Review
Food Science & Technology
Li Wang, Matthijs Dekker, Jenneke Heising, Liming Zhao, Vincenzo Fogliano
Summary: Antimicrobial agents are safe preservatives that protect food from microbial spoilage and extend shelf life. The effectiveness of these agents is influenced by factors such as chemical features, storage environments, delivery methods, and diffusion in foods. This review focuses on the impact of the food matrix, including components and (micro)structures, on the activities of antimicrobial agents. It summarizes recent studies on the effects of food structure on the growth of microorganisms and proposes mechanisms underlying the loss of antimicrobial activity in foods. Additionally, strategies and technologies to improve the protection of antimicrobial agents in specific food categories are discussed.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Tong Zhang, Wei An, Jiawei Sun, Fei Duan, Zeyu Shao, Fan Zhang, Ting Jiang, Xuliang Deng, Cyrille Boyer, Weiping Gao
Summary: Microbial resistance to antibiotics is a major challenge in global healthcare. A study found that a photoinduced cationic polymer conjugated with lysozyme can effectively overcome bacterial resistance and improve therapeutic efficacy in a rat periodontitis model. This discovery provides an efficient strategy to enhance antimicrobial activities and overcome antimicrobial resistance.
Article
Fisheries
Jing Wang, Guiying Li, Bai Liufu, Kaiqi Lin, Jinfeng Li, Shuping Zhang, Bei Wang, Zhongliang Wang
Summary: The TEP superfamily plays important roles in innate immune functions in both vertebrates and invertebrates. Pf-TEP gene from pearl oyster encodes a protein with characteristic structure features similar to its homologs, and is closely related to invertebrate TEPs. Pf-TEP is expressed in various tissues and its knockdown can reduce phagocytosis of pathogens by hemocytes, highlighting its crucial role in invertebrate immune system.
AQUACULTURE REPORTS
(2021)
Article
Endocrinology & Metabolism
Tomer Abramov, Saowaros Suwansa-ard, Patricia Mirella da Silva, Tianfang Wang, Michael Dove, Wayne O'Connor, Laura Parker, David A. Lovejoy, Scott F. Cummins, Abigail Elizur
Summary: This study characterized an invertebrate TCAP in the Sydney rock oyster and found that TCAP plays a role in cellular defense and stress response by protecting cells from apoptosis under oxidative stress and modulating the immune system. The study also demonstrated significant changes in gene expression associated with key metabolic and immune functions in stressed oysters administered with TCAP. These findings provide evidence for the importance of TCAP in oysters and contribute to our understanding of its function and mechanism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Katia Caamano, Raquel Heras-Mozos, Joaquin Calbo, Jesus Cases Diaz, Joao C. Waerenborgh, Bruno J. C. Vieira, Pilar Hernandez-Munoz, Rafael Gavara, Monica Gimenez-Marques
Summary: The development of a smart composite material with prolonged antibacterial activity is crucial for food safety. By entrapping a natural food preserving molecule into a mesoporous material and utilizing a reversible charge-transfer process, the material shows sustained activity against bacteria. The experimental results are supported by theoretical calculations.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Jinpeng Shen, Manjia Zeng, Pantian Huang, Bingbing Chen, Zhen Xia, Yong Cao, Jianyin Miao
Summary: Pearl oyster meat, a by-product of pearl production, was found to have potential anti-inflammatory activity in this study. Three novel anti-inflammatory peptides were identified and found to effectively bind to key regions in the COX-2 active site. These peptides also regulated the release of inflammatory mediators from macrophages, showing great anti-inflammatory activity. This study provides a theoretical reference for the development of functional foods or nutritional supplements with natural anti-inflammatory effects.
Article
Chemistry, Medicinal
Jung-Kil Seo, Dong-Gyun Kim, Ji-Eun Lee, Kwon-Sam Park, In-Ah Lee, Ki-Young Lee, Young-Ok Kim, Bo-Hye Nam
Summary: Five arginine-rich analogs were designed based on American oyster defensin (AOD), with A3 and A4 showing potent antimicrobial activity against various organisms without cell toxicity. These analogs possibly interact with DNA or DNA amplification reactions instead of directly acting on bacterial membranes, suggesting potential for novel antimicrobial agents.
