Synthesis and Histamine H3 and H4 Receptor Activity of Conformationally Restricted Cyanoguanidines Related to UR-PI376

Paradoxical Stimulatory Effects of the "Standard" Histamine H4-Receptor Antagonist JNJ7777120: the H4 Receptor Joins the Club of 7 Transmembrane Domain Receptors Exhibiting Functional Selectivity

(2011) R. Seifert et al.   MOLECULAR PHARMACOLOGY

Chiral NG-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity

(2010) Prasanta Ghorai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Histamine H4 receptor agonists

(2010) Patrick Igel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Agonist-Biased Signaling at the Histamine H4 Receptor: JNJ7777120 Recruits  -Arrestin without Activating G Proteins

(2010) E. M. Rosethorne et al.   MOLECULAR PHARMACOLOGY

Does the Histamine H4 Receptor Have a Pro- or Anti-Inflammatory Role in Murine Bronchial Asthma?

(2010) Detlef Neumann et al.   PHARMACOLOGY

Murine and human Langerhans cells express a functional histamine H4 receptor: modulation of cell migration and function

(2009) M. Gschwandtner et al.   ALLERGY

High Constitutive Activity and a G-Protein-Independent High-Affinity State of the Human Histamine H4-Receptor†

(2009) Erich H. Schneider et al.   BIOCHEMISTRY

The role of histamine H4 receptor in immune and inflammatory disorders

(2009) E Zampeli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Major advances in the development of histamine H4 receptor ligands

(2009) Rogier A. Smits et al.   DRUG DISCOVERY TODAY

Histamine H3and H4receptors as novel drug targets

(2009) Ekaterini Tiligada et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Histamine H4 receptor ligands and their potential therapeutic applications

(2009) Róbert Kiss et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The histamine H4 receptor is functionally expressed on TH2 cells

(2009) Ralf Gutzmer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation

(2009) Jeffery M. Cowden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NG-Acylated Imidazolylpropylguanidines as Potent Histamine H4Receptor Agonists: Selectivity by Variation of theNG-Substituent▽

(2009) Patrick Igel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure−Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H4Receptor Agonists§

(2009) Patrick Igel et al.   JOURNAL OF MEDICINAL CHEMISTRY

No Evidence for Functional Selectivity of Proxyfan at the Human Histamine H3 Receptor Coupled to Defined Gi/Go Protein Heterotrimers

(2009) D. Schnell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Histamine H4receptors modulate dendritic cell migration through skin - immunomodulatory role of histamine

(2008) W. Bäumer et al.   ALLERGY

Tritium-LabeledN1-[3-(1H-imidazol-4-yl)propyl]-N2-propionylguanidine ([3H]UR-PI294), a High-Affinity Histamine H3and H4Receptor Radioligand

(2008) Patrick Igel et al.   ChemMedChem

Acylguanidines as Bioisosteres of Guanidines:NG-Acylated Imidazolylpropylguanidines, a New Class of Histamine H2Receptor Agonists

(2008) Prasanta Ghorai et al.   JOURNAL OF MEDICINAL CHEMISTRY