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Multidisciplinary Sciences
Hasan Ejaz, Sonia Younas, Khalid O. A. Abosalif, Kashaf Junaid, Badr Alzahrani, Abdullah Alsrhani, Abualgasim Elgaili Abdalla, Muhammad Ikram Ullah, Muhammad Usman Qamar, Sanaa S. M. Hamam
Summary: The colonization of ESBL-producing Enterobacteriaceae in animal gut microbiota poses a significant global threat, with a high prevalence of bla(CTX-M), bla(TEM), and bla(SHV) variants among enterobacteria. These genes, along with integrons, contribute to extensive drug resistance in human strains, highlighting the limited therapeutic options available.
Article
Infectious Diseases
Mohamed Belmahdi, Nadia Safia Chenouf, Abdelkrim Ait Belkacem, Sandra Martinez-Alvarez, Mario Sergio Pino-Hurtado, Zahra Benkhechiba, Samiha Lahrech, Ahcene Hakem, Carmen Torres
Summary: This study investigates the antimicrobial resistance and virulence threats of Escherichia coli isolates recovered from intestinal and fecal samples of chickens, turkeys, and sparrows. The study finds that sparrows could be a vector in the dissemination of ESBL-producing E. coli isolates to other environments. Additionally, this study reports the first detection of the bla(CTX-M-14) gene from sparrows at a global level and in turkeys in Algeria.
Article
Infectious Diseases
Selene Rebecca Boncompagni, Maria Micieli, Tiziana Di Maggio, Antonia Mantella, Anna Liz Villagran, Tatiana Briggesth Miranda, Carmen Revollo, Veronica Poma, Herlan Gamboa, Michele Spinicci, Marianne Strohmeyer, Alessandro Bartoloni, Gian Maria Rossolini, Lucia Pallecchi
Summary: This study examined the fecal carriage of CTX-M-producing Enterobacterales in school-aged children from rural areas of the Bolivian Chaco. The results showed a significant increase in the fecal carriage of CTX-M-producing Enterobacterales from 2016 to 2019. The study highlights the importance of understanding the dissemination dynamics of this resistance determinant.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Mingxing Yang, Dong Liu, Xiaoquan Li, Chuting Xiao, Yingge Mao, Jiaqi He, Jiao Feng, Li Wang
Summary: Gram-negative bacteria producing extended-spectrum beta-lactamase (ESBL) are common and pose a significant threat in both community and hospital settings. This study examined a strain of Escherichia coli isolated from a 7-day-old infant's blood in China, which carried multiple ESBL genes and drug resistance plasmids. The findings suggest that these bacteria are highly resistant to antibiotics and capable of maintaining resistance through chromosomal location of the ESBL genes.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Francesca Leoni, Luca Sacchini, Silvia Pieralisi, Gabriele Angelico, Chiara Francesca Magistrali, Lucilla Cucco, Francesca Romana Massacci, Elisa Albini, Anna Duranti, Cesare Camma, Barbara Secondini, Antonio Rinaldi, Francesca Barchiesi
Summary: This study investigated the occurrence of ESBL-producing E. coli in clams collected from the Central Adriatic Sea. The results showed that approximately 3% of the samples contained ESBL-producing E. coli, with the majority of the isolates being multidrug-resistant. These findings suggest that E. coli could serve as an indicator organism for ESBL-producing E. coli in bivalves.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Andrew Cameron, Rupinder Mangat, Heba H. Mostafa, Samantha Taffner, Jun Wang, Ghinwa Dumyati, Richard A. Stanton, Jonathan B. Daniels, Davina Campbell, Joseph D. Lutgring, Nicole D. Pecora
Summary: Infections caused by ESBL-producing Escherichia coli are a significant health issue globally, with ST131 being the predominant clonal type. Besides bla(CTX-M-15), other ESBL variants may also be prevalent in certain regions. The identification of ST38 ESBL-producing E. coli in different regions of the United States, carrying bla(CTX-M-27) on distinct plasmid types, suggests the potential emergence of new ESBL lineages.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Amel Mhaya, Rahma Trabelsi, Sabine Aillerie, Fatima M'Zali, Dominique Begu, Slim Tounsi, Radhouane Gdoura, Corinne Arpin
Summary: Multiple ESBL-producing strains were identified in Tunisian patients, including two emerging virulent clones, ST131-C2 and ST131-C1-M27, which were found to be prevalent in both community and hospital settings.
