Article
Biochemical Research Methods
Niels Boehnke, Markus Berger, Nils Griebenow, Antje Rottmann, Michael Erkelenz, Stefanie Hammer, Sandra Berndt, Judith Guenther, Antje M. Wengner, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Jorissen, Naomi Barak, Ulf Boemer, Roman C. Hillig, Uwe Eberspaecher, Jorg Weiske, Anja Giese, Dominik Mumberg, Carl Friedrich Nising, Hilmar Weinmann, Anette Sommer
Summary: A new class of NAMPT inhibitors as ADC payloads was developed, optimizing their structures to create highly potent effector chemistries. The optimized NAMPTi-ADCs demonstrated potent in vivo antitumor efficacy with a very good selectivity profile.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Junfei Cheng, Shipeng He, Jun Xu, Min Huang, Guoqiang Dong, Chunquan Sheng
Summary: Proteolysis-targeting chimera (PROTAC) is a promising technology in targeted protein degradation and drug discovery. This study designed the first fluorescent and theranostic PROTACs for real-time imaging of the degradation of nicotinamide phosphoribosyltransferase (NAMPT) in living cells. The results showed efficient degradation of NAMPT and significant reduction of nicotinamide adenine dinucleotide (NAD(+)), leading to potent antitumor activities in vitro and in vivo. This proof-of-concept study provides a new strategy for real-time visualization of protein degradation and improvement of diagnosis and therapeutic efficacy of PROTACs.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Yumeng Zhu, Ping Xu, Xuan Huang, Wen Shuai, Li Liu, Shuai Zhang, Rui Zhao, Xiuying Hu, Guan Wang
Summary: Nicotinamide phosphoribosyltransferase (NAMPT) plays a significant role in mammals by synthesizing nicotinamide mononucleotide (NMN) for metabolic homeostasis and cell survival, serving as a key protein in the host's defense mechanism. Neurodegenerative diseases pose a serious threat to human health, but effective drugs are limited. NAMPT has active biological functions in neurogenesis, making it a powerful therapeutic target for neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Chen Shen, Cong Chen, Tong Wang, Tong-Yao Gao, Min Zeng, Yun-Bi Lu, Wei-Ping Zhang
Summary: Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme in the salvaging synthesis pathway of nicotinamide adenine dinucleotide (NAD). Depletion of NAMPT can lead to cognitive deficiency in hippocampus neurons and increase the risk of neurodegeneration due to mitochondrial dysfunction.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yichen Wei, Haotian Xiang, Wenqiu Zhang
Summary: NAMPT is an overexpressed rate-limiting enzyme in several types of cancers, impacting the NAD and NADPH pool. NAMPT inhibitors have shown significant anti-tumor efficacy, but early clinical trials have had limited results, requiring additional strategies for improvement.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Nadia Sawicka-Gutaj, Hanna Komarowska, Dawid Gruszczynski, Aleksandra Derwich, Anna Klimont, Marek Ruchala
Summary: This study aimed to assess the clinical usefulness of visfatin/NAMPT serum level in discriminating between adrenocortical carcinomas (ACC) and benign adrenal tumors. The results showed that patients with ACC had significantly higher visfatin serum concentrations compared to patients with benign adrenocortical tumors, and visfatin levels were associated with clinical stage and metastases in ACC patients. Serum visfatin/NAMPT could potentially serve as a biomarker for distinguishing ACC, but further research is needed to confirm its accuracy and reliability.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Fisheries
Yiyang Tang, Xiaofeng Liu, Chen Feng, Zejun Zhou, Shaojun Liu
Summary: The study found that Nampt in hybrid crucian carp significantly increased the expression of antimicrobial molecules during bacterial infection, improving overall intestinal barrier function and enhancing the host's resistance against bacterial infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Oncology
Frederic A. Vallejo, Anthony Sanchez, Branko Cuglievan, Winston M. Walters, Guillermo De Angulo, Steven Vanni, Regina M. Graham
Summary: NAMPT has been identified as a potential therapeutic target for high-risk neuroblastoma. Inhibition of NAMPT leads to decreased ATP levels, induced apoptosis, reduced stem cell self-renewal, and blocked tumor growth.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yongxian Zhuang, Allison B. B. Haugrud, Meg A. A. Schaefer, Shanta M. M. Messerli, W. Keith Miskimins
Summary: Depletion of cellular NAD+ is a critical factor in the sensitivity of cancer cells to the cytotoxic effects of metformin. NAMPT plays a key role in maintaining sufficient levels of NAD+, and cancer cells that express elevated levels of NAMPT are resistant to metformin's killing effect.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maximilian Clausing, Doreen William, Matthias Preussler, Julia Biedermann, Konrad Gruetzmann, Susan Richter, Frank Buchholz, Achim Temme, Evelin Schroeck, Barbara Klink
Summary: The IDH1(R132H) mutation in glioma leads to the production of the oncometabolite 2-HG and changes in cellular redox balance. The study reveals that targeting the NAD(+) synthesis pathway is a promising therapeutic strategy in IDH mutant gliomas, but the available NAMPT inhibitors are not suitable for this purpose.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Wencui Wan, Wei Zhu, Yan Wu, Yang Long, Hongzhuo Liu, Weiwei Wan, Guangming Wan, Jing Yu
Summary: The study demonstrates that GSPE may alleviate RPE cellular senescence through the NAMPT/SIRT1/NLRP3 pathway, highlighting its potential effects on degenerative retinopathy.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoqun Lv, Jinguo Zhang, Jun Zhang, Wencai Guan, Weifang Ren, Yujuan Liu, Guoxiong Xu
Summary: NAMPT is overexpressed in colorectal cancer (CRC) and associated with short overall survival. It promotes the protein expression levels of components in the transforming growth factor-beta (TGF-beta) signaling pathway and TGF-beta 1 secretion. Treatment with TGF-beta 1 down-regulates NAMPT expression in CRC cells, partly through up-regulation of miR-1-3p that directly binds to the NAMPT 3'-UTR.
ONCOTARGETS AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Thomas B. Huffaker, H. Atakan Ekiz, Cindy Barba, Soh-Hyun Lee, Marah C. Runtsch, Morgan C. Nelson, Kaylyn M. Bauer, William W. Tang, Timothy L. Mosbruger, James E. Cox, June L. Round, Warren P. Voth, Ryan M. O'Connell
Summary: This study highlights the role of IFN gamma and STAT1-inducible Nampt in shaping the metabolic program and function of tumor-associated macrophages. IFNy can polarize macrophages in the tumour microenvironment to an inflammatory state, impacting their anti-tumour function. The activation of NRE1, a regulatory region within the NAMPT gene, by IFNy-driven STAT1 plays a key role in regulating TAM functions.
NATURE COMMUNICATIONS
(2021)
Article
Obstetrics & Gynecology
Priscila R. Nunes, Ricardo C. Cavalli, Vanessa A. Belo, Valeria C. Sandrim, Marcelo R. Luizon
Summary: This study conducted the first longitudinal study of plasma visfatin levels in healthy pregnant women, finding that visfatin levels were significantly higher in the third trimester compared to the second trimester, and significantly reduced in the postpartum period. These findings suggest the potential of visfatin as a biomarker for pregnancy complications.
REPRODUCTIVE SCIENCES
(2023)
Article
Neurosciences
Jue Wang, Runxuan Sun, Linhan Xia, Xinying Zhu, Qi Zhang, Yilu Ye
Summary: This study aimed to investigate the potential therapeutic effects of NAMPT-mediated NAD biosynthesis in depression models. It was found that the contents of NAMPT and NAD decreased in the prefrontal cortex of depressed mice. Depression-like behaviors, cognitive function deterioration, and decreased social ability were observed in the mice. The elevated NAD level by nicotinamide riboside improved depressive symptoms and increased BDNF expression in rats.
Review
Neurosciences
Elisa Le Roux, Nathan P. De Jong, Stephane Blanc, Chantal Simon, Daniel H. Bessesen, Audrey Bergouignan
Summary: Physical inactivity and sedentary behaviors are associated with increased risk for common metabolic diseases. High volumes of sedentary behaviors can be detrimental to metabolic health, even in the presence of regular exercise. While exercise training can prevent muscle mass and function loss, it may not fully counteract the negative metabolic adaptations triggered by inactivity.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Peripheral Vascular Disease
Mary O. Whipple, Kevin S. Masters, Amy G. Huebschmann, Rebecca L. Scalzo, Jane E. B. Reusch, Audrey Bergouignan, Judith G. Regensteiner
Summary: This systematic review evaluates the acute effects of interrupting prolonged sedentary behavior on vascular health among individuals at risk for type 2 diabetes. The evidence suggests that light and moderate intensity activity breaks can acutely lower blood pressure, but further research is needed to understand the impact on other vascular outcomes.
Article
Multidisciplinary Sciences
Priscilla Duboz, Enguerran Macia, Amadou H. Diallo, Emmanuel Cohen, Audrey Bergouignan, Sidy M. Seck
Summary: This interdisciplinary study aimed to understand the emic representations of the good life in rural and urban Senegal and to compare satisfaction levels between the two populations. Surprisingly, the research found that life satisfaction is higher in the rural Ferlo region compared to the capital, Dakar, possibly due to less meaningful social comparisons and a closer relationship with nature for stress restoration. However, the rural Fulani's way of life in the Ferlo region is being threatened by global climate disturbances, requiring rapid adaptations to prevent the disappearance of their identity-based pastoralism.
Article
Medicine, Research & Experimental
Terry Guirado, Lore Metz, Bruno Pereira, Audrey Bergouignan, David Thivel, Martine Duclos
Summary: The REMOVE study aims to evaluate the health effects of a 24-week cycling desk intervention among office workers, with 80 office workers randomized into two intervention groups for the study. The study will provide important information on the potential health benefits of implementing cycling workstations in office workers.
Article
Nutrition & Dietetics
Nathan P. De Jong, Michael C. Rudolph, Matthew R. Jackman, Rachel R. Sharp, Ken Jones, Julie Houck, Zhaoxing Pan, Jane E. B. Reusch, Paul S. MacLean, Daniel H. Bessesen, Audrey Bergouignan
Summary: Breaking up sedentary behavior with short-frequent bouts of physical activity has different effects on metabolic health compared to a single continuous bout of matched active time. However, the underlying mechanisms are unknown. This study compared the effects of breaks vs. a single continuous bout of physical activity on skeletal muscle mitochondrial respiration and molecular adaptations in overweight/obese inactive adults. The results showed that breaking up sedentary behavior led to molecular adaptations favoring oxidative capacity in skeletal muscle, but did not improve mitochondrial function in the short term.
Article
Geriatrics & Gerontology
Claire Laurens, Franziska Grundler, Anthony Damiot, Isabelle Chery, Anne-Laure Le Maho, Alexandre Zahariev, Yvon Le Maho, Audrey Bergouignan, Guillemette Gauquelin-Koch, Chantal Simon, Stephane Blanc, Francoise Wilhelmi de Toledo
Summary: Fasting for 10 days appears to be safe in healthy humans, with early protein loss decreasing as ketogenesis increases. Combining fasting with physical activity does not negatively impact muscle function.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Editorial Material
Nutrition & Dietetics
Jose E. Galgani, Audrey Bergouignan, Jennifer Rieusset, Cedric Moro, Julie-Anne Nazare
FRONTIERS IN NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Terry Guirado, Lore Metz, Bruno Pereira, Carole Brun, Anthony Birat, Audrey Boscaro, Audrey Bergouignan, David Thivel, Martine Duclos
Summary: This study found that providing a portable pedal machine intervention for 60 minutes per day improved cardiometabolic risk factors and reduced the negative health effects of prolonged sitting for healthy tertiary employees.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Sport Sciences
Pierre Bourdier, Alexandre Zahariev, Dale A. Schoeller, Isabelle Chery, Elisa Le Roux, Cecile Thevenot, Alain Maillet, Mael Garnotel, Guillemette Gauquelin-Koch, Audrey Bergouignan, Stephane Blanc, Chantal Simon
Summary: This study investigated the energy balance and body composition changes in astronauts during 6-month missions on the International Space Station. The results showed that ground fitness and inflight overall physical activity are associated with spaceflight-induced energy expenditure and body composition changes. New instruments are needed to measure real-time individual changes in inflight energy balance components.
Article
Multidisciplinary Sciences
Terry Guirado, Pierre Bourdier, Bruno Pereira, Elisa Le Roux, Audrey Bergouignan, Anthony Birat, Laurie Isacco, David Thivel, Martine Duclos, Lore Metz
Summary: Active-desks are strategies aimed at reducing sedentary time while working. This study compared the metabolic and physical profile of individuals categorized as high spenders (H-Spenders) versus low spenders (L-Spenders) based on energy expenditure during a cycle-desk low intensity exercise. The results showed that individuals expending more energy during the exercise had a less healthy metabolic profile compared to those expending less energy.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Mary O. Whipple, Ana J. Pinto, Layla A. Abushamat, Audrey Bergouignan, Kristina Chapman, Amy G. Huebschmann, Kevin S. Masters, Kristen J. Nadeau, Rebecca L. Scalzo, Irene E. Schauer, Deirdre Rafferty, Jane E. B. Reusch, Judith G. Regensteiner
Summary: The review and meta-analysis found that there were no sex differences in meeting PA guidelines among adolescents but males were more likely to meet PA guidelines among adults and older adults with T2DM. Females consistently engaged in less MVPA than males across the life span.
Review
Endocrinology & Metabolism
Pierre Bourdier, Chantal Simon, Daniel H. Bessesen, Stephane Blanc, Audrey Bergouignan
Summary: The role of physical activity in regulating body weight is still debated. Studies have mainly focused on the effects of moderate/vigorous physical activity, ignoring the impact of light-intensity physical activity and sedentary behaviors. Recent findings suggest that all components of physical activity, including light-intensity activity and sedentary behaviors, play an important role in weight regulation.
Meeting Abstract
Endocrinology & Metabolism
Nathan De Jong, Michael Rudolph, Matthew Jackman, Rachel Sharp, Kenneth Jones, Zhaoxing Pan, Jane Reusch, Paul MacLean, Daniel Bessesen, Audrey Bergouignan
Article
Nutrition & Dietetics
Pierre Bourdier, Priscilla Duboz, Enguerran Macia, Abdou Ka, Julie-Anne Nazare, Emmanuel Cohen, Gilles Boetsch, Stephane Blanc, Chantal Simon, Audrey Bergouignan
Summary: Despite global efforts to manage obesity, its prevalence continues to rise to pandemic levels due to complex interactions between biological, behavioral, and socio-ecological factors. Physical activity plays a key role in regulating body weight and fat mass, with levels below a certain threshold leading to metabolic control impairment and excessive weight gain. Technological advances have likely decreased physical activity levels, contributing to the obesity epidemic in Westernized countries.
CAHIERS DE NUTRITION ET DE DIETETIQUE
(2021)
Article
Public, Environmental & Occupational Health
Paddy C. Dempsey, Chuck E. Matthews, S. Ghazaleh Dashti, Aiden R. Doherty, Audrey Bergouignan, Eline H. van Roekel, David W. Dunstan, Nicholas J. Wareham, Thomas E. Yates, Katrien Wijndaele, Brigid M. Lynch
JOURNAL OF PHYSICAL ACTIVITY & HEALTH
(2020)
