Article
Acoustics
Beomseok Cha, Song Ha Lee, Syed Atif Iqrar, Hee-Gyeong Yi, Jangho Kim, Jinsoo Park
Summary: In this study, a vertical-type ultrasonic SAW-based microfluidic mixer was proposed for rapid flow mixing with improved efficiency and controllability. Computational fluid dynamics simulations and experimental investigations were conducted to elucidate the acousto-hydrodynamic phenomenon of the vertical-type SAW-induced ASF. The SAW-induced vortices acted as a hydrodynamic barrier for controlled flow mixing, and proof-of-concept application demonstrated rapid red blood cell lysis with high efficiency based on the physical interactions with the SAW-induced acoustic vortical flows.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Mechanics
Yifan Liu, Fengxian Xin
Summary: The static deformation of red blood cells in a microfluidic channel driven by traveling surface acoustic wave (SAW) is investigated theoretically and numerically. The computational framework considers the coupling effect of acoustic and mechanic, where the deformed cell reshapes the acoustic field generated by the propagating acoustic wave. The results show that the SAW creates acoustic pressure nodes in the fluid channel, trapping the cells and causing them to orient and stretch along the direction of the SAW propagation. The parallel cell manipulation is also simulated to demonstrate the high-throughput characteristics of the acoustic deformation method.
INTERNATIONAL JOURNAL OF SOLIDS AND STRUCTURES
(2023)
Article
Materials Science, Multidisciplinary
Yifan Liu, Fengxian Xin
Summary: This study theoretically and numerically investigates the deformation of biconcave red blood cells (RBCs) driven by ultrasonic standing waves in a fluid environment. The RBCs are modeled as a cell containing homogeneous cytosol enclosed by a thin biological membrane. The acoustic induced force on the cell membrane is calculated using the acoustic radiation stress theory, and the interaction between cell deformation and acoustic wave propagation is numerically simulated. The results show that the trapped RBCs gradually transform into an oblate disc shape with increasing acoustic input, and parametric studies are performed to analyze the effects of cell properties and acoustic wavelength on deformation. This work is important in diagnosing RBC-related diseases and studying mechanotransduction using acoustic deformation techniques.
MECHANICS OF MATERIALS
(2023)
Article
Chemistry, Analytical
Dhrubajyoti Das, Hsuan-An Chen, Yung-Chun Lee, Jae-Sung Kwon, Han-Sheng Chuang
Summary: In the early stages of disease, the concentration of biomarkers is low, making rapid screening essential for early diagnosis. This study developed a bead-based immunosensing technique using surface acoustic wave (SAW) for rapid and sensitive on-chip detection of the diabetic retinopathy biomarker lipocalin 1. The integration of SAW and high sensitivity immunoassay allowed for enhanced fluorescence signal detection within 5 seconds and a limit of detection of 40 pg/mL in 3 minutes with a small sample volume.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Yang Jun Kang
Summary: In this study, three rheological properties (viscoelasticity, RBC aggregation, and blood junction pressure) were measured by analyzing blood velocity and image intensity in a microfluidic device. The analytical formula for viscoelasticity was derived based on the discrete fluidic circuit model. RBC aggregation was obtained by reducing blood velocity and analyzing microscopic image intensity. The blood junction pressure was obtained by integrating blood velocity within an air compliance unit.
Article
Environmental Sciences
Yuming Zeng, Siyi Shen, Zhiwei Xu
Summary: Feature extraction and recognition of underwater targets were studied using a millimeter wave (mmWave) radar. The continuous wavelet transform (CWT) method showed better detection performance, and the mmWave radar accurately detected even weak water surface acoustic wave (WSAW) signals. The experiments demonstrated the potential of mmWave radar for cross-medium detection and recognition of underwater targets.
Article
Biochemical Research Methods
Takumi Inui, Jiyang Mei, Chikahiro Imashiro, Yuta Kurashina, James Friend, Kenjiro Takemura
Summary: A new method involving surface acoustic waves to locally remove cells in cell culture has been developed, with a success rate of 90%. This targeted cell removal method may significantly improve the quality of cultured cells, particularly useful for the selective removal of colonies of iPS cells.
Article
Geochemistry & Geophysics
Jie Shao, Yibo Wang, Ling Chen
Summary: This study investigates the near-surface characterization using high-speed train seismic data recorded by DAS. The results demonstrate the effectiveness and reliability of DAS-based acquisition and data analysis in near-surface characterization using the high-speed train type of moving sources.
IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING
(2022)
Article
Geosciences, Multidisciplinary
Jie Shao, Yibo Wang, Yikang Zheng, Yi Yao, Shaojiang Wu, Zesheng Yang, Qingfeng Xue
Summary: This study investigates the near-surface characterization of urban traffic noise using the recently developed fiber-optic distributed acoustic sensing (DAS) technology. The traffic noise seismic data were recorded by a DAS line and seismic interferometry techniques were applied to reconstruct seismic surface waves. The near-surface shear wave velocity profile was obtained using surface wave dispersion curve inversion with a Bayesian Markov Chain Monte Carlo method. The results demonstrate the effectiveness of DAS in near-surface characterization.
FRONTIERS IN EARTH SCIENCE
(2022)
Article
Acoustics
Christopher Hakoda, Cristian Pantea, Vamshi Krishna Chillara
Summary: The paper presents a simple method for designing localized regions with minimal SAW amplitude, achieved by controlling the beat phenomenon. These regions can have variable widths and be positioned consecutively. The efficacy of the proposed method for SAW wave propagation is demonstrated through supplementary simulations.
JOURNAL OF SOUND AND VIBRATION
(2021)
Article
Chemistry, Analytical
Umar Farooq, Xiufang Liu, Wei Zhou, Muhammad Hassan, Lili Niu, Long Meng
Summary: This method utilizes the collision between nanowires and cells to induce cell lysis efficiently, with advantages of low power consumption, fast processing, reusability, and minimal sample consumption. Ni coated Ag-nanowires show promise for applications in point of care diagnostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Multidisciplinary
Shenxin Yin, Huapan Xiao, Zhiwen Cui, Tribikram Kundu
Summary: The article proposes a localization technique using triangular pyramid shaped sensor clusters for acoustic source localization in 3D structures, which analyzes the time difference of arrival of acoustic signals between different sensors. It works well for both homogeneous and heterogeneous media, and has been experimentally and numerically verified for reliability. This technique is effective for localizing acoustic sources with few sensors in monitoring large 3D structures.
STRUCTURAL HEALTH MONITORING-AN INTERNATIONAL JOURNAL
(2021)
Article
Physics, Multidisciplinary
Yawen Fang, Yang Xu, Kaifei Kang, Benyamin Davaji, Kenji Watanabe, Takashi Taniguchi, Amit Lal, Kin Fai Mak, Jie Shan, B. J. Ramshaw
Summary: Surface acoustic waves (SAWs) provide a contactless method for measuring wave-vector-dependent conductivity. In this study, SAW resonant cavities fabricated on LiNbO3 substrates were used to access the quantum Hall regime of high-mobility, hexagonal boron nitride encapsulated, graphene heterostructures. The results indicate that SAW resonant cavities can be a viable platform for contactless conductivity measurements in the quantum transport regime of van der Waals materials.
PHYSICAL REVIEW LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Martin Poblet, Rodrigo Berte, Hilario D. Boggiano, Yi Li, Emiliano Cortes, Gustavo Grinblat, Stefan A. Maier, Andrea Bragas
Summary: Hypersound waves can efficiently mediate optical signals at the nanoscale, with the ability to be controlled and focused in a small region of space. This study demonstrates the coupling of two optical nanoantennas through an acoustic wave, investigating the generation and detection processes, and proposing new designs to enhance the directionality of the hypersonic surface acoustic wave.
Article
Acoustics
Chang Liu, Fotis Georgiou, Maarten Hornikx
Summary: Vegetated roof systems can help mitigate traffic noise by acting as absorbers. The properties of substratum and plant coverage are crucial for the acoustic absorption of vegetated roofs. Most studies on acoustic absorption are based on laboratory experiments or numerical models, with limited research focusing on in-situ measurement for impedance prediction.
Article
Biochemical Research Methods
Jason Brenker, Katja Henzler, Camelia N. Borca, Thomas Huthwelker, Tuncay Alan
Summary: This paper presents an X-ray compatible microfluidic platform for in situ characterization of chemical reactions at synchrotron light sources. The new approach with polydimethylsiloxane (PDMS) microfluidic channels sandwiched between ultrathin, X-ray transparent silicon nitride observation windows and rigid substrates demonstrates easy to implement techniques to probe reacting solutions and study their reactions in real-time. This platform has the advantages of being suitable for high energy and tender X-rays, operable in a vacuum environment, and robust enough for continuous scanning with high spatial and time resolution.
Article
Multidisciplinary Sciences
Wai Hoe Chin, Ciaren Kett, Oren Cooper, Deike Museler, Yaqi Zhang, Rebecca S. Bamert, Ruzeen Patwa, Laura C. Woods, Citsabehsan Devendran, Denis Korneev, Joe Tiralongo, Trevor Lithgow, Michael J. McDonald, Adrian Neild, Jeremy J. Barr
Summary: The majority of viruses in the gut are bacterial viruses known as bacteriophages, which coevolve with gut bacteria. This study investigated the evolutionary interactions between bacteriophages, bacterial hosts, and the mammalian gut mucosa. The researchers found that bacteriophages can evolve in response to a mammalian-derived mucosal environment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
William Sean Harley, Kirill Kolesnik, Mingxin Xu, Daniel Edward Heath, David John Collins
Summary: This work demonstrates a method to generate designed and highly localized acoustic fields using 3D resonant mass-spring microstructures, enabling rapid and spatially defined controllable micromanipulation. This sub-wavelength, 3D acoustofluidic approach has potential applications in sample preparation, cell analysis, and diagnostics.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mingxin Xu, William S. Harley, Zhichao Ma, Peter V. S. Lee, David J. Collins
Summary: Acoustic metasurfaces with complex 3D structures complicate their fabrication and applicability to higher frequencies, but an ultrathin metasurface approach utilizing planarized micropillars in a discretized phase array is demonstrated here. This subwavelength metasurface can be easily produced via a single-step etching process and is suitable for megahertz-scale applications. The flexibility of this approach is further demonstrated in the production of complex acoustic patterns via acoustic holography. This metasurface approach, combined with predictive models, has broad potential for robust, high-frequency acoustic manipulation in various applications.
ADVANCED MATERIALS
(2023)
Article
Biochemical Research Methods
Bryan Ang, Ankush Sookram, Citsabehsan Devendran, Vincent He, Kellie Tuck, Victor Cadarso, Adrian Neild
Summary: Surface acoustic wave (SAW) driven devices often use polymeric microfluidic channels with low acoustic impedance mismatch to the fluid in contact for precise control of the wave field. This work demonstrates the successful implementation of integrating a glass insert at the ceiling of the PDMS microfluidic channel in a SAW activated nanosieve, resulting in a significant increase in flow rate and maintenance of high capture efficiencies. The glass-inserted device allows for processing larger volume samples, overcoming a main limitation of these devices.
Article
Chemistry, Analytical
Bryan Ang, Ruhollah Habibi, Ciaren Kett, Wai Hoe Chin, Kellie L. Tuck, Adrian Neild, Victor J. Cadarso
Summary: Microfluidic concentration technology can detect low concentrations of bacteria in samples, making it suitable for time-sensitive situations such as clinical settings and food quality control. By using a packed bed of micro-particles activated by surface acoustic waves, bacteria can be efficiently captured and recovered for further analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Materials Science, Multidisciplinary
Mohammad Mosarof Hossain, Babar Shabbir, Jingying Liu, Zhichen Wan, Sumeet Walia, Qiaoliang Bao, Tuncay Alan, Sudha Mokkapati
Summary: Bisphenol A exposure is associated with increased risk of various diseases. Monitoring BPA exposure is important for human healthcare. A microfluidic device based on MoS2 field-effect transistor has been developed to detect biomolecules at low concentrations. The functionalized MoS2 FET sensors show high sensitivity and can detect BPA concentration as low as 1 pg mL(-1).