Article
Microbiology
Ke Ma, Zhiyong Zong
Summary: This study investigated the mechanism of aztreonam-avibactam resistance in a carbapenem-resistant clinical strain of Escherichia coli. The results showed that E. coli strains with the YRIK insertion in PBP3, and producing CTX-M-15 or CTX-M-199 enzymes, were resistant to aztreonam-avibactam.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Zhen-Yu Wang, Yue Jiang, Yi-Qiao Shao, Heng-Fan Lu, Meng-Jun Lu, Xinan Jiao, Jing Wang, Qiu-Chun Li
Summary: This study investigates the prevalence and dissemination mechanism of ESBL-producing E. coli from healthy individuals in a community in Yangzhou, China. The study found nasal colonization of CTX-M-55-producing E. coli strains among healthy individuals in the community, indicating a potential risk of antimicrobial resistance dissemination through close contact or environmental transmission.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Mabel Kamweli Aworh, Eme Ekeng, Pernille Nilsson, Beverly Egyir, Christian Owusu-Nyantakyi, Rene S. Hendriksen
Summary: This study investigated the zoonotic transmission of extended-spectrum beta-lactamase-producing E. coli (ESBL-EC) among humans, beef cattle, and abattoir environments in Nigeria. The study found a high prevalence of ESBL-EC in beef cattle and abattoir workers, highlighting the importance of genomic surveillance and raising awareness among healthcare workers.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Khuliso Ramaite, Mutshiene Deogratias Ekwanzala, Maggy Ndombo Benteke Momba
Summary: ESBL-producing STEC from a cattle farm can contaminate the water environment, posing a potential threat to public health. The study highlighted the importance of continuous surveillance and control measures to prevent STEC-related illnesses originating from livestock environments.
Article
Microbiology
Shihan Zeng, Jiajun Luo, Xiaoyan Li, Chao Zhuo, Aiwu Wu, Xiankai Chen, LiShao Huang
Summary: The CTX-M-55 extended-spectrum beta-lactamase (ESBL)-positive rate has been increasing in recent years, showing resistance to ceftriaxone but sensitivity to ceftazidime, cefepime, and carbapenems among isolates with bla(CTX-M-55) gene. ST1193 is a common clone strain found carrying the bla(CTX-M-55) gene. The plasmids IncI1 and IncFII, along with mobile elements like ISEcp1 and IS26, may play a key role in the dissemination of CTX-M-55 genotypes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Yan Zhang, Yin-Huan Sun, Jiang-Yang Wang, Man-Xia Chang, Qiu-Yun Zhao, Hong-Xia Jiang
Summary: The study elucidated the prevalence of bla(CTX-M-27)-producing Escherichia coli and transmission mechanisms in swine farms in China. The main mechanism of transmission was through plasmids, with a novel structure identified that increased the stability of the bla(CTX-M-27) gene. Over time, the predominant vehicle for bla(CTX-M-27) transmission has diversified.
Article
Microbiology
Jin-Tao Yang, Li-Juan Zhang, Yang Lu, Rong-Min Zhang, Hong-Xia Jiang
Summary: CTX-M-55 was first discovered in Thailand in 2004 and has become the most common subtype of CTX-M enzyme in animal-origin E. coli in China. The widespread dissemination of bla(CTX-M-55)-positive E. coli poses a growing public health problem. This study constructed a global genomic data set of bla(CTX-M-55)-positive E. coli and explored its epidemiology and potential impact using high-resolution bioinformatics methods.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Celia Leao, Lurdes Clemente, Laura Moura, Anne Mette Seyfarth, Inge M. Hansen, Rene S. Hendriksen, Ana Amaro
Summary: The study identified CTX-M-65-producing E. coli strains in food products of animal origin in Portugal. These strains share identical genetic environment, resistance genes, and plasmids, indicating possible common origins and transmission routes.
FRONTIERS IN MICROBIOLOGY
(2021)