Review
Chemistry, Analytical
Mahmoud Hamed, Inas A. Abdallah, Alaa Bedair, Fotouh R. Mansour
Summary: Quercetin and its glycosides have attracted a lot of attention for their potential applications in preventing and treating various diseases. Accurately determining the amount of quercetin in plants and foods is crucial to assess their quality. Traditional sample preparation methods are expensive and time-consuming, while advanced methods achieve higher enrichment factors and are more environmentally friendly.
MICROCHEMICAL JOURNAL
(2023)
Article
Food Science & Technology
Vera Ribeiro, Federico Ferreres, Tiago Macedo, Angel Gil-Izquierdo, Andreia P. Oliveira, Nelson G. M. Gomes, Luisa Araujo, David M. Pereira, Paula B. Andrade, Patricia Valenta
Summary: The study investigated the phenolic composition of Xylopia aethiopica fruits and found potent cytotoxic effects against cancer cells, particularly towards AGS cells. The extract induced apoptosis and activated caspase-3, shedding light on the anticancer mechanisms of X. aethiopica fruits. Further research is needed to identify non-phenolic constituents contributing to these effects and to detail the anticancer mechanisms.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Applied
Giulia Simonetti, Francesca Buiarelli, Flaminia Bernardini, Patrizia Di Filippo, Carmela Riccardi, Donatella Pomata
Summary: This study analyzed the content of quercetin and its derivatives in wines from different varieties in Italy using HPLC-ESIMS/MS. Wines produced from Sangiovese and Nero d'Avola grapes were found to be richest in quercetin compounds.
Article
Plant Sciences
Yejin Ahn, Hee Hwan Lee, Byung-Hak Kim, Sang Jae Park, Young Suk Kim, Hyung Joo Suh, Kyungae Jo
Summary: The study found that Heukharang lettuce leaf extract (HLE) with increased lactucin content has sleep-promoting effects and can significantly improve sleep quality by acting on GABAA receptors. Therefore, HLE can be used as a novel sleep-enhancing agent in the pharmaceutical and food industries.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Hossam Kamli, Ahmad Shaikh, Mehedi Hasan Bappi, Antonio Raposo, Md Faruque Ahmad, Fatema Akter Sonia, Md. Showkoth Akbor, Abdullah Al Shamsh Prottay, Sheila Alves Goncalves, Isaac Moura Araujo, Henrique Douglas Melo Coutinho, Ehab Y. Elbendary, Linda Heejung Lho, Heesup Han, Muhammad Torequl Islam
Summary: This study evaluated the effects of sclareol, with or without caffeine and quercetin, using in vivo and in silico studies. The combination of sclareol, caffeine, and quercetin significantly decreased sleep duration and increased sleep onset latency. In addition, these compounds showed stronger interactions with GABAA receptor subunits compared to caffeine, suggesting their potential as antidepressant agents.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mehedi Hasan Bappi, Abdullah Al Shamsh Prottay, Hossam Kamli, Fatema Akter Sonia, Md. Nayem Mia, Md. Showkoth Akbor, Md. Munnaf Hossen, Samir Awadallah, Mohammad S. S. Mubarak, Muhammad Torequl Islam
Summary: Sedatives are used for calmness or sleepiness in surgery or severe stress. Depression negatively affects emotional well-being and can be treated with anti-depressants. This study evaluated the effects of quercetin and linalool on sleeping mice induced by thiopental sodium and investigated their combined effects using in silico studies.
