Article
Engineering, Multidisciplinary
Amit Chanda, Sujeet K. Sinha, Naresh Datla
Summary: This study investigated the effect of carbon nanofiber (CNF) alignment on the mixed mode fracture toughness of CNF/epoxy nanocomposite adhesive joints. The results showed that aligned CNF/epoxy had significantly improved fracture toughness in mixed mode and mode-II compared to neat epoxy. Fracture surface analysis revealed that CNF pull-out, debonding, and plastic void growth of epoxy were the key toughening mechanisms.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Jialing Li, Sha Luo, Fenfang Li, Shengyi Dong
Summary: This article introduces a new type of pressure-sensitive adhesive that can be directly operated at low temperatures and exhibits excellent mechanical properties and adhesion capacity. The results of the study show that the adhesive has strong adhesion strength at -60 degrees Celsius and can stably adhere to various surfaces.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Fabrizio Moroni, Alessandro Pirondi, Chiara Pernechele, Luca Vescovi
Summary: This study compared the effects of co-bonding and cold-bonding on the CFRP laminate-aluminum connection and found that cold-bonding resulted in composite delamination in lap-shear tests, while co-bonding led to cohesive failure. The tensile and Mode I fracture tests showed that the failure path was predominantly in the composite.
Article
Engineering, Chemical
Stefania Minosi, Fabrizio Moroni, Alessandro Pirondi
Summary: The demand for lighter structures has led to increased interest in bonding as a joining method, especially for materials that are difficult to weld or bolt. Structural adhesives can be toughened by changing their chemical composition or adding nanometric-size fillers. Nanomaterials with high surface area and limited defects can enhance adhesive mechanical properties based on their nature, quantity, size, and interfacial adhesion. This study analyzed the fracture toughness of joints bonded with METLBOND (R) 1515-4M epoxy film and XantuLayr electrospun XD 10 polyamide nanofibers. Joint configurations with nanofibers at the substrate/adhesive interface showed a 32% improvement in Mode I fracture toughness, reaching a value of 0.55 N/mm. SEM images confirmed the positive contribution of stretched and pulled out nanofibers. No variation in fracture toughness was observed in joints with nanofibers in the middle of the adhesive layer.
Article
Chemistry, Multidisciplinary
Adriana Sierra-Romero, Katarina Novakovic, Mark Geoghegan
Summary: A reversible water-based electrostatic adhesive has been developed, with intermediate bond strength between pressure-sensitive and structural adhesives, suitable for large-scale recycling and dismantling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Kota Nakamura, Yu Sekiguchi, Kazumasa Shimamoto, Keiji Houjou, Haruhisa Akiyama, Chiaki Sato
Summary: The double cantilever beam (DCB) test method, combined with a creep load and spring, was used to measure the energy release rate (ERR) and investigate the combined effects of creep, moisture, and temperature. The study demonstrated the validity of the spring-loaded DCB test method in studying the long-term durability of adhesive joints.
Article
Engineering, Biomedical
Julia Lubauer, Renan Belli, Tony Lorey, Stefanie Max, Ulrich Lohbauer
Summary: This study introduces a new method to evaluate the bonding performance of adhesive systems to dental restorative materials. By using split-Chevron-Notched Beam specimens and considering the influence of different materials, reasonable results within a known range were obtained. The method is applicable to different adhesive systems and pretreatment procedures and can assess the sensitivity to different bond qualities.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Niwut Juntavee, Apa Juntavee, Nuttida Rengpattanakij
Summary: This study investigated the effect of sintering temperatures and times on the bond strength and interfacial fracture toughness of metal-ceramic. The results showed that the bond strength was influenced by the alloy type, sintering temperature, and time. The adhesion between ceramic and CAD-milled alloy was stronger and the surface was rougher compared to casting alloy. Increasing the sintering temperature and time enhanced the bond strength of the casting alloy, while extended sintering improved the bond strength of the CAD-milled alloy.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Engineering, Chemical
A. Pirondi, F. Moroni, D. Ambrosini
Summary: This study investigates the effect of infill ratio on the Mode I fracture toughness of adhesive joints of AM materials. Experimental testing and finite element simulations were conducted to analyze the strain energy release rate at the crack front, observing changes in fracture toughness at both global and local scales.
JOURNAL OF ADHESION
(2022)
Article
Mechanics
Antonios G. Stamopoulos, Silvia Ilaria Scipioni, Francesco Lambiase
Summary: The aim of this study is to determine the inter-layer fracture toughness behavior of FDM parts using double cantilever beam specimens. A new sample configuration was proposed to overcome limitations in sample preparation influenced by human factors. The results indicated that the insertion of Polyimide and pause time required may alter the thermal history, leading to underestimation of mechanical behavior. On the other hand, the proposed sample with nested spacers provides a more reliable measurement of interlayer fracture toughness without introducing artifacts in the thermal history.
