Article
Geriatrics & Gerontology
Manuela Tondelli, Francesca Benuzzi, Daniela Ballotta, Maria Angela Molinari, Annalisa Chiari, Giovanna Zamboni
Summary: Recent studies on anosognosia in dementia have suggested the presence of implicit self-awareness that regulates responses, even in patients without explicit awareness. A preserved response of the posterior cingulate cortex to dementia-related stimuli may indicate preserved implicit self-awareness.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Behavioral Sciences
Eric Salmon, Francois Meyer, Sarah Genon, Fabienne Collette, Christine Bastin
Summary: Self-unawareness of symptoms in Alzheimer's disease is a challenging clinical issue, which can be explained by complex biopsychosocial mechanisms and impaired cognitive processes. This review focuses on the impaired cognitive processes observed in unaware AD participants during task-based fMRI, highlighting the related impaired brain activity. The unawareness can be attributed to dysfunction or disconnection between brain regions involved in accessing, retrieving, updating, monitoring, evaluating, or controlling self-information. The review provides a framework for clinicians to understand the processes underlying unawareness in dementia.
Article
Psychology, Clinical
Sergio Della Sala, Gianna Cocchini, Nicoletta Beschin, Elizabeth A. Fowler, Patrick Kaschel, Robert D. McIntosh
Summary: This study aimed to investigate the awareness of stroke patients regarding their own problems with daily activities. A new test, the Visual-Analogue Test for Anosognosia for Activities of Daily Living (VATA-ADL), was used to overcome methodological problems of traditional interviews and questionnaires. The results showed that many stroke patients had poor appreciation of their functional disabilities, with some overestimating their abilities and others underestimating their abilities.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Victor Calil, Andrea Silveira de Souza, Felipe Kenji Sudo, Gustavo Santiago-Bravo, Naima Assuncao, Claudia Drummond, Fernanda Rodrigues, Rejane Soares, Natalia Oliveira, Alina Teldeschi, Gabriel Bernardes, Gabriel Lima, Camila Lima, Marco Antonio Lima, Paulo Mattos
Summary: This study compared anosognosia for memory between individuals with DLB and dementia due to AD, finding that individuals with DLB had worse awareness of memory deficits. While there were no significant differences in age, education, sex, or disease duration between DLB and AD groups, DLB patients had a higher index of anosognosia compared to AD patients.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Jose Manuel Valera-Bermejo, Matteo De Marco, Annalena Venneri
Summary: Decline in self-awareness is a common symptom in Alzheimer's disease, and it is closely associated with the early breakdown of the brain's default mode network. The contribution of other large-scale networks to self-awareness abilities is still poorly understood. The study found that memory anosognosia in early-stage AD patients is associated with decreased fronto-temporal connectivity and increased parieto-temporal connectivity. Non-memory anosognosia is associated with increased connectivity between the anterior default mode network and the cerebellum, as well as increased connectivity between specific seeds in the left medial prefrontal cortex and the contralateral prefrontal cortex. Total anosognosia is associated with alterations in large-scale networks, including reduced expression of the left central executive fronto-parietal network in the left posterior cingulate and increased expression in the right anterior cingulate. Seed-based analyses showed significant connectivity differences in the left hippocampal seed, indicating lower intercommunication with the right prefrontal cortex and higher connectivity with the left caudate nucleus. These findings suggest that alterations in functional connectivity of frontal lobe regions involved in executive-related mechanisms are associated with domain-specific anosognosia in early AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Varvara Valotassiou, Nikolaos Sifakis, Chara Tzavara, Evi Lykou, Niki Tsinia, Vasiliki Kamtsadeli, Dimitra Sali, George Angelidis, Dimitrios Psimadas, Eudoxia Theodorou, Ioannis Tsougos, Sokratis G. Papageorgiou, Panagiotis Georgoulias, John Papatriantafyllou
Summary: The study evaluated the perfusion correlates of anosognosia in various types of dementia using automated analysis, finding that cognitive anosognosia was associated with hypoperfusion in multiple areas of the right hemisphere, while no association was found with behavioral-mood anosognosia.
