Article
Biochemistry & Molecular Biology
Yuriko Tanaka, Mayu Onozato, Tetuo Mikami, Terumi Kohwi-Shigematsu, Takeshi Fukushima, Motonari Kondo
Summary: The study found that early signs of Sjogren's Syndrome were observed in SATB1cKO mice, with IFN-dependent IDO expression induction being a crucial early event in the disease. Serum L-KYN could potentially be used as a marker for early SS diagnosis before autoantibodies become detectable.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xiaodong Jiao, Zhiwei Ma, Jingqi Lei, Pinghu Liu, Xiaoyu Cai, Pawan K. Shahi, Chi-Chao Chan, Robert Fariss, Bikash R. Pattnaik, Lijin Dong, J. Fielding Hejtmancik
Summary: By constructing knockout and conditional knockout mice for KCNJ13, this study provides insights into the pathology of Snowflake Vitreoretinal Degeneration (SVD) and Retinitis pigmentosa (RP), and offers a potential model system for gene therapy trials.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Huijun Liu, Danni Wang, Yang Ma, Huiting Sun, Linxiao Wang, Yichao Shi, Jiaping Wang, Xia Chen
Summary: This study investigated the relationship between abnormal lipid metabolism caused by ApoE-deficient and male reproduction, and assessed the effect of hyperbaric oxygen (HBO) therapy on ApoE-knockout male mice. The results showed that ApoE knockout decreased male reproductive capacity and HBO treatment improved semen quality by accelerating serum lipoprotein metabolism and ameliorating the testicular microenvironment.
REPRODUCTIVE SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Emanuela B. Pucko, Robert P. Ostrowski
Summary: CK2 inhibitors, such as benzimidazole and isothiourea derivatives, have shown promising efficacy in targeting glioma tumour cells. Combined with hyperbaric oxygenation, they increase the susceptibility of these cells to apoptosis. Further research is needed to optimize the treatment regimen and investigate the effectiveness of these inhibitors in combination with other antiglioma agents.
Article
Biochemistry & Molecular Biology
Bao Ngoc Tran, Lucie Valek, Annett Wilken-Schmitz, Dominik Christian Fuhrmann, Dimitry Namgaladze, Ilka Wittig, Irmgard Tegeder
Summary: The study showed that Nucleoredoxin plays a crucial role in neuronal function, impacting neuronal plasticity and synaptic protein activity. Mice deficient in synaptic protein Nestin-NXN-/- displayed normal behavior in tests, but showed reduced interest in rewards.
Article
Ophthalmology
Alaa Abu-Diab, Prakadeeswari Gopalakrishnan, Chen Matsevich, Marije de Jong, Alexey Obolensky, Ayat Khalaileh, Manar Salameh, Ayala Ejzenberg, Menachem Gross, Eyal Banin, Dror Sharon, Samer Khateb
Summary: This study generated a Cep250 knockout mouse model, which exhibited both retinal degeneration and hearing loss with a relatively late age of onset. This model may provide insights into the association between CEP250 and retinal and hearing deficits, and could serve as an efficient platform for developing treatment modalities for Usher syndrome.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jianhe Liang, Xu Sun, Lei Yi, Jinyuan Lv
Summary: Hyperbaric oxygen therapy (HBO) can promote weight loss and reduce hyperlipidemia in rats, with a more noticeable effect at 6 h/d therapy. However, prolonged therapy may cause liver damage. HBO therapy has cardio and kidney protection effects in hyperlipidemia rats.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jain Jeong, Soyoung Jang, Song Park, Wookbong Kwon, Si-Yong Kim, Soyoen Jang, Jiwon Ko, Si Jun Park, Su-geun Lim, Duhak Yoon, Junkoo Yi, Sanggyu Lee, Myoung Ok Kim, Seong-Kyoon Choi, Zae Young Ryoo
Summary: The study highlighted the important role of JAZF1 in adipocyte differentiation and related metabolism through experiments in vitro and in vivo. Heterozygous JAZF1 knockout mice exhibited abnormalities in adipose tissue mass and glucose metabolism, providing new insights for treating obesity and metabolic disorders.
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lucie Valek, Bao Ngoc Tran, Irmgard Tegeder
Summary: The study found that nucleoredoxin (NXN) plays an important role in regulating thermal sensation and nociception. The loss of NXN in neurons leads to increased sensitivity to cold temperature and heightened heat nociception in mice. These abnormal responses are associated with changes in calcium influx, mitochondrial dysfunction, and increased density of neurite trees in sensory neurons.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Anatomy & Morphology
E. Aloni, S. Verbitsky, L. Kushnireva, E. Korkotian, M. Segal
Summary: Research indicates that Synaptopodin (SP) plays a key role in the spine apparatus of central excitatory neurons and the axon initial segment. Lack of SP in SPKO mice results in cognitive deficiencies, increased excitability in hippocampal cells, and higher expression of arc staining.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Biochemistry & Molecular Biology
Ken Ichiro Tanaka, Sachie Shiota, Okina Sakakibara, Mikako Shimoda, Ayaka Takafuji, Misaki Takabatake, Yoshito Kadota, Takashige Kawakami, Shinya Suzuki, Masahiro Kawahara
Summary: Metallothionein plays an important role in the development of chronic obstructive pulmonary disease (COPD) by suppressing elastase-induced lung injury through the inhibition of reactive oxygen species production.
Article
Clinical Neurology
Piotr H. Skarzynski, Aleksandra Kolodziejak, Elzbieta Gos, Magdalena B. Skarzynska, Natalia Czajka, Henryk Skarzynski
Summary: A retrospective clinical study was conducted to investigate the impact of hyperbaric oxygen therapy (HBOT) on the treatment outcomes of patients with sudden sensorineural hearing loss (SSNHL). The study found that adding HBOT to glucocorticoid treatment did not significantly improve hearing recovery compared to glucocorticoid treatment alone.
FRONTIERS IN NEUROLOGY
(2023)
Article
Cell Biology
A. Tate Lasher, Liou Y. Sun
Summary: Our previous research has shown that mice lacking functional GHRH exhibit unique physiological characteristics and an extended lifespan. In this study, we investigated the response to glucagon in these mice and found that they exhibit reduced glucose production and increased energy expenditure. Alterations in pancreatic islet architecture and hepatic glucagon signaling were also observed. These findings suggest that changes in glucagon signaling may contribute to the metabolic phenotype observed in these long-lived mice.
Article
Endocrinology & Metabolism
Benjamin A. Kugler, Jared Lourie, Nicolas Berger, Nana Lin, Paul Nguyen, Edzana Dossantos, Abir Ali, Amira Sesay, H. Grace Rosen, Baby Kalemba, Gregory M. Hendricks, Joseph A. Houmard, Hiromi Sesaki, Philimon Gona, Tongjian You, Zhen Yan, Kai Zou
Summary: This study demonstrates that partial loss of skeletal muscle-specific Drp1 expression is sufficient to improve whole-body glucose homeostasis and insulin sensitivity under obese, insulin-resistant conditions. This improvement may be due to reduced mitochondrial H2O2 production. Furthermore, the findings revealed divergent effects of Drp1 on whole-body metabolism under lean healthy or obese insulin-resistant conditions in mice.