Article
Biochemistry & Molecular Biology
Ilandarage Menu Neelaka Molagoda, Mirissa Hewage Dumindu Kavinda, Hyung Won Ryu, Yung Hyun Choi, Jin-Woo Jeong, Sanghyuck Kang, Gi-Young Kim
Summary: The study demonstrates that GABA can significantly inhibit melanin synthesis by suppressing MITF and tyrosinase expression, reducing cAMP and CREB levels. GABA inhibits Ca2+ accumulation through GABA(A) and GABA(B) receptors, thereby reducing melanin production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agronomy
Jung-A Ryu, Shucheng Duan, Chan Saem Gil, Ho Young Jeong, Chanhui Lee, In-Kyu Kang, Seok Hyun Eom
Summary: The red color of postharvest apples is an important quality factor. This study found that short-term combination treatment with UV-B and MeJA is an efficient method for improving postharvest apple coloration.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Review
Chemistry, Analytical
Fotouh R. Mansour, Inas A. Abdallah, Alaa Bedair, Mahmoud Hamed
Summary: This review provides an overview of sample preparation and determination methods for quercetin in different matrices. It discusses various analytical techniques and their advantages and disadvantages. The review emphasizes the determination methods for quercetin and its glycosides in pharmaceutical and biological samples.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Rajib Hossain, Khattab Al-Khafaji, Rasel Ahmed Khan, Chandan Sarkar, Md. Shahazul Islam, Dipta Dey, Divya Jain, Farhana Faria, Rukaya Akbor, Olubunmi Atolani, Sonia M. R. Oliveira, Abolghasem Siyadatpanah, Maria de Lourdes Pereira, Muhammad Torequl Islam
Summary: Depressive disorder is a common illness that poses a challenge in the treatment of treatment-resistant depression. Research suggests that pre-treatment with quercetin and ascorbic acid can modify the sleep patterns of mice, potentially acting through the GABA receptor pathways.
Article
Multidisciplinary Sciences
Luiz Leonardo Saldanha, Aislan Quintiliano Delgado, Laurence Marcourt, Nathalia Aparecida de Paula Camaforte, Priscilla Maria Ponce Vareda, Samad Nejad Ebrahimi, Wagner Vilegas, Anne Ligia Dokkedal, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Jose Roberto Bosqueiro
Summary: The leaves of Bauhinia holophylla, traditionally used in Brazil to treat diabetes, have been found to contain multiple compounds that exhibit hypoglycemic activity, including lithospermoside. The hypoglycemic properties of the leaves seem to be the result of the activity of three unrelated classes of compounds, supporting their traditional use in treating diabetes.
Review
Neurosciences
Xianshu Bai, Frank Kirchhoff, Anja Scheller
Summary: This review focuses on the role of GABA as the main inhibitory neurotransmitter in the CNS, particularly in the oligodendrocyte lineage. It discusses the physiological functions of GABA receptors within this lineage and their potential as targets for treatments of CNS diseases.
NEUROSCIENCE BULLETIN
(2021)
Article
Engineering, Chemical
Maria G. Campos, Christian Frigerio, Otilia Bobis, Adriana C. Urcan, Nelson G. M. Gomes
Summary: Bee pollen is a nutritious substance that is prone to degradation during storage due to high moisture content, but an infrared-based technology can be used to determine moisture content and develop a drying technology without compromising its bioactive effects. This approach shows good reproducibility, reduces drying time and energy consumption, and can be scaled up for industrial use with low environmental impact as long as no degradation occurs during the radiation process.
Article
Chemistry, Multidisciplinary
Weidong Shang, Sheng-Nan Su, Rong Shi, Ze-Dong Mou, Guo-Qiang Yu, Xia Zhang, Dawen Niu
Summary: Glycosyl sulfoxides appended with an aryl iodide moiety are reported as stable precursors to glycosyl radicals, which can be converted rapidly and efficiently through intramolecular radical substitution for the synthesis of complex C-linked glycoconjugates under mild conditions, including glycopeptidomimetics and carbohydrate-DNA conjugates in aqueous media.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Neurosciences
Istvan P. Lukacs, Ruggiero Francavilla, Martin Field, Emily Hunter, Michael Howarth, Sawa Horie, Puneet Plaha, Richard Stacey, Laurent Livermore, Olaf Ansorge, Gabor Tamas, Peter Somogyi
Summary: This study investigates the effects of presynaptic metabotropic glutamate receptors (mGluRs) on GABAergic synaptic transmission in human neocortex. They found that activation of group III mGluRs had different effects on two types of GABAergic interneurons, with increased frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) in one type and suppressed frequency in the other type. The results indicate that dendritic spines receive specialized, diverse GABAergic inputs and mGluRs play a role in regulating GABAergic synaptic transmission in the human cortex.