Article
Neurosciences
Jaehyun Kim, Tae Hyon Ha, Kiwon Kim, Eun-Mi Lee, Hyekyeong Kim, Doh Kwan Kim, Hong-Hee Won, Matthew Lewis, Hyewon Lee, Woojae Myung
Summary: The study found that the use of atypical antipsychotic drugs in elderly individuals with depressive disorders is associated with a significantly higher risk of subsequent dementia. Risperidone showed the highest risk for dementia among atypical antipsychotics. Healthcare professionals should be aware of this potential long-term risk when prescribing these medications.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Geriatrics & Gerontology
N. J. O'Shaughnessy, J. E. Chan, R. Bhome, P. Gallagher, H. Zhang, L. Clare, E. L. Sampson, P. Stone, J. Huntley
Summary: Our study found that lower level sensory awareness is relatively maintained in severe AD, while findings for higher level awareness are variable. Environmental and contextual factors have a significant impact on the presence of awareness in individuals with severe AD.
AGING & MENTAL HEALTH
(2021)
Article
Clinical Neurology
Tao Wu, Chenglong Li, Yidan Zhu, Yanjun Ma, Rong Hua, Baoliang Zhong, Wuxiang Xie
Summary: This study found that depressive symptoms in mid-to late-life are associated with incident dementia, coronary heart disease (CHD), stroke, and all-cause mortality. Even mild depressive symptoms increase the risk of these diseases. However, managed depressive symptoms are not significantly associated with these risks.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Geriatrics & Gerontology
Erika Olofsson, Yngve Gustafson, Sebastian Mukka, Eva Tengman, Lenita Lindgren, Birgitta Olofsson
Summary: Hip fracture is a significant cause of mortality among older people, and almost half of the patients with hip fracture have dementia, which further increases the mortality risk. Both dementia and depressive disorders are independent risk factors for poor outcome after hip fracture, but most studies evaluate them separately.
Article
Biology
Beata Pietrzak, Jolanta Kujawa, Anna Lipert
Summary: This study analyzed the frequency of depressive disorders in older people and their influence on cognitive and physical function. The results showed a correlation between depressive disorders and instrumental activities of daily living, indicating that the early symptoms of depression may serve as an indication for further dementia diagnosis.
Article
Multidisciplinary Sciences
Timo Marcel Buchwitz, Marina Christine Ruppert-Junck, Andrea Greuel, Franziska Maier, Franziska Thieken, Viktoria Jakobs, Carsten Eggers
Summary: This study aimed to explore the impaired self-awareness of motor symptoms in Parkinson's Disease and its connection with dispositional mindfulness and functional connectivity. The results showed that a high percentage of patients exhibited impaired self-awareness. Awareness for hypokinetic movements was related to mindfulness and three facets, while awareness for dyskinetic movements was not. Functional connectivity analyses identified several brain regions associated with impaired self-awareness scores. These findings suggest that impaired self-awareness of motor symptoms in Parkinson's Disease is not related to dispositional mindfulness.
Article
Psychiatry
Manuela Tondelli, Chiara Galli, Giulia Vinceti, Luigi Fiondella, Simone Salemme, Chiara Carbone, Maria Angela Molinari, Annalisa Chiari, Giovanna Zamboni
Summary: Anosognosia levels were not significantly different between early-onset dementia (EOD) and late-onset dementia (LOD) patients, but increased with disease progression, especially in frontotemporal dementia cases. Early anosognosia was associated with higher frequency and severity of subsequent neuropsychiatric symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Andrew J. Larner
Summary: Functional cognitive disorders (FCD) have garnered increasing clinical interest in recent years due to their high prevalence among patients attending memory clinics. While empirical understanding of FCD is growing based on observational studies, theoretical understanding has been lacking. One novel suggestion posits FCD as metacognitive disorders, specifically disorders of metamemory. This metacognitive formulation of FCD may offer guidance for future hypothesis-driven research and management strategies despite its current lack of mechanistic sophistication.
Article
Rehabilitation
Amina Ben Salah, Pierre-Francois Pradat, Marie Villain, Alexander Balcerac, Pascale Pradat-Diehl, Francois Salachas, Lucette Lacomblez, Eleonore Bayen
Summary: ALS patients may experience anosognosia, particularly in terms of cognitive-behavioral disorders and apathy symptoms. Caregivers often report more severe symptoms of patients compared to what the patients themselves recognize.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Medicine, Legal
Florence Hellen, Christian Lange-Asschenfeldt, Stefanie Ritz-Timme, Sandra Verhuelsdonk, Benno Hartung
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2015)
Meeting Abstract
Psychiatry
S. Verhuelsdonk, B. Hoeft, T. Supprian, C. Lange-Asschenfeldt
EUROPEAN PSYCHIATRY
(2016)
Article
Geriatrics & Gerontology
Sandra Verhuelsdonk, T. Supprian, B. Hoeft
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE
(2017)
Article
Clinical Neurology
S. Verhuelsdonk, F. Hellen, B. Hoeft, T. Supprian, C. Lange-Asschenfeldt
ACTA NEUROLOGICA SCANDINAVICA
(2015)
Article
Neurosciences
Julia Christl, Sandra Verhuelsdonk, Francesca Pessanha, Til Menge, Ruediger J. Seitz, Milenko Kujovic, Barbara Hoeft, Tillmann Supprian, Christian Lange-Asschenfeldt
JOURNAL OF ALZHEIMERS DISEASE
(2019)
Article
Medicine, Legal
Florence Hellen, Sandra Verhulsdonk, Birgit Janssen, Stefanie Ritz-Timme, Benno Hartung
Summary: Filicides pose questions about motives and prevention methods. A study of child killings by parents in Dusseldorf's catchment area reveals diverse perpetrator-victim dynamics and motives. Overburdening emerges as a common risk factor, except in cases of homicide-suicide. Establishing preventive measures is challenging, with a focus on awareness campaigns and multi-professional support.
AUSTRALIAN JOURNAL OF FORENSIC SCIENCES
(2023)
Article
Nursing
Julia Christl, Clara Sonneborn, Sandra Verhuelsdonk, Tillmann Supprian
Summary: This follow-up study used phone contacts to conduct a one-year follow-up on hospitalized patients aged 65 and older who had attempted suicide, and found that phone contacts were feasible in this vulnerable population. While the affective state remained relatively stable, activities and social isolation could not be modified.
ISSUES IN MENTAL HEALTH NURSING
(2022)
Article
Criminology & Penology
S. Verhuelsdonk, A. K. Folkerts, S. Hufnagel, C. Bohn, B. Hoeft, T. Supprian, E. Kalbe
Summary: A pilot project was conducted in forensic hospitals in North Rhine Westphalia, Germany, collecting sociodemographics, crime-related characteristics, and medical data of inpatients aged 60 years and older. Preliminary data from the project indicate that cognitive impairment in older forensic patients in Germany is more frequent than reported for the older general population in Germany. Based on these findings, the extent to which diagnostic routines should be implemented and the complex factors that need to be taken into account are discussed.
JOURNAL OF FORENSIC PSYCHIATRY & PSYCHOLOGY
(2023)
Article
Law
S. Verhuelsdonk, A. K. Folkerts, K. Dietrich, B. Hoeft, T. Supprian, M. Jaenner, E. Kalbe
Summary: The number of elderly delinquent individuals living in prisons and forensic hospitals is increasing. Both groups have complex needs related to age-related changes and frequent somatic disorders as well as mental disorders, especially depressive symptoms. Cognitive impairments are a major challenge in both settings and the detection of these deficits is crucial for therapy and release planning.