MOLECULAR METABOLISM
(2023)
Article
Pharmacology & Pharmacy
Ilaria Morella, Veronika Pohorala, Claudia Calpe-Lopez, Riccardo Brambilla, Rainer Spanagel, Rick E. Bernardi
Summary: This study examined the role of the Ras-ERK signaling pathway in nicotine-related reward behaviors and found that RasGRF2 regulates the activity of this pathway after nicotine exposure. Additionally, RasGRF2 KO mice demonstrated increased self-administration of nicotine compared to WT mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Morgan D. Strong, Matthew D. Hart, Tony Z. Tang, Babajide A. Ojo, Lei Wu, Mariah R. Nacke, Workneh T. Agidew, Hong J. Hwang, Peter R. Hoyt, Ahmed Bettaieb, Stephen L. Clarke, Brenda J. Smith, Barbara J. Stoecker, Edralin A. Lucas, Dingbo Lin, Winyoo Chowanadisai
Article
Biochemistry & Molecular Biology
Lei Wu, Peiran Lu, Xin Guo, Kun Song, Yi Lyu, James Bothwell, Jinglong Wu, Olivia Hawkins, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith, Winyoo Chowanadisai, Steve D. Hartson, Jerry W. Ritchey, Weiqun Wang, Denis M. Medeiros, Shitao Li, Dingbo Lin
Summary: BCO2 plays a crucial role in mitochondrial respiration and metabolic homeostasis in mammals. Its deficiency or decreased expression leads to mitochondrial oxidative stress, low-grade inflammation, and the subsequent development of metabolic disorders.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Babajide A. Ojo, Peiran Lu, Sanmi E. Alake, Bryant Keirns, Kendall Anderson, Grace Gallucci, Matthew D. Hart, Guadalupe Davila El-Rassi, Jerry W. Ritchey, Winyoo Chowanadisai, Dingbo Lin, Stephen Clarke, Brenda J. Smith, Edralin A. Lucas
Summary: Supplementing with pinto beans (PB) has positive effects on the gut microbiota, SCFAs, distal ileal antigen presentation markers, and antimicrobial peptide genes in mice. It can improve microbial composition, increase antimicrobial peptide expression, and address glucose tolerance and fasting blood glucose levels.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Lei Wu, Xin Guo, Siau Yen Wong, Peiran Lu, Steven D. Hartson, Denis M. Medeiros, Weiqun Wang, Stephen L. Clarke, Edralin A. Lucas, Brenda J. Smith, Winyoo Chowanadisai, Dingbo Lin
Summary: This study demonstrates that deficiency of BCO2 induces alterations in hypothalamic mitochondrial proteome, inflammation, and affects mitochondrial dynamics and DNA sensing signaling. These changes may lead to mitochondrial fragmentation, oxidative stress, and activation of the STING-IRF3 signaling pathway in the mouse hypothalamus.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Plant Sciences
Xuan Li, Yuan Deng, Lianchang Kang, Lianghua Chen, Zhizhong Zheng, Wen Huang, Chuanjun Xu, Guoyin Kai, Dingbo Lin, Qingxuan Tong, Yi Lin, Yanlin Ming
Summary: This study is the first report on the isolation and evaluation of anti-tumor components in Voacanga africana seeds, with the alkaloid compound tabersonine showing potential as an anti-tumor agent.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Genetics & Heredity
Evan R. Hermann, Emily Chambers, Danielle N. Davis, McKale R. Montgomery, Dingbo Lin, Winyoo Chowanadisai
Summary: The study identifies various brain MRI phenotypes associated with the SLC39A8 gene, with the missense ZIP8 polymorphism rs13107325 strongly linked to 22 brain MRI phenotypes. Rare ZIP8 variants are also associated with certain brain MRI phenotypes, in addition to new probable causative SNPs identified in the study. This provides insights into how genetic variation in SLC39A8 may influence brain structure and function.
FRONTIERS IN GENETICS
(2021)
Article
Nutrition & Dietetics
Parniyan Goodarzi, Mohammad Habibi, Kennedy Roberts, Julia Sutton, Cedrick Ndhumba Shili, Dingbo Lin, Adel Pezeshki
Summary: The study found that tryptophan supplementation can reduce hepatic lipogenesis and gluconeogenesis, but increase glycolysis in LBW piglets. Peripheral serotonin is likely involved in the regulation of feeding behavior, particularly in LBW piglets fed with diets supplemented with a higher dose of tryptophan.
Article
Genetics & Heredity
Danielle N. Davis, Morgan D. Strong, Emily Chambers, Matthew D. Hart, Ahmed Bettaieb, Stephen L. Clarke, Brenda J. Smith, Barbara J. Stoecker, Edralin A. Lucas, Dingbo Lin, Winyoo Chowanadisai
Summary: The ZIP12 gene plays a crucial role in the nervous system and is associated with various diseases such as neural tube defects, psychiatric illnesses, and pulmonary hypertension. Drug compounds targeting ZIP12 function may be potential treatments for these conditions.