Article
Fisheries
Yao-Wu Fu, Wei-Feng Chen, Meng-Han He, Lei Tang, Shu-Quan Guo, Qi-Zhong Zhang
Summary: The study characterized an integrin family protein, ChInt alpha 4, in Crassostrea hongkongensis and found that it plays an important role in defending against pathogenic bacterium infection and regulating phagocytosis.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Zhao Lv, Limei Qiu, Weilin Wang, Zhaoqun Liu, Qing Liu, Lingling Wang, Linsheng Song
Summary: This study identified a specific hemocyte population, RGD(+) hemocytes, which exhibit high migration activity in response to pathogen infection and potentially enhance antimicrobial peptide production by highly expressing IL-17s.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xue Qiao, Conghui Liu, Weilin Wang, Chuanyan Yang, Meijia Li, Qilin Yi, Ning Kong, Limei Qiu, Xiyang Liu, Lingling Wang, Linsheng Song
Summary: Neural cell adhesion molecules (NCAMs) are large cell-surface glycoproteins that play important roles in cell-cell and cell-extracellular matrix interactions in the nervous system. A recent study identified a homologue of NCAM (CgNCAM) in the Pacific oyster Crassostrea gigas. CgNCAM was found to be widely distributed in oyster tissues, particularly in the mantle, labial palp, and haemolymph. It showed increased expression in oyster haemocytes after stimulation with Vibrio splendidus and Staphylococcus aureus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Fisheries
Samantha J. Nowland, Wayne A. O'Connor, Abigail Elizur, Paul C. Southgate
Summary: The study discovered that a concentration of 30 g/L of MgCl2 serves as an effective muscle relaxant for black-lip rock oyster broodstock; and that reducing salinity is the key factor for inducing spawning. A combination of physical and chemical induction showed the best results, with 80% of broodstock spawning within 19 minutes.
AQUACULTURE REPORTS
(2021)
Article
Fisheries
Yu Liu, Weilin Wang, Chenghua Li, Meijia Li, Chi Zhang, Miren Dong, Lingling Wang, Linsheng Song
Summary: The Rab protein CgRab1 identified in Pacific oyster plays a crucial role in regulating phagocytosis in haemocytes by influencing the expression of Cgcathepsin L1. Knockdown of CgRab1 expression through RNA interference resulted in decreased expression of Cgcathepsin L1 protein, leading to a reduction in phagocytic rate and index in haemocytes post stimulation with Vibro splendidus in oysters.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Review
Oncology
Kumara Swamy
Summary: Anti-angiogenics, radiotherapy/chemotherapy, and immunotherapy are crucial in modern cancer therapy. The strategic initiation of cancer cell disruption can be achieved during the normalization window, where controlled cancer cell death and immunological enhancement can occur. Inducing immunogenic cell death and enhancing professional phagocytosis through chemotherapy/radiotherapy, along with reducing interstitial pressure, improves oxygen perfusion, immune-friendly pH, and opens up the tumor microenvironment for tumor-infiltrating lymphocytes. Adjuvant-assisted neoantigen-immune cell interaction promotes a virtuous cycle of cancer cell death induction and tumor cell-specific antigenic reaction, ultimately leading to vascular normalization.
FRONTIERS IN ONCOLOGY
(2022)
Article
Fisheries
Yan Wang, Zhihong Liu, Xi Chen, Liqing Zhou, Xiujun Sun, Tao Yu, Xiaomei Wang, Yanxin Zheng, Biao Wu
Summary: Glycogen, an important energy form for aquatic shellfish, contributes to the flavor and quality of oysters. In this study, the genes GYS and GSK3 beta were identified and their functions in glycogen synthesis were explored. The expression of GYS was positively correlated with glycogen content, while the expression of GSK3 beta was negatively correlated. Knockdown of GSK3 beta reduced GYS expression, indicating its negative regulatory effect.
Article
Biotechnology & Applied Microbiology
G. E. Lakatos, K. Ranglova, J. Camara Manoel, T. Grivalsky, J. Masojidek
Summary: Chlorophyll fluorescence and oxygen evolution are rapid and non-invasive monitoring techniques that can provide information about photosynthesis performance in microalgae cultures. By using these techniques in a nitrogen-limited culture of Synechocystis sp. PCC 6803, the study examined the correlation between changes in photosynthetic activities, growth, and glycogen accumulation to determine the optimal harvesting time for biomass rich in glycogen. The results showed that monitoring photosynthetic activities can effectively indicate the physiological changes leading to high glycogen accumulation in the culture.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Fisheries
Qiuran Yu, Fenglu Han, Maoxian Huang, Xiaodan Wang, Jian G. Qin, Liqiao Chen, Erchao Li
Summary: This study found that different doses of myo-inositol can significantly affect the growth performance, body composition, serum metabolite composition, hepatopancreatic metabolite content, and digestive enzyme activity in juvenile Pacific white shrimp. It suggests that myo-inositol can promote shrimp growth by improving lipid utilization.
Article
Biochemistry & Molecular Biology
Jiadai Liu, Cong Zhang, Xiaodan Wang, Xinyu Li, Qincheng Huang, Han Wang, Yixin Miao, Erchao Li, Jianguang Qin, Liqiao Chen
Summary: This study investigated the potential of high dietary methionine levels in alleviating chronic heat stress in Chinese mitten crab Eriocheir sinensis. The results showed that under high water temperatures, the crabs exhibited decreased feed conversion ratio and increased weight gain, specific growth rate, molting frequency, and protein efficiency ratio. However, survival rate decreased. The high-methionine diet was found to reduce lipid accumulation and increase protein content, while also mitigating oxidative stress and activating immune function.
Article
Fisheries
Jingyu Pan, Liqiao Chen, Yuzhou Ji, Yuxing Huang, Xianyong Bu, Jiahua Zhu, Erchao Li, Jianguang Qin, Xiaodan Wang
Summary: This study aimed to investigate the relationship between inositol metabolism and carbohydrate metabolism in Nile tilapia under acute hyperosmotic stress. Glucose solution and PBS were injected into the experimental and control group fish, respectively, followed by exposing them to brackish water for different time points. The hyperosmotic stress increased osmotic pressure, glucose content, and metabolic processes in the liver of fish. Genes related to inositol synthesis and transport were induced by hypertonicity in gill, kidney, and liver tissues. Glucose injection decreased inositol synthesis and apoptosis in the liver, but increased Na+K+-ATPase activity and osmoregulation ability in the gill.
AQUACULTURE REPORTS
(2023)
Article
Fisheries
Qincheng Huang, Xiaodan Wang, Zhideng Lin, Jiadai Liu, Han Wang, Cong Zhang, Zhenyu Du, Jianguang Qin, Liqiao Chen
Summary: The present study investigated the effect of vitamin A on growth performance, lipid metabolism, fatty acid composition, antioxidant ability and inflammatory response of crabs fed different vegetable oils. The interaction between vitamin A and lipid source did not influence the survival rate, final body weight, weight gain and specific growth rate of crabs. Crabs fed perilla oil showed optimal growth performance with the lowest body lipid content and hemolymph triglyceride, while crabs fed coconut oil showed the worst growth performance and aggravating inflammation. Dietary vitamin A improved growth performance and relieved inflammation of crabs fed different lipid sources, enhancing antioxidant activity and mitigating lipid peroxidation.
Article
Fisheries
Xianyong Bu, Qincheng Huang, Ying Song, Changle Qi, Zhideng Lin, Xiaodan Wang, Meiling Zhang, Chuanjie Qin, Jian G. Qin, Liqiao Chen
Summary: This study evaluates the effects of dietary myo-inositol (MI) on the ovarian development of female Chinese mitten crab (Eriocheir sinensis). The results showed that feeding crabs diets supplemented with 1600 and 3200 mg/kg MI significantly promoted ovarian development, increased gonadosomatic index and yolk granule deposition. MI supplementation also enhanced vitellogenin synthesis, lipid metabolism, and transport-related gene expression in the hepatopancreas and ovary. Thus, feeding a diet with 1600mg/kg MI can effectively promote ovarian development in Chinese mitten crabs.