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Nanoscience & Nanotechnology
Kajal Sharma, Shipra Pandey, Hariharan Sekar, Tuncay Alan, Venkat Gundabala
Summary: In this study, curcumin loaded alginate microfibers were generated using microfluidic technique and their efficacy in combination therapy (blue light + curcumin) against drug resistant Staphylococcus aureus (S. aureus) was evaluated. The results showed that the curcumin loaded microfibers exhibited good antibacterial activity and effectively eliminated biofilms formed by multidrug resistant S. aureus.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ali-Reza Shokouhi, Yaping Chen, Hao Zhe Yoh, Jason Brenker, Tuncay Alan, Takahide Murayama, Koukou Suu, Yasuhiro Morikawa, Nicolas H. Voelcker, Roey Elnathan
Summary: A non-viral electroactive nanoinjection (ENI) platform is developed to efficiently deliver and express CAR genes in primary human T cells, with high transfection efficiency and minimal cellular perturbation. The ENI-transfected CAR-T cells show effective suppression of lymphoma cell growth, demonstrating the platform's potential for ex vivo cell engineering in CAR-T cell therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Vincent He, Victor J. Cadarso, Susanne Seibt, Ben J. Boyd, Adrian Neild
Summary: In this study, a microfluidic approach was used to prepare different aqueous and lipid droplets and induce phase transformations in the liquid medium. The results showed that when the lipid droplets and aqueous droplets coalesced, distinct structures with different compositions formed on the two sides of the merged droplet. Through diffusion limited interface, water molecules gradually hydrated the lipid portion, leading to a series of phase transformations. This study provides a new approach for studying the kinetics of phase transformations and identifying non-equilibrium phases in droplet-based lyotropic liquid systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Nastaran Meftahi, Maciej Adam Surmiak, Sebastian O. Fuerer, Kevin James Rietwyk, Jianfeng Lu, Sonia Ruiz Raga, Caria Evans, Monika Michalska, Hao Deng, David P. McMeekin, Tuncay Alan, Doojin Vak, Anthony S. R. Chesman, Andrew J. Christofferson, David A. Winkler, Udo Bach, Salvy P. Russo
Summary: Organic-inorganic perovskite solar cells (PSCs) have the potential to become the next-generation, cost-effective solar panels due to their competitive cost and high efficiency. However, their poor stability is a major drawback. A new subset of PSCs called quasi-two-dimensional Ruddlesden-Popper PSCs (quasi-2D RP PSCs) has shown improved photostability and resilience to environmental conditions. In this study, a combinatorial, machine learning enhanced high-throughput perovskite film fabrication and optimization approach is proposed to accelerate the search for new quasi-2D RP PSCs. By using spin-coating free robotic fabrication processes, perovskite films with different compositions are produced, and their performance data is used to train a machine learning model for materials optimization and design. The ML-optimized quasi-2D RP perovskite films achieved solar cells with power conversion efficiencies of up to 16.9%.
ADVANCED ENERGY MATERIALS
(2023)
Article
Chemistry, Analytical
Kirill Kolesnik, Daniel Quang Le Pham, Jessica Fong, David John Collins
Summary: Researchers have found that a particle focusing spot in the center of a rotating fluid is formed by the secondary flow. The rotational velocity and the shape of the vessel significantly influence the particle's equilibrium position. This study demonstrates the formation of a single focusing spot in the center of the vessel and the repeatable formation of stable ring-shaped particle arrangements.
Correction
Chemistry, Multidisciplinary
Shu Huang, Chuang Feng, Edwin L. H. Mayes, Bicheng Yao, Zijun He, Sajjad Asadi, Tuncay Alan, Jie Yang
Article
Biochemical Research Methods
Kirill Kolesnik, Philipp Segeritz, Daniel J. Scott, Vijay Rajagopal, David J. Collins
Summary: Acoustofluidic devices can manipulate particles and cells in arbitrary configurations at the microscale without complex patterning. This approach is enabling for cell studies and tissue engineering applications.
Article
Nanoscience & Nanotechnology
Kajal Sharma, Shipra Pandey, Hariharan Sekar, Tuncay Alan, Venkat Gundabala
Summary: In this study, curcumin loaded alginate microfibers were generated using the microfluidic technique. The efficacy of a combined therapy (blue light + curcumin) against drug resistant Staphylococcus aureus biofilm was assessed. The results showed that the curcumin loaded alginate microfibers exhibited good eradication activity against drug resistant S. aureus biofilms under blue light irradiation.
ACS APPLIED BIO MATERIALS
(2023)
