Article
Psychology, Clinical
John S. McIntyre, Joel Yager, Anita Everett, Cathryn A. Galanter, Jeffrey M. Lyness, James Nininger, Victor Reus, Michael Vergare
Summary: The development of DSM-5 involved the establishment of two review committees, including the CPHC which focused on reviewing proposals related to clinical and public health aspects. External review processes were deemed essential for future DSM efforts, highlighting the importance of separate committees to assess scientific merit and clinical/public health impact.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Neurosciences
Alexandra Polcher, Steffen Wolfsgruber, Oliver Peters, Lutz Froelich, Jens Wiltfang, Johannes Kornhuber, Michael Huell, Eckart Ruether, Piotr Lewczuk, Wolfgang Maier, Frank Jessen, Michael Wagner
Summary: This study aimed to identify the best operational criteria for mild cognitive impairment (MCI) in predicting conversion to dementia or Alzheimer's disease (AD). Four definitions of MCI were retrospectively applied to memory clinic patients, and the base rate corrected MCI definition had the highest prognostic accuracy. These operational criteria can help identify individuals at high risk of clinical progression and assist in calibrating test results and defining risk-enriched groups for clinical trials.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Substance Abuse
Nicole D. Fitzgerald, Catherine W. Striley, Joseph J. Palamar, Jan Copeland, Steven Kurtz, Linda B. Cottler
Summary: This study found that DSM-5 adopted criteria for ketamine use disorder are reliable, with 70.7% of participants meeting the criteria. The most commonly endorsed individual criterion was continued use of ketamine despite knowledge of physical or psychological problems, followed by reported withdrawal symptoms and physically hazardous use.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Clinical Neurology
Jun-Sang Sunwoo, Daeyoung Kim, Min Kyung Chu, Chang-Ho Yun, Kwang Ik Yang
Summary: Fatigue is significantly associated with depression independent of excessive daytime sleepiness (EDS). Further research is needed to better understand the pathophysiological relationship between fatigue, depression, and sleep. The study also found that fatigue is related to EDS, depression, perceived insufficient sleep, free-day catch-up sleep, less alcohol intake, and physical inactivity. Subgroup analysis showed additional associations with short workday sleep duration in individuals without EDS, and with depression and less alcohol intake in those with EDS.
SLEEP AND BREATHING
(2022)
Article
Clinical Neurology
Sijie Cai, Zhiqiang Li, Jing Wang, Qiaojun Wang, Rui Chen
Summary: The aim of this study was to investigate the impact of excessive daytime sleepiness (EDS) on cognitive function among young and middle-aged Chinese patients with obstructive sleep apnea (OSA). The results showed that patients with moderate to severe OSA had cognitive dysfunction, specifically impaired delayed recall. Excessive daytime sleepiness was significantly associated with cognitive dysfunction in this population.
SLEEP AND BREATHING
(2023)
Article
Psychiatry
Salma Mawfek Khaled, Catalina Petcu, Maryam Ali Al-Thani, Aisha Mohammed H. A. Al-Hamadi, Suhad Daher-Nashif, Monica Zolezzi, Peter Woodruff
Summary: The study in the general population of Qatar estimated the prevalence of insomnia and found that factors associated with insomnia included Arab ethnicity, young age, unemployment, marital status, low education, poor health, anxiety, and depression. The prevalence of insomnia was lower than previously reported in developed Western countries, highlighting the importance of raising awareness and improving sleep hygiene among at-risk groups.
Article
Psychiatry
Yinan Jiang, Jing Wei, Kurt Fritzsche, Anne Christin Toussaint, Tao Li, Jinya Cao, Lan Zhang, Yaoyin Zhang, Hua Chen, Heng Wu, Xiquan Ma, Wentian Li, Jie Ren, Wei Lu, Rainer Leonhart
Summary: The study showed that SCID-5-RV for SSD can effectively differentiate between patients with SSD and those without, as well as between severe and non-severe cases. It has good discriminative validity and aligns with the DSM-5 diagnostic approach emphasizing excessive emotional, thinking, and behavioral responses related to symptoms.
Article
Clinical Neurology
Poul Jennum, JeanPierre Coaquira Castro, Sam Mettam, Tatiana Kharkevitch, M. Janelle Cambron-Mellott
Summary: This study evaluated the impact of excessive daytime sleepiness on the burden of illness among adult patients with obstructive sleep apnoea. Results showed that OSA patients with EDS had higher rates of comorbidities and worse health outcomes compared to those without EDS, with the severity of EDS being associated with poorer quality of life, work productivity, and healthcare utilization.
Article
Clinical Neurology
Reyila Abudoureyimu, Mulalibieke Heizhati, Lin Wang, Mei Li, Delian Zhang, Zhongrong Wang, Zhikang Yang, Jing Hong, Nanfang Li
Summary: This study found a potential association between low potassium intake and excessive daytime sleepiness in the general population. In the study sample, 24-hour urinary potassium levels were negatively correlated with the severity of daytime sleepiness.