Article
Fisheries
Ying Song, Xinyu Cai, Xianyong Bu, Shubin Liu, Mingqi Song, Yiwen Yang, Xiaodan Wang, Qingchao Shi, Jianguang Qin, Liqiao Chen
Summary: This study evaluates the effects of dietary iron and vitamin C on the growth performance, iron utilization, antioxidant capacity, and nonspecific immunity of the Chinese mitten crab. The results show that dietary supplementation of 700.90 mg/kg of vitamin C can improve iron absorption and utilization, thereby increasing the growth, immunity, and disease resistance of the crab.
AQUACULTURE NUTRITION
(2023)
Article
Fisheries
Cong Zhang, Jiadai Liu, Xiaodan Wang, Erchao Li, Mingqi Song, Yiwen Yang, Chuanjie Qin, Jianguang Qin, Liqiao Chen
Summary: Previous research has shown that hypoxia can be harmful to the neural system of Chinese mitten crabs, but this study found that GABA can provide neuroprotection against hypoxia-induced damage. Through feeding and hypoxia challenge experiments, it was discovered that GABA can protect the neural system of Chinese mitten crabs and regulate their metabolism.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Trung T. T. Nguyen, Thanh Hoang, Tuyet Pham, Vi Khanh Truong, Xuan Luo, Jian Qin, Wei Zhang
Summary: Shell wastes impose burdens on the shellfish industry, but they can be used for commercial chitin production to minimize negative impacts and maximize economic value.
Article
Materials Science, Biomaterials
Pei Cao, Nasim Amiralian, Jingjing Wang, Bing Sun, Amirali Popat, Fengwei Xie, Zhi Ping Xu, Yan Li, Li Li
Summary: Oral vaccine is an ideal non-invasive method to protect communities from infectious diseases. Researchers developed alginate/chitosan-coated cellulose nanocrystal and nanofibril nanocomposites to enhance ovalbumin delivery in the intestine. In vitro and in vivo experiments showed that the nanocomposites generated strong immune responses. However, no significant differences in specific ovalbumin immune responses were observed due to the complexity of the small intestine.
BIOMATERIALS ADVANCES
(2023)
Article
Agriculture, Dairy & Animal Science
Jiahua Zhu, Fan Zhang, Yuxing Huang, Jingyu Pan, Erchao Li, Jian G. Qin, Liqiao Chen, Xiaodan Wang
Summary: This research explores the influence of myo-inositol on the hypertonic stress adaptation of Nile tilapia by increasing lipid utilization and improving osmotic regulation ability. It was found that myo-inositol supplementation improved growth performance, promoted protein deposition, reduced fat accumulation, and alleviated liver lipid accumulation. Additionally, it reduced serum lipids and upregulated the expression of ion transporter-related genes. The findings suggest that dietary supplementation with myo-inositol can regulate lipid metabolism and improve the physiological response of Nile tilapia to hypertonic stress.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2023)
Article
Fisheries
Xiaochen Zhu, Penny Miller-Ezzy, Mark Gluis, Yingying Zhao, Jianguang Qin, Youhong Tang, Yibing Liu, Xiaoxu Li
Summary: Pacific oysters are important in aquaculture, and this study investigated how to improve larval cryopreservation techniques. The results showed that adding the lipid POPC to the base CPA significantly increased larval development after thawing. Adding tocopherol alone had no significant effect. However, combining POPC and tocopherol improved survival rates and doubled the spat production compared to the base CPA.
Article
Fisheries
Kate Seinor, Steven W. Purcell, Hamish Malcolm, Stephen D. A. Smith, Kirsten Benkendorff
Summary: This study investigated the reproductive cycle of the Australian turbinid, Turbo militaris, and found that it has an extended pattern of reproduction that is closely related to environmental conditions. The findings of this study are important for the development of fisheries management measures.
FISHERIES OCEANOGRAPHY
(2024)
Article
Marine & Freshwater Biology
Meryl F. Larkin, Tom R. Davis, David Harasti, Stephen D. A. Smith, Tracy D. Ainsworth, Kirsten Benkendorff
Summary: This study documents the sexual reproduction and asexual clonal replication of the endangered 'cauliflower' soft coral Dendronephthya australis. The species is found to be gonochoric and is capable of both sexual and asexual reproduction. Observations suggest that spawning activity coincides with the seasonal increase in water temperature and occurs for a continuous period of five months.
