Article
Environmental Sciences
Yan Lv, Liming Chang, Jiongyu Liu, Qiheng Chen, Jianping Jiang, Wei Zhu
Summary: The impacts of lead/Pb2+ on ecosystems have been widely studied. While lead compounds are known to suppress growth in aquatic animals, some studies have reported growth-promoting effects. These complex outcomes can be explained by the presence of accompanying anions or multiple toxic mechanisms/pathways. In this study, researchers examined how Bufo gargarizans tadpoles responded to lead exposure using transcriptomics and microbiomics. The results showed that lead exposure delayed development but increased somatic growth in a dose-dependent manner, which was attributed to the effects of NO3- and Pb2+ ions. Transcriptomics revealed that NO3- downregulated the MAPK pathway, explaining the development-suppressing effect, while Pb2+ upregulated detoxification pathways, indicating cellular stress and contradicting the growth advantage. Furthermore, lead exposure significantly altered the gut microbiota, leading to improved food utilization efficiency and increased allocation of nutrients to the host, explaining the growth advantage observed in the lead-exposed tadpoles. Overall, this study highlights the multiple toxic pathways of lead and the role of gut microbiota in mediating pollution outcomes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Microbiology
Esther Ndungo, Johanna B. Holm, Syze Gama, Andrea G. Buchwald, Sharon M. Tennant, Miriam K. Laufer, Marcela F. Pasetti, David A. Rasko
Summary: Shigella continues to be a major contributor to diarrheal illness and dysentery in children under 5 in low- and middle-income countries. This study explored the impact of Shigella infection on the developing gastrointestinal microbiome in infants and found temporal changes in the microbiota associated with the infection. These findings highlight the need for further research on the microbial communities associated with disease susceptibility and resolution.
Article
Microbiology
Raj Kalkeri, Kevin Walters, William Van der Pol, Braden C. McFarland, Nathan Fisher, Fusataka Koide, Casey D. Morrow, Vijay K. Singh
Summary: The study reveals substantial alterations in the gut microbiome of nonhuman primates following high-dose radiation exposure, with significant differences in microbiome composition after irradiation compared to baseline. Animals experiencing diarrhea post-irradiation showed specific changes in microbiome composition which may be associated with differential susceptibility to radiation-induced diarrhea.
Article
Ophthalmology
Shalem Raj Padakandla, Taraprasad Das, Gumpili Sai Prashanthi, Kiran Kumar Angadi, S. Sreenivasa Reddy, G. Bhanuprakash Reddy, Sisinthy Shivaji
Summary: The gut bacterial microbiome of diabetic rats with retinal changes showed dysbiosis compared to control rats at phylum and genus levels. This study could potentially lead to the development of novel therapeutics for diabetic individuals with retinal changes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Fisheries
Olga Burtseva, Anna Kublanovskaya, Tatiana Fedorenko, Elena Lobakova, Konstantin Chekanov
Summary: This study revealed the previously undescribed bacterial diversity in the White Sea fish gut microbiota using 16S rRNA metabarcoding, showing specific patterns of bacteria common in the water of this region.
Article
Biotechnology & Applied Microbiology
Ping Li, Jiyang Jiang, Yifei Li, Yue Lan, Fan Yang, Jiao Wang, Yuxin Xie, Fei Xiong, Jinhui Wu, Hanmin Liu, Zhenxin Fan
Summary: The study observed significant differences in the gut microbiome of obese children compared to controls, with the bacterial pathogen Campylobacter rectus significantly more abundant in obese children. Functional annotation of microbial genes indicated the presence of gut inflammation in obese children, while the gut microbiomes of overweight children were in a transitional state between obese and control children. Additionally, Trichuris trichiura was found to be significantly more abundant in the guts of obese Mexican children compared to obese Chinese children, highlighting differences in gut microbial composition between populations.
Review
Immunology
Walid Ghazi Al Hakeem, Keila Acevedo Y. Villanueva, Ramesh K. Selvaraj
Summary: The gut contains millions of different bacterial species, which coexist with the host in a symbiotic relationship. These gut bacteria have a significant impact on the host's metabolism, nutrition, physiology, and immune functions. Understanding the interaction between commensal bacteria and pathogens like Campylobacter jejuni is crucial for reducing pathogen load in broiler chickens.