INTERNATIONAL JOURNAL OF LAW AND PSYCHIATRY
(2023)
Article
Criminology & Penology
Verhuelsdonk Sandra, Bohn Claire, Neyer Nora, Supprian Tillmann, Christl Julia, Kalbe Elke, Folkerts Ann-Kristin
Summary: This study aimed to analyze the feasibility of implementing cognitive training in the prison setting for older prisoners. The results showed that the study protocol was feasible and the implementation of cognitive training was successful. Prisoners demonstrated high motivation and satisfaction with cognitive training, and were willing to recommend it to others.
Article
Public, Environmental & Occupational Health
Sandra Verhuelsdonk, Ann-Kristin Folkerts, Barbara Hoeft, Tillmann Supprian, Josef Kessler, Elke Kalbe
Summary: This study aimed to investigate cognitive and affective state in elderly prisoners in Germany, finding that a significant portion of them show cognitive impairment and depressive symptoms. The study revealed significant associations between cognitive scores and factors such as age, education, sentence duration, and duration of current incarceration. There is an urgent need for proper management of cognitively impaired older prisoners, including routine cognitive testing and guidelines-oriented treatment.
INTERNATIONAL JOURNAL OF PRISONER HEALTH
(2021)
Article
Clinical Neurology
Sandra Verhuelsdonk, Christian Lange-Asschenfeldt, Barbara Hoeft, Holger Schwender, Tillmann Supprian, Florence Hellen, Elke Kalbe
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
(2017)
Article
Psychology, Developmental
Sandra Verhuelsdonk, Sabine Engel
GEROPSYCH-THE JOURNAL OF GERONTOPSYCHOLOGY AND GERIATRIC PSYCHIATRY
(2012)
Article
Geriatrics & Gerontology
Wen Hao, Yi-fan Shan, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Satoe Okabayashi, Kenji Wakai, Masahiko Ando, Akiko Tamakoshi
Summary: The study found that dual decline in gait speed and cognition is associated with a higher risk of late-life dementia, particularly in older Japanese men. These findings highlight the importance of early screening for dual decline.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Lijun Zhao, Kexin Hu, Weiting Liu, Haonan Qi, Guodong Li, Jun Chen, Limin Han
Summary: This study found that Anemonin (ANE) can delay cellular senescence through the PARP1-NAD+-SIRT1 signaling pathway, suggesting it as a potential effective anti-aging strategy.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Mohammad Soleimani Farsani, Mohammad Fathi, Zahra Hemati Farsani, Zinab Gourgin Karaji
Summary: Swimming training has a significant effect on the expression of Neural cell adhesion molecule (NCAM), Semaphorin 3A (SEMA3A), and Profilin-1 (PFN1) proteins in the gastrocnemius muscle of Alzheimer-like phenotype rats.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Hailin Zhang, Kai Kang, Shuaijie Chen, Qiong Su, Weijie Zhang, Lishan Zeng, Xiaoyan Lin, Feng Peng, Jinxiu Lin, Dajun Chai
Summary: This study found that longitudinal changes in cardiac function in patients with AMI were independently associated with high baseline serum LDH levels. Baseline LDH levels may be an important parameter for predicting future cardiac dysfunction after AMI, especially in the elderly.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Alberto Pilotto, Marina Barbagelata, Wanda Morganti, Emanuele Seminerio, Guido Iaccarino, Armando Genazzani, Carlo Trompetto, Gennarina Arabia, Maddalena Illario, Erica Volta, Carlo Custodero, Alberto Cella
Summary: The prevention and treatment of frailty condition among multimorbid older adults is becoming a healthcare priority. A multidimensional approach using information and communication technology (ICT) offers a way to implement and monitor personalized interventions. The MULTIPLAT_AGE project aims to provide multidimensional interventions for older adults using a shared online platform, including transitional care, automatic home-care, appropriate drug prescription, tele-rehabilitation, and remote cognitive stimulation.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Weida Lyu, Tomoki Tanaka, Bo-Kyung Son, Yasuyo Yoshizawa, Masahiro Akishita, Katsuya Iijima
Summary: The study found that the Eleven-Check questionnaire could be used to screen frailty and sarcopenia status in community-dwelling older adults. The high-risk group had a higher risk of frailty and sarcopenia.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Editorial Material
Geriatrics & Gerontology
Liang-Kung Chen
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Robbert J. J. Gobbens, Sandra Kuiper, Henriette Dijkshoornf, Marcel A. L. M. van Assen
Summary: This study examined the associations between chronic diseases and multidimensional frailty comprising physical, psychological, and social frailty. The results showed that chronic diseases, especially urinary incontinence and severe back disorder, were associated with frailty. The study recommends assigning different weights to individual chronic diseases in measuring multimorbidity and its effects on multidimensional frailty.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Kimi Estela Kobayashi-Cuya, Ryota Sakurai, Naoko Sakuma, Hiroyuki Suzuki, Susumu Ogawa, Toru Takebayashi, Yoshinori Fujiwara
Summary: The study found a positive bidirectional association between hand dexterity and maximum gait speed with executive function performance, while handgrip strength and usual gait speed showed no associations. This suggests that hand dexterity and motor speed have an important impact on cognitive function and are mutually dependent on each other.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Sunghwan Ji, Ji Yeon Baek, Eunju Lee, Il-Young Jang, Hee-Won Jung
Summary: By validating the KWGS guideline in older Korean adults, this study found that different phenotypes of sarcopenia were associated with increased frailty and higher risks of institutionalization and mortality. Functional sarcopenia demonstrated comparable prognosis with sarcopenia (not severe) and was linked to greater frailty.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Review
Geriatrics & Gerontology
Masatoshi Nakamura, Kosuke Takeuchi, Taizan Fukaya, Gakuto Nakao, Andreas Konrad, Takamasa Mizuno
Summary: Static stretching can decrease the passive stiffness of the muscle-tendon unit (MTU) and/or muscles in older adults. The effects of static stretching on stiffness are comparable between older and young adults.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Ji Liu, Qiaoyi Chen
Summary: This study examines the relationship between depressive symptoms, sleep duration, and cognitive performance among older adults. The results suggest that early depressive symptoms are associated with increased depressive symptoms, shortened sleep duration, and worsened cognition. Sleep duration and depression progression mediate the relationship between early depressive symptoms and cognitive performance.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Yong-Hao Pua, Berend Terluin, Laura Tay, Ross Allan Clark, Julian Thumboo, Ee-Ling Tay, Shi-Min Mah, Yee-Sien Ng
Summary: This study introduces and demonstrates the utility of an item response theory (IRT) method in estimating frailty index (FI) interpretation thresholds in community-dwelling adults, providing a new tool and reference for defining frailty.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Mengxiao Hu, Haiyang Yu, Yike Zhang, Bowen Xiang, Qing Wang
Summary: This study found bidirectional associations among the accumulation of chronic conditions, disability, and depressive symptoms, especially between disability and depression. Women were more sensitive to the accumulation of chronic conditions through disability.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Juan Carlos Pineiro-Fernandez, Ramon Rabunal-Rey, Ana Maseda, Eva Romay-Lema, Roi Suarez-Gil, Sonia Pertega-Diaz
Summary: This study describes the distribution and temporal trends of the centenarian population and their hospital admissions in Spain over the past two decades. It found a significant increase in the centenarian population and hospital admissions, with regional and sex-based differences. Women represented a larger proportion of centenarians and hospital admissions. Understanding these trends and differences is crucial for implementing interventions that ensure adequate healthcare for centenarians.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
