Article
Virology
Camilla Rodrigues de Almeida Ribeiro, Nathalia Alves Araujo de Almeida, Katrini Guidolini Martinelli, Marcia Amendola Pires, Carlos Eduardo Brandao Mello, Jose J. Barros, Vanessa Salete de Paula
Summary: In this study, cytokine levels were examined in patients with HBV occult infection and chronic hepatitis C. The results showed that there were higher levels of cytokines in OBI/HCV patients compared to the control group and HBV monoinfected patients. IL-17A was found to be high in the HBV monoinfected group, while TNF-alpha, IL-10, IL-6, IL-4, and IL-2 were elevated in OBI/HCV patients.
Review
Virology
Carlo Saitta, Teresa Pollicino, Giovanni Raimondo
Summary: Occult hepatitis B virus infection refers to the presence of replication-competent viral DNA in the liver of individuals testing negative for HBsAg. The low replication activity is mainly controlled by the host's immune system and epigenetic factors. This infection has various clinical impacts, including transmission of hepatitis B, reactivation during immunosuppression, acceleration of chronic liver disease progression, and promotion of hepatocellular carcinoma development.
Article
Hematology
Julian Leberzammer, Stijn M. Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T. A. Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Doring, Natalie J. Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W. M. Heemskerk, Tilman M. Hackeng, Kevin H. Mayo, Christian Weber, Philipp von Hundelshausen
Summary: The study explored the molecular mechanisms of CXCL12 in arterial thrombosis, revealing that inhibition of CXCR4 can attenuate platelet aggregation and limit arterial thrombosis. Mechanistically, CXCL12 activates Btk leading to platelet aggregation, while the interaction between CXCL12 and CCL5 can inhibit this process. A novel peptide was found to inhibit CXCL12-induced platelet aggregation without prolonging bleeding time.
Review
Gastroenterology & Hepatology
Maria Stella Franze, Teresa Pollicino, Giovanni Raimondo, Giovanni Squadrito
Summary: The clinical implications of hepatitis B virus occult infection (OBI) are still uncertain, particularly in the development of liver disease and hepatocellular carcinoma (HCC). OBI may contribute to worsening liver disease and promote HCC development through specific mechanisms. However, data on OBI prevalence and clinical impact in non-hepatitis C virus (HCV)-related liver disease are limited.
LIVER INTERNATIONAL
(2022)
Article
Microbiology
Hao Wang, Fenfang Liao, Junmo Xie, Wenbo Gao, Min Wang, Jieting Huang, Ru Xu, Qiao Liao, Zhengang Shan, Yourong Zheng, Xia Rong, Chengyao Li, Yongshui Fu
Summary: The study revealed that E2G/A/V/D mutations significantly influence the detection of HBsAg, with different underlying mechanisms for OBI caused by E2 mutations in genotype B and genotype C. Additionally, E2G/A mutations may result in a N-terminal truncated S protein, contributing to HBsAg secretion impairment in OBI.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Qingqin Hao, Zheng Wang, Qinghui Wang, Bo Chen, Huizhong Qian, Xiao Liu, Hong Cao, Wei Xia, Jian Jiang, Zhonghua Lu
Summary: In patients with OBI, the plasma level of AP000253 decreased significantly, similar expression was observed in liver tissues. Functional experiments suggested that AP000253 could promote HBV transcription and replication in hepatoma cell lines.
Article
Virology
Xuelian Deng, Dan Liu, Maelenn Pailine Delcourt, Huihui Gao, Lu Zhou, Daniel Candotti
Summary: Between 2011 and 2021, a total of 869,633 blood donations were collected from prequalified donors in Dalian, China. Only 0.12% of the samples were confirmed to be positive for hepatitis B virus (HBV). Testing for hepatitis delta virus (HDV) antibodies in 2175 donations revealed that only 0.09% of the samples showed weak reactivity, but they were confirmed to be false positives upon repeat testing. Among the confirmed occult HBV infection (OBI) samples, only one non-Chinese donor showed repeated reactivity to HDV antibodies, suggesting that HDV/HBV coinfection does not play a significant role in the genesis of OBI. Overall, the data indicated a very low prevalence of HDV infection among blood donors in Liaoning province, Northeast China.