Review
Endocrinology & Metabolism
Stacyann Bailey, Keith Fraser
Summary: The gut microbiome's microbial diversity is related to osteoporosis, primarily mediated by microbiome-derived metabolites and signaling molecules. Perturbations in the gut microbiome caused by chronic diseases can alter bacterial diversity and metabolic profiles, impacting bone mineralization and density.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Elena Biagi, Margherita Musella, Giorgia Palladino, Valeria Angelini, Sauro Pari, Chiara Roncari, Daniel Scicchitano, Simone Rampelli, Silvia Franzellitti, Marco Candela
Summary: The study found that almost all fecal samples from rescued sea turtles in the Northwestern Adriatic Sea between 2017 and 2019 contained plastic debris (PD), reflecting high levels of plastic pollution in the area. Higher plastic contamination was associated with putative marine pathogens, indicating that PD can transport environmental pathogenic bacteria into marine organisms. Sea turtles play a crucial role as flagship species for plastic pollution in the marine environment and the ingestion of PD may have potential impacts on the microbial community of large marine organisms, affecting animal and ecosystem health.
FRONTIERS IN MARINE SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ruxandra Florentina Ionescu, Robert Mihai Enache, Sanda Maria Cretoiu, Bogdan Severus Gaspar
Summary: This article summarizes the recent findings on the correlation between gestational diabetes mellitus (GDM) and dysbiosis, as well as the prevention and treatment methods. The most common changes in the microbiome of GDM patients are an increase in Firmicutes phylum or a decrease in Bacteroidetes and Actinobacteria phyla. Gut dysbiosis persists postpartum and affects the development of newborns. Probiotic supplementation and regular physical activity have strong evidence in controlling blood glucose levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Prince P. Mathai, Muruleedhara N. Byappanahalli, Nicholas S. Johnson, Michael J. Sadowsky
Summary: The gut bacterial communities associated with sea lamprey differ significantly among its larval, parasitic juvenile, and adult life stages, with a notable shift in bacterial community structure and reduction in alpha diversity from larval to parasitic juvenile stage. Different phyla are enriched at different life stages, indicating a dynamic change in the gut microbiota composition throughout the lamprey's life cycle.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Maik Pietzner, Kathrin Budde, Malte Ruehlemann, Henry Voelzke, Georg Homuth, Frank U. Weiss, Markus M. Lerch, Fabian Frost
Summary: Exocrine pancreatic function is associated with changes in gut microbiota composition and blood metabolites, with a significant portion of the effect mediated through gut microbiota abundance changes, particularly affecting circulating serotonin and lysophosphatidylcholines.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Tommi Vatanen, Qi Yan Ang, Lea Siegwald, Shafiqul Alam Sarker, Caroline Le Roy, Stephane Duboux, Omar Delannoy-Bruno, Catherine Ngom-Bru, Claire L. Boulange, Martin Strazar, Julian Avila-Pacheco, Amy Deik, Kerry Pierce, Kevin Bullock, Courtney Dennis, Shamima Sultana, Sharika Sayed, Mahbubar Rahman, Tahmeed Ahmed, Monica Modesto, Paola Mattarelli, Clary B. Clish, Hera Vlamakis, Damian R. Plichta, Olga Sakwinska, Ramnik J. Xavier
Summary: This study investigated the gut microbiome and metabolome of 222 young children in Dhaka, Bangladesh during the first two years of life. It found that a specific Bifidobacterium longum clade expanded after the introduction of solid foods and had enzymes for utilizing both breast milk and solid food substrates. The clade was prevalent in Bangladesh, present globally (at lower prevalence), and correlated with other gut taxa and metabolites, indicating its important role in gut ecology.
Article
Gastroenterology & Hepatology
Min-Jung Lee, Yoon Mee Park, Byunghyun Kim, In Hwan Tae, Nam-Eun Kim, Marina Pranata, Taewon Kim, Sungho Won, Nam Joo Kang, Yun Kyung Lee, Dong-Woo Lee, Myung Hee Nam, Soo-Jong Hong, Bong-Soo Kim
Summary: The gut microbiome plays a role in the development of allergic diseases, specifically atopic dermatitis (AD), during early childhood. This study found that the development of the gut microbiome is disrupted in AD patients, leading to abnormal production of short-chain fatty acids and increased IgE levels. The deficiency of butyrate, a type of short-chain fatty acid, was identified as a potential factor affecting the gut microbiome and disturbing the balance between the microbiome and the host.
