Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes

Improving lung health in low-income and middle-income countries: from challenges to solutions

(2021) Jamilah Meghji et al.   LANCET

Overuse of short-acting β2-agonists in asthma is associated with increased risk of exacerbation and mortality: A nationwide cohort study of the global SABINA programme

(2020) Bright I. Nwaru et al.   EUROPEAN RESPIRATORY JOURNAL

Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial

(2020) Ian D Pavord et al.   Lancet Respiratory Medicine

Once-daily, single-inhaler mometasone–indacaterol–glycopyrronium versus mometasone–indacaterol or twice-daily fluticasone–salmeterol in patients with inadequately controlled asthma (IRIDIUM): a randomised, double-blind, controlled phase 3 study

(2020) Huib A M Kerstjens et al.   Lancet Respiratory Medicine

Effect of a single day of increased as-needed budesonide–formoterol use on short-term risk of severe exacerbations in patients with mild asthma: a post-hoc analysis of the SYGMA 1 study

(2020) Paul M O'Byrne et al.   Lancet Respiratory Medicine

Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial

(2020) Laurie A Lee et al.   Lancet Respiratory Medicine

Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma

(2019) Richard Beasley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized clinical trial of high concentration versus titrated oxygen use in pediatric asthma

(2019) Bhavi Patel et al.   PEDIATRIC PULMONOLOGY

GINA 2019: a fundamental change in asthma management

(2019) Helen K. Reddel et al.   EUROPEAN RESPIRATORY JOURNAL

Symptoms and perception of airway obstruction in asthma: clinical implications for use of reliever medications

(2019) Peter J. Barnes et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Pragmatic Trial of Symptom-Based Inhaled Corticosteroid Use in African-American Children with Mild Asthma

(2019) Kaharu Sumino et al.   Journal of Allergy and Clinical Immunology-In Practice

Management of Severe Asthma: a European Respiratory Society/American Thoracic Society Guideline

(2019) Fernando Holguin et al.   EUROPEAN RESPIRATORY JOURNAL

Does maintenance azithromycin reduce asthma exacerbations? An individual participant data meta-analysis

(2019) Sarah A. Hiles et al.   EUROPEAN RESPIRATORY JOURNAL

Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial

(2019) Jo Hardy et al.   LANCET

Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials

(2019) Johann Christian Virchow et al.   LANCET

Tiotropium Respimat® add-on therapy to inhaled corticosteroids in patients with symptomatic asthma improves clinical outcomes regardless of baseline characteristics

(2019) Thomas B. Casale et al.   RESPIRATORY MEDICINE

Observational Studies of Inhaled Corticosteroid Effectiveness in COPD

(2018) Samy Suissa et al.   CHEST

Budesonide/formoterol maintenance and reliever therapy in adolescent patients with asthma

(2018) Carin Jorup et al.   EUROPEAN RESPIRATORY JOURNAL

Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma

(2018) Diana M. Sobieraj et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma

(2018) Diana M. Sobieraj et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma

(2018) Paul M. O’Byrne et al.   NEW ENGLAND JOURNAL OF MEDICINE

As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma

(2018) Eric D. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations

(2018) Tricia McKeever et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxygen therapy for acutely ill medical patients: a clinical practice guideline

(2018) Reed A C Siemieniuk et al.   BMJ-British Medical Journal

Calling time on asthma deaths in tropical regions—how much longer must people wait for essential medicines?

(2018) Innes Asher et al.   Lancet Respiratory Medicine

“I have lost in every facet of my life”: the hidden burden of severe asthma

(2017) Juliet M. Foster et al.   EUROPEAN RESPIRATORY JOURNAL

Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma

(2017) Shawn D. Aaron et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Should recommendations about starting inhaled corticosteroid treatment for mild asthma be based on symptom frequency: a post-hoc efficacy analysis of the START study

(2017) Helen K Reddel et al.   LANCET

Risks associated with managing asthma without a preventer: urgent healthcare, poor asthma control and over-the-counter reliever use in a cross-sectional population survey

