Review
Biochemistry & Molecular Biology
Victoria E. de Knegt, Paula L. Hedley, Jorgen K. Kanters, Ida N. Thagaard, Lone Krebs, Michael Christiansen, Ulrik Lausten-Thomsen
Summary: Leptin plays a crucial role in regulating pregnancy-related functions and its dysregulation during pregnancy can lead to pre-eclampsia and restricted fetal growth. The regulatory mechanisms involving leptin in pre-eclampsia are specific to each situation, and the dysregulation of leptin likely affects fetal growth through complex interactions with parallel pregnancy systems throughout pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Giorgia Sebastiani, Elisabet Navarro-Tapia, Laura Almeida-Toledano, Mariona Serra-Delgado, Anna Lucia Paltrinieri, Oscar Garcia-Algar, Vicente Andreu-Fernandez
Summary: Hypoxia and oxidative stress are crucial for fetal development during pregnancy, but an imbalance in oxidative molecules can lead to complications. Antioxidants may be a promising tool for treating these complications.
Article
Acoustics
A. Basso, L. Youssef, A. Nakaki, C. Paules, J. Miranda, G. Casu, L. Salazar, E. Gratacos, E. Eixarch, F. Crispi, F. Crovetto
Summary: This study aims to explore the pattern of fetal cortical development in pregnancies complicated by pre-eclampsia (PE), with and without a small-for-gestational-age (SGA) fetus, compared to uncomplicated pregnancies. The results showed that pregnancies with PE, whether with a SGA or AGA fetus, had similar cortical development patterns that were comparable to those observed in small fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Computer Science, Information Systems
Lola Gomez-Jemes, Andreea Madalina Oprescu, Angel Chimenea-Toscano, Lutgardo Garcia-Diaz, Maria del Carmen Romero-Ternero
Summary: The use of artificial intelligence in healthcare, especially in obstetrics and gynecology, has great potential. This study proposes a machine learning model to predict risk events in pregnancy, specifically pre-eclampsia and intrauterine growth restriction, using specific measurements. The variation of the decision tree classifier was found to be the best performing model.
Article
Obstetrics & Gynecology
Vaeochan Govender, Thinagrin D. Naidoo, Serantha Foolchand
Summary: The feasibility of using ductus venosus Doppler (DVD) to time delivery in early-onset fetal growth restriction (FGR) and pre-eclampsia was assessed in this study. The results showed that abnormal DVD was associated with increased perinatal morbidity and mortality, as well as increased risk of placental abruption.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Acoustics
C. A. Cluver, L. Bergman, J. Bergkvist, H. Imberg, L. Geerts, D. R. Hall, B. W. Mol, S. Tong, S. P. Walker
Summary: This study assessed whether coexisting fetal growth restriction (FGR) influences pregnancy latency and maternal and perinatal outcomes in women with preterm pre-eclampsia. The results showed that FGR is associated with shorter pregnancy latency, more emergency Cesarean deliveries, fewer successful inductions of labor, and increased rates of neonatal morbidity and mortality.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ting Xiong, Yuanjue Wu, Li Huang, Xi Chen, Yu Zhang, Chunrong Zhong, Qin Gao, Miao Hong, Xingwen Hu, Xuefeng Yang, Nianhong Yang, Liping Hao
Summary: This study aimed to investigate the association between maternal serum albumin (MAlb) levels and fetal growth as well as the risk of fetal growth restriction (FGR). The findings revealed a reverse U-shaped relationship between MAlb and fetal growth, indicating an increased risk of FGR when MAlb levels were either too low or too high. These findings are important for understanding the relationship between maternal serum albumin and fetal health.
FERTILITY AND STERILITY
(2022)
Article
Physiology
Ke-Hua Huang, Feng-Yi Chen, Zhao-Zhen Liu, Jin-Ying Luo, Rong-Li Xu, Ling-Ling Jiang, Jian-Ying Yan
Summary: An artificial neural network model based on maternal peripheral blood parameters has a good predictive value for the occurrence of PE complicated by FGR and its adverse perinatal outcomes, such as the severity of FGR and preterm births in these patients.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Rianne C. Bijl, Jerome M. J. Cornette, Blanka Vasak, Arie Franx, A. Titia Lely, Michiel L. Bots, Bas B. van Rijn, Maria P. H. Koster
Summary: The study found that pregnancy complications related to fetal growth restriction (FGR) can lead to unfavorable cardiometabolic risk factors in mothers after delivery, independent of the presence of hypertension. Therefore, women with a history of FGR may benefit from cardiovascular risk assessment and subsequent risk reduction strategies.
JOURNAL OF WOMENS HEALTH
(2022)
Review
Neurosciences
Rachel Farrelly, Margeurite Gina Kennedy, Rebecca Spencer, Karen Forbes
Summary: In high income countries, a significant percentage of pregnancies are complicated by conditions such as pre-eclampsia, preterm birth, fetal growth restriction, and gestational diabetes. Despite the lack of effective preventive or treatment methods, recent research has shown the potential of studying maternal and placental extracellular vesicles as predictive and diagnostic biomarkers for these obstetric disorders. Further research is needed to enhance understanding and management of these pathologies.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Engineering, Environmental
Zahra Aghaei, John G. Sled, John C. Kingdom, Ahmet A. Baschat, Paul A. Helm, Karl J. Jobst, Lindsay S. Cahill
Summary: This study investigated the effects of maternal exposure to microplastics and nanoplastics on fetal and placental growth using experimental mice. The results showed that fetuses from dams exposed to plastics exhibited growth restriction in late gestation, with a 12% decrease in fetal weight at the highest exposure concentration.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Agriculture, Dairy & Animal Science
Claire Stenhouse, Yennifer Cortes-Araya, F. Xavier Donadeu, Cheryl J. Ashworth
Summary: This study aimed to investigate the temporal changes in testicular gene expression during testes development in fetuses of different size. The results showed that testes weight and testes weight as a percentage of fetal weight were not associated with fetal size at gestational days 60 and 90. Fetal size was not associated with seminiferous tubule area and number, as well as the number of germ or Sertoli cells per tubule. The expression of DMRT1 and SPP1 mRNA was lower in testes associated with the lightest fetuses compared to the closest to mean litter weight fetuses at gestational day 90. These findings provide insights into the expression profiles of genes associated with testicular development and function.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Samprikta Manna, Colm J. J. Mc Elwain, Gillian M. M. Maher, Marta Giralt Martin, Andrea Musumeci, Fergus P. P. McCarthy, Cathal McCarthy
Summary: This study investigated the cellular senescence phenotypes of pre-eclampsia and intrauterine growth restriction (IUGR) pregnancies by measuring multiple biomarkers of senescence. The results showed signs of premature senescence in IUGR pregnancies, while pre-eclampsia activated cell cycle checkpoint regulators but with a phenotype of cell repair and proliferation rather than senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Iohanna Deckmann, Julio Santos-Terra, Fatima Martel, Jaqueline Vieira Carletti
Summary: This article reviews the effects of polyphenols intake during pregnancy on three common pregnancy-associated complications: preeclampsia, gestational diabetes, and fetal growth restriction. The analysis includes studies conducted in human, animal, and in vitro models, highlighting the protective effects of polyphenols. The review provides a critical analysis of the literature and a summary of evidence for future research and evaluation using polyphenols.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Acoustics
A. C. M. Kluivers, A. Biesbroek, W. Visser, L. Saleh, H. Russcher, A. H. J. Danser, R. I. Neuman
Summary: This study aims to evaluate the levels of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and free PlGF in women with pre-eclampsia (PE) with or without a small-for-gestational-age (SGA) neonate. The findings suggest that diminished PlGF production is an important cause of low free PlGF levels, particularly in pregnancies with early-onset PE and SGA. The upregulation of sFlt-1 occurs synergistically in women with both PE and SGA.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)