Article
Clinical Neurology
Xiaoxiao Fan, Tianzi Zang, Jun Liu, Jiamiao Dai, Jinbing Bai, Yanqun Liu
Summary: This study used a longitudinal cohort to investigate the associations between changes in gut microbiome and temperament in toddlers in the first two years of life. The results confirmed the associations between changes in gut microbiome diversity and composition in the first two years of life and toddlers' temperament.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Kari Dunfield, Christopher Yost
CANADIAN JOURNAL OF MICROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
David F. Nieuwenhuijse, Bas B. Oude Munnink, My V. T. Phan, Patrick Munk, Shweta Venkatakrishnan, Frank M. Aarestrup, Matthew Cotten, Marion P. G. Koopmans, Rene S. Hendriksen, Artan Bego, Catherine Rees, Elizabeth Heather Neilson, Kris Coventry, Peter Collignon, Franz Allerberger, Teddie O. Rahube, Guilherme Oliveira, Ivan Ivanov, Thet Sopheak, Yith Vuthy, Christopher K. Yost, Djim-adjim Tabo, Sara Cuadros-Orellana, Changwen Ke, Huanying Zheng, Li Baisheng, Xiaoyang Jiao, Pilar Donado-Godoy, Kalpy Julien Coulibaly, Jasna Hrenovic, Matijana Jergovic, Renata Karpiskova, Bodil Elsborg, Mengistu Legesse, Tadesse Eguale, Annamari Heikinheimo, Jose Eduardo Villacis, Bakary Sanneh, Lile Malania, Andreas Nitsche, Annika Brinkmann, Courage Kosi Setsoafa Saba, Bela Kocsis, Norbert Solymosi, Thorunn R. Thorsteinsdottir, Abdulla Mohamed Hatha, Masoud Alebouyeh, Dearbhaile Morris, Louise O'Connor, Martin Cormican, Jacob Moran-Gilad, Antonio Battisti, Patricia Alba, Zeinegul Shakenova, Ciira Kiiyukia, Eric Ng'eno, Lul Raka, Aivars Berzins, Jelena Avsejenko, Vadims Bartkevics, Christian Penny, Heraa Rajandas, Sivachandran Parimannan, Malcolm Vella Haber, Pushkar Pal, Heike Schmitt, Mark van Passel, Milou G. M. van de Schans, Tina Zuidema, Gert-Jan Jeunen, Neil Gemmell, Kayode Fashae, Astrid Louise Wester, Rune Holmstad, Rumina Hasan, Sadia Shakoor, Maria Luz Zamudio Rojas, Dariusz Wasyl, Golubinka Bosevska, Mihail Kochubovski, Cojocaru Radu, Amy Gassama, Vladimir Radosavljevic, Moon Y. F. Tay, Rogelio Zuniga-Montanez, Stefan Wuertz, Dagmar Gavacova, Marija Trkov, Karen Keddy, Kerneels Esterhuyse, Marta Cerda-Cuellar, Sujatha Pathirage, D. G. Joakim Larsson, Leif Norrgren, Stefan Orn, Tanja Van der Heijden, Happiness Houka Kumburu, Ana Maria de RodaHusman, Berthe-Marie Njanpop-Lafourcade, Pawou Bidjada, Somtinda Christelle Nikiema-Pessinaba, Belkis Levent, John Scott Meschke, Nicola Koren Beck, Chinh Van Dang, Doan Minh Nguyen Tran, Nguyen Do Phuc, Geofrey Kwenda
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
K. M. Damitha Gunathilake, Anupama P. Halmillawewa, Keith D. MacKenzie, Benjamin J. Perry, Christopher K. Yost, Michael F. Hynes
Summary: Mesorhizobium phage vB_MloS_Cp1R7A-A1 is a novel B3 morphotype virus with a distinct prolate capsid, containing 238 predicted genes in its genome. The gene arrangement shows a partially modular organization, and the replication module may use a recombination-based mechanism similar to Enterobacteria phage T5.
CANADIAN JOURNAL OF MICROBIOLOGY
(2021)
Review
Environmental Sciences
Jennifer N. Russell, Christopher K. Yost
Summary: The prevalence of antibiotic resistance in the environment is a critical public health concern, particularly in wastewater treatment environments. Many currently proposed methods for removing antibiotics from wastewater are unsafe for environmental use, leading researchers to seek alternative environmentally safe methods to mitigate environmental antibiotic resistance selection.
Article
Environmental Sciences
Jennifer L. Hayward, Yannan Huang, Lisbeth Truelstrup Hansen, Christopher K. Yost, Craig Lake, Rob C. Jamieson
Summary: This study investigated the mechanisms responsible for antimicrobial resistance attenuation in on-site wastewater treatment systems, focusing on lateral flow sand filters. The primary mechanisms identified were degradation and filtration, with attenuation occurring along the entire length of each filter. The results support the use of conservative design guidelines and separation distances for reducing antimicrobial resistance transmission.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Adeyinka O. Ajayi, Benjamin J. Perry, Christopher K. Yost, Rob C. Jamieson, Lisbeth Truelstrup Hansen, Teddie O. Rahube
Summary: The study isolated and sequenced plasmids encoding meropenem resistance from bacterial hosts within Canadian wastewater treatment plants, identifying a multi-resistance plasmid with various antibiotic resistance genes. This discovery could have significant implications for human and veterinary medicine. Extensive research is needed to further understand the fitness trade-offs of plasmids with different types of conjugative transfer and maintenance modules.
CANADIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Environmental Sciences
Jennifer N. Russell, Benjamin J. Perry, Jordyn Bergsveinson, Claire N. Freeman, Claudia Sheedy, Denise Nilsson, Larry Braul, Christopher K. Yost
Summary: Biobeds are agricultural bioremediation tools designed to safely contain and degrade pesticide waste on farms, reducing environmental impacts. A study using metagenomic and metatranscriptomic techniques examined the microbial community in a Canadian biobed system before and after a season of pesticide application, identifying enriched xenobiotic-degrading bacteria and genes. Transcription of these genes was linked to specific bacterial taxa.
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Joshua P. Ramsay, Tahlia R. Bastholm, Callum J. Verdonk, Dinah D. Tambalo, John T. Sullivan, Liam K. Harold, Beatrice A. Panganiban, Elena Colombi, Benjamin J. Perry, William Jowsey, Calum Morris, Michael F. Hynes, Charles S. Bond, Andrew D. S. Cameron, Christopher K. Yost, Clive W. Ronson
Summary: The horizontal transfer of ICEMlSym (R7A) can cause non-symbiotic Mesorhizobium spp. to become nitrogen-fixing legume symbionts. A subpopulation of Mesorhizobium japonicum R7A called R7A* is epigenetically primed for quorum sensing and horizontal transfer, maintained in laboratory culture. The epigenetic maintenance of the R7A* state requires ICEMlSym (R7A)-encoded copies of both qseC and qseC2, forming a stable epigenetic switch that controls qseM transcription and primes a subpopulation of R7A cells for quorum sensing and horizontal transfer.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ashebir T. Godebo, Naomi Marie J. Wee, Christopher K. Yost, Fran L. Walley, James J. Germida
Summary: The effectiveness of biocontrol agents in suppressing aphanomyces root rot was analyzed using a meta-analysis approach, which revealed a high overall effectiveness. Various factors such as application method, biocontrol agent type, and study type were found to have significant impacts on the effectiveness. Soil amendments, seed coating and suspension applications, bacterial and fungal biocontrol agents were associated with positive outcomes for aphanomyces root rot suppression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fabian Rohden, Christopher J. Nelson, Christopher K. Yost, Cody Anderson, Rebecca Moritz, Svenja Vinke, Hans-Joachim Wieden
Summary: This article provides an overview of the Dual Use Research of Concern (DURC) Panel Discussion, organized by Synbio Canada and the Alberta RNA Research and Training Institute (ARRTI), which took place on June 23, 2021. The panel brought together stakeholders from different fields to discuss the challenges and solutions related to DURC. The stakeholders emphasized the need for bottom-up approaches and open communication, while acknowledging the potential risks associated with information hazards.
CANADIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
J. N. Russell, C. K. Yost
Summary: This study found that the use of pesticides in on-farm biobed systems can increase the presence of multidrug, sulphonamide, aminoglycoside, and beta-lactam resistance genes. Furthermore, genes associated with gene mobilization, transposons, and integrases were also enriched.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Supriya Bhat, Heather Maughan, Andrew D. S. Cameron, Christopher K. Yost
Summary: Delftia is a diverse genus of bacteria with ecological versatility and industrial relevance. Phylogenomic comparison of published genomes revealed distinct clades and highlighted the importance of industrially relevant functions in their ecological roles.
MICROBIAL GENOMICS
(2022)
Article
Microbiology
Ashebir T. Godebo, Keith D. MacKenzie, Fran L. Walley, James J. Germida, Christopher K. Yost
Summary: The biocontrol strain Pseudomonas simiae K-Hf-L9 can inhibit Aphanomyces euteiches and suppress root rot in field peas.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2021)
Article
Genetics & Heredity
Danae M. Suchan, Jordyn Bergsveinson, Lori Manzon, Alexa Pierce, Yuriy Kryachko, Darren Korber, Yifang Tan, Dinah D. Tambalo, Nurul H. Khan, Michael Whiting, Christopher K. Yost
MICROBIAL GENOMICS
(2020)
Article
Microbiology
K. M. Damitha Gunathilake, Supriya Bhat, Christopher K. Yost, Michael F. Hynes
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2020)