(2017) Helen K Reddel et al.   BMJ Open

Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study

(2017) Akbar K Waljee et al.   BMJ-British Medical Journal

Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study

(2017) Akbar K Waljee et al.   BMJ-British Medical Journal

Treatable traits: toward precision medicine of chronic airway diseases

(2016) Alvar Agusti et al.   EUROPEAN RESPIRATORY JOURNAL

Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma

(2016) David A. Stempel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preventing Exacerbations in Preschoolers With Recurrent Wheeze: A Meta-analysis

(2016) S. V. Kaiser et al.   PEDIATRICS

Acute and chronic systemic corticosteroid–related complications in patients with severe asthma

(2015) Patrick Lefebvre et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The prevalence of severe refractory asthma

(2015) Pieter-Paul W. Hekking et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Risk factors for asthma: is prevention possible?

(2015) Richard Beasley et al.   LANCET

Combination Long-Acting β-Agonists and Inhaled Corticosteroids Compared With Long-Acting β-Agonists Alone in Older Adults With Chronic Obstructive Pulmonary Disease

(2014) Andrea S. Gershon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Asthma and Adherence to Inhaled Corticosteroids: Current Status and Future Perspectives

(2014) C. B. Barnes et al.   Respiratory Care

An Official American Thoracic Society Clinical Practice Guideline: Exercise-induced Bronchoconstriction

(2013) Jonathan P. Parsons et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction

(2013) Nikolaos Lazarinis et al.   THORAX

Efficacy and safety of maintenance and reliever combination budesonide–formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial

(2013) Mitesh Patel et al.   Lancet Respiratory Medicine

Beclometasone–formoterol as maintenance and reliever treatment in patients with asthma: a double-blind, randomised controlled trial

(2013) Alberto Papi et al.   Lancet Respiratory Medicine

Chapter 14: Acute severe asthma (status asthmaticus)

(2012) Rachna Shah et al.   ALLERGY AND ASTHMA PROCEEDINGS

Short-acting β-agonist use and its ability to predict future asthma-related outcomes

(2012) Richard H. Stanford et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

A guide to the translation of the Global Initiative for Asthma (GINA) strategy into improved care

(2012) Louis-Philippe Boulet et al.   EUROPEAN RESPIRATORY JOURNAL

Comparison of Physician-, Biomarker-, and Symptom-Based Strategies for Adjustment of Inhaled Corticosteroid Therapy in Adults With Asthma

(2012) William J. Calhoun   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The effect of budesonide/formoterol maintenance and reliever therapy on the risk of severe asthma exacerbations following episodes of high reliever use: an exploratory analysis of two randomised, controlled studies with comparisons to standard therapy

(2012) Roland Buhl et al.   RESPIRATORY RESEARCH

Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial

(2011) Fernando D Martinez et al.   LANCET

Randomised controlled trial of high concentration versus titrated oxygen therapy in severe exacerbations of asthma

(2011) K. Perrin et al.   THORAX

Formoterol for acute asthma in the emergency department: a systematic review with meta-analysis

(2010) Gustavo J. Rodrigo et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Asthma in Pregnancy

(2010) Vanessa E. Murphy et al.   CLINICS IN CHEST MEDICINE

Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 Revision

(2010) Jan L. Brożek et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations

(2009) Helen K. Reddel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The minimally important difference of the Asthma Control Test

(2009) Michael Schatz et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Preemptive Use of High-Dose Fluticasone for Virus-Induced Wheezing in Young Children

(2009) Francine M. Ducharme et al.   NEW ENGLAND JOURNAL OF MEDICINE

Similar efficacy of ciclesonide versus prednisolone to treat asthma worsening after steroid tapering

(2009) M. van den Berge et al.   RESPIRATORY MEDICINE

Budesonide/formoterol maintenance and reliever therapy versus conventional best practice

(2009) Pascal Demoly et al.   RESPIRATORY MEDICINE

Severe Exacerbations and Decline in Lung Function in Asthma

(2008) Paul M. O'Byrne et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE