Article
Biochemistry & Molecular Biology
Kathrin Luntzer, Ina Lackner, Birte Weber, Yvonne Moedinger, Anita Ignatius, Florian Gebhard, Susann-Yvonne Mihaljevic, Melanie Haffner-Luntzer, Miriam Kalbitz
Summary: Periodontitis and tooth resorption are two oral diseases associated with destruction of tooth-supporting tissues. Research suggests that MCs and the complement system may play a role in alveolar bone and tooth resorption, as they were found to be increased in TR patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Jamie G. Anderson, Connie A. Rojas, Elisa Scarsella, Zhandra Entrolezo, Guillaume Jospin, Sharon L. Hoffman, Judy Force, Roxane H. Maclellan, Mike Peak, Bonnie H. Shope, Anson J. Tsugawa, Holly H. Ganz
Summary: This study used 16S rRNA gene sequencing to analyze the oral microbiome in cats with feline chronic gingivostomatitis (FCGS), healthy cats, and cats with other oral conditions. The results showed that the microbiomes of cats with FCGS were different from those of healthy cats, indicating dysbiosis throughout the oral cavity. The study also found that different oral conditions have varying effects on the microbiome. Additionally, the microbiome data obtained from oral swabs were comparable to those obtained from plaque samples. These findings contribute to a better understanding of FCGS and have implications for the prevention, diagnosis, and treatment of this condition.
Review
Immunology
Xiaoyu Sun, Jike Gao, Xiang Meng, Xiaoxuan Lu, Lei Zhang, Ran Chen
Summary: Macrophages play crucial roles in periodontitis, with different types impacting the immune system and the destruction and repair of periodontal tissues. Polarized M1 and M2 macrophages are involved in inflammatory and anti-inflammatory stages respectively, regulating the progression of periodontitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
YunJeong Choi, Soon Chul Heo, Yu Na Kim, Ji-Young Joo, Jae Joon Hwang, Moon-Kyoung Bae, Hyung Joon Kim
Summary: GRP modulates osteoclastogenesis by influencing the differentiation of bone marrow-derived cells, potentially contributing to the pathogenesis of periodontitis. Stimulation by P. gingivalis can enhance crosstalk between epithelial cells and bone marrow-derived cells, leading to increased osteoclast formation.
Article
Immunology
Izabel C. V. de Oliveira, Leonardo V. Galvao-Moreira, Juliana L. Vilela, Murillo Duarte-Silva, Lucas D. Aguiar-da-Silva, Cesar A. A. Pereira, Domingos M. S. Pereira, Aruana J. M. C. R. Pinheiro, Lidio G. Lima-Neto, Elizabeth S. Fernandes, Cristina R. B. Cardoso, Luciana S. Branco-de-Almeida
Summary: Cinnamaldehyde treatment reduces periodontal bone loss, attenuates inflammatory mediators, and regulates human PBMC responses, suggesting its potential therapeutic effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Xinrong Jiang, Qingtong Zhao, Zhanyu Huang, Fengyu Ma, Kexiao Chen, Zejian Li
Summary: Mucosal-associated invariant T (MAIT) cells are unconventional T cells that recognize microbial vitamin B metabolites presented by MR1 and rapidly produce proinflammatory cytokines. In the oral mucosa, MAIT cells tend to accumulate near the basal lamina and secrete IL-17 when activated. This paper discusses the pathogenesis of periodontitis and the potential contribution of MAIT cells to this disease.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hyo Jeong Kim, Ka-Young Ryu, Yong-Gun Kim, Myoung Ok Kim, Ji Hye Lee, Min-Kyoung Song, Young-Jin Youn, Nitin Kumar Pohkrel, Sung-Hyun Kim, Jae-Young Kim, Hye-Jin Jung, Woo-Shin Kim, Chang-Won Hong, Hong-Hee Kim, Youngkyun Lee
Summary: The study revealed the crucial role of PTP1B in osteoclast differentiation, with PTP1B deficiency leading to decreased osteoclast number and activity. This highlights the potential of PTP1B as a therapeutic target for bone-lytic diseases.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Marjory Xavier Rodrigues, Nadine Fiani, Rodrigo Carvalho Bicalho, Santiago Peralta
Summary: This study investigated the functional potential of subgingival microbial communities in domestic cats using shotgun metagenomic approach, comparing findings between periodontally healthy cats and cats with various periodontal diseases. The study revealed significant differences in the Respiration category among groups, indicating potential associations between microbial functional features and disease development.
SCIENTIFIC REPORTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Natalie Aparecida Rodrigues Fernandes, Angelo Constantino Camilli, Laura Andrea Gonzalez Maldonado, Cindy Grace Perez Pacheco, Amanda Favoreto Silva, Rafael Scaf Molon, Luiz Carlos Spolidorio, Leticia Ribeiro de Assis, Luis Octavio Regasini, Carlos Rossa Junior, Morgana Rodrigues Guimaraes-Stabili
Summary: Chalcone T4 demonstrated anti-inflammatory effects and inhibition of bone resorption in a murine model of periodontitis and on RANKL-induced osteoclastogenesis in vitro, suggesting a potential therapeutic role in the treatment of periodontitis.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Review
Dentistry, Oral Surgery & Medicine
M. G. Balta, E. Papathanasiou, I. J. Blix, T. E. Van Dyke
Summary: Periodontitis is the sixth-most prevalent disease in the world and the leading cause of tooth loss in adults. Recent studies have shown that synthetic and biological disease-modifying antirheumatic drugs, such as rituximab and tocilizumab, can improve periodontal clinical parameters. Probiotics and nutritional supplements have also been found to provide anti-inflammatory benefits in the treatment of periodontitis.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
N. Da Ponte Leguizamon, R. S. de Molo, G. Coletto-Nunes, A. V. B. Nogueira, S. Rocha, D. M. Neo-Justino, A. Soares-Costa, P. S. Cerri, U. H. Lerner, P. P. C. Souza, J. A. Cirelli
Summary: CsinCPI-2 inhibits inflammatory processes and alveolar bone loss caused by periodontal disease, as well as directly affecting osteoclastogenesis. In mice models, CsinCPI-2 significantly reduces inflammatory cell infiltration and prevents alveolar bone loss, offering potential for periodontal disease treatment.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jia Hou, Ling Li, Xuetong Zhang, Yuan An, Liang Zhao
Summary: This study assessed the efficacy of PTEN eBM-MSCs in treating periodontitis. It was found that PTEN eBM-MSCs inhibited inflammation, osteoclast formation, and alveolar bone resorption.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Mariane Maffei Azuma, Carolina de Barros Morais Cardoso, Cristiane Cantiga da Silva, Pedro Henrique Chaves de Oliveira, Rogerio de Castilho Jacinto, Ana Cristina Andrada, Luciano Tavares Angelo Cintra
Summary: Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) play important roles in the treatment of inflammatory oral diseases, reducing pro-inflammatory mediators, suppressing bone resorption, promoting bone formation, and alleviating painful symptoms of stomatitis. However, more research is needed to better understand their specific effects.
Article
Dentistry, Oral Surgery & Medicine
Ying-Wu Chen, Ming-Lun Lee, Cheng-Yang Chiang, Earl Fu
Summary: This study examined the effects of Bifidobacterium and Lactobacillus on periodontitis using a rat model. The results showed that the combination of these probiotics enhanced IL-10 levels and ameliorated the symptoms of periodontitis. Single-use of probiotics also had some alleviating effects.
JOURNAL OF DENTAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jorge F. Lima Teixeira, Petra Henning, Fernando A. Cintra Magalhaes, Glaucia Coletto-Nunes, Thais Floriano-Marcelino, Anna Westerlund, Sofia Moverare-Skrtic, Guilherme J. P. L. Oliveira, Ulf H. Lerner, Pedro Paulo C. Souza
Summary: This study found that interleukin-4 (IL-4) can reduce lipoprotein-induced periodontal bone loss through multiple mechanisms, including direct inhibition of osteoclast progenitors, decreased expression of osteoclast-regulating cytokines in osteoblasts, and decreased inflammation.
Article
Cell & Tissue Engineering
Boaz Arzi, Emily Mills-Ko, Frank J. M. Verstraete, Amir Kol, Naomi J. Walker, Megan R. Badgley, Nasim Fazel, William J. Murphy, Natalia Vapniarsky, Dori L. Borjesson
STEM CELLS TRANSLATIONAL MEDICINE
(2016)
Article
Veterinary Sciences
Boaz Arzi, Susan M. Stover, Tanya C. Garcia, Dustin M. Leale, Frank J. M. Verstraete
AMERICAN JOURNAL OF VETERINARY RESEARCH
(2016)
Article
Pathology
J. N. Winer, B. Arzi, D. M. Leale, P. H. Kass, F. J. M. Verstraete
JOURNAL OF COMPARATIVE PATHOLOGY
(2016)
Article
Pathology
J. N. Winer, B. Arzi, D. M. Leale, P. H. Kass, F. J. M. Verstraete
JOURNAL OF COMPARATIVE PATHOLOGY
(2016)
Article
Pathology
A. Aghashani, A. S. Kim, P. H. Kass, F. J. M. Verstraete
JOURNAL OF COMPARATIVE PATHOLOGY
(2016)
Article
Pathology
J. N. Winer, B. Arzi, S. Doring, P. H. Kass, F. J. M. Verstraete
JOURNAL OF COMPARATIVE PATHOLOGY
(2017)
Article
Pathology
E. J. Clark, S. R. Chesnutt, J. N. Winer, P. H. Kass, F. J. M. Verstraete
JOURNAL OF COMPARATIVE PATHOLOGY
(2017)
Article
Pathology
J. N. Winer, B. Arzi, D. M. Leale, P. H. Kass, F. J. M. Verstraete
JOURNAL OF COMPARATIVE PATHOLOGY
(2017)
Article
Pathology
A. Aghashani, A. S. Kim, P. H. Kass, F. J. M. Verstraete
JOURNAL OF COMPARATIVE PATHOLOGY
(2017)
Article
Pathology
S. Doring, B. Arzi, J. N. Winer, P. H. Kass, F. J. M. Verstraete
JOURNAL OF COMPARATIVE PATHOLOGY
(2018)
Article
Pathology
J. V. Evenhuis, I. Zisman, P. H. Kass, F. J. M. Verstraete
JOURNAL OF COMPARATIVE PATHOLOGY
(2018)
Article
Pathology
Ching Ching Shirley Kot, Boaz Arzi, Janny V. Evenhuis, Philip H. Kass, Frank J. M. Verstraete
Summary: Through examining the skulls of Steller sea lions, it was found that adults had more dental issues and temporomandibular joint problems than young adults, which could play a significant role in their health and survival.
JOURNAL OF COMPARATIVE PATHOLOGY
(2022)
Article
Pathology
Anneka L. M. Christie, Michelle X. Y. Lee, Janny Evenhuis, Siobhan S. Rickert, Philip H. Kass, Frank J. M. Verstraete
Summary: A macroscopic examination was conducted on 318 skull specimens of island foxes, revealing various dental issues and bone changes, including missing teeth, supernumerary teeth, periodontitis, and bone fenestrations. The study evaluated the impacts of factors such as gender, age, and dental status on the skulls.
JOURNAL OF COMPARATIVE PATHOLOGY
(2023)
Article
Pathology
Janny Evenhuis, Ching Ching Shirley Kot, Boaz Arzi, Philip H. Kass, Frank J. M. Verstraete
Summary: Macroscopic examination of 224 Arctic fox skull specimens revealed common pathological changes such as periodontitis, dental fractures, and attrition/abrasion, while temporomandibular joint pathology was rare.
JOURNAL OF COMPARATIVE PATHOLOGY
(2023)
Letter
Anesthesiology
Elise C. Hyman, Sorin J. Brull
Article
Dentistry, Oral Surgery & Medicine
Engku Nasiha Engku Ngah Sayuddin, Muhammad Taher, Mohd Hafiz Arzmi, Nor Aszlitah Burhanudin, Muhamad Ashraf Rostam
Summary: This article reviews the role of podoplanin in oral cancer and its potential as a therapeutic agent. High expression of podoplanin has been observed in oral cancer and pre-cancerous lesions, suggesting that inhibitors targeting podoplanin could be effective in treating oral cancer.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Doris Haydee Rosero Salazar, Sydney Honnlee, Zi-Jun Liu
Summary: This study analyzed the dynamics and coordination of oropharyngeal muscles during natural chewing and swallowing, revealing the key role of palatal and pharyngeal muscles in chewing and the simultaneous changes in muscle activity and respiratory cycle during these processes.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Junkang Quan, Yang Liu, Lingli Ji, Yuming Zhao, Shuguo Zheng
Summary: This study identified a new DLX3 gene mutation in a Chinese family with enamel dysplasia and found that this mutation may affect ameloblast differentiation by inhibiting the transcriptional activity of Amelx/Odam/Klk4, thereby interfering with enamel formation.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Viviane Martins dos Santos Ribeiro, Mauricio Gonsalves da Costa Sousa, Paula Ribeiro Garcia, Lucas Souza dos Santos, Eliza Carla Barroso Duarte, Jose Raimundo Correa, Carlos Alberto Labate, Thais Regiani Cataldi, Rosiane Andrade da Costa, Marcelo Henrique Soller Ramada, Juliana Lott de Carvalho, Taia Maria Berto Rezende
Summary: This study compared the structural and proteomic architecture of decellularized human dental pulp using two different protocols. The results showed that the ECM preserved in the MG protocol was more intact. Proteomic analysis revealed that the MG protocol maintained around 69.56% of the proteins identified in the untreated pulp tissue, while the SG protocol only maintained 28.26%.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Summary: The study investigated the effects of varying glucose concentrations on the proliferation and senescence of SHED and hBMSC. It was found that high glucose levels promoted proliferation in both cell types, but delayed senescence in SHED through autophagy inhibition and accelerated senescence in hBMSC. Additionally, the glycolysis in SHED was enhanced under high glucose culture conditions compared to hBMSC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Luciana O. Almeida, Luan Cesar Silva, Carolina Emerick, Juliana Amorim dos Santos, Rogerio M. Castilho, Cristiane H. Squarize
Summary: This study found that the loss of PTEN signaling increases the population of HNSCC CSCs, which can be targeted by rapamycin. However, a deficiency in mTORC2 can lead to problematic selection of the parasphere CSC subtype.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Elham Mohebbi, Zainab Alimoradi, Laura S. Rozek, Azadeh Mohebbi, Elahe Jafari
Summary: This study conducted a systematic review and meta-analysis to investigate the risk of head and neck cancer among opium users. The findings showed a significant correlation between opium use and the development of head and neck cancers, particularly lip and oral cavity cancers and laryngeal cancer. This highlights the importance of further research and targeted preventive measures to address this concerning association.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Antonio Alexandre Coelho, Rute Romao Carvalho, Ana Luiza Muniz, Andre Alves Crispim, Anderson Maia Meneses, Carla Welch da Silva, Dayrine Silveira de Paula, Ana Paula Negreiros Nunes Alves, Fabricio Bitu Sousa, Paulo Goberlanio de Barros Silva
Summary: The study aimed to evaluate the role of CD20 + cells in the healing process of oral traumatic ulcers (OTU) in rats. The results showed that blocking CD20 + cells with anti-CD20 rituximab (RTX) reduced cell migration, acute inflammation, and wound healing in OTU.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Summary: This study explored the characteristics of human papillomavirus (HPV) in oropharyngeal carcinoma (OPC) and found that high-risk HPV infection is common in OPC patients, with higher prevalence in North America, Oceania, and Europe. Females and older patients are more susceptible to infection. Tonsil and base of tongue are the most frequent sites of infection. This study provides important theoretical basis for the prevention and treatment of OPC.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Xiaoyue Guan, Chen Shi, Yuting Wang, Yani He, Yingxue Li, Yao Yang, Wenli Mu, Wenlan Li, Tiezhou Hou
Summary: The study revealed that Gremlin1 expression levels are significantly increased in periapical lesions and may be positively correlated with IL-18 levels. Blocking Gremlin1 can significantly suppress bone resorption loss and restrain inflammatory status by affecting the activation levels of phosphorylated-CREB, ICAM-1, VCAM-1, IL-18.
ARCHIVES OF ORAL BIOLOGY
(2024)
Article
Dentistry, Oral Surgery & Medicine
Giliano Nicolini Verzeletti, Eduardo Jose Gaio, Keilla Gomes Machado, Tobias Rauber Spuldaro, Clarissa Favero Demeda, Rafaele Frassini, Andre Felipe Streck, Sidnei Moura E. Silva, Cassiano Kuchenbecker Rosing, Joao Antonio Pegas Henriques, Mariana Roesch-Ely
Summary: This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
ARCHIVES OF ORAL BIOLOGY
(2024)