COMPOSITE STRUCTURES
(2023)
Article
Polymer Science
Zvikomborero Machikiti, Behnam Pourdeyhimi, Jan Genzer, Kirill Efimenko
Summary: This study investigates the adhesion strength between PA6 and PET modified with specific modifiers, aiming to tailor the adhesion at the PA6/PET interface for easy polymer splitting in microfibers production.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Xiaochun Liu, Si Qin, Lei Xu, Guo Fu, Yongjun Huang, Chaoqun Yu, Guoyun Cheng, Ying Li, Yunzhi He, Yong Qi, Dawei Sun
Summary: In this study, a tough adhesive hydrogel with good mechanical stability for non-invasive wound repair was developed. The hydrogel is composed of polyethylene glycol dimethacrylate (PEGDA), chitosan (CS), and chitin nano-whisker (CW). PEGDA and CS form interpenetrating network hydrogel through free radical polymerization reaction under UV light. The introduction of CW enhances the toughness of the hydrogel. The adhesive hydrogel shows promising potential for wound closure repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Composites
Nathan Hostettler, Pascal Hubert
Summary: The addition of polycaprolactone (PCL) and graphene to unsaturated polyester resins can significantly enhance their toughness. PCL creates phase-separated microstructures, while graphene forms self-assembled networks, both of which contribute to improved toughness and electrical conductivity.
COMPOSITES SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhewen Ma, Xiaochen Liu, Xiaodong Xu, Lei Liu, Bin Yu, Cristian Maluk, Guobo Huang, Hao Wang, Pingan Song
Summary: This study presents a biomimetic strategy to design a polymeric coating with strong adhesion and flame-retardant properties, which can self-extinguish during vertical burning and release low heat and smoke, outperforming previous products.
Article
Materials Science, Characterization & Testing
M. Ortega-Iguna, M. Chludzinski, C. Churiaque, R. E. Dos Santos, M. Porrua-Lara, F. Abad-Fraga, J. M. Sanchez-Amaya
Summary: The study focuses on the use of adhesives in the naval industry, particularly the industrial interest in double-sided Pressure Sensitive Adhesives (PSAs) for connecting low weight components. The research reveals that curing conditions, surface preparation, and paint roughness have significant effects on the adhesive joints resistance.
Article
Engineering, Biomedical
Beom Jin Kim, Yu Fang, Hongjian He, Bing Xu
Summary: This study discovered a readily available peptide that selectively inhibits cancer cells by forming peptide assemblies on the endoplasmic reticulum (ER) through enzyme-instructed self-assembly (EISA), resulting in ER stress and eventual cell death. It offers a promising new strategy for potential cancer therapy by targeting cancer cell subcellular organelles.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Dongsik Yang, Beom Jin Kim, Hongjian He, Bing Xu
Summary: A new type of tryptophan-rich short peptides has been discovered, which act as hydrogelators, form supramolecular assemblies via enzymatic dephosphorylation, and exhibit cell compatibility. These peptides largely accumulate in lysosomes, are compatible with mammalian cells, and can transiently reduce the cytotoxicity of phenylalanine-rich peptide assemblies.
Article
Biochemistry & Molecular Biology
Adrianna N. Shy, Huaimin Wang, Zhaoqianqi Feng, Bing Xu
Summary: This study successfully developed new materials with the ability to form heterotypic peptide hydrogels using information revealed by structural biology. The ratio of complementary peptides affects the properties of the resulting hydrogels, while electrostatic interactions modulate the self-assembly process.
Article
Biochemical Research Methods
Dongsik Yang, Hongjian He, Beom Jin Kim, Bing Xu
Summary: This study found that peptides with negatively charged peptides (NCPs) can self-assemble to form micelles at neutral or basic pH, facilitating the trafficking of histone proteins. Structure-activity studies revealed that self-assembly, proper stereochemistry, and acidic repeats are crucial for successful trafficking of H2B.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Weiyi Tan, Qiuxin Zhang, Jiaqing Wang, Meihui Yi, Hongjian He, Bing Xu
Summary: Introducing a sulfur atom into phosphopeptides enables rapid targeting of Golgi apparatus and selective killing of cancer cells. The resulting thiophosphopeptide self-assembles after alkaline phosphatase-catalyzed dephosphorylation, enters cells, and accumulates in Golgi apparatus, inhibiting cancer cells effectively.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Hongjian He, Jiaqi Guo, Jiashu Xu, Jiaqing Wang, Shuang Liu, Bing Xu
Summary: This study demonstrates how nanoscale phosphopeptide assemblies cluster ALP to enable cellular uptake through caveolae-mediated endocytosis and endosomal escape. Dephosphorylation of phosphopeptides leads to the formation of peptidic nanofibers for endosomal escape. Inhibiting TNAP or disrupting lipid rafts abolishes the endocytosis process, while decreasing the transformation to nanofibers prevents endosomal escape.
