Article
Agriculture, Multidisciplinary
Xiaoxia Liu, Yunhui Zhang, Wanhua Li, Bowei Zhang, Jia Yin, Sijing Liuqi, Jin Wang, Bo Peng, Shuo Wang
Summary: Gut dysbiosis and bile acid metabolism disturbance are involved in the pathogenesis of ulcerative colitis. This study aimed to investigate the effect of fucoidan on BA metabolism and gut microbiota in dextran sulfate sodium-induced colitis mice. Our results showed that fucoidan effectively suppressed colonic inflammation and repaired the gut barrier. In addition, fucoidan increased the relative abundance of certain bacteria families and short-chain fatty acids, while modulating bile acid metabolism. These findings suggest that fucoidan may be a potential functional food for colitis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Article
Microbiology
Qiongyun Chen, Yanyun Fan, Bangzhou Zhang, Changsheng Yan, Qiang Zhang, Yuhao Ke, Zhangran Chen, Lin Wang, Huaxiu Shi, Yiqun Hu, Qingwen Huang, Jingling Su, Chenxi Xie, Xu Zhang, Lixiang Zhou, Jianlin Ren, Hongzhi Xu
Summary: Fecal microbiota transplantation (FMT) can induce clinical remission in ulcerative colitis (UC) patients. In this study, capsulized FMT was successfully administered to UC patients, resulting in clinical remission in 57.1% of patients and clinical response in 76.2%.
MICROBIOLOGY SPECTRUM
(2023)
Article
Cell Biology
Chunlan Huang, Qixiang Mei, Lihong Lou, Zehua Huang, Yang Fu, Junjie Fan, Jingjing Wang, Nuoming Yin, Yi Zheng, Yingying Lu, Yue Zeng
Summary: The colonization of Faecalibacterium after fecal microbiota transplantation plays a crucial role in the remission of ulcerative colitis by alleviating intestinal inflammation. This anti-inflammatory effect of Faecalibacterium may be achieved by regulating the imbalance of Th17/Treg levels in ulcerative colitis.
Article
Microbiology
Hao-Ming Xu, Hong-Li Huang, Jing Xu, Jie He, Chong Zhao, Yao Peng, Hai-Lan Zhao, Wen-Qi Huang, Chuang-Yu Cao, Yong-Jian Zhou, You-Lian Zhou, Yu-Qiang Nie
Summary: FMT can increase fecal butyric acid levels in UC patients, and combination with butyrate-producing bacteria may prolong the therapeutic effect of FMT on UC.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Xiaochen Zhang, Dai Ishikawa, Kei Nomura, Naoyuki Fukuda, Mayuko Haraikawa, Keiichi Haga, Tomoyoshi Shibuya, Toshihiro Mita, Akihito Nagahara
Summary: Fecal microbiota transplantation is considered a promising treatment for dysbiosis-related diseases. The authors report their experience with donor screening and provide references to improve future donor screening criteria.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Wei Li, Le Zhang, Qingbiao Xu, Wenbo Yang, Jianan Zhao, Ying Ren, Zhendong Yu, Libao Ma
Summary: This study found that taxifolin can ameliorate DSS-induced colitis by altering gut microbiota to increase the production of SCFAs, thereby reducing intestinal inflammation and mucosal damage.
Article
Food Science & Technology
Su Zhou, Jiaying Yang, Yani Pan, Xinyu Feng, Hao Hu, Shicheng Ma, Cansong Ou, Fangyuan Fan, Shuying Gong, Yuefei Wang, Ping Chen, Qiang Chu
Summary: Numerous investigations have shown that Pu' er raw tea extract (PRTE) has a remarkable therapeutic effect on ulcerative colitis (UC). By restoring intestinal barrier function and maintaining gut microbiota homeostasis, PRTE can alleviate UC symptoms and provide a safe and effective new strategy for UC prevention and treatment, while also supporting the medical application of Pu' er raw tea.
Article
Medicine, Research & Experimental
Chunlan Huang, Zehua Huang, Ling Ding, Yang Fu, Junjie Fan, Qixiang Mei, Lihong Lou, Jingjing Wang, Nuoming Yin, Yingying Lu, Sanwei Guo, Yue Zeng
Summary: This study compared the efficacy and safety of fecal microbiota transplantation (FMT) with glucocorticoids as induction therapy in ulcerative colitis (UC). The results showed that FMT was as effective as glucocorticoids in inducing remission in active mild to moderate UC, with fewer adverse events. Changes in certain cytokines in the serum might be related to the efficacy of FMT therapy in UC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Tao Wang, Caihong Shi, Shuxuan Wang, Yu Zhang, Shuang Wang, Mohamedelfaieh Ismael, Jing Zhang, Xin Wang, Xin Lu
Summary: This study used fecal microbiota transplantation (FMT) to verify the potential of Companilactobacillus crustorum MN047 (CCMN) in regulating gut microbiota and alleviating inflammation in ulcerative colitis (UC).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Nutrition & Dietetics
Xue Guo, Chen Huang, Jing Xu, Haoming Xu, Le Liu, Hailan Zhao, Jiaqi Wang, Wenqi Huang, Wu Peng, Ye Chen, Yuqiang Nie, Yongjian Zhou, Youlian Zhou
Summary: Inflammatory bowel disease (IBD) is characterized by relapse and remission, making it challenging to diagnose and assess disease activity. Traditional biomarkers from plasma and stool lack specificity, while changes in gut microbiota are closely associated with IBD etiology and pathogenesis.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Multidisciplinary
