4.7 Article

Perhydrolase-nanotube paint composites with sporicidal and antiviral activity

Journal

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 97, Issue 19, Pages 8813-8821

Publisher

SPRINGER
DOI: 10.1007/s00253-012-4573-3

Keywords

Perhydrolase; AcT; B. cereus and B. anthracis spores; Influenza virus; Multi-walled carbon nanotubes; Nanocomposites

Funding

  1. U.S. Army Corps of Engineers [W913T-10-2-0006, W913T-11-R-0033]

Ask authors/readers for more resources

AcT (perhydrolase) containing paint composites were prepared leading to broad-spectrum decontamination. AcT was immobilized onto multi-walled carbon nanotubes (MWNTs) and then incorporated into latex-based paints to form catalytic coatings. These AcT-based paint composites showed a 6-log reduction in the viability of spores of Bacillus cereus and Bacillus anthracis (Sterne) within 60 min. The paint composites also showed > 4-log reduction in the titer of influenza virus (X-31) within 10 min (initially challenged with 10(7) PFU/mL). AcT-based paint composites were also tested using various perhydrolase acyl donor substrates, including propylene glycol diacetate (PGD), glyceryl triacetate, and ethyl acetate, with PGD observed to be the best among the substrates tested for generation of peracetic acid and killing of bacillus spores. The operational stability of paint composites was also studied at different relative humidities and temperatures to simulate real-life operation.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Allergy

Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery

Rachel S. Resop, Marc Douaisi, Joshua Craft, Loes C. M. Jachimowski, Bianca Blom, Christel H. Uittenbogaart

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Nanoscience & Nanotechnology

Nanostructured glycan architecture is important in the inhibition of influenza A virus infection

Seok-Joon Kwon, Dong Hee Na, Jong Hwan Kwak, Marc Douaisi, Fuming Zhang, Eun Ji Park, Jong-Hwan Park, Hana Youn, Chang-Seon Song, Ravi S. Kane, Jonathan S. Dordick, Kyung Bok Lee, Robert J. Linhardt

NATURE NANOTECHNOLOGY (2017)

Article Immunology

CD31, a Valuable Marker to Identify Early and Late Stages of T Cell Differentiation in the Human Thymus

Marc Douaisi, Rachel S. Resop, Maho Nagasawa, Joshua Craft, Beth D. Jamieson, Bianca Blom, Christel H. Uittenbogaart

JOURNAL OF IMMUNOLOGY (2017)

Article Chemistry, Analytical

Hybrid Surface and Bulk Resonant Acoustics for Concurrent Actuation and Sensing on a Single Microfluidic Device

Emily P. Nguyen, Lillian Lee, Amgad R. Rezk, Ylias M. Sabri, Suresh K. Bhargava, Leslie Y. Yeo

ANALYTICAL CHEMISTRY (2018)

Article Chemistry, Multidisciplinary

Design of Monodisperse and Well-Defined Polypeptide-Based Polyvalent Inhibitors of Anthrax Toxin

Sanket Patke, Mohan Boggara, Ronak Maheshwari, Sunit K. Srivastava, Manish Arha, Marc Douaisi, Jacob T. Martin, Ian B. Harvey, Matthew Brier, Tania Rosen, Jeremy Mogridge, Ravi S. Kane

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Chemistry, Multidisciplinary

Programmed Degradation of DNA Multilayer Films

Lillian Lee, Angus P. R. Johnston, Frank Caruso

SMALL (2014)

Article Multidisciplinary Sciences

Enhancing rate of water absorption in seeds via a miniature surface acoustic wave device

Kiing S. Wong, Lillian Lee, Leslie Y. Yeo, Ming K. Tan

ROYAL SOCIETY OPEN SCIENCE (2019)

Article Chemistry, Multidisciplinary

Exploring New Applications of Lysozyme-Shelled Microbubbles

Lillian Lee, Francesca Cavalieri, Muthupandian Ashokkumar

LANGMUIR (2019)

Article Multidisciplinary Sciences

Acoustomicrofluidic assembly of oriented and simultaneously activated metal-organic frameworks

Heba Ahmed, Amgad R. Rezk, Joseph J. Richardson, Lauren K. Macreadie, Ravichandar Babarao, Edwin L. H. Mayes, Lillian Lee, Leslie Y. Yeo

NATURE COMMUNICATIONS (2019)

Article Chemistry, Medicinal

Preparation of Low Molecular Weight Heparin from a Remodeled Bovine Intestinal Heparin

Sultan N. Baytas, Sony S. Varghese, Weihua Jin, Yanlei Yu, Peng He, Marc Douaisi, Fuming Zhang, Paul Brodfuehrer, Ke Xia, Jonathan S. Dordick, Robert J. Linhardt

Summary: Bovine intestinal heparins differ structurally and in anticoagulant activity from porcine intestinal heparins, but can be enhanced by treatment with 3-O-sulfotransferase. Remodeled bovine intestinal heparins can be used to prepare low molecular weight heparins with similar activity and structure to Enoxaparin. Additionally, heparin-derived Enoxaparin from bovine intestinal sources may have low levels of heparin induced thrombocytopenia.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Biotechnology & Applied Microbiology

Isobutanol production by combined in vivo and in vitro metabolic engineering

Mamta Gupta, Matthew Wong, Kamran Jawed, Kamil Gedeon, Hannah Barrett, Marcelo Bassalo, Clifford Morrison, Danish Eqbal, Syed Shams Yazdani, Ryan T. Gill, Jiaqi Huang, Marc Douaisi, Jonathan Dordick, Georges Belfort, Mattheos A. G. Koffas

Summary: This study successfully produced isobutanol in E. coli by combining in vivo and in vitro metabolic engineering. The in vivo production of alpha-ketoisovalerate (KIV) was achieved through CRISPR-mediated integration and CRISPRi technology. Subsequent in vitro conversion to isobutanol was carried out using engineered enzymes. This two-step approach resulted in high yields and productivities, making it a promising method for producing important metabolites.

METABOLIC ENGINEERING COMMUNICATIONS (2022)

Meeting Abstract Chemistry, Multidisciplinary

Nanostructured glycan architecture is important in the inhibition of influenza A virus infection

Seok-Joon Kwon Kwon, Dong Na, Jong Kwak, Marc Douaisi, Fuming Zhang, Eun Park, Jong-Hwan Park, Hana Youn, Chang-Seon Song, Ravi Kane, Jonathan Dordick, Kyung Lee, Robert Linhardt

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2017)

Meeting Abstract Immunology

A role for CD31 (PECAM-1) during T cell differentiation in the human thymus

Marc Douaisi, Rachel Resop, Beth Jamieson, Christel Uittenbogaart

JOURNAL OF IMMUNOLOGY (2015)

Meeting Abstract Chemistry, Multidisciplinary

Synthesis of polyvalent aptamer-toxin-polymer conjugates

Jacob Martin, Marc Douaisi, Christina Kratschmer, Matthew Levy, Ravindra Kane

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2015)

Article Chemistry, Multidisciplinary

A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies

Heba Ahmed, Lillian Lee, Connie Darmanin, Leslie Y. Yeo

ADVANCED MATERIALS (2018)

No Data Available