Article
Chemistry, Organic
Qiuxin Zhang, Weiyi Tan, Bing Xu
Summary: In this study, we synthesized pyrrole-conjugated phosphopeptides and investigated their effects on cell viability. The results showed that the introduction of a heteroaromatic motif at the N-terminal of short peptides reduced their inhibitory activity against cancer cells and hindered morphological changes during enzymatic dephosphorylation.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemical Research Methods
Weiyi Tan, Qiuxin Zhang, Pengyu Hong, Bing Xu
Summary: This study utilizes an enzyme-instructed self-assembling thiophosphopeptide as a probe to reveal the state of the Golgi Apparatus (GA) in live cells. Results show that the probe accumulates in the GA at different rates depending on cell types and is sensitive to alkaline phosphatase expression. This self-assembling probe offers a novel approach for high-resolution imaging of subcellular organelles.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Weiyi Tan, Qiuxin Zhang, Monica C. Quinones-Frias, Alan Y. Hsu, Yichi Zhang, Avital Rodal, Pengyu Hong, Hongbo R. Luo, Bing Xu
Summary: This study demonstrates the effectiveness of unconventional peptide thioesters in selectively targeting the Golgi apparatus, thereby controlling cell fate. These peptide thioesters enter cells through specific endocytic pathways and accumulate in the Golgi apparatus, disrupting protein trafficking and leading to cell death.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
Qiuxin Zhang, Weiyi Tan, Bing Xu
Summary: Enzymatic noncovalent synthesis (ENS) is a mechanism that utilizes enzymatic reactions to produce spatially organized higher-order supramolecular assemblies, which can modulate cellular processes. This Review highlights the recent progress in the application of ENS for targeted subcellular organelles, showcasing its potential in understanding diseases, controlling cell behaviors, and developing new therapeutics.
Article
Chemistry, Multidisciplinary
Meihui Yi, Fengbin Wang, Weiyi Tan, Jer-Tsong Hsieh, Edward H. Egelman, Bing Xu
Summary: This study demonstrates the use of enzymatic responsive rigid-rod aromatics as substrates to target undruggable phosphatases and kill cancer cells in a bone microenvironment. The compounds effectively kill metastatic prostate cancer cells and mimic osteoblast cells, with high cellular uptake rate.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Shuang Liu, Qiuxin Zhang, Hongjian He, Meihui Yi, Weiyi Tan, Jiaqi Guo, Bing Xu
Summary: In this study, intranuclear nanoribbons formed by dephosphorylation of phosphorylated peptides catalyzed by alkaline phosphatase were demonstrated to selectively kill osteosarcoma cells. These peptides rapidly kill the cancer cells by interacting with histone proteins, while being nontoxic to normal cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Adrianna N. Shy, Jiashu Xu, Beom Jin Kim, Bing Xu
Summary: This study focuses on the enzyme-instructed self-assembly (EISA) of a phosphopeptide (1P) derived from the protein crystal structures of Merlin and CRL4(DCAF-1). The results demonstrate that even with the presence of a hydrophilic peptide, 1P can form a hydrogel at a very low volume fraction. Additionally, diastereomer 2P and enantiomer 3P of 1P are able to form hydrogels via EISA at higher concentrations than 1P.
Article
Chemistry, Multidisciplinary
Huyeon Choi, Gaeun Park, Eunhye Shin, Seon Woo Shin, Batakrishna Jana, Seongeon Jin, Sangpil Kim, Huaimin Wang, Sang Kyu Kwak, Bing Xu, Ja-Hyoung Ryu
Summary: Mitochondria-targeting nucleopeptide can sequester ATP by self-assembling, leading to apoptosis of cancer cells.
Review
Chemistry, Multidisciplinary
Meihui Yi, Weiyi Tan, Jiaqi Guo, Bing Xu
Summary: Enzymatic noncovalent synthesis allows for the control of multimolecular crowding in cells, offering opportunities for modulating cellular functions and various biomedical applications.
CHEMICAL COMMUNICATIONS
(2021)
