Histamine H3and H4receptors as novel drug targets

The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment.

(2010) Vanina Medina et al.   CANCER BIOLOGY & THERAPY

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

(2009) Carla Ferrada et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox−/− mice

(2009) RX Guo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Altered histamine H3 receptor radioligand binding in post-mortem brain samples from subjects with psychiatric diseases

(2009) CY Jin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular and biochemical pharmacology of the histamine H4 receptor

(2009) Rob Leurs et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of histamine H4 receptor in immune and inflammatory disorders

(2009) E Zampeli et al.   BRITISH JOURNAL OF PHARMACOLOGY

Homology Model Adjustment and Ligand Screening with a Pseudoreceptor of the Human Histamine H4Receptor

(2009) Yusuf Tanrikulu et al.   ChemMedChem

The histamine H4 receptor antagonist JNJ7777120 induces increases in the histamine content of the rat conjunctiva

(2009) E. Zampeli et al.   INFLAMMATION RESEARCH

NG-Acylated Imidazolylpropylguanidines as Potent Histamine H4Receptor Agonists: Selectivity by Variation of theNG-Substituent▽

(2009) Patrick Igel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histamine H4receptors modulate dendritic cell migration through skin - immunomodulatory role of histamine

(2008) W. Bäumer et al.   ALLERGY

The role of histamine on cognition

(2008) Edgardo O. Alvarez   BEHAVIOURAL BRAIN RESEARCH

Histamine H3 Receptor Antagonists Go to Clinics

(2008) Kerstin Sander et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Potential utility of histamine H3 receptor antagonist pharmacophore in antipsychotics

(2008) Y. von Coburg et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine

(2008) Katalin Boer et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cloning and characterization of the monkey histamine H3 receptor isoforms

(2008) Marina I. Strakhova et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Histamine H4receptor antagonism reduces hapten-induced scratching behaviour but not inflammation

(2008) Kristine Roßbach et al.   EXPERIMENTAL DERMATOLOGY

Expression of histamine H4 receptor in human osteoarthritic synovial tissue

(2008) A. Grzybowska-Kowalczyk et al.   INFLAMMATION RESEARCH

Histamine Action on Vertebrate GABAAReceptors

(2008) Arunesh Saras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia

(2008) Huaqing Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models

(2008) Marlon D. Cowart et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Human Histamine H4 Receptor Ligands by Large-Scale Structure-Based Virtual Screening

(2008) Róbert Kiss et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autoregulation of McA-RH7777 Hepatoma Cell Proliferation by Histamine H3 Receptors

(2008) E. Davenas et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

(2008) Robin L. Thurmond et al.   NATURE REVIEWS DRUG DISCOVERY

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

(2008) Carla Ferrada et al.   NEUROPHARMACOLOGY

Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain

(2008) Stephen J. Medhurst et al.   PAIN

Preclinical investigations into the antipsychotic potential of the novel histamine H3 receptor antagonist GSK207040

(2008) Eric Southam et al.   PSYCHOPHARMACOLOGY

Antigen inhalation induces mast cells and eosinophils infiltration in the guinea pig esophageal epithelium involving histamine-mediated pathway

(2007) Shaoyong Yu et al.   LIFE SCIENCES

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients

(2007) Jian-Sheng Lin et al.   NEUROBIOLOGY OF DISEASE