Yan Liu, Weisu Huang, Yuhang Zhu, Tian Zhao, Fan Xiao, Yixuan Wang, Baiyi Lu
Summary: The study found that Osmanthus fragrans flower extract (OFE) and acteoside can alleviate murine colitis symptoms by improving intestinal inflammation, oxidative stress, and activation of nuclear factor-kappa B. Additionally, OFE or acteoside also partially restored gut microbiome dysbiosis and gut metabolome dysfunctions in colitic mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Microbiology
Fangyuan Zhu, Yifan Ke, Yiting Luo, Jiaqian Wu, Pei Wu, Fangxiao Ma, Yingchao Liu
Summary: Ulcerative colitis (UC) is a chronic inflammatory bowel disease, and fecal microbiota transplantation (FMT) has been shown to improve UC symptoms. Results of the study indicate that frozen FMT has a better therapeutic effect in treating UC in rat models compared to fresh FMT.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Essi K. Karjalainen, Laura Renkonen-Sinisalo, Reetta Satokari, Harri Mustonen, Ari Ristimaki, Perttu Arkkila, Anna H. Lepisto
Summary: The fecal microbiota transplantation treatment did not show efficacy in treating chronic pouchitis, however the safety profile was good. Among patients who were using continuous antibiotics before the study, the relapse-free survival was shorter in the intervention group.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Immunology
Qiongyun Chen, Yanyun Fan, Bangzhou Zhang, Changsheng Yan, Zhangran Chen, Lin Wang, Yiqun Hu, Qingwen Huang, Jingling Su, Jianlin Ren, Hongzhi Xu
Summary: This study examined the association between gut fungal community and capsulized FMT outcomes in ulcerative colitis (UC) patients. The results showed that capsulized FMT improved fungal diversity and induced remission in UC patients. Specific fungal species were identified to be associated with the induction of remission. This study provides important insights into the mechanism of FMT treatment for UC.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemical Research Methods
Wei Yang, Bin Wei, Ru Yan
Article
Pharmacology & Pharmacy
Xue-Jiao Gao, Ting Li, Bin Wei, Zhi-Xiang Yan, Nan Hu, Yan-Juan Huang, Bei-Lei Han, Tai-Seng Wai, Wei Yang, Ru Yan
DRUG METABOLISM AND DISPOSITION
(2018)
Article
Plant Sciences
Hong Shen, Xue-Jiao Gao, Ting Li, Wang-Hui Jing, Bei-Lei Han, Yu-Meng Jia, Nan Hu, Zhi-Xiang Yan, Song-Lin Li, Ru Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2018)
Article
Medicine, Research & Experimental
Qianqian Zhao, Nikhila Miriyala, Yan Su, Weijie Chen, Xuejiao Gao, Ling Shao, Ru Yan, Haifeng Li, Xiaojun Yao, Dongsheng Cao, Yitao Wang, Defang Ouyang
MOLECULAR PHARMACEUTICS
(2018)
Article
Nanoscience & Nanotechnology
Lin Sun, Zeyu Liu, Zibei Lin, Dongmei Cun, Henry H. Y. Tong, Ru Yan, Ruibing Wang, Ying Zheng
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2018)
Article
Endocrinology & Metabolism
Zhixiang Yan, Ting Li, Bin Wei, Panpan Wang, Jianbo Wan, Yitao Wang, Ru Yan
Article
Gastroenterology & Hepatology
Lu Lin, Xiayang Jiang, Zhenling Zhang, Siwen Huang, Zhenyi Zhang, Zhaoxiong Fang, Zhiqiang Gu, Liangqing Gao, Honggang Shi, Lei Mai, Yuan Liu, Xianqi Lin, Renxu Lai, Zhixiang Yan, Xiaofeng Li, Hong Shan
Article
Microbiology
Zhixiang Yan, Feixiang He, Fei Xiao, Huanhuan He, Dan Li, Li Cong, Lu Lin, Huijin Zhu, Yanyan Wu, Ru Yan, Xiaofeng Li, Hong Shan
Summary: The study developed a semi-tryptic peptide centric metaproteomic mining approach to investigate gut microbial proteolysis signatures. The approach was validated by identifying altered proteolysis signatures of Escherichia coli heat shock response and potential signatures of altered gut microbial proteolysis in inflammatory bowel disease patients. This strategy provides valuable insights into the complex and diverse proteolytic events of the gut microbiome.
Article
Chemistry, Analytical
Feixiang He, Ting Zhang, Kewen Xue, Zhaoxiong Fang, Guanmin Jiang, Siwen Huang, Kexue Li, Zhiqiang Gu, Honggang Shi, Zhenyi Zhang, Huijin Zhu, Lu Lin, Jialin Li, Fei Xiao, Hong Shan, Ru Yan, Xiaofeng Li, Zhixiang Yan
Summary: The gut ecosystem has profound effects on host physiology and health, with COVID-19 causing disruptions in gut proteomes. These disruptions may play a role in the development of symptoms in COVID-19 and highlight the need for ongoing investigation into gut molecular and microbial alterations during the recovery process.
ANALYTICA CHIMICA ACTA
(2021)
Article
Toxicology
Yijia Chen, Weiyi Song, Wei Ge, Ru Yan
Summary: Larval zebrafish, with its mammalian-like metabolic function, has emerged as an ideal model organism for high-throughput screening of drug-induced liver injury and mechanistic study of bioactivation-based DILI.
TOXICOLOGICAL SCIENCES
(2022)
Article
Chemistry, Applied
Huili Hao, Manqin Fu, Ru Yan, Baolin He, Meiying Li, Qiabiao Liu, Yimian Cai, Xiaoyong Zhang, Riming Huang
FOOD AND AGRICULTURAL IMMUNOLOGY
(2019)
Article
Chemistry, Analytical
Zhixiang Yan, Ru Yan
ANALYTICAL CHEMISTRY
(2018)