Article
Environmental Sciences
Tanika C. Shalders, Curtis Champion, Kirsten Benkendorff, Tom Davis, Thomas Wernberg, Stephen Morris, Melinda A. Coleman
Summary: Ocean warming and extreme events have limited effects on the nutritional quality of seaweeds, but there are significant variations in nutritional quality between different species, which may have implications for energy transfer in food webs.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Fisheries
Xiaochen Zhu, Penny Miller-Ezzy, Mark Gluis, Jianguang Qin, Youhong Tang, Yibing Liu, Yingying Zhao, Xiaoxu Li
Summary: This study investigated the effect of adding lipids and antioxidants on the survival rate of frozen mussel oocytes. The results showed that supplementing phospholipids or antioxidants in the base cryoprotectant agent significantly increased the survival rate of mussel larvae. Additionally, adding salmon lipid extract resulted in the highest survival rate and increased the number of mussel spat.
Article
Fisheries
Hunter S. Bailey, Ashley N. Fincannon, Lee A. Fuiman
Summary: This study investigated the transfer of fatty acids from broodstock diets to eggs and the time needed for the eggs to equilibrate to the diet in Southern flounder. The findings indicate that different diet treatments significantly affect the fatty acid composition of eggs, and it takes 8-16 weeks for the eggs to adapt to changes in the adult diet. These results are important for improving broodstock diets and feeding protocols in stock-enhancement programs.
Article
Fisheries
Yu Liu, Mingtao Lei, Hector Victor, Yan Wang
Summary: This study confirms the feasibility of replacing raw fish diet with a formulated diet in commercial farming of large yellow croaker, which can increase fish survival and yield, and reduce feed cost and body lipid deposition.
Article
Fisheries
Xiaoyan Zhang, Lize San, Yucong Yang, Yuehong Tao, Jiangong Ren, Yufeng Liu, Zhongwei He, Jiashuo Di, Ziteng Pei, Guixing Wang, Jilun Hou
Summary: Gynogenesis is an effective technique for establishing homogeneous lines and confirming potential chromosomal mechanisms of sex determination in fish. This study successfully induced gynogenetic families in Thamnaconus modestus and established a complete method for gynogenesis induction.
Article
Fisheries
Julieta C. Martinelli, Megan Considine, Helen R. Casendino, Carolyn M. Tarpey, Isadora Jimenez-Hidalgo, Jacqueline L. Padilla-Gamino, Teri L. King, Lorenz Hauser, Steven Rumrill, Chelsea L. Wood
Summary: Shell-boring polychaetes have caused significant damage to mariculture operations worldwide, particularly in the US Pacific region. This study provides a comprehensive dataset on the prevalence, species distribution, and environmental associations of these parasites, highlighting the impact of season, culturing methods, and environmental factors on infestation.
Article
Fisheries
Juan Gao, Xueshan Li, Kangle Lu, Kai Song, Jian Zhang, Ling Wang, Chunxiao Zhang
Summary: This study investigated the effects of dietary protein levels on growth performance, antioxidant capacity, digestive enzyme activity, and metamorphosis rate of bullfrog tadpoles. The optimal dietary protein level for bullfrog tadpoles was estimated to be 42.49%-46.50% of the diet.
Article
Fisheries
Qiang Li, Lijun Duan, Dongsheng Jin, Yuxin Chen, Yirong Lou, Qianjin Zhou, Zhongjie Xu, Fangjie Chen, Hongxian Chen, Guizong Xu, Maocang Yan, Guanjun Yang, Jianfei Lu, Yanjun Zhang, Jiong Chen
Summary: This study developed a centrifugal microfluidic chip with on-chip RPA to detect five pathogenic microorganisms. The chip enabled the parallel analysis of six genetic markers from a single sample and allowed for the highly automated detection of multiple samples. Compared with PCR and DNA sequencing, the on-chip RPA assay showed high sensitivity and specificity for detecting multiple pathogens in shrimp aquaculture.
Article
Fisheries
Xingchen Huo, Pengxu Wang, Fengxia Zhao, Qian Liu, Qingqing Tian, Lingjie Tang, Maolin Lv, Zhaohui Wei, Chunrong Yang, Jianguo Su
Summary: Bacterial diseases in aquaculture ponds have negative effects on sustainable development. The use of composite I20 biotherapy has been shown to effectively treat bacterial diseases in bullfrog ponds, providing a new strategy for controlling bacterial diseases in aquaculture.
Article
Fisheries
Peng Yin, Takaya Saito, Per Gunnar Fjelldal, Bjorn Tharandur Bjornsson, Sofie Charlotte Remo, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: This study aims to investigate the effect of seasonal changes in temperature and photoperiod on the redox metabolism of Atlantic salmon at the molecular level. The research findings suggest that the changing photoperiod and temperature influenced the redox metabolism of Atlantic salmon, highlighting the importance of oxidative status in the ecological implications.
Article
Fisheries
Nicholas Oppong Mensah, Jeffery Kofi Asare, Emmanuel Tetteh-Doku Mensah, Ernest Christlieb Amrago, Frank Osei Tutu, Anthony Donkor
Summary: This study investigates aquaculture farmers' preference for climate-smart aquaculture insurance products, the challenges they face, and their preferred insurance coverage. The results show that farmers prefer Climate-Induced Aquaculture Stock Mortality Insurance and the most significant constraint is the delay in claim settlement.
Article
Fisheries
Qiu-Ping Chai, Pei Wu, Wei-Dan Jiang, Yang Liu, Hong-Mei Ren, Xiao-Wan Jin, Lin Feng, Xiao-Qiu Zhou
Summary: The study found that appropriate levels of potassium diformate (KDF) can enhance the immune defense and mediate the inflammatory process in fish, possibly through the regulation of T cell differentiation via JAK-STAT and NF-kappa B signaling pathways.
Article
Fisheries
Tian Zhu, Haomin Jia, Haopeng Zhang, Yujing Xiao, Cui Han, Jiaxin Yang
Summary: Chicken manure has significant effects on the cultivation of Chlorella and rotifers. The optimal amount of chicken manure extract for continuous cultivation is 10 mLL-1. Chicken manure can promote the growth of Chlorella and improve the fatty acid composition, indirectly enhancing the growth condition and fatty acid content of rotifers.
Article
Fisheries
Zheng Luo, Yang Yu, Zhenning Bao, Fuhua Li
Summary: This study analyzed the heritability and genetic correlation of two growth traits in Pacific white shrimp and evaluated the genomic prediction using different genomic selection models. The results showed that the NeuralNet model had the highest prediction accuracy and better prospects for predicting shrimp growth traits.
Article
Fisheries
Alberto Ruiz, Ignasi Sanahuja, Karl B. Andree, Dolors Furones, Paul G. Holhorea, Josep A. Calduch-Giner, Jose J. Pastor, Marc Vinas, Jaume Perez-Sanchez, Sofia Morais, Enric Gisbert
Summary: Supplementing diets with a combination of spice oleoresins can reduce lipid accumulation and inflammation in farmed fish. The combination of spice oleoresins also has an immunomodulatory effect on the fish's intestinal immune system, potentially offering anti-inflammatory benefits.
Article
Fisheries
Beibei Zhao, Renhui Mei, Le Li, Di Hu, Lei Li
Summary: This study reveals that JfCXCL8_L1a and JfCXCL8_L1b have different immune pathways, and JfCXCL8_L1b plays a significant role in enhancing the adaptive immunity of T cell-dependent antigen.
Article
Fisheries
Yuhang Liu, Danying Cao, Nan Wu, Xuyang Zhao, Qingsong Zhu, Lian Su, Fatima Altaf, Qianqian Zhang, Haokun Liu, Yongming Li, Bruno Hamish Unger, Yingyin Cheng, Wanting Zhang, Aihua Li, Yaping Wang, Xiao-Qin Xia
Summary: Based on previous research, sinomenine has been found to protect mucosal immunity in farmed fish species by preventing intestinal pathological changes and regulating gene expression related to inflammation. It also enhances immune homeostasis and controls the growth of pathogenic bacteria.