Article
Microbiology
Renxiang Xia, Jing Peng, Jian He, Ping Jiang, Chunyan Yuan, Xiaoli Liu, Yunqing Yao
Summary: This study investigated the clinical and virological characteristics of individuals in China with chronic occult hepatitis B virus infection (HBV) and their correlation with hepatocellular carcinoma (HCC). Findings revealed that there are at least 21 million individuals with occult HBV infection in China. The presence of HBcAb(+) indicated not only chronic HBV infection, but also a dangerous marker for surface antigen-negative patients. Regular check-ups every six months or one year are recommended for early detection of HCC in occult infection patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Jing Peng, Xueying Yao, Chunyan Yuan, Xiaoli Liu, Renxiang Xia, Jian He, Rui Li, Yunqing Yao
Summary: This study investigated the potential mechanism and therapeutic potential of hepatitis B vaccine immunotherapy for occult hepatitis B virus infection (OBI) patients. The results showed that hepatitis B vaccine significantly increased the levels of hepatitis B surface antibodies in patients and had a significant impact on the number of peripheral blood B lymphocytes and CD8(+) T lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ruijun Wang, Chang Liu, Taoyang Chen, Yuting Wang, Chunsun Fan, Lingling Lu, Fengmin Lu, Chunfeng Qu
Summary: Among elder children/young adults who received hepatitis B virus (HBV) vaccination during infancy, the serological status of HBsAg(-)/anti-HBc(+) was frequently reported, indicating potential occult HBV infection (OBI). Neonatal HBV vaccination provided effective protection against OBI in mature adults, with unvaccinated individuals having a higher infection rate. The prevalence of HBsAg(-)/anti-HBc(+) increased with age in unvaccinated individuals.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Infectious Diseases
An-qun Hu, Qian-ying Cai, Miao Zhang, Hai-yan Liu, Tian-lei Wang, Wen-hui Han, Qing Li, Wei Fan, Yi-jie Li, Yi-ning He, Ying-jie Zheng
Summary: This study investigated different types of hepatitis B infection among mothers and infants, evaluating the effectiveness of vaccination against hepatitis B infection. The refinement of classification based on transmission types improved the estimate of vaccine effectiveness, particularly for certain types of transmission.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Tobias Riedl, Suzanne Faure-Dupuy, Maude Rolland, Svenja Schuehle, Zohier Hizir, Silvia Calderazzo, Xiaodong Zhuang, Jochen Wettengel, Martin Alexander Lopez, Romain Barnault, Valbona Mirakaj, Sandra Prokosch, Danijela Heide, Corinna Leuchtenberger, Martin Schneider, Bernd Hessling, Benjamin Stottmeier, Isabel M. Wessbecher, Peter Schirmacher, Jane A. McKeating, Ulrike Protzer, David Durantel, Julie Lucifora, Emmanuel Dejardin, Mathias Heikenwalder
Summary: The stabilization of HIF1 alpha was found to inhibit the expression of APOBEC3B and its antiviral effects against HBV. Inhibiting the expression or stabilization of HIF1 alpha could serve as an anti-HBV strategy. High levels of HIF1 alpha may provide a reservoir for HBV survival in immune-active patients, and therefore should be considered as a constraining factor in the development of immune therapies.
Article
Virology
Lok-Ka Lam, Thomas Sau Yan Chan, Yu-Yan Hwang, Lung-Yi Mak, Wai-Kay Seto, Yok-Lam Kwong, Man-Fung Yuen
Summary: This case report describes the reactivation of hepatitis B virus in a patient undergoing ibrutinib treatment. The authors emphasize the importance of systematic screening for hepatitis B exposure prior to ibrutinib treatment and subsequent monitoring of serological and molecular markers of hepatitis B.
