Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253

(2011) Won Seok Jung et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation

(2010) Yihua Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Generation of high rapamycin producing strain via rational metabolic pathway-based mutagenesis and further titer improvement with fed-batch bioprocess optimization

(2010) Xiangcheng Zhu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of bacteria producing a thermophilic lipase with positional non-specificity and characterization of the lipase

(2009) Yaping Lu et al.   ANNALS OF MICROBIOLOGY

Generation of high-yield rapamycin-producing strains through protoplasts-related techniques

(2009) Xiyang Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Strain development of Streptomyces sp. for tacrolimus production using sequential adaptation

(2009) Sangwon Jung et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

(2009) SangJoon Mo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants

(2008) Germán Sierra-Paredes et al.   CNS Neuroscience & Therapeutics

Change in colony morphology and kinetics of tylosin production after UV and gamma irradiation mutagenesis of Streptomyces fradiae NRRL-2702

(2007) Shazia Khaliq et al.   MICROBIOLOGICAL RESEARCH