Article
Neurosciences
Sun-Hye Choi, Hyeon-Joong Kim, Hee-Jung Cho, Sang-Deuk Park, Na-Eun Lee, Sung-Hee Hwang, Ik-Hyun Cho, Hongik Hwang, Hyewhon Rhim, Hyoung-Chun Kim, Seung-Yeol Nah
MOLECULAR NEUROBIOLOGY
(2019)
Article
Food Science & Technology
Ji-Hye Kwon, Hyeon Gyu Lee, Kun-Ho Seo, Hyunsook Kim
MOLECULAR NUTRITION & FOOD RESEARCH
(2019)
Article
Biotechnology & Applied Microbiology
Jaewoon Jeong, Hyunsook Kim, Kun-Ho Seo
JOURNAL OF FOOD PROTECTION
(2019)
Article
Food Science & Technology
Hyo-Won Jeong, Jin-ah Kim, Su-Jin Jeon, Seong-Seon Choi, Min-Kyeong Kim, Hye-Jin Yi, Seok-Ju Cho, Il-Young Kim, Jung-Whan Chon, Dong-Hyeon Kim, Dongryeoul Bae, Hyunsook Kim, Kun-Ho Seo
FOODBORNE PATHOGENS AND DISEASE
(2020)
Article
Biotechnology & Applied Microbiology
Dong-Hyeon Kim, Hyunsook Kim, Kun-Ho Seo
JOURNAL OF FOOD SAFETY
(2020)
Article
Food Science & Technology
Dong-Hyeon Kim, Jung-Whan Chon, Hyunsook Kim, Kun-Ho Seo
Article
Agriculture, Multidisciplinary
Kun-Ho Seo, Dong-Hyeon Kim, Wallace H. Yokoyama, Hyunsook Kim
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Environmental Sciences
Hyeon-Joong Kim, Sun-Hye Choi, Na-Eun Lee, Hee-Jung Cho, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Agriculture, Dairy & Animal Science
Dongryeoul Bae, Jung-Whan Chon, Dong-Hyeon Kim, Hyunsook Kim, Kun-Ho Seo
Summary: Folic acid (FA) is an important micronutrient in humans and has effects on bovine mammary epithelial (BME) cells. This study found that FA supplementation can increase cell proliferation and decrease apoptosis, which may be associated with increased milk yield.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Microbiology
Yong-Seok Jang, Dong-Hyeon Kim, Dongryeoul Bae, Se-Hyung Kim, Hyunsook Kim, Jin-San Moon, Kwang-Young Song, Jung-Whan Chon, Kun-Ho Seo
Article
Food Science & Technology
Ho-Seok Chang, Kwang-Young Song, Young-Ji Kim, Jung-Whan Chon, Hyunsook Kim, Keum-Il Jang, Eui-Su Kim, Kun-Ho Seo
FOOD SCIENCE AND BIOTECHNOLOGY
(2020)
Article
Food Science & Technology
Jung-Whan Chon, Jhun-Woo Kim, Kwang-Young Song, Jong-Soo Lim, Dongryeoul Bae, Hyunsook Kim, Kun-Ho Seo
LWT-FOOD SCIENCE AND TECHNOLOGY
(2020)
Article
Plant Sciences
Do-Geun Kim, Hyeon-Joong Kim, Sun-Hye Choi, Sung Min Nam, Hyoung-Chun Kim, Hyewhon Rhim, Ik-Hyun Cho, Man Hee Rhee, Seung-Yeol Nah
Summary: Gintonin, a ginseng-derived exogenous G-protein-coupled LPA receptor ligand, has been shown to influence the migration and morphology of adult mouse brain neurons in vivo. The effects of gintonin on hNPCs were also observed in vitro, with changes in morphology and migration. These findings suggest that gintonin may have potential therapeutic effects on neurological diseases by affecting the morphology and migration of brain neurons.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Food Science & Technology
Kun-Ho Seo, Wallace Yokoyama, Hyunsook Kim
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Nutrition & Dietetics
Kun-Ho Seo, Jaewoon Jeong, Hyunsook Kim