Article
Microbiology
Chunyan Yuan, Jing Peng, Renxiang Xia, Jian He, Tianji Qiu, Yunqing Yao
Summary: This study reports a middle-aged female patient with occult hepatitis B virus infection (OBI) who experienced HBV reactivation during intermittent entecavir antiviral therapy. Genetic analysis revealed mutations in the S gene region and a drug resistance mutation. The case highlights the importance of genotype, mutation, and drug resistance gene testing in the diagnosis and treatment of OBI.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Qingqin Hao, Qinghui Wang, Huizhong Qian, Jian Jiang, Xiao Liu, Wei Xia
Summary: This study found that miR-451a and miR-340-3p were significantly up-regulated in plasma of OBI, ASC, and CHB patients compared to healthy controls. ROC curve analysis showed that both miR-451a and miR-340-3p could moderately distinguish OBI from HCs. Functional experiments demonstrated that overexpression of miR-451a might suppress HBV replication and gene expression by directly targeting ATF2.
MICROBIAL PATHOGENESIS
(2021)
Article
Clinical Neurology
Amir Moghadam-Ahmadi, Hossein Khorramdelazad, Gholamhossein Hassanshahi, Sasan Shahsavari, Ali Moadab, Alireza Vakilian
ACTA NEUROLOGICA BELGICA
(2020)
Review
Medicine, Research & Experimental
Javad Masoumi, Abdollah Jafarzadeh, Hossein Khorramdelazad, Morteza Abbasloui, Jalal Abdolalizadeh, Najmeh Jamali
ADVANCES IN MEDICAL SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Mohammad M. Y. Khorasani, Gholamhossein Hassanshahi, Aniela Brodzikowska, Hossein Khorramdelazad
Article
Public, Environmental & Occupational Health
Gholamreza Farnoosh, Mostafa Ghanei, Hossein Khorramdelazad, Gholamhossein Alishiri, Alireza Jalali Farahani, Alireza Shahriary, Seyed Reza Hosseini Zijoud
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2020)
Review
Immunology
Shokrollah Assar, Reza Nosratabadi, Hossein Khorramdel Azad, Javad Masoumi, Mahshad Mohamadi, Gholamhossein Hassanshahi
Summary: Past research highlights that some antibiotics have immunomodulatory effects in addition to their antimicrobial properties. Fluoroquinolones (FQs) are synthetic antibiotics that decompose DNA to prevent bacterial growth and indirectly modulate immune responses by suppressing pro-inflammatory cytokines and affecting lymphocyte activity and cytokine expression.
IMMUNOLOGICAL INVESTIGATIONS
(2021)
Article
Biochemistry & Molecular Biology
Majid Mollahosseini, Hadis Ahmadirad, Reza Goujani, Hossein Khorramdelazad
Summary: The study demonstrated that patients with a femoral fracture and TBI have significantly elevated serum levels of certain growth factors and cytokines, leading to accelerated healing compared to other groups.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Correction
Cell Biology
Maryam Masoumi, Hamidreza Bashiri, Hossein Khorramdelazad, Khadijeh Barzaman, Nader Hashemi, Hale Abdoli Sereshki, Amirhossein Sahebkar, Jafar Karami
Article
Allergy
Mitra Abassifard, Hossein Khorramdelazad, Shayan Rezaee, Abdollah Jafarzadeh
Summary: The study found significantly higher serum IL-38 levels in OA patients compared to healthy controls, with the levels possibly influenced by WOMAC, VAS, and BMI indices. It suggests that IL-38 may serve as a valuable marker for OA and its expression in serum may be elevated in patients with more severe disease to modulate inflammatory responses.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Review
Medicine, Research & Experimental
Fatemeh Moadab, Hossein Khorramdelazad, Mitra Abbasifard
Summary: The CCL2/CCR2 axis plays a crucial role in the pathogenesis of rheumatoid arthritis, triggering various immunological events such as inflammation and being involved in multiple processes of RA development. Targeting the CCL2/CCR2 axis offers potential opportunities for immunotherapy in RA treatment.
