed Ahmad, Shahid Ali, Sibhghatulla Shaikh, Eun Ju Lee, Inho Choi
Summary: This article provides an overview of the functions of MSTN in muscle development and its involvement in various muscle-related disorders. Different methods and strategies used to inhibit MSTN activity are reviewed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Won Gun Choi, Wonsuk Choi, Tae Jung Oh, Hye-Na Cha, Inseon Hwang, Yun Kyung Lee, Seung Yeon Lee, Hyemi Shin, Ajin Lim, Dongryeol Ryu, Jae Myoung Suh, So-Young Park, Sung Hee Choi, Hail Kim
Summary: Inhibition of serotonin signaling in adipose tissues can improve insulin resistance by reducing lipolysis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