SLEEP AND BREATHING
(2022)
Article
Oncology
Christopher J. Recklitis, Alexis Michaud, Jaime Elizabeth Blackmon, Susan Orsillo, Grace Chang
Summary: The DSM-5 criteria for PTSD have narrowed down the conditions under which life-threatening illnesses qualify as a traumatic event. This study investigates the impact of this change on the identification of PTSD in young adult cancer survivors and finds a reduction in the prevalence of qualifying traumatic events using DSM-5 criteria compared to DSM-IV.
Review
History & Philosophy Of Science
M. Cristina Amoretti, Elisabetta Lalumera, Davide Serpico
Summary: The latest edition of the DSM-5 introduced Social (Pragmatic) Communication Disorder (SPCD) as a new mental disorder characterized by deficits in pragmatic abilities. Researchers have identified major issues with the introduction of SPCD, particularly regarding its close resemblance to Autism Spectrum Disorder (ASD), leading to potential different diagnoses and treatments for individuals with similar symptoms. The debate surrounding SPCD's independence from ASD highlights the need to further explore its validity, reliability, and potential role in contemporary psychiatry.
HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES
(2021)
Article
Clinical Neurology
Keith Tolley, Joanne Noble-Longster, Sam Mettam, Rachel Hibbs, Matthew Cawson, Luke Stainer, Tom Snell, Ari Manuel
Summary: This study quantified the impact of excessive daytime sleepiness (EDS) on the health-related quality of life for both patients and their partners. The study utilized time trade-off methodology to measure utility values for different obstructive sleep apnea-associated EDS severities. The results showed that EDS had a significant negative impact on the health states of both patients and partners.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Substance Abuse
A. Lundin, M. Waern, J. Love, S. Lovestad, G. Hensing, A-K Danielsson
Summary: The study found that the proposed ICD-11 algorithm for dependence yielded a higher prevalence compared to ICD-10 and DSM-III-R /-IV, but had lower agreement with previous diagnostic systems, lower longitudinal stability, and weaker associations with clinical correlates.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Meteorology & Atmospheric Sciences
Heather Dawn Reeves, Daniel D. Tripp, Michael E. Baldwin, Andrew A. Rosenow
Summary: In this study, three precipitation-type algorithms were compared and it was found that it is not possible to objectively determine superiority and claim advantage. The performance of algorithms depends on the choice of performance metrics and precipitation types. The uncertainty of microphysical processes also affects algorithm performance. Therefore, a multi-algorithm approach is advocated to account for uncertainty.
WEATHER AND FORECASTING
(2023)
Review
Clinical Neurology
Lars Vedel Kessing, Ana Gonzalez-Pinto, Andrea Fagiolini, Andreas Bechdolf, Andreas Reif, Aysegul Yildiz, Bruno Etain, Chantal Henry, Emanuel Severus, Eva Z. Reininghaus, Gunnar Morken, Guy M. Goodwin, Jan Scott, John R. Geddes, Marcella Rietschel, Mikael Landen, Mirko Manchia, Michael Bauer, Monica Martinez-Cengotitabengoa, Ole A. Andreassen, Philipp Ritter, Ralph Kupka, Rasmus W. Licht, Rene Ernst Nielsen, Thomas G. Schulze, Tomas Hajek, Trine Vik Lagerberg, Veerle Bergink, Eduard Vieta
Summary: This narrative review discusses the impact of DSM-5 and ICD-11 classification systems on the prevalence and validity of bipolar disorder diagnosis. It suggests a significant decrease in the point prevalence of bipolar disorder with DSM-5 compared to DSM-IV, but a smaller decrease in lifetime prevalence. Future research is needed to explore the implications of these diagnostic systems on bipolar disorder.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Maurice M. Ohayon, Maggie McCue, Andrew Krystal, Katherine J. Selzler, Lambros Chrones, Debra Lawrence, Marie-Lise Cote
Summary: This study aimed to understand the evolution of depression and treatment satisfaction over a 3-year period in primary care settings. Results showed a high prevalence of depression and low rates of remission. Dissatisfaction with treatment, frequent switching of antidepressants, and changing care providers were identified as challenges that need to be addressed in future research.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Ilona Merikanto, Yves Dauvilliers, Frances Chung, Yun Kwok Wing, Luigi De Gennaro, Brigitte Holzinger, Bjorn Bjorvatn, Charles M. Morin, Thomas Penzel, Christian Benedict, Adrijana Koscec Bjelajac, Ngan Yin Chan, Colin A. Espie, Harald Hrubos-Strom, Yuichi Inoue, Maria Korman, Anne-Marie Landtblom, Damien Leger, Kentaro Matsui, Sergio Mota-Rolim, Michael R. Nadorff, Giuseppe Plazzi, Catia Reis, Juliana Yordanova, Markku Partinen
Summary: An international survey study reveals that post-acute sequelae of COVID-19 symptoms are more prevalent among severe cases and long-lasting sleep problems are at the core of these symptoms. Understanding the importance of sleep-related symptoms has clinical relevance in diagnosing and treating long-COVID.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Regis Lopez, Lucie Barateau, Sofiene Chenini, Anna Laura Rassu, Yves Dauvilliers
Summary: This study evaluated the feasibility, acceptability, and usefulness of home nocturnal infrared video recording in assessing the frequency and complexity of non-rapid eye movement sleep parasomnias in adults, as well as monitoring treatment response.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Regis Lopez, Lucie Barateau, Anna Laura Rassu, Elisa Evangelista, Sofiene Chenini, Sabine Scholz, Isabelle Jaussent, Yves Dauvilliers
Summary: The study aims to evaluate alternative measures of the multiple sleep latency test (MSLT) for identifying hypocretin-deficiency in patients with hypersomnolence, including narcolepsy patients. The results show that compared to the current neurophysiological standard criteria, alternative MSLT measures are more effective in identifying hypocretin-deficient patients with hypersomnolence and narcolepsy. Daytime REM sleep duration is highlighted as a relevant neurophysiological biomarker of hypocretin-deficiency, which can be used in clinical and research settings.
Article
Clinical Neurology
Dieter Kunz, Yves Dauvilliers, Heike Benes, Diego Garcia-Borreguero, Giuseppe Plazzi, Dalma Seboek Kinter, Preciosa Coloma, Magdalene Rausch, Mouna Sassi-Sayadi, Stephen Thein
Summary: In this 40-week extension study, Daridorexant was found to be safe and well-tolerated for long-term treatment of insomnia disorder. It improved sleep and daytime functioning, with the most pronounced effects observed with the 50 mg dose.
Article
Clinical Neurology
Marie-Laure Ancelin, Isabelle Jaussent, Karen Ritchie, Alain Besset, Joanne Ryan, Yves Dauvilliers
Summary: This study examines the association between BDNF variants and promoter I methylation with sleep disturbances in older adults. The results show that wake time after sleep onset (WASO) is associated with four SNPs in participants not taking psychotropic drugs, while the associations are either not significant or in the reverse direction in participants taking drugs. Higher BDNF methylation levels are found in participants with long WASO, and this varies depending on psychotropic drug use.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Sofiene Chenini, Lucie Barateau, Lily Guiraud, Marie-Lou Rollin, Regis Lopez, Isabelle Jaussent, Severine Beziat, Yves Dauvilliers
Summary: One-third of patients with restless legs syndrome reported a decrease in symptoms during cognitive activities, and this improvement was confirmed during a sustained cognitive task.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Yves Dauvilliers, Thomas Roth, Richard Bogan, Michael J. Thorpy, Anne Marie Morse, Asim Roy, Jordan Dubow, Jennifer Gudeman
Summary: This study evaluated the efficacy of extended-release once-nightly sodium oxybate (ON-SXB; FT218) compared to placebo for daytime sleepiness and disrupted nighttime sleep in narcolepsy type 1 (NT1) and 2 (NT2). The results showed significant improvements in sleep latency, sleep quality, nocturnal arousals, and daytime sleepiness for both NT1 and NT2 subgroups treated with ON-SXB compared to placebo.
Article
Clinical Neurology
Luisa da Costa Lopes, Dalva Lucia Rollemberg Poyares, Sergio Tufik, Sophia La Banca de Oliveira, Julia Ribeiro da Silva Vallim, Vanessa Kiyomi Ota, Maria Isabel Melaragno, Maurice Ohayon, Claudia Berlim de Mello
Summary: This study aimed to evaluate the effect of the BDNF Val66Met polymorphism on the performance of adolescents in attentional tests, circadian preferences, and activity-rest rhythm. The results showed that the time that the students attended school had an impact on all types of attention, regardless of chronotype. The presence of the BDNF Val66Met polymorphism was only associated with alternate attention performance.
Article
Clinical Neurology
Tobias Di Marco, Thomas E. Scammell, Michael Meinel, Dalma Seboek Kinter, Alexandre N. Datta, Gary Zammit, Yves Dauvilliers
Summary: The study aimed to explore the effect of daridorexant, a dual orexin receptor antagonist, on nighttime wake bouts and their correlation with daytime functioning. Results showed that daridorexant reduced the number and duration of long wake bouts during the night compared with placebo, corresponding with improved daytime functioning.
Review
Immunology
Roland S. Liblau, Daniela Latorre, Birgitte R. Kornum, Yves Dauvilliers, Emmanuel J. Mignot
Summary: Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by the loss of certain hypothalamic neurons. It is suspected to have an immune-mediated basis, supported by genetic evidence and increased incidence after vaccination. The search for antigens recognized by pathogenic T cell response in NT1 is ongoing, and animal models provide insights into the roles of autoreactive T cells.
NATURE REVIEWS IMMUNOLOGY
(2023)
Meeting Abstract
Clinical Neurology
Maurice Ohayon, Marie-Lise Cote
Meeting Abstract
Clinical Neurology
Maurice Ohayon, Marie-Lise Cote
Meeting Abstract
Clinical Neurology
Michael Thorpy, Colin Shapiro, Clete Kushida, Maurice Ohayon, Jordan Dubow, Jennifer Gudeman
Meeting Abstract
Clinical Neurology
Maurice Ohayon, Amir Pakpour, Marie Lise Cote