Article
Immunology
Hossein Khorramdelazad, Mohammad Hossein Kazemi, Alireza Najafi, Maryam Keykhaee, Reza Zolfaghari Emameh, Reza Falak
Summary: The article discusses the similarities and differences between SARS-CoV-2 and influenza virus, as well as the possibility of co-infection, and proposes important understandings and approaches in facing both viruses.
MICROBIAL PATHOGENESIS
(2021)
Review
Oncology
Maryam Katoueezadeh, Niloofar Pilehvari, Ahmad Fatemi, Gholamhossein Hassanshahi, Seyedeh Atekeh Torabizadeh
Summary: In response to the alarming increase in acute lymphoblastic leukemia cases, researchers are investigating new therapeutic strategies targeting DNA damage response pathways to overcome resistance to chemotherapy and radiotherapy. This review aims to evaluate the synergistic effects of DNA damage response pathway inhibitors with radiation in the treatment of leukemia.
Review
Immunology
Khadijeh Barzaman, Shima Moradi-Kalbolandi, Aysooda Hosseinzadeh, Mohammad Hossein Kazemi, Hossein Khorramdelazad, Elahe Safari, Leila Farahmand
Summary: The study emphasizes the crucial role of the immune system in breast cancer treatment, and discusses the importance of using various immunotherapy methods in conjunction with traditional chemotherapy to improve patient survival rates, while pointing out the obstacles that still need to be addressed.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Allergy
Fereshteh Taghipour, Omolbanin Oladpour, Mohammad Taghi Rezayati, Hossein Khorramdelazad, Maryam Nemati, Zahra Taghipour, Javad Masoumi, Zuhair Mohammad Hassan, Abdollah Jafarzadeh
Summary: The study showed that metformin alone or in combination with cimetidine/ibuprofen in breast cancer treatment can increase Th1 cell frequency and interferon-gamma concentration, decrease regulatory T cell frequency and expression of related proteins, as well as improve survival rate and reduce tumor size and spleen index.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Akram Norouzi, Marzieh Motaghi, Gholamhossein Hassanshahi, Mahdieh Nazari-Robati
Summary: This study found that there was no significant difference in serum 25(OH) vitamin D levels between patients with acute lymphoblastic leukemia (ALL) and healthy subjects, but a significant reduction in the expression of VDR and H19 was observed in ALL patients.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)
Review
Cell Biology
Maryam Masoumi, Hamidreza Bashiri, Hossein Khorramdelazad, Khadijeh Barzaman, Nader Hashemi, Hale Abdoli Sereshki, Amirhossein Sahebkar, Jafar Karami
Summary: Fibroblast-like synoviocytes (FLSs) are crucial in joint diseases such as rheumatoid arthritis, playing a role in joint destruction and inflammation through interactions with immune and non-immune cells. While the pathological role of RA FLS cells has been reported extensively, the molecular and cellular mechanisms are still not fully understood.
Article
Medicine, Research & Experimental
Bincy Varghese, Sreeranjini Babu, Aishwarya Jala, Panchanan Das, Rajesh Raju, Roshan M. Borkar, Ramu Adela
Summary: Through integrating next-generation sequencing and metabolomics multi-omics analysis of placenta, this study identified differentially expressed miRNAs, their target genes, altered metabolites, and metabolic pathways in gestational hypertension (GH) patients. The findings obtained from this study may contribute to further understanding of the molecular pathways associated with GH and the evaluation of prognostic markers.
ARCHIVES OF MEDICAL RESEARCH
(2024)