Article
Nutrition & Dietetics
Richard C. Baybutt, Joseph T. Standard, Daniel Dim, Tim Quinn, Hana Hamdan, Dingbo Lin, Kyle Kunz, Zachary S. Bomstein, Benjamin J. Estorge, Betty Herndon, Hamid Zia, Ahmad Mansour, Manesha Lankachandra, Agostino Molteni
Summary: The study aimed to evaluate the impact of replenishing vitamin A on bone thickness in vitamin A-deficient rats, with results showing that cod liver oil (COD) supplementation more effectively restored abnormal bone thickness in the rats compared to retinoic acid (RA) treatment.
Article
Biochemistry & Molecular Biology
Thais Oliveira, Evan Hermann, Daniel Lin, Winyoo Chowanadisai, Elizabeth Hull, McKale Montgomery
Summary: Epithelial-to-mesenchymal transition (EMT) is a crucial process in development and wound healing, but it can also contribute to the progression and spread of aggressive tumors in cancer, as well as increase resistance to therapy. This study used the SW13 cell line to investigate the connection between iron metabolism and EMT, finding that HDAC inhibitor treatment led to increased iron accumulation, reduced expression of iron export proteins, and enhanced sensitivity to a form of iron-mediated cell death called ferroptosis. These findings suggest potential implications for improving iron-targeted chemotherapeutic strategies in cancer treatment.
Article
Nutrition & Dietetics
Amritpal Kaur, Babajide A. Ojo, Siau Yen Wong, Sanmi E. Alake, Madison Pastor, Guadalupe Davila-El Rassi, Dingbo Lin, Brenda J. Smith, Edralin A. Lucas
Summary: This study investigated the effects of TC supplementation on the gut microbiota, markers of gut health, and metabolic parameters in mice fed a western diet. The results showed that TC supplementation improved markers of glucose homeostasis but had modest effects on gut microbial population and SCFAs production.
NUTRITION RESEARCH
(2022)
Article
Nutrition & Dietetics
Rui Wang, Julianna Maria Santos, Jannette M. Dufour, Emily R. Stephens, Jonathan M. Miranda, Rachel L. Washburn, Taylor Hibler, Gurvinder Kaur, Dingbo Lin, Chwan-Li Shen
Summary: The study revealed that ginger root extract improved glucose homeostasis in diabetic rats, partly by enhancing intestinal integrity and mitochondrial function for gastrointestinal health.
Article
Nutrition & Dietetics
Babajide A. Ojo, Sanmi E. Alake, Amritpal Kaur, Siau Yen Wong, Bryant Keirns, Jerry W. Ritchey, Winyoo Chowanadisai, Dingbo Lin, Stephen Clarke, Brenda J. Smith, Edralin A. Lucas
Summary: Wheat germ can improve gut and adipose tissue inflammation in obese mice by activating the STAT3 pathway and inhibiting nuclear Nf-kappa B activation. In mice fed a high-fat and sucrose diet, wheat germ increases the production of gut antimicrobial peptides and reduces immune cell infiltration in adipose tissue, thereby improving obesity-related leaky gut and chronic inflammation.
CURRENT DEVELOPMENTS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Dingbo Lin, Denis M. Medeiros
Summary: The composition and function of the human gut microbiome have been recognized as important factors in host health and disease. Dietary factors can influence the gut microbiota and subsequently affect the host immune response and disease risks. Imbalance of the gut microbiome has been linked to various chronic diseases. Future research directions include precision microbiome studies.
NUTRITION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mohammad Habibi, Parniyan Goodarzi, Cedrick Ndhumba Shili, Julia Sutton, Caitlyn Marie Wileman, Dohyung Markus Kim, Dingbo Lin, Adel Pezeshki
Summary: This study found that a combination of valine and isoleucine can improve the growth performance of pigs under severe protein restriction by improving gut development, hepatic IGF-1 expression and bioavailability, and plasma metabolomics profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)