Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice

Regulation of muscle and mitochondrial health by the mitochondrial fission protein Drp1 in aged mice

(2021) Maude Dulac et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mitochondrial dysfunction in skeletal muscle contributes to the development of acute insulin resistance in mice

(2021) Hyunjung Lee et al.   Journal of Cachexia Sarcopenia and Muscle

Drp1 overexpression induces desmin disassembling and drives kinesin-1 activation promoting mitochondrial trafficking in skeletal muscle

(2020) Matteo Giovarelli et al.   CELL DEATH AND DIFFERENTIATION

Guidelines and Considerations for Metabolic Tolerance Tests in Mice

(2020) Raquel Benedé-Ubieto et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Muscle-organ crosstalk: the emerging roles of myokines

(2020) Mai Charlotte Krogh Severinsen et al.   ENDOCRINE REVIEWS

Distinct Adaptations of Mitochondrial Dynamics to Electrical Pulse Stimulation in Lean and Severely Obese Primary Myotubes

(2020) Benjamin A. Kugler et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Uremic metabolites impair skeletal muscle mitochondrial energetics through disruption of the electron transport system and matrix dehydrogenase activity

(2019) Trace Thome et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Altered Mitochondrial Network Morphology and Regulatory Proteins in Mitochondrial Quality Control in Myotubes from Severely Obese Humans With or Without Type 2 Diabetes

(2019) Anders E. Gundersen et al.   Applied Physiology Nutrition and Metabolism

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

(2019) Giulia Favaro et al.   Nature Communications

Roux-en-Y gastric bypass surgery restores insulin-mediated glucose partitioning and mitochondrial dynamics in primary myotubes from severely obese humans

(2019) Benjamin A. Kugler et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity leads to impairments in the morphology and organization of human skeletal muscle lipid droplets and mitochondrial networks, which are resolved with gastric bypass surgery-induced improvements in insulin sensitivity

(2018) M. D. Kristensen et al.   Acta Physiologica

MyoVision: software for automated high-content analysis of skeletal muscle immunohistochemistry

(2018) Yuan Wen et al.   JOURNAL OF APPLIED PHYSIOLOGY

Isolation of mitochondrial subpopulations from skeletal muscle: Optimizing recovery and preserving integrity

(2018) Nicola Lai et al.   Acta Physiologica

Maintenance of Skeletal Muscle Mitochondria in Health, Exercise, and Aging

(2018) David A. Hood et al.   Annual Review of Physiology

Mitochondrial dynamics in skeletal muscle insulin resistance and type 2 diabetes

(2018) CiarÁn E. Fealy et al.   Translational Research

Oxidative Modifications of Mitochondrial Complex II are associated with insulin resistance of visceral fat in obesity.

(2018) Doan TM Ngo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle

(2018) Timothy M. Moore et al.   Molecular Metabolism

Skeletal muscle insulin resistance: role of mitochondria and other ROS sources

(2017) Sergio Di Meo et al.   JOURNAL OF ENDOCRINOLOGY

Differential acute and chronic responses in insulin action in cultured myotubes following from nondiabetic severely obese humans following gastric bypass surgery

(2017) J. Matthew Hinkley et al.   Surgery for Obesity and Related Diseases

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

(2016) Vicent Ribas et al.   Science Translational Medicine

Calcineurin Links Mitochondrial Elongation with Energy Metabolism

(2015) Paul T. Pfluger et al.   Cell Metabolism

Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation

(2015) T Touvier et al.   Cell Death & Disease

Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle

(2014) Ciaran E. Fealy et al.   JOURNAL OF APPLIED PHYSIOLOGY

Impaired Mitochondrial Dynamics and Bioenergetics in Diabetic Skeletal Muscle

(2014) Ruohai Liu et al.   PLoS One

Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle

(2013) Melissa E. Smith et al.   BIOCHEMICAL JOURNAL

Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload

(2013) Kelsey H. Fisher-Wellman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overfeeding Reduces Insulin Sensitivity and Increases Oxidative Stress, without Altering Markers of Mitochondrial Content and Function in Humans

(2012) Dorit Samocha-Bonet et al.   PLoS One

Linking mitochondrial bioenergetics to insulin resistance via redox biology

(2012) Kelsey H. Fisher-Wellman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans

(2011) K E Boyle et al.   INTERNATIONAL JOURNAL OF OBESITY

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

High Fat Diet-Induced Changes in Mouse Muscle Mitochondrial Phospholipids Do Not Impair Mitochondrial Respiration Despite Insulin Resistance

(2011) Joris Hoeks et al.   PLoS One

Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

(2011) A. S. Rambold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity

(2010) Scott P. Naples et al.   Applied Physiology Nutrition and Metabolism

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

(2010) N. Lefort et al.   DIABETES

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

(2010) Hidenori Otera et al.   JOURNAL OF CELL BIOLOGY

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

(2009) Junko Wakabayashi et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY