On the Emergence of RNA

Progress Toward Synthetic Cells

(2014) J. Craig Blain et al.   Annual Review of Biochemistry

Chain-Length Heterogeneity Allows for the Assembly of Fatty Acid Vesicles in Dilute Solutions

(2014) Itay Budin et al.   BIOPHYSICAL JOURNAL

The Expanding View of RNA and DNA Function

(2014) Ronald R. Breaker et al.   CHEMISTRY & BIOLOGY

Experimental fitness landscapes to understand the molecular evolution of RNA-based life

(2014) Shreyas S Athavale et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Crystal Structure Studies of RNA Duplexes Containing s2U:A and s2U:U Base Pairs

(2014) Jia Sheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chiral self-sorting and amplification in isotropic liquids of achiral molecules

(2014) Christian Dressel et al.   Nature Chemistry

Base-Pairing Properties of a Structural Isomer of Glycerol Nucleic Acid

(2013) Phaneendrasai Karri et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Origin of RNA and “My Grandfather’s Axe”

(2013) Nicholas V. Hud et al.   CHEMISTRY & BIOLOGY

Detection of Potential TNA and RNA Nucleoside Precursors in a Prebiotic Mixture by Pure Shift Diffusion-Ordered NMR Spectroscopy

(2013) Saidul Islam et al.   CHEMISTRY-A EUROPEAN JOURNAL

On the Origin of the Canonical Nucleobases: An Assessment of Selection Pressures across Chemical and Early Biological Evolution

(2013) Andro C. Rios et al.   ISRAEL JOURNAL OF CHEMISTRY

Spontaneous Prebiotic Formation of a β-Ribofuranoside That Self-Assembles with a Complementary Heterocycle

(2013) Michael C. Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional RNAs exhibit tolerance for non-heritable 2′–5′ versus 3′–5′ backbone heterogeneity

(2013) Aaron E. Engelhart et al.   Nature Chemistry

Nucleobases bind to and stabilize aggregates of a prebiotic amphiphile, providing a viable mechanism for the emergence of protocells

(2013) R. A. Black et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer

(2013) S. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of pKa of Nucleobases in the Origins of Chemical Evolution

(2012) Ramanarayanan Krishnamurthy   ACCOUNTS OF CHEMICAL RESEARCH

Asphalt, Water, and the Prebiotic Synthesis of Ribose, Ribonucleosides, and RNA

(2012) Steven A. Benner et al.   ACCOUNTS OF CHEMICAL RESEARCH

The XNA world: progress towards replication and evolution of synthetic genetic polymers

(2012) Vitor B Pinheiro et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Multicomponent Assembly of Proposed DNA Precursors in Water

(2012) Matthew W. Powner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spontaneous network formation among cooperative RNA replicators

(2012) Nilesh Vaidya et al.   NATURE

Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor

(2012) Hanyang Yu et al.   Nature Chemistry

Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences

(2012) Julien Derr et al.   NUCLEIC ACIDS RESEARCH

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Etiology of Potentially Primordial Biomolecular Structures: From Vitamin B12 to the Nucleic Acids and an Inquiry into the Chemistry of Life’s Origin: A Retrospective

(2011) Albert Eschenmoser   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transient Hoogsteen base pairs in canonical duplex DNA

(2011) Evgenia N. Nikolova et al.   NATURE

Prebiotic chemistry: a new modus operandi

(2011) M. W. Powner et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

An optimal degree of physical and chemical heterogeneity for the origin of life?

(2011) J. W. Szostak   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity

(2011) S. G. Trevino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carbonaceous meteorites contain a wide range of extraterrestrial nucleobases

(2011) M. P. Callahan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Origins of Nucleotides

(2011) Matthew Powner et al.   SYNLETT

Synthesis and Properties of the Simplified Nucleic Acid Glycol Nucleic Acid

(2010) Eric Meggers et al.   ACCOUNTS OF CHEMICAL RESEARCH

Expanding Roles for Diverse Physical Phenomena During the Origin of Life

(2010) Itay Budin et al.   Annual Review of Biophysics

Ribonucleotides

(2010) J. D. Sutherland   Cold Spring Harbor Perspectives in Biology

Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligo-dipeptides Tagged with Orotic Acid Derivatives as Recognition Elements

(2009) Xuejun Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High Fidelity Base Pairing at the 3′-Terminus

(2009) Amritraj Patra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

(2009) Matthew W. Powner et al.   NATURE

Minimal nucleotide duplex formation in water through enclathration in self-assembled hosts

(2009) Tomohisa Sawada et al.   Nature Chemistry

Self-Sustained Replication of an RNA Enzyme

(2009) T. A. Lincoln et al.   SCIENCE

An Alternative Nucleobase Code: Characterization of Purine-Purine DNA Double Helices Bearing Guanine-Isoguanine and Diaminopurine 7-Deaza-Xanthine Base Pairs

(2008) Benjamin D. Heuberger et al.   CHEMBIOCHEM

The prebiotic geochemistry of formaldehyde

(2008) H. James Cleaves II   PRECAMBRIAN RESEARCH